Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder / Jason SCHIFFMAN in Development and Psychopathology, 27-4 (Part 1) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1323-1330 Titre : Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jason SCHIFFMAN, Auteur ; Vijay MITTAL, Auteur ; Emily KLINE, Auteur ; Erik L. MORTENSEN, Auteur ; Niels MICHELSEN, Auteur ; Morten EKSTRØM, Auteur ; Zachary B. MILLMAN, Auteur ; Sarnoff A. MEDNICK, Auteur ; Holger J. SØRENSEN, Auteur Année de publication : 2015 Article en page(s) : p.1323-1330 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective–psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10–13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective–psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, ?2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective–psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective–psychosis-spectrum disorders. En ligne : http://dx.doi.org/10.1017/S0954579414001436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder [Texte imprimé et/ou numérique] / Jason SCHIFFMAN, Auteur ; Vijay MITTAL, Auteur ; Emily KLINE, Auteur ; Erik L. MORTENSEN, Auteur ; Niels MICHELSEN, Auteur ; Morten EKSTRØM, Auteur ; Zachary B. MILLMAN, Auteur ; Sarnoff A. MEDNICK, Auteur ; Holger J. SØRENSEN, Auteur . - 2015 . - p.1323-1330. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1323-1330 Index. décimale : PER Périodiques Résumé : Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective–psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10–13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective–psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, ?2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective–psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective–psychosis-spectrum disorders. En ligne : http://dx.doi.org/10.1017/S0954579414001436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

---

1 (1 - 1 / 1)