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Détail de l'auteur
Auteur Stephen M. LAWRIE |
Documents disponibles écrits par cet auteur (2)
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Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study / Stella W. Y. CHAN in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)
[article]
Titre : Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study Type de document : Texte imprimé et/ou numérique Auteurs : Stella W. Y. CHAN, Auteur ; Jessika E. SUSSMANN, Auteur ; Liana ROMANIUK, Auteur ; Tiffany STEWART, Auteur ; Stephen M. LAWRIE, Auteur ; Jeremy HALL, Auteur ; Andrew M. MCINTOSH, Auteur ; Heather C. WHALLEY, Auteur Article en page(s) : p.1277-1286 Langues : Anglais (eng) Mots-clés : Mood disorder major depressive disorder fMRI anterior cingulate facial recognition familial risk Index. décimale : PER Périodiques Résumé : Background Studies have identified perturbations in facial processing in bipolar disorder and major depressive disorder (MDD), but their relationship to genetic risk and early development of illness is unclear. Methods The Scottish Bipolar Family Study is a prospective longitudinal investigation examining young individuals (age 16–25) at familial risk of mood disorder. Participants underwent functional MRI using an implicit facial processing task employing angry and neutral faces. An explicit facial expression recognition task was completed outside the scanner. Clinical outcomes obtained 2 years after the scan were used to categorise participants into controls (n = 54), high-risk individuals who had developed MDD (HR MDD; n = 30) and high-risk individuals who remained well (HR Well, n = 43). Results All groups demonstrated activation patterns typically observed during facial processing, including activation of the amygdala, hippocampus, fusiform gyrus and middle frontal regions. Notably, the HR MDD group showed reduced activation of the anterior cingulate gyrus versus both the control and HR Well group for angry faces, and versus the HR Well group for neutral faces. Outside the scanner, the HR MDD group was less accurate in recognising fearful expressions than the HR Well group. Conclusions Here, we demonstrate functional abnormalities of the anterior cingulate cortex alongside facial emotional recognition deficits in high-risk individuals in the early stages of depression compared with both controls and at-risk individuals who remained well. These neural changes were associated with a current or future diagnosis of MDD and were not simply associated with increased familial risk. En ligne : http://dx.doi.org/10.1111/jcpp.12591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295
in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1277-1286[article] Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study [Texte imprimé et/ou numérique] / Stella W. Y. CHAN, Auteur ; Jessika E. SUSSMANN, Auteur ; Liana ROMANIUK, Auteur ; Tiffany STEWART, Auteur ; Stephen M. LAWRIE, Auteur ; Jeremy HALL, Auteur ; Andrew M. MCINTOSH, Auteur ; Heather C. WHALLEY, Auteur . - p.1277-1286.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1277-1286
Mots-clés : Mood disorder major depressive disorder fMRI anterior cingulate facial recognition familial risk Index. décimale : PER Périodiques Résumé : Background Studies have identified perturbations in facial processing in bipolar disorder and major depressive disorder (MDD), but their relationship to genetic risk and early development of illness is unclear. Methods The Scottish Bipolar Family Study is a prospective longitudinal investigation examining young individuals (age 16–25) at familial risk of mood disorder. Participants underwent functional MRI using an implicit facial processing task employing angry and neutral faces. An explicit facial expression recognition task was completed outside the scanner. Clinical outcomes obtained 2 years after the scan were used to categorise participants into controls (n = 54), high-risk individuals who had developed MDD (HR MDD; n = 30) and high-risk individuals who remained well (HR Well, n = 43). Results All groups demonstrated activation patterns typically observed during facial processing, including activation of the amygdala, hippocampus, fusiform gyrus and middle frontal regions. Notably, the HR MDD group showed reduced activation of the anterior cingulate gyrus versus both the control and HR Well group for angry faces, and versus the HR Well group for neutral faces. Outside the scanner, the HR MDD group was less accurate in recognising fearful expressions than the HR Well group. Conclusions Here, we demonstrate functional abnormalities of the anterior cingulate cortex alongside facial emotional recognition deficits in high-risk individuals in the early stages of depression compared with both controls and at-risk individuals who remained well. These neural changes were associated with a current or future diagnosis of MDD and were not simply associated with increased familial risk. En ligne : http://dx.doi.org/10.1111/jcpp.12591 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 Lessons learned from running an adult autism diagnostic assessment service for 12 years / Jane NEIL-MACLACHLAN in Good Autism Practice - GAP, 15-2 (October 2014)
[article]
Titre : Lessons learned from running an adult autism diagnostic assessment service for 12 years Type de document : Texte imprimé et/ou numérique Auteurs : Jane NEIL-MACLACHLAN, Auteur ; Joan FLETCHER, Auteur ; David GREGORY, Auteur ; Stephen M. LAWRIE, Auteur Article en page(s) : p.71-78 Index. décimale : PER Périodiques Résumé : Dr Jane Neil-MacLachlan is a Speech and Language Therapist and coordinator of the diagnostic service. Professor Stephen Lawrie is a psychiatrist and together with colleagues they developed the diagnostic service that is the subject of this paper – the Regional Autism Spectrum Disorder Consultancy Service (RASDCS). Joan Fletcher was the clinical governance facilitator and David Gregory, who worked as a volunteer psychology assistant, carried out the evaluation of the care pathway documents in 2013. The study did not receive any research funding and was carried out as part of the NHS remit. In this paper, the authors give details of the referrals made over the 12 year period and consider the issues arising in setting up the service. In addition to making assessments, RASDCS also had a training function in that those making the referrals were invited to observe the assessment to develop their knowledge and skills. The team did not have the capacity to offer post diagnostic support other than identifying needs and suggesting how these might be addressed. There is thus a pressing need to develop services for adults who are newly diagnosed and some areas of Scotland do have services in place which may be expanded into other areas as suggested in the Scottish strategy for autism. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=244
in Good Autism Practice - GAP > 15-2 (October 2014) . - p.71-78[article] Lessons learned from running an adult autism diagnostic assessment service for 12 years [Texte imprimé et/ou numérique] / Jane NEIL-MACLACHLAN, Auteur ; Joan FLETCHER, Auteur ; David GREGORY, Auteur ; Stephen M. LAWRIE, Auteur . - p.71-78.
in Good Autism Practice - GAP > 15-2 (October 2014) . - p.71-78
Index. décimale : PER Périodiques Résumé : Dr Jane Neil-MacLachlan is a Speech and Language Therapist and coordinator of the diagnostic service. Professor Stephen Lawrie is a psychiatrist and together with colleagues they developed the diagnostic service that is the subject of this paper – the Regional Autism Spectrum Disorder Consultancy Service (RASDCS). Joan Fletcher was the clinical governance facilitator and David Gregory, who worked as a volunteer psychology assistant, carried out the evaluation of the care pathway documents in 2013. The study did not receive any research funding and was carried out as part of the NHS remit. In this paper, the authors give details of the referrals made over the 12 year period and consider the issues arising in setting up the service. In addition to making assessments, RASDCS also had a training function in that those making the referrals were invited to observe the assessment to develop their knowledge and skills. The team did not have the capacity to offer post diagnostic support other than identifying needs and suggesting how these might be addressed. There is thus a pressing need to develop services for adults who are newly diagnosed and some areas of Scotland do have services in place which may be expanded into other areas as suggested in the Scottish strategy for autism. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=244