Cognitive Set Shifting Deficits and Their Relationship to Repetitive Behaviors in Autism Spectrum Disorder / Haylie L. MILLER in Journal of Autism and Developmental Disorders, 45-3 (March 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.805-815 Titre : Cognitive Set Shifting Deficits and Their Relationship to Repetitive Behaviors in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Haylie L. MILLER, Auteur ; Michael E. RAGOZZINO, Auteur ; Edwin H. Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur Article en page(s) : p.805-815 Langues : Anglais (eng) Mots-clés : Cognitive flexibility  Insistence on sameness  Repetitive behavior Index. décimale : PER Périodiques Résumé : The neurocognitive impairments associated with restricted and repetitive behaviors (RRBs) in autism spectrum disorder (ASD) are not yet clear. Prior studies indicate that individuals with ASD show reduced cognitive flexibility, which could reflect difficulty shifting from a previously learned response pattern or a failure to maintain a new response set. We examined different error types on a test of set-shifting completed by 60 individuals with ASD and 55 age- and nonverbal IQ-matched controls. Individuals with ASD were able to initially shift sets, but they exhibited difficulty maintaining new response sets. Difficulty with set maintenance was related to increased severity of RRBs. General difficulty maintaining new response sets and a heightened tendency to revert to old preferences may contribute to RRBs. En ligne : http://dx.doi.org/10.1007/s10803-014-2244-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Cognitive Set Shifting Deficits and Their Relationship to Repetitive Behaviors in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Haylie L. MILLER, Auteur ; Michael E. RAGOZZINO, Auteur ; Edwin H. Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur . - p.805-815. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.805-815 Mots-clés : Cognitive flexibility  Insistence on sameness  Repetitive behavior Index. décimale : PER Périodiques Résumé : The neurocognitive impairments associated with restricted and repetitive behaviors (RRBs) in autism spectrum disorder (ASD) are not yet clear. Prior studies indicate that individuals with ASD show reduced cognitive flexibility, which could reflect difficulty shifting from a previously learned response pattern or a failure to maintain a new response set. We examined different error types on a test of set-shifting completed by 60 individuals with ASD and 55 age- and nonverbal IQ-matched controls. Individuals with ASD were able to initially shift sets, but they exhibited difficulty maintaining new response sets. Difficulty with set maintenance was related to increased severity of RRBs. General difficulty maintaining new response sets and a heightened tendency to revert to old preferences may contribute to RRBs. En ligne : http://dx.doi.org/10.1007/s10803-014-2244-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Commentary: Making the brain matter in assessing and treating adolescent substance use – a commentary on Conrod and Nikolaou (2016) / Matthew W. MOSCONI in Journal of Child Psychology and Psychiatry, 57-3 (March 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.395-397 Titre : Commentary: Making the brain matter in assessing and treating adolescent substance use – a commentary on Conrod and Nikolaou (2016) Type de document : Texte imprimé et/ou numérique Auteurs : Matthew W. MOSCONI, Auteur ; Carl W. LEJUEZ, Auteur Article en page(s) : p.395-397 Langues : Anglais (eng) Mots-clés : Substance use Index. décimale : PER Périodiques Résumé : Adolescence represents a period of vulnerability to psychiatric problems due to a range of factors, including advances in social and cognitive abilities, increased levels of autonomy in decision-making and behavioral governance, and greater exposure to opportunities for risk-taking behavior. Adding to these psychological and social challenges, adolescence also is marked by robust maturational changes affecting both the microcircuitry and connectivity between widely distributed brain systems. These changes alter the communication among parallel, distributed brain networks, have implications for one's vulnerability to engage in risk behavior and make the brain particularly susceptible to external perturbations, such as exposure to neurotoxic substances. En ligne : http://dx.doi.org/10.1111/jcpp.12532 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Commentary: Making the brain matter in assessing and treating adolescent substance use – a commentary on Conrod and Nikolaou (2016) [Texte imprimé et/ou numérique] / Matthew W. MOSCONI, Auteur ; Carl W. LEJUEZ, Auteur . - p.395-397. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.395-397 Mots-clés : Substance use Index. décimale : PER Périodiques Résumé : Adolescence represents a period of vulnerability to psychiatric problems due to a range of factors, including advances in social and cognitive abilities, increased levels of autonomy in decision-making and behavioral governance, and greater exposure to opportunities for risk-taking behavior. Adding to these psychological and social challenges, adolescence also is marked by robust maturational changes affecting both the microcircuitry and connectivity between widely distributed brain systems. These changes alter the communication among parallel, distributed brain networks, have implications for one's vulnerability to engage in risk behavior and make the brain particularly susceptible to external perturbations, such as exposure to neurotoxic substances. En ligne : http://dx.doi.org/10.1111/jcpp.12532 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Motor Functioning and Dyspraxia in Autism Spectrum Disorders / Matthew W. MOSCONI

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Motor Functioning and Dyspraxia in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Matthew W. MOSCONI, Auteur ; Yukari TAKARAE, Auteur ; John A. SWEENEY, Auteur Année de publication : 2011 Importance : p.355-380 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL Motor Functioning and Dyspraxia in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Matthew W. MOSCONI, Auteur ; Yukari TAKARAE, Auteur ; John A. SWEENEY, Auteur . - 2011 . - p.355-380. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

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Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem / Lauren M. SCHMITT in Molecular Autism, (September 2014)  

Public ISBD [article]  inMolecular Autism > (September 2014) . - p.1-13 Titre : Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem Type de document : Texte imprimé et/ou numérique Auteurs : Lauren M. SCHMITT, Auteur ; Edwin H. Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur Article en page(s) : p.1-13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) show atypical scan paths during social interaction and when viewing faces, and recent evidence suggests that they also show abnormal saccadic eye movement dynamics and accuracy when viewing less complex and non-social stimuli. Eye movements are a uniquely promising target for studies of ASD as their spatial and temporal characteristics can be measured precisely and the brain circuits supporting them are well-defined. Control of saccade metrics is supported by discrete circuits within the cerebellum and brainstem - two brain regions implicated in magnetic resonance (MR) morphometry and histopathological studies of ASD. The functional integrity of these distinct brain systems can be examined by evaluating different parameters of visually-guided saccades. En ligne : http://dx.doi.org/10.1186/2040-2392-5-47 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276 [article] Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem [Texte imprimé et/ou numérique] / Lauren M. SCHMITT, Auteur ; Edwin H. Jr COOK, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur . - p.1-13. Langues : Anglais (eng) in Molecular Autism > (September 2014) . - p.1-13 Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) show atypical scan paths during social interaction and when viewing faces, and recent evidence suggests that they also show abnormal saccadic eye movement dynamics and accuracy when viewing less complex and non-social stimuli. Eye movements are a uniquely promising target for studies of ASD as their spatial and temporal characteristics can be measured precisely and the brain circuits supporting them are well-defined. Control of saccade metrics is supported by discrete circuits within the cerebellum and brainstem - two brain regions implicated in magnetic resonance (MR) morphometry and histopathological studies of ASD. The functional integrity of these distinct brain systems can be examined by evaluating different parameters of visually-guided saccades. En ligne : http://dx.doi.org/10.1186/2040-2392-5-47 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=276

Sensorimotor Behavior in Individuals With Autism Spectrum Disorder and Their Unaffected Biological Parents / Erin K. BOJANEK in Autism Research, 18-3 (March 2025)  

Public ISBD [article]  inAutism Research > 18-3 (March 2025) . - p.498-514 Titre : Sensorimotor Behavior in Individuals With Autism Spectrum Disorder and Their Unaffected Biological Parents Type de document : Texte imprimé et/ou numérique Auteurs : Erin K. BOJANEK, Auteur ; Shannon E. KELLY, Auteur ; Lauren M. SCHMITT, Auteur ; Stormi L. PULVER, Auteur ; John A. SWEENEY, Auteur ; Andreas SPRENGER, Auteur ; Kathryn E. UNRUH, Auteur ; Matthew W. MOSCONI, Auteur Article en page(s) : p.498-514 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  broader autism phenotype  endophenotype  familiality  heritable likelihood   sensorimotor Index. décimale : PER Périodiques Résumé : ABSTRACT Sensorimotor impairments are common in autism spectrum disorder (ASD) and evident in unaffected first-degree relatives, suggesting that they may serve as endophenotypes associated with inherited autism likelihood. We tested the familiality of sensorimotor impairments in autism across multiple motor behaviors and effector systems and in relation to parental broader autism phenotypic (BAP) characteristics. Fifty-seven autistic individuals (probands), 109 parents, and 89 neurotypical control participants completed tests of manual motor and oculomotor control. Sensorimotor tests varied in their involvement of rapid, feedforward control and sustained, sensory feedback control processes. Subgroup analyses compared families with at least one parent showing BAP traits (BAP+) and those in which neither parent showed BAP traits (BAP?). Results show that probands with BAP? parents (BAP? probands) showed atypical control of rapid oculomotor behaviors, while BAP+ probands showed impairments of sustained manual motor and oculomotor behaviors compared to controls. BAP? parents showed impaired rapid oculomotor and sustained manual motor abilities relative to BAP+ parents and controls. Rapid oculomotor behaviors were highly intercorrelated among probands and their biological parents. These findings indicate that rapid oculomotor behaviors are selectively impacted in BAP? probands and their parents and may reflect a familial likelihood for autism independent of parental autistic traits. In contrast, sustained sensorimotor behaviors were affected in BAP+ probands and BAP? parents, suggesting separate familial pathways associated with autism. Finally, atypical saccade dynamics may serve as strong endophenotypes for autism. These findings provide new evidence that rapid and sustained sensorimotor alterations represent strong but separate familial pathways of inherited likelihood for autism. En ligne : https://doi.org/10.1002/aur.70000 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550 [article] Sensorimotor Behavior in Individuals With Autism Spectrum Disorder and Their Unaffected Biological Parents [Texte imprimé et/ou numérique] / Erin K. BOJANEK, Auteur ; Shannon E. KELLY, Auteur ; Lauren M. SCHMITT, Auteur ; Stormi L. PULVER, Auteur ; John A. SWEENEY, Auteur ; Andreas SPRENGER, Auteur ; Kathryn E. UNRUH, Auteur ; Matthew W. MOSCONI, Auteur . - p.498-514. Langues : Anglais (eng) in Autism Research > 18-3 (March 2025) . - p.498-514 Mots-clés : autism spectrum disorder  broader autism phenotype  endophenotype  familiality  heritable likelihood   sensorimotor Index. décimale : PER Périodiques Résumé : ABSTRACT Sensorimotor impairments are common in autism spectrum disorder (ASD) and evident in unaffected first-degree relatives, suggesting that they may serve as endophenotypes associated with inherited autism likelihood. We tested the familiality of sensorimotor impairments in autism across multiple motor behaviors and effector systems and in relation to parental broader autism phenotypic (BAP) characteristics. Fifty-seven autistic individuals (probands), 109 parents, and 89 neurotypical control participants completed tests of manual motor and oculomotor control. Sensorimotor tests varied in their involvement of rapid, feedforward control and sustained, sensory feedback control processes. Subgroup analyses compared families with at least one parent showing BAP traits (BAP+) and those in which neither parent showed BAP traits (BAP?). Results show that probands with BAP? parents (BAP? probands) showed atypical control of rapid oculomotor behaviors, while BAP+ probands showed impairments of sustained manual motor and oculomotor behaviors compared to controls. BAP? parents showed impaired rapid oculomotor and sustained manual motor abilities relative to BAP+ parents and controls. Rapid oculomotor behaviors were highly intercorrelated among probands and their biological parents. These findings indicate that rapid oculomotor behaviors are selectively impacted in BAP? probands and their parents and may reflect a familial likelihood for autism independent of parental autistic traits. In contrast, sustained sensorimotor behaviors were affected in BAP+ probands and BAP? parents, suggesting separate familial pathways associated with autism. Finally, atypical saccade dynamics may serve as strong endophenotypes for autism. These findings provide new evidence that rapid and sustained sensorimotor alterations represent strong but separate familial pathways of inherited likelihood for autism. En ligne : https://doi.org/10.1002/aur.70000 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550

The Social Orienting Continuum and Response Scale (SOC-RS): A Dimensional Measure for Preschool-aged Children / Matthew W. MOSCONI in Journal of Autism and Developmental Disorders, 39-2 (February 2009)  

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