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Auteur Richard DELORME |
Documents disponibles écrits par cet auteur (22)
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Particularités sémiologiques des troubles du spectre autistique durant l’enfance / Valérie VANTALON
Titre : Particularités sémiologiques des troubles du spectre autistique durant l’enfance Type de document : Texte imprimé et/ou numérique Auteurs : Valérie VANTALON, Auteur ; Richard DELORME, Auteur Année de publication : 2023 Importance : p.44-55 Langues : Français (fre) Index. décimale : AUT-A AUT-A - L'Autisme - Pour Démarrer Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=516 Particularités sémiologiques des troubles du spectre autistique durant l’enfance [Texte imprimé et/ou numérique] / Valérie VANTALON, Auteur ; Richard DELORME, Auteur . - 2023 . - p.44-55.
Langues : Français (fre)
Index. décimale : AUT-A AUT-A - L'Autisme - Pour Démarrer Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=516 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Preserved navigation abilities and spatio-temporal memory in individuals with autism spectrum disorder / Nathan NEU ; Aurélie WATILLIAUX ; Axelle MARTINEZ-TERUEL ; Mihoby RAZAFINIMANANA ; Jennifer BOISGONTIER ; Sevan HOTIER ; Marc-Antoine D'ALBIS ; Richard DELORME ; Anouck AMESTOY ; Å tefan HOLIGA ; Myriam Ly-Le MOAL ; Pierrick COUPÃ ; Marion LEBOYER ; Josselin HOUENOU ; Laure RONDI-REIG ; Anne-Lise PARADIS in Autism Research, 16-2 (February 2023)
[article]
Titre : Preserved navigation abilities and spatio-temporal memory in individuals with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nathan NEU, Auteur ; Aurélie WATILLIAUX, Auteur ; Axelle MARTINEZ-TERUEL, Auteur ; Mihoby RAZAFINIMANANA, Auteur ; Jennifer BOISGONTIER, Auteur ; Sevan HOTIER, Auteur ; Marc-Antoine D'ALBIS, Auteur ; Richard DELORME, Auteur ; Anouck AMESTOY, Auteur ; Å tefan HOLIGA, Auteur ; Myriam Ly-Le MOAL, Auteur ; Pierrick COUPÃ, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur ; Laure RONDI-REIG, Auteur ; Anne-Lise PARADIS, Auteur Article en page(s) : p.280-293 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Cerebellar abnormalities have been reported in autism spectrum disorder (ASD). Beyond its role in hallmark features of ASD, the cerebellum and its connectivity with forebrain structures also play a role in navigation. However, the current understanding of navigation abilities in ASD is equivocal, as is the impact of the disorder on the functional anatomy of the cerebellum. In the present study, we investigated the navigation behavior of a population of ASD and typically developing (TD) adults related to their brain anatomy as assessed by structural and functional MRI at rest. We used the Starmaze task, which permits assessing and distinguishing two complex navigation behaviors, one based on allocentric learning and the other on egocentric learning of a route with multiple decision points. Compared to TD controls, individuals with ASD showed similar exploration, learning, and strategy performance and preference. In addition, there was no difference in the structural or functional anatomy of the cerebellar circuits involved in navigation between the two groups. The findings of our work suggest that navigation abilities, spatio-temporal memory, and their underlying circuits are preserved in individuals with ASD. En ligne : https://doi.org/10.1002/aur.2865 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495
in Autism Research > 16-2 (February 2023) . - p.280-293[article] Preserved navigation abilities and spatio-temporal memory in individuals with autism spectrum disorder [Texte imprimé et/ou numérique] / Nathan NEU, Auteur ; Aurélie WATILLIAUX, Auteur ; Axelle MARTINEZ-TERUEL, Auteur ; Mihoby RAZAFINIMANANA, Auteur ; Jennifer BOISGONTIER, Auteur ; Sevan HOTIER, Auteur ; Marc-Antoine D'ALBIS, Auteur ; Richard DELORME, Auteur ; Anouck AMESTOY, Auteur ; Å tefan HOLIGA, Auteur ; Myriam Ly-Le MOAL, Auteur ; Pierrick COUPÃ, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur ; Laure RONDI-REIG, Auteur ; Anne-Lise PARADIS, Auteur . - p.280-293.
Langues : Anglais (eng)
in Autism Research > 16-2 (February 2023) . - p.280-293
Index. décimale : PER Périodiques Résumé : Abstract Cerebellar abnormalities have been reported in autism spectrum disorder (ASD). Beyond its role in hallmark features of ASD, the cerebellum and its connectivity with forebrain structures also play a role in navigation. However, the current understanding of navigation abilities in ASD is equivocal, as is the impact of the disorder on the functional anatomy of the cerebellum. In the present study, we investigated the navigation behavior of a population of ASD and typically developing (TD) adults related to their brain anatomy as assessed by structural and functional MRI at rest. We used the Starmaze task, which permits assessing and distinguishing two complex navigation behaviors, one based on allocentric learning and the other on egocentric learning of a route with multiple decision points. Compared to TD controls, individuals with ASD showed similar exploration, learning, and strategy performance and preference. In addition, there was no difference in the structural or functional anatomy of the cerebellar circuits involved in navigation between the two groups. The findings of our work suggest that navigation abilities, spatio-temporal memory, and their underlying circuits are preserved in individuals with ASD. En ligne : https://doi.org/10.1002/aur.2865 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495 "Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study / Matias BALTAZAR in Autism Research, 14-2 (February 2021)
[article]
Titre : "Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study Type de document : Texte imprimé et/ou numérique Auteurs : Matias BALTAZAR, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Christopher H. CHATHAM, Auteur ; Manuel P. BOUVARD, Auteur ; Axelle MARTINEZ TERUEL, Auteur ; David MONNET, Auteur ; Isabelle SCHEID, Auteur ; Eleonora MURZI, Auteur ; Sandrine COUFFIN-CADIERGUES, Auteur ; Daniel UMBRICHT, Auteur ; Lorraine MURTAGH, Auteur ; Richard DELORME, Auteur ; Myriam LY LE-MOAL, Auteur ; Marion LEBOYER, Auteur ; Anouck AMESTOY, Auteur Article en page(s) : p.380-388 Langues : Anglais (eng) Mots-clés : Generalized Linear Mixed Model Reading the Mind in the Eyes autism spectrum disorders difficulty valence Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are heterogeneous and complex neurodevelopmental conditions that urgently need reliable and sensitive measures to inform diagnosis properly. The Reading the Mind in the Eyes Task (or Eyes Test from now on) is widely used for this purpose. A recent study showed that subcategories of items of the children version of the Eyes Test could be especially discriminative to distinguish ASD and control children. Here, we analyzed the performance on the Eyes Test of 30 high functioning (IQ?>?70) adults with ASD and 29 controls from the InFoR cohort multicentric study, using a Generalized Linear Mixed Model. We found that valence and difficulty modulate the performance on the Eyes Test, with easy and positive items being the most discriminative to distinguish ASD and controls. In particular, we suggest this result might be actionable to discriminate ASD patients from controls in subgroups where their overall scores show less difference with controls. We propose for future research the computation of two additional indexes when using the Eyes Test: the first focusing on the easy and positive items (applying a threshold of 70% of correct responses for these items, above which people are at very low risk of having ASD) and the second focusing on the performance gain from difficult to easy items (with a progression of less than 15% showing high risk of having ASD). Our findings open the possibility for a major change in how the Eyes Test is used to inform diagnosis in ASD. LAY SUMMARY: The Eyes Test is used worldwide to inform autism spectrum disorders (ASD) diagnosis. We show here that ASD and neurotypical adults show the most difference in performance on subgroups of items: ASD adults do not improve as expected when comparing easy and difficult items, and they do not show an improvement for items displaying a positive feeling. We advise clinicians to focus on these comparisons to increase the property of the test to distinguish people with ASD from neurotypical adults. En ligne : http://dx.doi.org/10.1002/aur.2390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441
in Autism Research > 14-2 (February 2021) . - p.380-388[article] "Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study [Texte imprimé et/ou numérique] / Matias BALTAZAR, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Christopher H. CHATHAM, Auteur ; Manuel P. BOUVARD, Auteur ; Axelle MARTINEZ TERUEL, Auteur ; David MONNET, Auteur ; Isabelle SCHEID, Auteur ; Eleonora MURZI, Auteur ; Sandrine COUFFIN-CADIERGUES, Auteur ; Daniel UMBRICHT, Auteur ; Lorraine MURTAGH, Auteur ; Richard DELORME, Auteur ; Myriam LY LE-MOAL, Auteur ; Marion LEBOYER, Auteur ; Anouck AMESTOY, Auteur . - p.380-388.
Langues : Anglais (eng)
in Autism Research > 14-2 (February 2021) . - p.380-388
Mots-clés : Generalized Linear Mixed Model Reading the Mind in the Eyes autism spectrum disorders difficulty valence Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are heterogeneous and complex neurodevelopmental conditions that urgently need reliable and sensitive measures to inform diagnosis properly. The Reading the Mind in the Eyes Task (or Eyes Test from now on) is widely used for this purpose. A recent study showed that subcategories of items of the children version of the Eyes Test could be especially discriminative to distinguish ASD and control children. Here, we analyzed the performance on the Eyes Test of 30 high functioning (IQ?>?70) adults with ASD and 29 controls from the InFoR cohort multicentric study, using a Generalized Linear Mixed Model. We found that valence and difficulty modulate the performance on the Eyes Test, with easy and positive items being the most discriminative to distinguish ASD and controls. In particular, we suggest this result might be actionable to discriminate ASD patients from controls in subgroups where their overall scores show less difference with controls. We propose for future research the computation of two additional indexes when using the Eyes Test: the first focusing on the easy and positive items (applying a threshold of 70% of correct responses for these items, above which people are at very low risk of having ASD) and the second focusing on the performance gain from difficult to easy items (with a progression of less than 15% showing high risk of having ASD). Our findings open the possibility for a major change in how the Eyes Test is used to inform diagnosis in ASD. LAY SUMMARY: The Eyes Test is used worldwide to inform autism spectrum disorders (ASD) diagnosis. We show here that ASD and neurotypical adults show the most difference in performance on subgroups of items: ASD adults do not improve as expected when comparing easy and difficult items, and they do not show an improvement for items displaying a positive feeling. We advise clinicians to focus on these comparisons to increase the property of the test to distinguish people with ASD from neurotypical adults. En ligne : http://dx.doi.org/10.1002/aur.2390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 Spatial and temporal analysis of postural control in children with high functioning Autism Spectrum Disorder / Nathalie GOULÈME in Research in Autism Spectrum Disorders, 40 (August 2017)
[article]
Titre : Spatial and temporal analysis of postural control in children with high functioning Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nathalie GOULÈME, Auteur ; Isabelle SCHEID, Auteur ; Hugo PEYRE, Auteur ; Anna MARUANI, Auteur ; Julia CLARKE, Auteur ; Richard DELORME, Auteur ; Maria Pia BUCCI, Auteur Article en page(s) : p.13-23 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Children Postural control Wavelet transformation Sensorial inputs Index. décimale : PER Périodiques Résumé : AbstractBackground Children with autism spectrum disorders (ASD) have poor postural stability. The objective of our study was to explore further postural capabilities in ASD children by measuring spatial as well as temporal displacement of the center of pressure using wavelet analysis. Method Thirty children with ASD (12.1 ± 2.9 years) and 30 sex-, age- and IQ-matched typically developing children participated in the study. We recorded postural control using Multitest, also called Balance Quest, Equilibre from Framiral® in three viewing conditions (eyes open, eyes closed and with perturbed vision) and in two postural conditions (stable and unstable). Results Our results show that children with ASD displayed a deficit in postural stability in comparison with typically developing children, especially when sensory inputs are not all available. Conclusion Such poor postural control in children with ASD could be due to both an impairment in using sensorial inputs appropriately and a deficit in the ability to compensate for sensorial changes. En ligne : https://doi.org/10.1016/j.rasd.2017.05.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317
in Research in Autism Spectrum Disorders > 40 (August 2017) . - p.13-23[article] Spatial and temporal analysis of postural control in children with high functioning Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Nathalie GOULÈME, Auteur ; Isabelle SCHEID, Auteur ; Hugo PEYRE, Auteur ; Anna MARUANI, Auteur ; Julia CLARKE, Auteur ; Richard DELORME, Auteur ; Maria Pia BUCCI, Auteur . - p.13-23.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 40 (August 2017) . - p.13-23
Mots-clés : Autism spectrum disorder Children Postural control Wavelet transformation Sensorial inputs Index. décimale : PER Périodiques Résumé : AbstractBackground Children with autism spectrum disorders (ASD) have poor postural stability. The objective of our study was to explore further postural capabilities in ASD children by measuring spatial as well as temporal displacement of the center of pressure using wavelet analysis. Method Thirty children with ASD (12.1 ± 2.9 years) and 30 sex-, age- and IQ-matched typically developing children participated in the study. We recorded postural control using Multitest, also called Balance Quest, Equilibre from Framiral® in three viewing conditions (eyes open, eyes closed and with perturbed vision) and in two postural conditions (stable and unstable). Results Our results show that children with ASD displayed a deficit in postural stability in comparison with typically developing children, especially when sensory inputs are not all available. Conclusion Such poor postural control in children with ASD could be due to both an impairment in using sensorial inputs appropriately and a deficit in the ability to compensate for sensorial changes. En ligne : https://doi.org/10.1016/j.rasd.2017.05.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways / Julian TILLMANN ; Freddy CLIQUET ; Frédérique AMSELLEM ; Anna MARUANI ; Claire LEBLOND ; Anita BEGGIATO ; David GERMANAUD ; Anouck AMESTOY ; Myriam LY-LE MOAL ; Daniel UMBRICHT ; Christopher CHATHAM ; Lorraine MURTAGH ; Manuel BOUVARD ; Marion LEBOYER ; Tony CHARMAN ; Thomas BOURGERON ; Richard DELORME ; Guillaume DUMAS ; EU-AIMS LEAP Group in Autism Research, 16-2 (February 2023)
[article]
Titre : Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways Type de document : Texte imprimé et/ou numérique Auteurs : Julian TILLMANN, Auteur ; Freddy CLIQUET, Auteur ; Frédérique AMSELLEM, Auteur ; Anna MARUANI, Auteur ; Claire LEBLOND, Auteur ; Anita BEGGIATO, Auteur ; David GERMANAUD, Auteur ; Anouck AMESTOY, Auteur ; Myriam LY-LE MOAL, Auteur ; Daniel UMBRICHT, Auteur ; Christopher CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Manuel BOUVARD, Auteur ; Marion LEBOYER, Auteur ; Tony CHARMAN, Auteur ; Thomas BOURGERON, Auteur ; Richard DELORME, Auteur ; Guillaume DUMAS, Auteur ; EU-AIMS LEAP Group, Auteur Article en page(s) : p.364-378 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract As an integral part of autism spectrum symptoms, sensory processing issues including both hypo and hyper sensory sensitivities. These sensory specificities may result from an excitation/inhibition imbalance with a poorly understood of their level of convergence with genetic alterations in GABA-ergic and glutamatergic pathways. In our study, we aimed to characterize the hypo/hyper-sensory profile among autistic individuals. We then explored its link with the burden of deleterious mutations in a subset of individuals with available whole-genome sequencing data. To characterize the hypo/hyper-sensory profile, the differential Short Sensory Profile (dSSP) was defined as a normalized and centralized hypo/hypersensitivity ratio from the Short Sensory Profile (SSP). Including 1136 participants (533 autistic individuals, 210 first-degree relatives, and 267 controls) from two independent study samples (PARIS and LEAP), we observed a statistically significant dSSP mean difference between autistic individuals and controls, driven mostly by a high dSSP variability, with an intermediated profile represented by relatives. Our genetic analysis tended to associate the dSSP and the hyposensitivity with mutations of the GABAergic pathway. The major limitation was the dSSP difficulty to discriminate subjects with a similar quantum of hypo- and hyper-sensory symptoms to those with no such symptoms, resulting both in a similar ratio score of 0. However, the dSSP could be a relevant clinical score, and combined with additional sensory descriptions, genetics and endophenotypic substrates, will improve the exploration of the underlying neurobiological mechanisms of sensory processing differences in autism spectrum. En ligne : https://doi.org/10.1002/aur.2861 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=496
in Autism Research > 16-2 (February 2023) . - p.364-378[article] Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways [Texte imprimé et/ou numérique] / Julian TILLMANN, Auteur ; Freddy CLIQUET, Auteur ; Frédérique AMSELLEM, Auteur ; Anna MARUANI, Auteur ; Claire LEBLOND, Auteur ; Anita BEGGIATO, Auteur ; David GERMANAUD, Auteur ; Anouck AMESTOY, Auteur ; Myriam LY-LE MOAL, Auteur ; Daniel UMBRICHT, Auteur ; Christopher CHATHAM, Auteur ; Lorraine MURTAGH, Auteur ; Manuel BOUVARD, Auteur ; Marion LEBOYER, Auteur ; Tony CHARMAN, Auteur ; Thomas BOURGERON, Auteur ; Richard DELORME, Auteur ; Guillaume DUMAS, Auteur ; EU-AIMS LEAP Group, Auteur . - p.364-378.
Langues : Anglais (eng)
in Autism Research > 16-2 (February 2023) . - p.364-378
Index. décimale : PER Périodiques Résumé : Abstract As an integral part of autism spectrum symptoms, sensory processing issues including both hypo and hyper sensory sensitivities. These sensory specificities may result from an excitation/inhibition imbalance with a poorly understood of their level of convergence with genetic alterations in GABA-ergic and glutamatergic pathways. In our study, we aimed to characterize the hypo/hyper-sensory profile among autistic individuals. We then explored its link with the burden of deleterious mutations in a subset of individuals with available whole-genome sequencing data. To characterize the hypo/hyper-sensory profile, the differential Short Sensory Profile (dSSP) was defined as a normalized and centralized hypo/hypersensitivity ratio from the Short Sensory Profile (SSP). Including 1136 participants (533 autistic individuals, 210 first-degree relatives, and 267 controls) from two independent study samples (PARIS and LEAP), we observed a statistically significant dSSP mean difference between autistic individuals and controls, driven mostly by a high dSSP variability, with an intermediated profile represented by relatives. Our genetic analysis tended to associate the dSSP and the hyposensitivity with mutations of the GABAergic pathway. The major limitation was the dSSP difficulty to discriminate subjects with a similar quantum of hypo- and hyper-sensory symptoms to those with no such symptoms, resulting both in a similar ratio score of 0. However, the dSSP could be a relevant clinical score, and combined with additional sensory descriptions, genetics and endophenotypic substrates, will improve the exploration of the underlying neurobiological mechanisms of sensory processing differences in autism spectrum. En ligne : https://doi.org/10.1002/aur.2861 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=496 Les tics et syndrome de Gilles de la Tourette / Richard DELORME
PermalinkTics et syndrome de Gilles de la Tourette: Symptomatologie clinique et traitement / Richard DELORME
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