Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder / Baptiste GANACHAUD in Autism Research, 19-8 (August 2026)  

Public ISBD [article]  inAutism Research > 19-8 (August 2026) . - p.e70328 Titre : Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Baptiste GANACHAUD, Auteur ; María José MENDOZA-LEÓN, Auteur ; Justine MARCHIX, Auteur ; Alonso Fernandez TELLO, Auteur ; Catherine Le Berre SCOUL, Auteur ; Ma Cecilia OPAZO, Auteur ; Michel NEUNLIST, Auteur ; Claudia A. RIEDEL, Auteur ; Martial CAILLAUD, Auteur ; Hélène BOUDIN, Auteur Article en page(s) : p.e70328 Langues : Anglais (eng) Mots-clés : autism  bacterial metabolites  enteric nervous system  enteric neuron  gut-brain axis  microbiota Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction, restricted interests, and repetitive behaviors. In addition to these core behavioral symptoms, gastrointestinal (GI) disorders are frequently reported, ranging from severe constipation to diarrhea. The links between ASD and gut dysfunction are further supported by alterations in gut microbiota composition and in bacteria-derived metabolites. As the intrinsic nervous system of the digestive tract, the enteric nervous system (ENS) plays a central role in gut physiology by exerting neuronal control on several gut functions, including motility. Located at the interface between the gut microbiota and intestinal function, the ENS may play a key role in the GI symptoms associated with ASD, as demonstrated in several mouse models. This review aims to summarize the interconnected alterations of the gut microbiota and the ENS in ASD, with a particular focus on the microbiota-derived mediators that are altered in ASD, among patients and animal models, and that may affect ENS development and function. By highlighting these interactions, this review seeks to provide new insights on the digestive pathophysiology of ASD, which may also contribute to the severity of behavioral symptoms. En ligne : https://doi.org/10.1002/aur.70328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder [texte imprimé] / Baptiste GANACHAUD, Auteur ; María José MENDOZA-LEÓN, Auteur ; Justine MARCHIX, Auteur ; Alonso Fernandez TELLO, Auteur ; Catherine Le Berre SCOUL, Auteur ; Ma Cecilia OPAZO, Auteur ; Michel NEUNLIST, Auteur ; Claudia A. RIEDEL, Auteur ; Martial CAILLAUD, Auteur ; Hélène BOUDIN, Auteur . - p.e70328. Langues : Anglais (eng) in Autism Research > 19-8 (August 2026) . - p.e70328 Mots-clés : autism  bacterial metabolites  enteric nervous system  enteric neuron  gut-brain axis  microbiota Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction, restricted interests, and repetitive behaviors. In addition to these core behavioral symptoms, gastrointestinal (GI) disorders are frequently reported, ranging from severe constipation to diarrhea. The links between ASD and gut dysfunction are further supported by alterations in gut microbiota composition and in bacteria-derived metabolites. As the intrinsic nervous system of the digestive tract, the enteric nervous system (ENS) plays a central role in gut physiology by exerting neuronal control on several gut functions, including motility. Located at the interface between the gut microbiota and intestinal function, the ENS may play a key role in the GI symptoms associated with ASD, as demonstrated in several mouse models. This review aims to summarize the interconnected alterations of the gut microbiota and the ENS in ASD, with a particular focus on the microbiota-derived mediators that are altered in ASD, among patients and animal models, and that may affect ENS development and function. By highlighting these interactions, this review seeks to provide new insights on the digestive pathophysiology of ASD, which may also contribute to the severity of behavioral symptoms. En ligne : https://doi.org/10.1002/aur.70328 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

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