[article]
Titre : |
Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Jason SCHIFFMAN, Auteur ; Vijay MITTAL, Auteur ; Emily KLINE, Auteur ; Erik L. MORTENSEN, Auteur ; Niels MICHELSEN, Auteur ; Morten EKSTRØM, Auteur ; Zachary B. MILLMAN, Auteur ; Sarnoff A. MEDNICK, Auteur ; Holger J. SØRENSEN, Auteur |
Année de publication : |
2015 |
Article en page(s) : |
p.1323-1330 |
Langues : |
Anglais (eng) |
Index. décimale : |
PER Périodiques |
Résumé : |
Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective–psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10–13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective–psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, ?2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective–psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective–psychosis-spectrum disorders. |
En ligne : |
http://dx.doi.org/10.1017/S0954579414001436 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 |
in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1323-1330
[article] Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder [Texte imprimé et/ou numérique] / Jason SCHIFFMAN, Auteur ; Vijay MITTAL, Auteur ; Emily KLINE, Auteur ; Erik L. MORTENSEN, Auteur ; Niels MICHELSEN, Auteur ; Morten EKSTRØM, Auteur ; Zachary B. MILLMAN, Auteur ; Sarnoff A. MEDNICK, Auteur ; Holger J. SØRENSEN, Auteur . - 2015 . - p.1323-1330. Langues : Anglais ( eng) in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1323-1330
Index. décimale : |
PER Périodiques |
Résumé : |
Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective–psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10–13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective–psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, ?2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective–psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective–psychosis-spectrum disorders. |
En ligne : |
http://dx.doi.org/10.1017/S0954579414001436 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 |
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