Commentary: Biological embedding of childhood adversity: where do we go from here? A reflection on Koss and Gunnar (2018) / A. DANESE in Journal of Child Psychology and Psychiatry, 59-4 (April 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.347-349 Titre : Commentary: Biological embedding of childhood adversity: where do we go from here? A reflection on Koss and Gunnar (2018) Type de document : Texte imprimé et/ou numérique Auteurs : A. DANESE, Auteur Article en page(s) : p.347-349 Langues : Anglais (eng) Mots-clés : Adversity Index. décimale : PER Périodiques Résumé : The review by Koss & Gunna provides a scholarly overview of the role of the hypothalamic-pituitary-adrenal (HPA) axis in mediating the association between childhood adversity and psychopathology. Through their insightful observations, the authors craft a rich framework to critically appraise the current evidence and inform future research in this area. Overall, the review calls for a new generation of studies testing biological embedding hypotheses with greater attention to design, measurement, statistical models, and translational approaches. These new studies are much needed. By uncovering the causal pathways underlying the biological embedding of childhood adversity, we can gain important new tools to prevent the most impairing forms of psychopathology among the most vulnerable individuals in society. En ligne : http://dx.doi.org/10.1111/jcpp.12891 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353 [article] Commentary: Biological embedding of childhood adversity: where do we go from here? A reflection on Koss and Gunnar (2018) [Texte imprimé et/ou numérique] / A. DANESE, Auteur . - p.347-349. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.347-349 Mots-clés : Adversity Index. décimale : PER Périodiques Résumé : The review by Koss & Gunna provides a scholarly overview of the role of the hypothalamic-pituitary-adrenal (HPA) axis in mediating the association between childhood adversity and psychopathology. Through their insightful observations, the authors craft a rich framework to critically appraise the current evidence and inform future research in this area. Overall, the review calls for a new generation of studies testing biological embedding hypotheses with greater attention to design, measurement, statistical models, and translational approaches. These new studies are much needed. By uncovering the causal pathways underlying the biological embedding of childhood adversity, we can gain important new tools to prevent the most impairing forms of psychopathology among the most vulnerable individuals in society. En ligne : http://dx.doi.org/10.1111/jcpp.12891 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353

Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood / L. J. H. RASMUSSEN in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.199-208 Titre : Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood Type de document : Texte imprimé et/ou numérique Auteurs : L. J. H. RASMUSSEN, Auteur ; T. E. MOFFITT, Auteur ; J. EUGEN-OLSEN, Auteur ; Daniel W. BELSKY, Auteur ; A. DANESE, Auteur ; H. HARRINGTON, Auteur ; R. M. HOUTS, Auteur ; R. POULTON, Auteur ; K. SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur Article en page(s) : p.199-208 Langues : Anglais (eng) Mots-clés : Adverse childhood experiences  inflammation  physical health  risk factors  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP). METHODS: Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP). RESULTS: Participants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001). CONCLUSIONS: Exposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden. En ligne : http://dx.doi.org/10.1111/jcpp.12928 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381 [article] Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood [Texte imprimé et/ou numérique] / L. J. H. RASMUSSEN, Auteur ; T. E. MOFFITT, Auteur ; J. EUGEN-OLSEN, Auteur ; Daniel W. BELSKY, Auteur ; A. DANESE, Auteur ; H. HARRINGTON, Auteur ; R. M. HOUTS, Auteur ; R. POULTON, Auteur ; K. SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur . - p.199-208. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.199-208 Mots-clés : Adverse childhood experiences  inflammation  physical health  risk factors  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP). METHODS: Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP). RESULTS: Participants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001). CONCLUSIONS: Exposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden. En ligne : http://dx.doi.org/10.1111/jcpp.12928 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381

Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence / Edward D. BARKER in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.1145-1156 Titre : Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Edward D. BARKER, Auteur ; Charlotte A. M. CECIL, Auteur ; E. WALTON, Auteur ; L. C. HOUTEPEN, Auteur ; T. G. O'CONNOR, Auteur ; A. DANESE, Auteur ; Sara R. JAFFEE, Auteur ; S. K. G. JENSEN, Auteur ; C. PARIANTE, Auteur ; W. MCARDLE, Auteur ; T. R. GAUNT, Auteur ; C. L. RELTON, Auteur ; S. ROBERTS, Auteur Article en page(s) : p.1145-1156 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health. En ligne : http://dx.doi.org/10.1017/s0954579418000330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence [Texte imprimé et/ou numérique] / Edward D. BARKER, Auteur ; Charlotte A. M. CECIL, Auteur ; E. WALTON, Auteur ; L. C. HOUTEPEN, Auteur ; T. G. O'CONNOR, Auteur ; A. DANESE, Auteur ; Sara R. JAFFEE, Auteur ; S. K. G. JENSEN, Auteur ; C. PARIANTE, Auteur ; W. MCARDLE, Auteur ; T. R. GAUNT, Auteur ; C. L. RELTON, Auteur ; S. ROBERTS, Auteur . - p.1145-1156. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.1145-1156 Index. décimale : PER Périodiques Résumé : In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health. En ligne : http://dx.doi.org/10.1017/s0954579418000330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

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