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Auteur R. POULTON |
Documents disponibles écrits par cet auteur (3)



Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 / D. MASON in Autism Research, 14-8 (August 2021)
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[article]
Titre : Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 Type de document : Texte imprimé et/ou numérique Auteurs : D. MASON, Auteur ; A. RONALD, Auteur ; A. AMBLER, Auteur ; Avshalom CASPI, Auteur ; R. HOUTS, Auteur ; R. POULTON, Auteur ; S. RAMRAKHA, Auteur ; J. WERTZ, Auteur ; T. E. MOFFITT, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.1684-1694 Langues : Anglais (eng) Mots-clés : Adult Aging Autism Spectrum Disorder Autistic Disorder Humans Middle Aged Surveys and Questionnaires aging autistic traits intelligence physical health socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45?years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (? = 0.09), facial age (? = 0.08), self- (? = -0.15), informant (? = -0.12), and interviewer-rated (? = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-8 (August 2021) . - p.1684-1694[article] Autistic traits are associated with faster pace of aging: Evidence from the Dunedin study at age 45 [Texte imprimé et/ou numérique] / D. MASON, Auteur ; A. RONALD, Auteur ; A. AMBLER, Auteur ; Avshalom CASPI, Auteur ; R. HOUTS, Auteur ; R. POULTON, Auteur ; S. RAMRAKHA, Auteur ; J. WERTZ, Auteur ; T. E. MOFFITT, Auteur ; Francesca HAPPE, Auteur . - p.1684-1694.
Langues : Anglais (eng)
in Autism Research > 14-8 (August 2021) . - p.1684-1694
Mots-clés : Adult Aging Autism Spectrum Disorder Autistic Disorder Humans Middle Aged Surveys and Questionnaires aging autistic traits intelligence physical health socioeconomic status Index. décimale : PER Périodiques Résumé : Growing evidence indicates that the defining characteristics of autism spectrum disorder (ASD) are distributed throughout the general population; hence, understanding the correlates of aging in people with high autistic traits could shed light on ASD and aging. 915 members of the Dunedin longitudinal birth cohort completed a measure of autistic traits at age 45. A composite measure of the "pace of aging" was derived by tracking the decline in 19 biomarkers across ages 26, 32, 38, and 45?years. Facial age was also assessed. Reports of perceived health were collected from participants themselves, informants, and interviewers. Higher self-reported autistic traits significantly correlated with a faster pace of aging, older facial age, and poorer self-, informant-, and interviewer-rated health. After control for sex, SES and IQ, autistic traits were significantly associated with each variable: pace of aging (? = 0.09), facial age (? = 0.08), self- (? = -0.15), informant (? = -0.12), and interviewer-rated (? = -0.17) health. Autistic traits measured at age 45 are associated with faster aging. Participants with high autistic traits appear to be more vulnerable to poor health outcomes, as previously reported for those clinically diagnosed with ASD. Therefore, autistic traits may have important health implications. Replicating these findings in samples of autistic people is needed to identify the mechanism of their effect on aging and physical health to improve outcomes for those with ASD diagnoses or high autistic traits. LAY SUMMARY: The role that autistic traits have in relation to health outcomes has not been investigated. We looked at how physical health and aging (measured with self-reported questions and decline in multiple biological measures) were related to autistic traits (measured with a questionnaire, at age 45). We found that higher autistic traits were associated with poorer reports of physical health, and a faster pace of aging. This suggests that both those with autism and those with higher autistic traits may be more likely to experience poorer health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2534 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood / L. J. H. RASMUSSEN in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)
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[article]
Titre : Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood Type de document : Texte imprimé et/ou numérique Auteurs : L. J. H. RASMUSSEN, Auteur ; T. E. MOFFITT, Auteur ; J. EUGEN-OLSEN, Auteur ; Daniel W. BELSKY, Auteur ; A. DANESE, Auteur ; H. HARRINGTON, Auteur ; R. M. HOUTS, Auteur ; R. POULTON, Auteur ; K. SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur Article en page(s) : p.199-208 Langues : Anglais (eng) Mots-clés : Adverse childhood experiences inflammation physical health risk factors self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP). METHODS: Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP). RESULTS: Participants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001). CONCLUSIONS: Exposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden. En ligne : http://dx.doi.org/10.1111/jcpp.12928 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381
in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.199-208[article] Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood [Texte imprimé et/ou numérique] / L. J. H. RASMUSSEN, Auteur ; T. E. MOFFITT, Auteur ; J. EUGEN-OLSEN, Auteur ; Daniel W. BELSKY, Auteur ; A. DANESE, Auteur ; H. HARRINGTON, Auteur ; R. M. HOUTS, Auteur ; R. POULTON, Auteur ; K. SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Avshalom CASPI, Auteur . - p.199-208.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.199-208
Mots-clés : Adverse childhood experiences inflammation physical health risk factors self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP). METHODS: Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP). RESULTS: Participants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001). CONCLUSIONS: Exposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden. En ligne : http://dx.doi.org/10.1111/jcpp.12928 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381 The high societal costs of childhood conduct problems: evidence from administrative records up to age 38 in a longitudinal birth cohort / J. G. RIVENBARK in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)
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[article]
Titre : The high societal costs of childhood conduct problems: evidence from administrative records up to age 38 in a longitudinal birth cohort Type de document : Texte imprimé et/ou numérique Auteurs : J. G. RIVENBARK, Auteur ; C. L. ODGERS, Auteur ; Avshalom CASPI, Auteur ; H. HARRINGTON, Auteur ; S. HOGAN, Auteur ; R. M. HOUTS, Auteur ; R. POULTON, Auteur ; T. E. MOFFITT, Auteur Article en page(s) : p.703-710 Langues : Anglais (eng) Mots-clés : Conduct disorder administrative data electronic medical data longitudinal study service utilization Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with conduct problems that persist into adulthood are at increased risk for future behavioral, health, and social problems. However, the longer term public service usage among these children has not been fully documented. To aid public health and intervention planning, adult service usage across criminal justice, health care, and social welfare domains is compared among all individuals from a representative cohort who followed different conduct problem trajectories from childhood into adulthood. METHODS: Participants are from the Dunedin Multidisciplinary Health and Development Study, a prospective, representative cohort of consecutive births (N = 1,037) from April 1972 to March 1973 in Dunedin, New Zealand. Regression analyses were used to compare levels of public service usage up to age 38, gathered via administrative and electronic medical records, between participants who displayed distinct subtypes of childhood conduct problems (low, childhood-limited, adolescent-onset, and life-course persistent). RESULTS: Children exhibiting life-course persistent conduct problems used significantly more services as adults than those with low levels of childhood conduct problems. Although this group comprised only 9.0% of the population, they accounted for 53.3% of all convictions, 15.7% of emergency department visits, 20.5% of prescription fills, 13.1% of injury claims, and 24.7% of welfare benefit months. Half of this group (50.0%) also accrued high service use across all three domains of criminal justice, health, and social welfare services, as compared to only 11.3% of those with low conduct problems (OR = 7.27, 95% CI = 4.42-12.0). CONCLUSIONS: Conduct problems in childhood signal high future costs in terms of service utilization across multiple sectors. Future evaluations of interventions aimed at conduct problems should also track potential reductions in health burden and service usage that stretch into midlife. En ligne : http://dx.doi.org/10.1111/jcpp.12850 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363
in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.703-710[article] The high societal costs of childhood conduct problems: evidence from administrative records up to age 38 in a longitudinal birth cohort [Texte imprimé et/ou numérique] / J. G. RIVENBARK, Auteur ; C. L. ODGERS, Auteur ; Avshalom CASPI, Auteur ; H. HARRINGTON, Auteur ; S. HOGAN, Auteur ; R. M. HOUTS, Auteur ; R. POULTON, Auteur ; T. E. MOFFITT, Auteur . - p.703-710.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.703-710
Mots-clés : Conduct disorder administrative data electronic medical data longitudinal study service utilization Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with conduct problems that persist into adulthood are at increased risk for future behavioral, health, and social problems. However, the longer term public service usage among these children has not been fully documented. To aid public health and intervention planning, adult service usage across criminal justice, health care, and social welfare domains is compared among all individuals from a representative cohort who followed different conduct problem trajectories from childhood into adulthood. METHODS: Participants are from the Dunedin Multidisciplinary Health and Development Study, a prospective, representative cohort of consecutive births (N = 1,037) from April 1972 to March 1973 in Dunedin, New Zealand. Regression analyses were used to compare levels of public service usage up to age 38, gathered via administrative and electronic medical records, between participants who displayed distinct subtypes of childhood conduct problems (low, childhood-limited, adolescent-onset, and life-course persistent). RESULTS: Children exhibiting life-course persistent conduct problems used significantly more services as adults than those with low levels of childhood conduct problems. Although this group comprised only 9.0% of the population, they accounted for 53.3% of all convictions, 15.7% of emergency department visits, 20.5% of prescription fills, 13.1% of injury claims, and 24.7% of welfare benefit months. Half of this group (50.0%) also accrued high service use across all three domains of criminal justice, health, and social welfare services, as compared to only 11.3% of those with low conduct problems (OR = 7.27, 95% CI = 4.42-12.0). CONCLUSIONS: Conduct problems in childhood signal high future costs in terms of service utilization across multiple sectors. Future evaluations of interventions aimed at conduct problems should also track potential reductions in health burden and service usage that stretch into midlife. En ligne : http://dx.doi.org/10.1111/jcpp.12850 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363