4 recherche sur le mot-clé 'Childhood psychopathology'

The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence / Andrea G. ALLEGRINI in Journal of Child Psychology and Psychiatry, 61-1 (January 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-1 (January 2020) . - p.30-39 Titre : The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Andrea G. ALLEGRINI, Auteur ; Rosa CHEESMAN, Auteur ; K. RIMFELD, Auteur ; S. SELZAM, Auteur ; J. B. PINGAULT, Auteur ; T. C. ELEY, Auteur ; R. PLOMIN, Auteur Article en page(s) : p.30-39 Langues : Anglais (eng) Mots-clés : Childhood psychopathology  behavioural genetics  genomics Index. décimale : PER Périodiques Résumé : BACKGROUND: Diverse behaviour problems in childhood correlate phenotypically, suggesting a general dimension of psychopathology that has been called the p factor. The shared genetic architecture between childhood psychopathology traits also supports a genetic p. This study systematically investigates the manifestation of this common dimension across self-, parent- and teacher-rated measures in childhood and adolescence. METHODS: The sample included 7,026 twin pairs from the Twins Early Development Study (TEDS). First, we employed multivariate twin models to estimate common genetic and environmental influences on p based on diverse measures of behaviour problems rated by children, parents and teachers at ages 7, 9, 12 and 16 (depressive traits, emotional problems, peer problems, autism traits, hyperactivity, antisocial behaviour, conduct problems and psychopathic tendencies). Second, to assess the stability of genetic and environmental influences on p across time, we conducted longitudinal twin modelling of the first phenotypic principal components of childhood psychopathological measures across each of the four ages. Third, we created a genetic p factor in 7,026 unrelated genotyped individuals based on eight polygenic scores for psychiatric disorders to estimate how a general polygenic predisposition to mostly adult psychiatric disorders relates to childhood p. RESULTS: Behaviour problems were consistently correlated phenotypically and genetically across ages and raters. The p factor is substantially heritable (50%-60%) and manifests consistently across diverse ages and raters. However, residual variation in the common factor models indicates unique contributions as well. Genetic correlations of p components across childhood and adolescence suggest stability over time (49%-78%). A polygenic general psychopathology factor derived from studies of psychiatric disorders consistently predicted a general phenotypic p factor across development (0.3%-0.9%). CONCLUSIONS: Diverse forms of psychopathology generally load on a common p factor, which is highly heritable. There are substantial genetic influences on the stability of p across childhood. Our analyses indicate genetic overlap between general risk for psychiatric disorders in adulthood and p in childhood, even as young as age 7. The p factor has far-reaching implications for genomic research and, eventually, for diagnosis and treatment of behaviour problems. En ligne : http://dx.doi.org/10.1111/jcpp.13113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413 [article] The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence [Texte imprimé et/ou numérique] / Andrea G. ALLEGRINI, Auteur ; Rosa CHEESMAN, Auteur ; K. RIMFELD, Auteur ; S. SELZAM, Auteur ; J. B. PINGAULT, Auteur ; T. C. ELEY, Auteur ; R. PLOMIN, Auteur . - p.30-39. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-1 (January 2020) . - p.30-39 Mots-clés : Childhood psychopathology  behavioural genetics  genomics Index. décimale : PER Périodiques Résumé : BACKGROUND: Diverse behaviour problems in childhood correlate phenotypically, suggesting a general dimension of psychopathology that has been called the p factor. The shared genetic architecture between childhood psychopathology traits also supports a genetic p. This study systematically investigates the manifestation of this common dimension across self-, parent- and teacher-rated measures in childhood and adolescence. METHODS: The sample included 7,026 twin pairs from the Twins Early Development Study (TEDS). First, we employed multivariate twin models to estimate common genetic and environmental influences on p based on diverse measures of behaviour problems rated by children, parents and teachers at ages 7, 9, 12 and 16 (depressive traits, emotional problems, peer problems, autism traits, hyperactivity, antisocial behaviour, conduct problems and psychopathic tendencies). Second, to assess the stability of genetic and environmental influences on p across time, we conducted longitudinal twin modelling of the first phenotypic principal components of childhood psychopathological measures across each of the four ages. Third, we created a genetic p factor in 7,026 unrelated genotyped individuals based on eight polygenic scores for psychiatric disorders to estimate how a general polygenic predisposition to mostly adult psychiatric disorders relates to childhood p. RESULTS: Behaviour problems were consistently correlated phenotypically and genetically across ages and raters. The p factor is substantially heritable (50%-60%) and manifests consistently across diverse ages and raters. However, residual variation in the common factor models indicates unique contributions as well. Genetic correlations of p components across childhood and adolescence suggest stability over time (49%-78%). A polygenic general psychopathology factor derived from studies of psychiatric disorders consistently predicted a general phenotypic p factor across development (0.3%-0.9%). CONCLUSIONS: Diverse forms of psychopathology generally load on a common p factor, which is highly heritable. There are substantial genetic influences on the stability of p across childhood. Our analyses indicate genetic overlap between general risk for psychiatric disorders in adulthood and p in childhood, even as young as age 7. The p factor has far-reaching implications for genomic research and, eventually, for diagnosis and treatment of behaviour problems. En ligne : http://dx.doi.org/10.1111/jcpp.13113 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=413

General psychopathology, internalising and externalising in children and functional outcomes in late adolescence / H. SALLIS in Journal of Child Psychology and Psychiatry, 60-11 (November 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-11 (November 2019) . - p.1183-1190 Titre : General psychopathology, internalising and externalising in children and functional outcomes in late adolescence Type de document : Texte imprimé et/ou numérique Auteurs : H. SALLIS, Auteur ; E. SZEKELY, Auteur ; A. NEUMANN, Auteur ; A. JOLICOEUR-MARTINEAU, Auteur ; IJZENDOORN M. VAN, Auteur ; M. HILLEGERS, Auteur ; Celia M. T. GREENWOOD, Auteur ; M. J. MEANEY, Auteur ; M. STEINER, Auteur ; H. TIEMEIER, Auteur ; A. WAZANA, Auteur ; R. M. PEARSON, Auteur ; J. EVANS, Auteur Article en page(s) : p.1183-1190 Langues : Anglais (eng) Mots-clés : Avon Longitudinal Study of Parents and Children  Childhood psychopathology  Generation Rotterdam  Maternal Adversity  Vulnerability and Neurodevelopment  developmental pathways Index. décimale : PER Périodiques Résumé : BACKGROUND: Internalising and externalising problems commonly co-occur in childhood. Yet, few developmental models describing the structure of child psychopathology appropriately account for this comorbidity. We evaluate a model of childhood psychopathology that separates the unique and shared contribution of individual psychological symptoms into specific internalising, externalising and general psychopathology factors and assess how these general and specific factors predict long-term outcomes concerning criminal behaviour, academic achievement and affective symptoms in three independent cohorts. METHODS: Data were drawn from independent birth cohorts (Avon Longitudinal Study of Parents and Children (ALSPAC), N = 11,612; Generation R, N = 7,946; Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN), N = 408). Child psychopathology was assessed between 4 and 8 years using a range of diagnostic and questionnaire-based measures, and multiple informants. First, structural equation models were used to assess the fit of hypothesised models of shared and unique components of psychopathology in all cohorts. Once the model was chosen, linear/logistic regressions were used to investigate whether these factors were associated with important outcomes such as criminal behaviour, academic achievement and well-being from late adolescence/early adulthood. RESULTS: The model that included specific factors for internalising/externalising and a general psychopathology factor capturing variance shared between symptoms regardless of their classification fits well for all of the cohorts. As hypothesised, general psychopathology factor scores were predictive of all outcomes of later functioning, while specific internalising factor scores predicted later internalising outcomes. Specific externalising factor scores, capturing variance not shared by any other psychological symptoms, were not predictive of later outcomes. CONCLUSIONS: Early symptoms of psychopathology carry information that is syndrome-specific as well as indicative of general vulnerability and the informant reporting on the child. The 'general psychopathology factor' might be more relevant for long-term outcomes than specific symptoms. These findings emphasise the importance of considering the co-occurrence of common internalising and externalising problems in childhood when considering long-term impact. En ligne : http://dx.doi.org/10.1111/jcpp.13067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] General psychopathology, internalising and externalising in children and functional outcomes in late adolescence [Texte imprimé et/ou numérique] / H. SALLIS, Auteur ; E. SZEKELY, Auteur ; A. NEUMANN, Auteur ; A. JOLICOEUR-MARTINEAU, Auteur ; IJZENDOORN M. VAN, Auteur ; M. HILLEGERS, Auteur ; Celia M. T. GREENWOOD, Auteur ; M. J. MEANEY, Auteur ; M. STEINER, Auteur ; H. TIEMEIER, Auteur ; A. WAZANA, Auteur ; R. M. PEARSON, Auteur ; J. EVANS, Auteur . - p.1183-1190. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-11 (November 2019) . - p.1183-1190 Mots-clés : Avon Longitudinal Study of Parents and Children  Childhood psychopathology  Generation Rotterdam  Maternal Adversity  Vulnerability and Neurodevelopment  developmental pathways Index. décimale : PER Périodiques Résumé : BACKGROUND: Internalising and externalising problems commonly co-occur in childhood. Yet, few developmental models describing the structure of child psychopathology appropriately account for this comorbidity. We evaluate a model of childhood psychopathology that separates the unique and shared contribution of individual psychological symptoms into specific internalising, externalising and general psychopathology factors and assess how these general and specific factors predict long-term outcomes concerning criminal behaviour, academic achievement and affective symptoms in three independent cohorts. METHODS: Data were drawn from independent birth cohorts (Avon Longitudinal Study of Parents and Children (ALSPAC), N = 11,612; Generation R, N = 7,946; Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN), N = 408). Child psychopathology was assessed between 4 and 8 years using a range of diagnostic and questionnaire-based measures, and multiple informants. First, structural equation models were used to assess the fit of hypothesised models of shared and unique components of psychopathology in all cohorts. Once the model was chosen, linear/logistic regressions were used to investigate whether these factors were associated with important outcomes such as criminal behaviour, academic achievement and well-being from late adolescence/early adulthood. RESULTS: The model that included specific factors for internalising/externalising and a general psychopathology factor capturing variance shared between symptoms regardless of their classification fits well for all of the cohorts. As hypothesised, general psychopathology factor scores were predictive of all outcomes of later functioning, while specific internalising factor scores predicted later internalising outcomes. Specific externalising factor scores, capturing variance not shared by any other psychological symptoms, were not predictive of later outcomes. CONCLUSIONS: Early symptoms of psychopathology carry information that is syndrome-specific as well as indicative of general vulnerability and the informant reporting on the child. The 'general psychopathology factor' might be more relevant for long-term outcomes than specific symptoms. These findings emphasise the importance of considering the co-occurrence of common internalising and externalising problems in childhood when considering long-term impact. En ligne : http://dx.doi.org/10.1111/jcpp.13067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Genetic risk by experience interaction for childhood internalizing problems: converging evidence across multiple methods / Matthew VENDLINSKI in Journal of Child Psychology and Psychiatry, 52-5 (May 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-5 (May 2011) . - p.607-618 Titre : Genetic risk by experience interaction for childhood internalizing problems: converging evidence across multiple methods Type de document : Texte imprimé et/ou numérique Auteurs : Matthew VENDLINSKI, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Marilyn J. ESSEX, Auteur ; H. HILL GOLDSMITH, Auteur Année de publication : 2011 Article en page(s) : p.607-618 Langues : Anglais (eng) Mots-clés : Gene–environment interaction  childhood psychopathology  internalizing problems  parental psychopathology  twins Index. décimale : PER Périodiques Résumé : Background:  Identifying how genetic risk interacts with experience to predict psychopathology is an important step toward understanding the etiology of mental health problems. Few studies have examined genetic risk by experience interaction (G×E) in the development of childhood psychopathology. Methods:  We used both co-twin and parent mental health as markers of genetic risk to test whether G×E predicted internalizing problems in a sample of 8-year-old twins. Multi-instrument composites were used to characterize both parent and child psychopathology, and five experiential risk factors (socioeconomic status, single parent upbringing, negative parent–child interactions, number of negative life events, negative impact of negative life events) composed a cumulative risk index. Results:  We found consistent evidence for G×E for child internalizing problems, with significant interaction effects emerging both when genetic risk was indexed by co-twin mental health and when it was based on parent mental health. When co-twin mental health was used to estimate genetic risk, child internalizing problems were more heritable for children at low rather than high experiential risk. When parent mental health was used to estimate genetic risk, the association between genetic risk and internalizing problems was stronger for children at elevated experiential risk. Consideration of the interaction effect sizes helps to reconcile these findings. Conclusions:  Our results suggest that the processes involved in both diathesis-stress and bioecological models of development may operate for child internalizing problems. Effect sizes indicated that the main effects of genetic and experiential risk were much better predictors of child internalizing problems than was their interaction. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02343.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 [article] Genetic risk by experience interaction for childhood internalizing problems: converging evidence across multiple methods [Texte imprimé et/ou numérique] / Matthew VENDLINSKI, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Marilyn J. ESSEX, Auteur ; H. HILL GOLDSMITH, Auteur . - 2011 . - p.607-618. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-5 (May 2011) . - p.607-618 Mots-clés : Gene–environment interaction  childhood psychopathology  internalizing problems  parental psychopathology  twins Index. décimale : PER Périodiques Résumé : Background:  Identifying how genetic risk interacts with experience to predict psychopathology is an important step toward understanding the etiology of mental health problems. Few studies have examined genetic risk by experience interaction (G×E) in the development of childhood psychopathology. Methods:  We used both co-twin and parent mental health as markers of genetic risk to test whether G×E predicted internalizing problems in a sample of 8-year-old twins. Multi-instrument composites were used to characterize both parent and child psychopathology, and five experiential risk factors (socioeconomic status, single parent upbringing, negative parent–child interactions, number of negative life events, negative impact of negative life events) composed a cumulative risk index. Results:  We found consistent evidence for G×E for child internalizing problems, with significant interaction effects emerging both when genetic risk was indexed by co-twin mental health and when it was based on parent mental health. When co-twin mental health was used to estimate genetic risk, child internalizing problems were more heritable for children at low rather than high experiential risk. When parent mental health was used to estimate genetic risk, the association between genetic risk and internalizing problems was stronger for children at elevated experiential risk. Consideration of the interaction effect sizes helps to reconcile these findings. Conclusions:  Our results suggest that the processes involved in both diathesis-stress and bioecological models of development may operate for child internalizing problems. Effect sizes indicated that the main effects of genetic and experiential risk were much better predictors of child internalizing problems than was their interaction. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02343.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121

Risk and resilience trajectories in war-exposed children across the first decade of life / Galit HALEVI in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1183-1193 Titre : Risk and resilience trajectories in war-exposed children across the first decade of life Type de document : Texte imprimé et/ou numérique Auteurs : Galit HALEVI, Auteur ; Amir DJALOVSKI, Auteur ; Adva VENGROBER, Auteur ; Ruth FELDMAN, Auteur Article en page(s) : p.1183-1193 Langues : Anglais (eng) Mots-clés : Trauma  early life stress  longitudinal studies  social engagement  childhood psychopathology Index. décimale : PER Périodiques Résumé : Background Although the effects of early-onset trauma on susceptibility to psychopathology are well-acknowledged, no study to date has followed risk and resilience trajectories in war-exposed young children over lengthy periods and charted predictors of individual pathways. Method In this prospective longitudinal study, we followed 232 children, including 148 exposed to repeated wartime trauma and 84 controls, at three time points: early childhood (1.5–5 years), middle childhood (5–8 years), and late childhood (9–11 years). Children were diagnosed at each time point and four trajectories defined: children exhibiting no pathology at any time point, those displaying early pathology that later remitted, those showing initial resilience followed by late pathology, and children presenting chronic pathology across the entire first decade. Maternal behavioral containment during trauma evocation and child social engagement during free play were observed in early childhood and maternal emotional distress self-reported across time. Results War-exposed children showed significantly higher rates of psychopathology, with 81% exhibiting pathology at some point during childhood. In middle childhood, exposed children displayed more posttraumatic stress disorders (PTSD), anxiety disorders, and attention-deficit/hyperactivity disorders (ADHD), and in late childhood more PTSD, conduct/oppositional defiant disorders, and ADHD. War-exposed children had more comorbid psychopathologies and number of comorbidities increased with age. Notably, war-exposure increased prevalence of chronic pathology by 24-fold. Maternal factors, including mother's uncontained style and emotional distress, increased risk for early and chronic psychopathology, whereas reduced child social engagement augmented risk for late pathology. Conclusions Early-onset chronic stress does not heal naturally, and its effects appear to exacerbate over time, with trauma-exposed children presenting a more comorbid, chronic, and externalizing profile as they grow older. Our findings demonstrate that responses to trauma are dynamic and variable and pinpoint age-specific effects of maternal and child factors on risk and resilience trajectories. Results highlight the importance of conducting long-term follow-up studies and constructing individually tailored early interventions following trauma exposure. En ligne : http://dx.doi.org/10.1111/jcpp.12622 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Risk and resilience trajectories in war-exposed children across the first decade of life [Texte imprimé et/ou numérique] / Galit HALEVI, Auteur ; Amir DJALOVSKI, Auteur ; Adva VENGROBER, Auteur ; Ruth FELDMAN, Auteur . - p.1183-1193. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1183-1193 Mots-clés : Trauma  early life stress  longitudinal studies  social engagement  childhood psychopathology Index. décimale : PER Périodiques Résumé : Background Although the effects of early-onset trauma on susceptibility to psychopathology are well-acknowledged, no study to date has followed risk and resilience trajectories in war-exposed young children over lengthy periods and charted predictors of individual pathways. Method In this prospective longitudinal study, we followed 232 children, including 148 exposed to repeated wartime trauma and 84 controls, at three time points: early childhood (1.5–5 years), middle childhood (5–8 years), and late childhood (9–11 years). Children were diagnosed at each time point and four trajectories defined: children exhibiting no pathology at any time point, those displaying early pathology that later remitted, those showing initial resilience followed by late pathology, and children presenting chronic pathology across the entire first decade. Maternal behavioral containment during trauma evocation and child social engagement during free play were observed in early childhood and maternal emotional distress self-reported across time. Results War-exposed children showed significantly higher rates of psychopathology, with 81% exhibiting pathology at some point during childhood. In middle childhood, exposed children displayed more posttraumatic stress disorders (PTSD), anxiety disorders, and attention-deficit/hyperactivity disorders (ADHD), and in late childhood more PTSD, conduct/oppositional defiant disorders, and ADHD. War-exposed children had more comorbid psychopathologies and number of comorbidities increased with age. Notably, war-exposure increased prevalence of chronic pathology by 24-fold. Maternal factors, including mother's uncontained style and emotional distress, increased risk for early and chronic psychopathology, whereas reduced child social engagement augmented risk for late pathology. Conclusions Early-onset chronic stress does not heal naturally, and its effects appear to exacerbate over time, with trauma-exposed children presenting a more comorbid, chronic, and externalizing profile as they grow older. Our findings demonstrate that responses to trauma are dynamic and variable and pinpoint age-specific effects of maternal and child factors on risk and resilience trajectories. Results highlight the importance of conducting long-term follow-up studies and constructing individually tailored early interventions following trauma exposure. En ligne : http://dx.doi.org/10.1111/jcpp.12622 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295