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Détail de l'auteur
Auteur Greg PERLMAN |
Documents disponibles écrits par cet auteur (2)
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Intrinsic neural circuitry of depression in adolescent females / Jingwen JIN in Journal of Child Psychology and Psychiatry, 61-4 (April 2020)
[article]
Titre : Intrinsic neural circuitry of depression in adolescent females Type de document : Texte imprimé et/ou numérique Auteurs : Jingwen JIN, Auteur ; Jared X. VAN SNELLENBERG, Auteur ; Greg PERLMAN, Auteur ; Christine DELORENZO, Auteur ; Daniel N. KLEIN, Auteur ; Roman KOTOV, Auteur ; Aprajita MOHANTY, Auteur Article en page(s) : p.480-491 Langues : Anglais (eng) Mots-clés : Depression adolescence fMRI neural network Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is characterized by affective and cognitive changes that increase vulnerability to depression, especially in females. Neurodevelopmental models attribute adolescent depression to abnormal responses in amygdala, striatum, and prefrontal cortex (PFC). We examined whether the strength of functional brain networks involving these regions predicts depression symptoms in adolescent females. METHODS: In this longitudinal study, we recorded resting-state functional connectivity (RSFC) in 174 adolescent females. Using a cross-validation strategy, we related RSFC profiles that included (a) a network consisting of amygdala, striatum, and PFC (within-circuit model), (b) connectivity of this network to the whole brain (extended-circuit model), and (c) a network consisting of the entire brain (whole-brain model) to depression symptoms assessed concurrently and 18 months later. RESULTS: In testing subsets, the within-circuit RSFC profiles were associated with depression symptoms concurrently and 18 months later, while the extended-circuit and whole-brain model did not explain any additional variance in depression symptoms. Connectivity related to anterior cingulate and ventromedial prefrontal cortex contributed most to the association. CONCLUSIONS: Our results demonstrate that RSFC-based brain networks that include amygdala, striatum, and PFC are stable neural signatures of concurrent and future depression symptoms, representing a significant step toward identifying the neural mechanism of depression in adolescence. En ligne : http://dx.doi.org/10.1111/jcpp.13123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421
in Journal of Child Psychology and Psychiatry > 61-4 (April 2020) . - p.480-491[article] Intrinsic neural circuitry of depression in adolescent females [Texte imprimé et/ou numérique] / Jingwen JIN, Auteur ; Jared X. VAN SNELLENBERG, Auteur ; Greg PERLMAN, Auteur ; Christine DELORENZO, Auteur ; Daniel N. KLEIN, Auteur ; Roman KOTOV, Auteur ; Aprajita MOHANTY, Auteur . - p.480-491.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-4 (April 2020) . - p.480-491
Mots-clés : Depression adolescence fMRI neural network Index. décimale : PER Périodiques Résumé : BACKGROUND: Adolescence is characterized by affective and cognitive changes that increase vulnerability to depression, especially in females. Neurodevelopmental models attribute adolescent depression to abnormal responses in amygdala, striatum, and prefrontal cortex (PFC). We examined whether the strength of functional brain networks involving these regions predicts depression symptoms in adolescent females. METHODS: In this longitudinal study, we recorded resting-state functional connectivity (RSFC) in 174 adolescent females. Using a cross-validation strategy, we related RSFC profiles that included (a) a network consisting of amygdala, striatum, and PFC (within-circuit model), (b) connectivity of this network to the whole brain (extended-circuit model), and (c) a network consisting of the entire brain (whole-brain model) to depression symptoms assessed concurrently and 18 months later. RESULTS: In testing subsets, the within-circuit RSFC profiles were associated with depression symptoms concurrently and 18 months later, while the extended-circuit and whole-brain model did not explain any additional variance in depression symptoms. Connectivity related to anterior cingulate and ventromedial prefrontal cortex contributed most to the association. CONCLUSIONS: Our results demonstrate that RSFC-based brain networks that include amygdala, striatum, and PFC are stable neural signatures of concurrent and future depression symptoms, representing a significant step toward identifying the neural mechanism of depression in adolescence. En ligne : http://dx.doi.org/10.1111/jcpp.13123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 Parent-Reported Developmental Regression in Autism: Epilepsy, IQ, Schizophrenia Spectrum Symptoms, and Special Education / Kenneth D. GADOW in Journal of Autism and Developmental Disorders, 47-4 (April 2017)
[article]
Titre : Parent-Reported Developmental Regression in Autism: Epilepsy, IQ, Schizophrenia Spectrum Symptoms, and Special Education Type de document : Texte imprimé et/ou numérique Auteurs : Kenneth D. GADOW, Auteur ; Greg PERLMAN, Auteur ; Rebecca J. WEBER, Auteur Article en page(s) : p.918-926 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Examined the psychiatric and clinical correlates of loss of previously acquired skills (regression) as reported by parents of youth with autism spectrum disorder (ASD). Study sample comprised 6- to 18-year old (N?=?213) children and adolescents with ASD. Parents reported regression in 77 (36%) youth. A more homogeneous subgroup with regression between 18 and 36 months (n?=?48) had higher rates of intellectual disability, epilepsy, and special education, more socially restrictive educational settings, and more severe ASD communication deficits and schizophrenia spectrum symptoms than non-regressed youth (n?=?136). Similar results were obtained for a more inclusive definition of regression (n?=?77). A brief parent report of developmental regression may be a useful clinical indicator of later general functioning. En ligne : http://dx.doi.org/10.1007/s10803-016-3004-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304
in Journal of Autism and Developmental Disorders > 47-4 (April 2017) . - p.918-926[article] Parent-Reported Developmental Regression in Autism: Epilepsy, IQ, Schizophrenia Spectrum Symptoms, and Special Education [Texte imprimé et/ou numérique] / Kenneth D. GADOW, Auteur ; Greg PERLMAN, Auteur ; Rebecca J. WEBER, Auteur . - p.918-926.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-4 (April 2017) . - p.918-926
Index. décimale : PER Périodiques Résumé : Examined the psychiatric and clinical correlates of loss of previously acquired skills (regression) as reported by parents of youth with autism spectrum disorder (ASD). Study sample comprised 6- to 18-year old (N?=?213) children and adolescents with ASD. Parents reported regression in 77 (36%) youth. A more homogeneous subgroup with regression between 18 and 36 months (n?=?48) had higher rates of intellectual disability, epilepsy, and special education, more socially restrictive educational settings, and more severe ASD communication deficits and schizophrenia spectrum symptoms than non-regressed youth (n?=?136). Similar results were obtained for a more inclusive definition of regression (n?=?77). A brief parent report of developmental regression may be a useful clinical indicator of later general functioning. En ligne : http://dx.doi.org/10.1007/s10803-016-3004-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304