Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder / Jason SCHIFFMAN in Development and Psychopathology, 27-4 (Part 1) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1323-1330 Titre : Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jason SCHIFFMAN, Auteur ; Vijay MITTAL, Auteur ; Emily KLINE, Auteur ; Erik L. MORTENSEN, Auteur ; Niels MICHELSEN, Auteur ; Morten EKSTRØM, Auteur ; Zachary B. MILLMAN, Auteur ; Sarnoff A. MEDNICK, Auteur ; Holger J. SØRENSEN, Auteur Année de publication : 2015 Article en page(s) : p.1323-1330 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective–psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10–13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective–psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, ?2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective–psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective–psychosis-spectrum disorders. En ligne : http://dx.doi.org/10.1017/S0954579414001436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder [Texte imprimé et/ou numérique] / Jason SCHIFFMAN, Auteur ; Vijay MITTAL, Auteur ; Emily KLINE, Auteur ; Erik L. MORTENSEN, Auteur ; Niels MICHELSEN, Auteur ; Morten EKSTRØM, Auteur ; Zachary B. MILLMAN, Auteur ; Sarnoff A. MEDNICK, Auteur ; Holger J. SØRENSEN, Auteur . - 2015 . - p.1323-1330. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1323-1330 Index. décimale : PER Périodiques Résumé : Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective–psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10–13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective–psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, ?2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective–psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective–psychosis-spectrum disorders. En ligne : http://dx.doi.org/10.1017/S0954579414001436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

In Utero Exposure to Selective Serotonin Reuptake Inhibitors and Risk for Autism Spectrum Disorder / Nicole B. GIDAYA in Journal of Autism and Developmental Disorders, 44-10 (October 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2558-2567 Titre : In Utero Exposure to Selective Serotonin Reuptake Inhibitors and Risk for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nicole B. GIDAYA, Auteur ; Brian K. LEE, Auteur ; Igor BURSTYN, Auteur ; Michael YUDELL, Auteur ; Erik L. MORTENSEN, Auteur ; Craig J. NEWSCHAFFER, Auteur Article en page(s) : p.2558-2567 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Selective serotonin reuptake inhibitors  Pregnancy  Depression Index. décimale : PER Périodiques Résumé : We investigated whether there is an association between increased risk for autism spectrum disorders (ASD) and selective serotonin reuptake inhibitors (SSRIs) used during pregnancy. This study used Denmark’s health and population registers to obtain information regarding prescription drugs, ASD diagnosis, and health and socioeconomic status. There were 1.5 % of cases and 0.7 % of controls exposed to SSRIs during the pregnancy period, and higher effect estimates observed with longer use. We found evidence that in utero exposure to SSRIs increases a child’s risk associated with ASD. These results, while adding to the limited knowledge on prenatal pharmacological exposures as potential ASD risk factors, need to be balanced against the benefits of indicated medication use by pregnant mothers. En ligne : http://dx.doi.org/10.1007/s10803-014-2128-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240 [article] In Utero Exposure to Selective Serotonin Reuptake Inhibitors and Risk for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Nicole B. GIDAYA, Auteur ; Brian K. LEE, Auteur ; Igor BURSTYN, Auteur ; Michael YUDELL, Auteur ; Erik L. MORTENSEN, Auteur ; Craig J. NEWSCHAFFER, Auteur . - p.2558-2567. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2558-2567 Mots-clés : Autism spectrum disorders  Selective serotonin reuptake inhibitors  Pregnancy  Depression Index. décimale : PER Périodiques Résumé : We investigated whether there is an association between increased risk for autism spectrum disorders (ASD) and selective serotonin reuptake inhibitors (SSRIs) used during pregnancy. This study used Denmark’s health and population registers to obtain information regarding prescription drugs, ASD diagnosis, and health and socioeconomic status. There were 1.5 % of cases and 0.7 % of controls exposed to SSRIs during the pregnancy period, and higher effect estimates observed with longer use. We found evidence that in utero exposure to SSRIs increases a child’s risk associated with ASD. These results, while adding to the limited knowledge on prenatal pharmacological exposures as potential ASD risk factors, need to be balanced against the benefits of indicated medication use by pregnant mothers. En ligne : http://dx.doi.org/10.1007/s10803-014-2128-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240

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