Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder / Jason SCHIFFMAN in Development and Psychopathology, 27-4 (Part 1) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1323-1330 Titre : Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jason SCHIFFMAN, Auteur ; Vijay MITTAL, Auteur ; Emily KLINE, Auteur ; Erik L. MORTENSEN, Auteur ; Niels MICHELSEN, Auteur ; Morten EKSTRØM, Auteur ; Zachary B. MILLMAN, Auteur ; Sarnoff A. MEDNICK, Auteur ; Holger J. SØRENSEN, Auteur Année de publication : 2015 Article en page(s) : p.1323-1330 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective–psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10–13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective–psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, ?2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective–psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective–psychosis-spectrum disorders. En ligne : http://dx.doi.org/10.1017/S0954579414001436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder [Texte imprimé et/ou numérique] / Jason SCHIFFMAN, Auteur ; Vijay MITTAL, Auteur ; Emily KLINE, Auteur ; Erik L. MORTENSEN, Auteur ; Niels MICHELSEN, Auteur ; Morten EKSTRØM, Auteur ; Zachary B. MILLMAN, Auteur ; Sarnoff A. MEDNICK, Auteur ; Holger J. SØRENSEN, Auteur . - 2015 . - p.1323-1330. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1323-1330 Index. décimale : PER Périodiques Résumé : Several neurological variables have been investigated as premorbid biomarkers of vulnerability for schizophrenia and other related disorders. The current study examined whether childhood dyspraxia predicted later adult nonaffective–psychosis-spectrum disorders. From a standardized neurological examination performed with children (aged 10–13) at genetic high risk of schizophrenia and controls, several measures of dyspraxia were used to create a scale composed of face/head dyspraxia, oral articulation, ideomotor dyspraxia (clumsiness), and dressing dyspraxia (n = 244). Multinomial logistic regression showed higher scores on the dyspraxia scale predict nonaffective–psychosis-spectrum disorders relative to other psychiatric disorders and no mental illness outcomes, even after controlling for genetic risk, ?2 (4, 244) = 18.61, p < .001. Findings that symptoms of dyspraxia in childhood (reflecting abnormalities spanning functionally distinct brain networks) specifically predict adult nonaffective–psychosis-spectrum disorders are consistent with a theory of abnormal connectivity, and they highlight a marked early-stage vulnerability in the pathophysiology of nonaffective–psychosis-spectrum disorders. En ligne : http://dx.doi.org/10.1017/S0954579414001436 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

A developmental increase in allostatic load from ages 3 to 11 years is associated with increased schizotypal personality at age 23 years / Melissa PESKIN in Development and Psychopathology, 23-4 (November 2011)  

Public ISBD [article]  inDevelopment and Psychopathology > 23-4 (November 2011) . - p.1059-1068 Titre : A developmental increase in allostatic load from ages 3 to 11 years is associated with increased schizotypal personality at age 23 years Type de document : Texte imprimé et/ou numérique Auteurs : Melissa PESKIN, Auteur ; Adrian RAINE, Auteur ; Yu GAO, Auteur ; Peter H. VENABLES, Auteur ; Sarnoff A. MEDNICK, Auteur Année de publication : 2011 Article en page(s) : p.1059-1068 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although allostatic load has been investigated in mood and anxiety disorders, no prior study has investigated developmental change in allostatic load as a precursor to schizotypal personality. This study employed a multilevel developmental framework to examine whether the development of increased allostatic load, as indicated by impaired sympathetic nervous system habituation from ages 3 to 11 years, predisposes to schizotypal personality at age 23 years. Electrodermal activity to six aversive tones was recorded in 995 subjects at age 3 years and again at 11 years. Habituation slopes at both ages were used to create groups who showed a developmental increase in habituation (decreased allostatic load), and those who showed a developmental decrease in habituation (increased allostatic load). Children who showed a developmental increase in allostatic load from ages 3 to 11 years had higher levels of schizotypal personality at 23 years. A breakdown of total schizotypy scores demonstrated specificity of findings to cognitive–perceptual features of schizotypy. Findings are the first to document a developmental abnormality in allostasis in relation to adult schizotypal personality. The relative failure to develop normal habituation to repeated stressors throughout childhood is hypothesized to result in an accumulation of allostatic load and consequently increased positive symptom schizotypy in adulthood. En ligne : http://dx.doi.org/10.1017/S0954579411000496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] A developmental increase in allostatic load from ages 3 to 11 years is associated with increased schizotypal personality at age 23 years [Texte imprimé et/ou numérique] / Melissa PESKIN, Auteur ; Adrian RAINE, Auteur ; Yu GAO, Auteur ; Peter H. VENABLES, Auteur ; Sarnoff A. MEDNICK, Auteur . - 2011 . - p.1059-1068. Langues : Anglais (eng) in Development and Psychopathology > 23-4 (November 2011) . - p.1059-1068 Index. décimale : PER Périodiques Résumé : Although allostatic load has been investigated in mood and anxiety disorders, no prior study has investigated developmental change in allostatic load as a precursor to schizotypal personality. This study employed a multilevel developmental framework to examine whether the development of increased allostatic load, as indicated by impaired sympathetic nervous system habituation from ages 3 to 11 years, predisposes to schizotypal personality at age 23 years. Electrodermal activity to six aversive tones was recorded in 995 subjects at age 3 years and again at 11 years. Habituation slopes at both ages were used to create groups who showed a developmental increase in habituation (decreased allostatic load), and those who showed a developmental decrease in habituation (increased allostatic load). Children who showed a developmental increase in allostatic load from ages 3 to 11 years had higher levels of schizotypal personality at 23 years. A breakdown of total schizotypy scores demonstrated specificity of findings to cognitive–perceptual features of schizotypy. Findings are the first to document a developmental abnormality in allostasis in relation to adult schizotypal personality. The relative failure to develop normal habituation to repeated stressors throughout childhood is hypothesized to result in an accumulation of allostatic load and consequently increased positive symptom schizotypy in adulthood. En ligne : http://dx.doi.org/10.1017/S0954579411000496 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

Reduced electrodermal fear conditioning from ages 3 to 8 years is associated with aggressive behavior at age 8 years / Yu GAO in Journal of Child Psychology and Psychiatry, 51-5 (May 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.550-558 Titre : Reduced electrodermal fear conditioning from ages 3 to 8 years is associated with aggressive behavior at age 8 years Type de document : Texte imprimé et/ou numérique Auteurs : Yu GAO, Auteur ; Adrian RAINE, Auteur ; Peter H. VENABLES, Auteur ; Michael E. DAWSON, Auteur ; Sarnoff A. MEDNICK, Auteur Année de publication : 2010 Article en page(s) : p.550-558 Langues : Anglais (eng) Mots-clés : Fear-conditioning child development aggression electrodermal Index. décimale : PER Périodiques Résumé : Background: Poor fear conditioning characterizes adult psychopathy and criminality, but it is not known whether it is related to aggressive/antisocial behavior in early childhood. Methods: Using a differential, partial reinforcement conditioning paradigm, electrodermal activity was recorded from 200 male and female children at ages 3, 4, 5, 6, and 8 years. Antisocial/aggressive and hyperactive-inattentive measures were collected at age 8. Results: Poor electrodermal fear conditioning from ages 3 to 8 years was associated with aggressive behavior at age 8 in both males and females. Conclusions: Results indicate that the relationship between poor fear conditioning and aggression occurs early in childhood. Enhanced electrodermal fear conditioning may protect children against future aggressive/violent behavior. Abnormal amygdala functioning, as indirectly assessed by fear conditioning, may be one of the factors influencing the development of childhood aggression. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02176.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] Reduced electrodermal fear conditioning from ages 3 to 8 years is associated with aggressive behavior at age 8 years [Texte imprimé et/ou numérique] / Yu GAO, Auteur ; Adrian RAINE, Auteur ; Peter H. VENABLES, Auteur ; Michael E. DAWSON, Auteur ; Sarnoff A. MEDNICK, Auteur . - 2010 . - p.550-558. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.550-558 Mots-clés : Fear-conditioning child development aggression electrodermal Index. décimale : PER Périodiques Résumé : Background: Poor fear conditioning characterizes adult psychopathy and criminality, but it is not known whether it is related to aggressive/antisocial behavior in early childhood. Methods: Using a differential, partial reinforcement conditioning paradigm, electrodermal activity was recorded from 200 male and female children at ages 3, 4, 5, 6, and 8 years. Antisocial/aggressive and hyperactive-inattentive measures were collected at age 8. Results: Poor electrodermal fear conditioning from ages 3 to 8 years was associated with aggressive behavior at age 8 in both males and females. Conclusions: Results indicate that the relationship between poor fear conditioning and aggression occurs early in childhood. Enhanced electrodermal fear conditioning may protect children against future aggressive/violent behavior. Abnormal amygdala functioning, as indirectly assessed by fear conditioning, may be one of the factors influencing the development of childhood aggression. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02176.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

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