General psychopathology, internalising and externalising in children and functional outcomes in late adolescence / H. SALLIS in Journal of Child Psychology and Psychiatry, 60-11 (November 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-11 (November 2019) . - p.1183-1190 Titre : General psychopathology, internalising and externalising in children and functional outcomes in late adolescence Type de document : Texte imprimé et/ou numérique Auteurs : H. SALLIS, Auteur ; E. SZEKELY, Auteur ; A. NEUMANN, Auteur ; A. JOLICOEUR-MARTINEAU, Auteur ; IJZENDOORN M. VAN, Auteur ; M. HILLEGERS, Auteur ; Celia M. T. GREENWOOD, Auteur ; M. J. MEANEY, Auteur ; M. STEINER, Auteur ; H. TIEMEIER, Auteur ; A. WAZANA, Auteur ; R. M. PEARSON, Auteur ; J. EVANS, Auteur Article en page(s) : p.1183-1190 Langues : Anglais (eng) Mots-clés : Avon Longitudinal Study of Parents and Children  Childhood psychopathology  Generation Rotterdam  Maternal Adversity  Vulnerability and Neurodevelopment  developmental pathways Index. décimale : PER Périodiques Résumé : BACKGROUND: Internalising and externalising problems commonly co-occur in childhood. Yet, few developmental models describing the structure of child psychopathology appropriately account for this comorbidity. We evaluate a model of childhood psychopathology that separates the unique and shared contribution of individual psychological symptoms into specific internalising, externalising and general psychopathology factors and assess how these general and specific factors predict long-term outcomes concerning criminal behaviour, academic achievement and affective symptoms in three independent cohorts. METHODS: Data were drawn from independent birth cohorts (Avon Longitudinal Study of Parents and Children (ALSPAC), N = 11,612; Generation R, N = 7,946; Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN), N = 408). Child psychopathology was assessed between 4 and 8 years using a range of diagnostic and questionnaire-based measures, and multiple informants. First, structural equation models were used to assess the fit of hypothesised models of shared and unique components of psychopathology in all cohorts. Once the model was chosen, linear/logistic regressions were used to investigate whether these factors were associated with important outcomes such as criminal behaviour, academic achievement and well-being from late adolescence/early adulthood. RESULTS: The model that included specific factors for internalising/externalising and a general psychopathology factor capturing variance shared between symptoms regardless of their classification fits well for all of the cohorts. As hypothesised, general psychopathology factor scores were predictive of all outcomes of later functioning, while specific internalising factor scores predicted later internalising outcomes. Specific externalising factor scores, capturing variance not shared by any other psychological symptoms, were not predictive of later outcomes. CONCLUSIONS: Early symptoms of psychopathology carry information that is syndrome-specific as well as indicative of general vulnerability and the informant reporting on the child. The 'general psychopathology factor' might be more relevant for long-term outcomes than specific symptoms. These findings emphasise the importance of considering the co-occurrence of common internalising and externalising problems in childhood when considering long-term impact. En ligne : http://dx.doi.org/10.1111/jcpp.13067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] General psychopathology, internalising and externalising in children and functional outcomes in late adolescence [Texte imprimé et/ou numérique] / H. SALLIS, Auteur ; E. SZEKELY, Auteur ; A. NEUMANN, Auteur ; A. JOLICOEUR-MARTINEAU, Auteur ; IJZENDOORN M. VAN, Auteur ; M. HILLEGERS, Auteur ; Celia M. T. GREENWOOD, Auteur ; M. J. MEANEY, Auteur ; M. STEINER, Auteur ; H. TIEMEIER, Auteur ; A. WAZANA, Auteur ; R. M. PEARSON, Auteur ; J. EVANS, Auteur . - p.1183-1190. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-11 (November 2019) . - p.1183-1190 Mots-clés : Avon Longitudinal Study of Parents and Children  Childhood psychopathology  Generation Rotterdam  Maternal Adversity  Vulnerability and Neurodevelopment  developmental pathways Index. décimale : PER Périodiques Résumé : BACKGROUND: Internalising and externalising problems commonly co-occur in childhood. Yet, few developmental models describing the structure of child psychopathology appropriately account for this comorbidity. We evaluate a model of childhood psychopathology that separates the unique and shared contribution of individual psychological symptoms into specific internalising, externalising and general psychopathology factors and assess how these general and specific factors predict long-term outcomes concerning criminal behaviour, academic achievement and affective symptoms in three independent cohorts. METHODS: Data were drawn from independent birth cohorts (Avon Longitudinal Study of Parents and Children (ALSPAC), N = 11,612; Generation R, N = 7,946; Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN), N = 408). Child psychopathology was assessed between 4 and 8 years using a range of diagnostic and questionnaire-based measures, and multiple informants. First, structural equation models were used to assess the fit of hypothesised models of shared and unique components of psychopathology in all cohorts. Once the model was chosen, linear/logistic regressions were used to investigate whether these factors were associated with important outcomes such as criminal behaviour, academic achievement and well-being from late adolescence/early adulthood. RESULTS: The model that included specific factors for internalising/externalising and a general psychopathology factor capturing variance shared between symptoms regardless of their classification fits well for all of the cohorts. As hypothesised, general psychopathology factor scores were predictive of all outcomes of later functioning, while specific internalising factor scores predicted later internalising outcomes. Specific externalising factor scores, capturing variance not shared by any other psychological symptoms, were not predictive of later outcomes. CONCLUSIONS: Early symptoms of psychopathology carry information that is syndrome-specific as well as indicative of general vulnerability and the informant reporting on the child. The 'general psychopathology factor' might be more relevant for long-term outcomes than specific symptoms. These findings emphasise the importance of considering the co-occurrence of common internalising and externalising problems in childhood when considering long-term impact. En ligne : http://dx.doi.org/10.1111/jcpp.13067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

The early care environment and DNA methylome variation in childhood / E. GARG in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.891-903 Titre : The early care environment and DNA methylome variation in childhood Type de document : Texte imprimé et/ou numérique Auteurs : E. GARG, Auteur ; L. CHEN, Auteur ; T. T. T. NGUYEN, Auteur ; I. POKHVISNEVA, Auteur ; L. M. CHEN, Auteur ; E. UNTERNAEHRER, Auteur ; J. L. MACISAAC, Auteur ; L. M. MCEWEN, Auteur ; S. M. MAH, Auteur ; H. GAUDREAU, Auteur ; R. LEVITAN, Auteur ; E. MOSS, Auteur ; M. B. SOKOLOWSKI, Auteur ; J. L. KENNEDY, Auteur ; M. S. STEINER, Auteur ; M. J. MEANEY, Auteur ; J. D. HOLBROOK, Auteur ; P. P. SILVEIRA, Auteur ; N. KARNANI, Auteur ; M. S. KOBOR, Auteur ; Kieran J. O'DONNELL, Auteur Article en page(s) : p.891-903 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Prenatal adversity shapes child neurodevelopment and risk for later mental health problems. The quality of the early care environment can buffer some of the negative effects of prenatal adversity on child development. Retrospective studies, in adult samples, highlight epigenetic modifications as sentinel markers of the quality of the early care environment; however, comparable data from pediatric cohorts are lacking. Participants were drawn from the Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) study, a longitudinal cohort with measures of infant attachment, infant development, and child mental health. Children provided buccal epithelial samples (mean age = 6.99, SD = 1.33 years, n = 226), which were used for analyses of genome-wide DNA methylation and genetic variation. We used a series of linear models to describe the association between infant attachment and (a) measures of child outcome and (b) DNA methylation across the genome. Paired genetic data was used to determine the genetic contribution to DNA methylation at attachment-associated sites. Infant attachment style was associated with infant cognitive development (Mental Development Index) and behavior (Behavior Rating Scale) assessed with the Bayley Scales of Infant Development at 36 months. Infant attachment style moderated the effects of prenatal adversity on Behavior Rating Scale scores at 36 months. Infant attachment was also significantly associated with a principal component that accounted for 11.9% of the variation in genome-wide DNA methylation. These effects were most apparent when comparing children with a secure versus a disorganized attachment style and most pronounced in females. The availability of paired genetic data revealed that DNA methylation at approximately half of all infant attachment-associated sites was best explained by considering both infant attachment and child genetic variation. This study provides further evidence that infant attachment can buffer some of the negative effects of early adversity on measures of infant behavior. We also highlight the interplay between infant attachment and child genotype in shaping variation in DNA methylation. Such findings provide preliminary evidence for a molecular signature of infant attachment and may help inform attachment-focused early intervention programs. En ligne : http://dx.doi.org/10.1017/s0954579418000627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] The early care environment and DNA methylome variation in childhood [Texte imprimé et/ou numérique] / E. GARG, Auteur ; L. CHEN, Auteur ; T. T. T. NGUYEN, Auteur ; I. POKHVISNEVA, Auteur ; L. M. CHEN, Auteur ; E. UNTERNAEHRER, Auteur ; J. L. MACISAAC, Auteur ; L. M. MCEWEN, Auteur ; S. M. MAH, Auteur ; H. GAUDREAU, Auteur ; R. LEVITAN, Auteur ; E. MOSS, Auteur ; M. B. SOKOLOWSKI, Auteur ; J. L. KENNEDY, Auteur ; M. S. STEINER, Auteur ; M. J. MEANEY, Auteur ; J. D. HOLBROOK, Auteur ; P. P. SILVEIRA, Auteur ; N. KARNANI, Auteur ; M. S. KOBOR, Auteur ; Kieran J. O'DONNELL, Auteur . - p.891-903. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.891-903 Index. décimale : PER Périodiques Résumé : Prenatal adversity shapes child neurodevelopment and risk for later mental health problems. The quality of the early care environment can buffer some of the negative effects of prenatal adversity on child development. Retrospective studies, in adult samples, highlight epigenetic modifications as sentinel markers of the quality of the early care environment; however, comparable data from pediatric cohorts are lacking. Participants were drawn from the Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) study, a longitudinal cohort with measures of infant attachment, infant development, and child mental health. Children provided buccal epithelial samples (mean age = 6.99, SD = 1.33 years, n = 226), which were used for analyses of genome-wide DNA methylation and genetic variation. We used a series of linear models to describe the association between infant attachment and (a) measures of child outcome and (b) DNA methylation across the genome. Paired genetic data was used to determine the genetic contribution to DNA methylation at attachment-associated sites. Infant attachment style was associated with infant cognitive development (Mental Development Index) and behavior (Behavior Rating Scale) assessed with the Bayley Scales of Infant Development at 36 months. Infant attachment style moderated the effects of prenatal adversity on Behavior Rating Scale scores at 36 months. Infant attachment was also significantly associated with a principal component that accounted for 11.9% of the variation in genome-wide DNA methylation. These effects were most apparent when comparing children with a secure versus a disorganized attachment style and most pronounced in females. The availability of paired genetic data revealed that DNA methylation at approximately half of all infant attachment-associated sites was best explained by considering both infant attachment and child genetic variation. This study provides further evidence that infant attachment can buffer some of the negative effects of early adversity on measures of infant behavior. We also highlight the interplay between infant attachment and child genotype in shaping variation in DNA methylation. Such findings provide preliminary evidence for a molecular signature of infant attachment and may help inform attachment-focused early intervention programs. En ligne : http://dx.doi.org/10.1017/s0954579418000627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

The psychometric properties of the Quantitative-Checklist for Autism in Toddlers (Q-CHAT) as a measure of autistic traits in a community sample of Singaporean infants and toddlers / I. MAGIATI in Molecular Autism, (June 2015)  

Public ISBD [article]  inMolecular Autism > (June 2015) . - p.1-14 Titre : The psychometric properties of the Quantitative-Checklist for Autism in Toddlers (Q-CHAT) as a measure of autistic traits in a community sample of Singaporean infants and toddlers Type de document : Texte imprimé et/ou numérique Auteurs : I. MAGIATI, Auteur ; D. A. GOH, Auteur ; S. J. LIM, Auteur ; D. Z. Q. GAN, Auteur ; J. C. L. LEONG, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; A. RIFKIN-GRABOI, Auteur ; Birit F. P. BROEKMAN, Auteur ; Seang Mei SAW, Auteur ; Yap Seng CHONG, Auteur ; K. KWEK, Auteur ; P. D. GLUCKMAN, Auteur ; S. B. LIM, Auteur ; M. J. MEANEY, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : There is growing research evidence that subclinical autistic traits are elevated in relatives of individuals with autism spectrum disorder (ASD), continuously distributed in the general population and likely to share common etiology with ASD. A number of measures have been developed to assess autistic traits quantitatively in unselected samples. So far, the Quantitative-Checklist for Autism in Toddlers (Q-CHAT) is one of very few measures developed for use with toddlers as young as 18 months, but little is known about its measurement properties and factor structure. En ligne : http://dx.doi.org/10.1186/s13229-015-0032-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] The psychometric properties of the Quantitative-Checklist for Autism in Toddlers (Q-CHAT) as a measure of autistic traits in a community sample of Singaporean infants and toddlers [Texte imprimé et/ou numérique] / I. MAGIATI, Auteur ; D. A. GOH, Auteur ; S. J. LIM, Auteur ; D. Z. Q. GAN, Auteur ; J. C. L. LEONG, Auteur ; Carrie ALLISON, Auteur ; Simon BARON-COHEN, Auteur ; A. RIFKIN-GRABOI, Auteur ; Birit F. P. BROEKMAN, Auteur ; Seang Mei SAW, Auteur ; Yap Seng CHONG, Auteur ; K. KWEK, Auteur ; P. D. GLUCKMAN, Auteur ; S. B. LIM, Auteur ; M. J. MEANEY, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (June 2015) . - p.1-14 Index. décimale : PER Périodiques Résumé : There is growing research evidence that subclinical autistic traits are elevated in relatives of individuals with autism spectrum disorder (ASD), continuously distributed in the general population and likely to share common etiology with ASD. A number of measures have been developed to assess autistic traits quantitatively in unselected samples. So far, the Quantitative-Checklist for Autism in Toddlers (Q-CHAT) is one of very few measures developed for use with toddlers as young as 18 months, but little is known about its measurement properties and factor structure. En ligne : http://dx.doi.org/10.1186/s13229-015-0032-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

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