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Auteur A. E. RICHARD |
Documents disponibles écrits par cet auteur (2)
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Neural synchrony examined with magnetoencephalography (MEG) during eye gaze processing in autism spectrum disorders: preliminary findings / R. LAJINESS-O'NEILL in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)
[article]
Titre : Neural synchrony examined with magnetoencephalography (MEG) during eye gaze processing in autism spectrum disorders: preliminary findings Type de document : Texte imprimé et/ou numérique Auteurs : R. LAJINESS-O'NEILL, Auteur ; A. E. RICHARD, Auteur ; J. E. MORAN, Auteur ; A. OLSZEWSKI, Auteur ; L. PAWLUK, Auteur ; D. JACOBSON, Auteur ; A. MANSOUR, Auteur ; K. VOGT, Auteur ; L. A. ERDODI, Auteur ; A. M. MOORE, Auteur ; S. M. BOWYER, Auteur Article en page(s) : p.15 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Coherence Eye gaze Magnetoencephalography Neural synchrony Social cognition Index. décimale : PER Périodiques Résumé : BACKGROUND: Gaze processing deficits are a seminal, early, and enduring behavioral deficit in autism spectrum disorder (ASD); however, a comprehensive characterization of the neural processes mediating abnormal gaze processing in ASD has yet to be conducted. METHODS: This study investigated whole-brain patterns of neural synchrony during passive viewing of direct and averted eye gaze in ASD adolescents and young adults (M Age = 16.6) compared to neurotypicals (NT) (M Age = 17.5) while undergoing magnetoencephalography. Coherence between each pair of 54 brain regions within each of three frequency bands (low frequency (0 to 15 Hz), beta (15 to 30 Hz), and low gamma (30 to 45 Hz)) was calculated. RESULTS: Significantly higher coherence and synchronization in posterior brain regions (temporo-parietal-occipital) across all frequencies was evident in ASD, particularly within the low 0 to 15 Hz frequency range. Higher coherence in fronto-temporo-parietal regions was noted in NT. A significantly higher number of low frequency cross-hemispheric synchronous connections and a near absence of right intra-hemispheric coherence in the beta frequency band were noted in ASD. Significantly higher low frequency coherent activity in bilateral temporo-parieto-occipital cortical regions and higher gamma band coherence in right temporo-parieto-occipital brain regions during averted gaze was related to more severe symptomology as reported on the Autism Diagnostic Interview-Revised (ADI-R). CONCLUSIONS: The preliminary results suggest a pattern of aberrant connectivity that includes higher low frequency synchronization in posterior cortical regions, lack of long-range right hemispheric beta and gamma coherence, and decreased coherence in fronto-temporo-parietal regions necessary for orienting to shifts in eye gaze in ASD; a critical behavior essential for social communication. En ligne : http://dx.doi.org/10.1186/1866-1955-6-15 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346
in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.15[article] Neural synchrony examined with magnetoencephalography (MEG) during eye gaze processing in autism spectrum disorders: preliminary findings [Texte imprimé et/ou numérique] / R. LAJINESS-O'NEILL, Auteur ; A. E. RICHARD, Auteur ; J. E. MORAN, Auteur ; A. OLSZEWSKI, Auteur ; L. PAWLUK, Auteur ; D. JACOBSON, Auteur ; A. MANSOUR, Auteur ; K. VOGT, Auteur ; L. A. ERDODI, Auteur ; A. M. MOORE, Auteur ; S. M. BOWYER, Auteur . - p.15.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.15
Mots-clés : Autism spectrum disorder Coherence Eye gaze Magnetoencephalography Neural synchrony Social cognition Index. décimale : PER Périodiques Résumé : BACKGROUND: Gaze processing deficits are a seminal, early, and enduring behavioral deficit in autism spectrum disorder (ASD); however, a comprehensive characterization of the neural processes mediating abnormal gaze processing in ASD has yet to be conducted. METHODS: This study investigated whole-brain patterns of neural synchrony during passive viewing of direct and averted eye gaze in ASD adolescents and young adults (M Age = 16.6) compared to neurotypicals (NT) (M Age = 17.5) while undergoing magnetoencephalography. Coherence between each pair of 54 brain regions within each of three frequency bands (low frequency (0 to 15 Hz), beta (15 to 30 Hz), and low gamma (30 to 45 Hz)) was calculated. RESULTS: Significantly higher coherence and synchronization in posterior brain regions (temporo-parietal-occipital) across all frequencies was evident in ASD, particularly within the low 0 to 15 Hz frequency range. Higher coherence in fronto-temporo-parietal regions was noted in NT. A significantly higher number of low frequency cross-hemispheric synchronous connections and a near absence of right intra-hemispheric coherence in the beta frequency band were noted in ASD. Significantly higher low frequency coherent activity in bilateral temporo-parieto-occipital cortical regions and higher gamma band coherence in right temporo-parieto-occipital brain regions during averted gaze was related to more severe symptomology as reported on the Autism Diagnostic Interview-Revised (ADI-R). CONCLUSIONS: The preliminary results suggest a pattern of aberrant connectivity that includes higher low frequency synchronization in posterior cortical regions, lack of long-range right hemispheric beta and gamma coherence, and decreased coherence in fronto-temporo-parietal regions necessary for orienting to shifts in eye gaze in ASD; a critical behavior essential for social communication. En ligne : http://dx.doi.org/10.1186/1866-1955-6-15 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 Patterns of altered neural synchrony in the default mode network in autism spectrum disorder revealed with magnetoencephalography (MEG): Relationship to clinical symptomatology / R. LAJINESS-O'NEILL in Autism Research, 11-3 (March 2018)
[article]
Titre : Patterns of altered neural synchrony in the default mode network in autism spectrum disorder revealed with magnetoencephalography (MEG): Relationship to clinical symptomatology Type de document : Texte imprimé et/ou numérique Auteurs : R. LAJINESS-O'NEILL, Auteur ; J. R. BRENNAN, Auteur ; J. E. MORAN, Auteur ; A. E. RICHARD, Auteur ; A. M. FLORES, Auteur ; C. SWICK, Auteur ; R. GOODCASE, Auteur ; T. ANDERSEN, Auteur ; K. MCFARLANE, Auteur ; K. RUSINIAK, Auteur ; I. KOVELMAN, Auteur ; N. WAGLEY, Auteur ; M. UGOLINI, Auteur ; Jordan ALBRIGHT, Auteur ; S. M. BOWYER, Auteur Article en page(s) : p.434-449 Langues : Anglais (eng) Mots-clés : autism spectrum disorder coherence default mode network gamma magnetoencephalography salience network synchrony Index. décimale : PER Périodiques Résumé : Disrupted neural synchrony may be a primary electrophysiological abnormality in autism spectrum disorders (ASD), altering communication between discrete brain regions and contributing to abnormalities in patterns of connectivity within identified neural networks. Studies exploring brain dynamics to comprehensively characterize and link connectivity to large-scale cortical networks and clinical symptoms are lagging considerably. Patterns of neural coherence within the Default Mode Network (DMN) and Salience Network (SN) during resting state were investigated in 12 children with ASD (MAge = 9.2) and 13 age and gender-matched neurotypicals (NT) (MAge = 9.3) with magnetoencephalography. Coherence between 231 brain region pairs within four frequency bands (theta (4-7 Hz), alpha, (8-12 Hz), beta (13-30 Hz), and gamma (30-80 Hz)) was calculated. Relationships between neural coherence and social functioning were examined. ASD was characterized by lower synchronization across all frequencies, reaching clinical significance in the gamma band. Lower gamma synchrony between fronto-temporo-parietal regions was observed, partially consistent with diminished default mode network (DMN) connectivity. Lower gamma coherence in ASD was evident in cross-hemispheric connections between: angular with inferior/middle frontal; middle temporal with middle/inferior frontal; and within right-hemispheric connections between angular, middle temporal, and inferior/middle frontal cortices. Lower gamma coherence between left angular and left superior frontal, right inferior/middle frontal, and right precuneus and between right angular and inferior/middle frontal cortices was related to lower social/social-communication functioning. Results suggest a pattern of lower gamma band coherence in a subset of regions within the DMN in ASD (angular and middle temporal cortical areas) related to lower social/social-communicative functioning. Autism Res 2018, 11: 434-449. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Communication between different areas of the brain was observed in children with ASD and neurotypical children while awake, but not working on a task. Magnetoencephalography was used to measure tiny magnetic fields naturally generated via brain activity. The brains of children with ASD showed less communication between areas that are important for social information processing compared to the brains of neurotypical children. The amount of communication between these areas was associated with social and social communication difficulties. En ligne : http://dx.doi.org/10.1002/aur.1908 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352
in Autism Research > 11-3 (March 2018) . - p.434-449[article] Patterns of altered neural synchrony in the default mode network in autism spectrum disorder revealed with magnetoencephalography (MEG): Relationship to clinical symptomatology [Texte imprimé et/ou numérique] / R. LAJINESS-O'NEILL, Auteur ; J. R. BRENNAN, Auteur ; J. E. MORAN, Auteur ; A. E. RICHARD, Auteur ; A. M. FLORES, Auteur ; C. SWICK, Auteur ; R. GOODCASE, Auteur ; T. ANDERSEN, Auteur ; K. MCFARLANE, Auteur ; K. RUSINIAK, Auteur ; I. KOVELMAN, Auteur ; N. WAGLEY, Auteur ; M. UGOLINI, Auteur ; Jordan ALBRIGHT, Auteur ; S. M. BOWYER, Auteur . - p.434-449.
Langues : Anglais (eng)
in Autism Research > 11-3 (March 2018) . - p.434-449
Mots-clés : autism spectrum disorder coherence default mode network gamma magnetoencephalography salience network synchrony Index. décimale : PER Périodiques Résumé : Disrupted neural synchrony may be a primary electrophysiological abnormality in autism spectrum disorders (ASD), altering communication between discrete brain regions and contributing to abnormalities in patterns of connectivity within identified neural networks. Studies exploring brain dynamics to comprehensively characterize and link connectivity to large-scale cortical networks and clinical symptoms are lagging considerably. Patterns of neural coherence within the Default Mode Network (DMN) and Salience Network (SN) during resting state were investigated in 12 children with ASD (MAge = 9.2) and 13 age and gender-matched neurotypicals (NT) (MAge = 9.3) with magnetoencephalography. Coherence between 231 brain region pairs within four frequency bands (theta (4-7 Hz), alpha, (8-12 Hz), beta (13-30 Hz), and gamma (30-80 Hz)) was calculated. Relationships between neural coherence and social functioning were examined. ASD was characterized by lower synchronization across all frequencies, reaching clinical significance in the gamma band. Lower gamma synchrony between fronto-temporo-parietal regions was observed, partially consistent with diminished default mode network (DMN) connectivity. Lower gamma coherence in ASD was evident in cross-hemispheric connections between: angular with inferior/middle frontal; middle temporal with middle/inferior frontal; and within right-hemispheric connections between angular, middle temporal, and inferior/middle frontal cortices. Lower gamma coherence between left angular and left superior frontal, right inferior/middle frontal, and right precuneus and between right angular and inferior/middle frontal cortices was related to lower social/social-communication functioning. Results suggest a pattern of lower gamma band coherence in a subset of regions within the DMN in ASD (angular and middle temporal cortical areas) related to lower social/social-communicative functioning. Autism Res 2018, 11: 434-449. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Communication between different areas of the brain was observed in children with ASD and neurotypical children while awake, but not working on a task. Magnetoencephalography was used to measure tiny magnetic fields naturally generated via brain activity. The brains of children with ASD showed less communication between areas that are important for social information processing compared to the brains of neurotypical children. The amount of communication between these areas was associated with social and social communication difficulties. En ligne : http://dx.doi.org/10.1002/aur.1908 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352