Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence / Edward D. BARKER in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.1145-1156 Titre : Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Edward D. BARKER, Auteur ; Charlotte A. M. CECIL, Auteur ; E. WALTON, Auteur ; L. C. HOUTEPEN, Auteur ; T. G. O'CONNOR, Auteur ; A. DANESE, Auteur ; Sara R. JAFFEE, Auteur ; S. K. G. JENSEN, Auteur ; C. PARIANTE, Auteur ; W. MCARDLE, Auteur ; T. R. GAUNT, Auteur ; C. L. RELTON, Auteur ; S. ROBERTS, Auteur Article en page(s) : p.1145-1156 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health. En ligne : http://dx.doi.org/10.1017/s0954579418000330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence [Texte imprimé et/ou numérique] / Edward D. BARKER, Auteur ; Charlotte A. M. CECIL, Auteur ; E. WALTON, Auteur ; L. C. HOUTEPEN, Auteur ; T. G. O'CONNOR, Auteur ; A. DANESE, Auteur ; Sara R. JAFFEE, Auteur ; S. K. G. JENSEN, Auteur ; C. PARIANTE, Auteur ; W. MCARDLE, Auteur ; T. R. GAUNT, Auteur ; C. L. RELTON, Auteur ; S. ROBERTS, Auteur . - p.1145-1156. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.1145-1156 Index. décimale : PER Périodiques Résumé : In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health. En ligne : http://dx.doi.org/10.1017/s0954579418000330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Risk Factors Associated with Self-Injurious Behaviors in Children and Adolescents with Autism Spectrum Disorders / Emma G. DUERDEN in Journal of Autism and Developmental Disorders, 42-11 (November 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2460-2470 Titre : Risk Factors Associated with Self-Injurious Behaviors in Children and Adolescents with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Emma G. DUERDEN, Auteur ; Hannah OATLEY, Auteur ; Kathleen M. MAK-FAN, Auteur ; Patricia MCGRATH, Auteur ; Margot J. TAYLOR, Auteur ; Peter SZATMARI, Auteur ; S. ROBERTS, Auteur Article en page(s) : p.2460-2470 Langues : Anglais (eng) Mots-clés : Pain  Sensory  Self-injury  Autism  Human Index. décimale : PER Périodiques Résumé : While self-injurious behaviors (SIB) can cause significant morbidity for children with autism spectrum disorders (ASD), little is known about its associated risk factors. We assessed 7 factors that may influence self-injury in a large cohort of children with ASD: (a) atypical sensory processing; (b) impaired cognitive ability; (c) abnormal functional communication; (d) abnormal social functioning; (e) age; (f) the need for sameness; (g) rituals and compulsions. Half (52.3%, n = 126) of the children (n = 241, aged 2–19 years) demonstrated SIB. Abnormal sensory processing was the strongest single predictor of self-injury followed by sameness, impaired cognitive ability and social functioning. Since atypical sensory processing and sameness have a greater relative impact on SIB, treatment approaches that focus on these factors may be beneficial in reducing self-harm in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1497-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 [article] Risk Factors Associated with Self-Injurious Behaviors in Children and Adolescents with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Emma G. DUERDEN, Auteur ; Hannah OATLEY, Auteur ; Kathleen M. MAK-FAN, Auteur ; Patricia MCGRATH, Auteur ; Margot J. TAYLOR, Auteur ; Peter SZATMARI, Auteur ; S. ROBERTS, Auteur . - p.2460-2470. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2460-2470 Mots-clés : Pain  Sensory  Self-injury  Autism  Human Index. décimale : PER Périodiques Résumé : While self-injurious behaviors (SIB) can cause significant morbidity for children with autism spectrum disorders (ASD), little is known about its associated risk factors. We assessed 7 factors that may influence self-injury in a large cohort of children with ASD: (a) atypical sensory processing; (b) impaired cognitive ability; (c) abnormal functional communication; (d) abnormal social functioning; (e) age; (f) the need for sameness; (g) rituals and compulsions. Half (52.3%, n = 126) of the children (n = 241, aged 2–19 years) demonstrated SIB. Abnormal sensory processing was the strongest single predictor of self-injury followed by sameness, impaired cognitive ability and social functioning. Since atypical sensory processing and sameness have a greater relative impact on SIB, treatment approaches that focus on these factors may be beneficial in reducing self-harm in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-012-1497-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183

The impact of treatment delivery format on response to cognitive behaviour therapy for preadolescent children with anxiety disorders / A. MCKINNON in Journal of Child Psychology and Psychiatry, 59-7 (July 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.763-772 Titre : The impact of treatment delivery format on response to cognitive behaviour therapy for preadolescent children with anxiety disorders Type de document : Texte imprimé et/ou numérique Auteurs : A. MCKINNON, Auteur ; R. KEERS, Auteur ; J. R. I. COLEMAN, Auteur ; K. J. LESTER, Auteur ; S. ROBERTS, Auteur ; Kristian ARENDT, Auteur ; Susan M. BOGELS, Auteur ; Peter COOPER, Auteur ; C. CRESWELL, Auteur ; Catharina A. HARTMAN, Auteur ; K. W. FJERMESTAD, Auteur ; T. IN-ALBON, Auteur ; K. LAVALLEE, Auteur ; H. J. LYNEHAM, Auteur ; P. SMITH, Auteur ; R. MEISER-STEDMAN, Auteur ; M. H. NAUTA, Auteur ; R. M. RAPEE, Auteur ; Y. REY, Auteur ; S. SCHNEIDER, Auteur ; W. K. SILVERMAN, Auteur ; M. THASTUM, Auteur ; K. THIRLWALL, Auteur ; Gro Janne WERGELAND, Auteur ; T. C. ELEY, Auteur ; J. L. HUDSON, Auteur Année de publication : 2018 Article en page(s) : p.763-772 Langues : Anglais (eng) Mots-clés : Anxiety  cognitive therapy  treatment trials Index. décimale : PER Périodiques Résumé : BACKGROUND: Several delivery formats of cognitive behaviour therapy (CBT) for child anxiety have been proposed, however, there is little consensus on the optimal delivery format. The primary goal of this study was to investigate the impact of the child's primary anxiety diagnosis on changes in clinical severity (of the primary problem) during individual CBT, group CBT and guided parent-led CBT. The secondary goal was to investigate the impact of the child's primary anxiety diagnosis on rates of remission for the three treatment formats. METHODS: A sample of 1,253 children (5-12 years; Mage = 9.3, SD = 1.7) was pooled from CBT trials carried out at 10 sites. Children had a primary diagnosis of generalised anxiety disorder (GAD), social anxiety disorder (SoAD), specific phobia (SP) or separation anxiety disorder (SAD). Children and parents completed a semistructured clinical interview to assess the presence and severity of DSM-IV psychiatric disorders at preintervention, postintervention and follow-up. Linear mixture modelling was used to evaluate the primary research question and logistic modelling was used to investigate the secondary research question. RESULTS: In children with primary GAD, SAD or SoAD, there were no significant differences between delivery formats. However, children with primary SP showed significantly larger reductions in clinical severity following individual CBT compared to group CBT and guided parent-led CBT. The results were mirrored in the analysis of remission responses with the exception that individual CBT was no longer superior to group CBT for children with a primary SP. The difference between individual and group was not significant when follow-up data were examined separately. CONCLUSIONS: Data show there may be greater clinical benefit by allocating children with a primary SP to individual CBT, although future research on cost-effectiveness is needed to determine whether the additional clinical benefits justify the additional resources required. En ligne : http://dx.doi.org/10.1111/jcpp.12872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] The impact of treatment delivery format on response to cognitive behaviour therapy for preadolescent children with anxiety disorders [Texte imprimé et/ou numérique] / A. MCKINNON, Auteur ; R. KEERS, Auteur ; J. R. I. COLEMAN, Auteur ; K. J. LESTER, Auteur ; S. ROBERTS, Auteur ; Kristian ARENDT, Auteur ; Susan M. BOGELS, Auteur ; Peter COOPER, Auteur ; C. CRESWELL, Auteur ; Catharina A. HARTMAN, Auteur ; K. W. FJERMESTAD, Auteur ; T. IN-ALBON, Auteur ; K. LAVALLEE, Auteur ; H. J. LYNEHAM, Auteur ; P. SMITH, Auteur ; R. MEISER-STEDMAN, Auteur ; M. H. NAUTA, Auteur ; R. M. RAPEE, Auteur ; Y. REY, Auteur ; S. SCHNEIDER, Auteur ; W. K. SILVERMAN, Auteur ; M. THASTUM, Auteur ; K. THIRLWALL, Auteur ; Gro Janne WERGELAND, Auteur ; T. C. ELEY, Auteur ; J. L. HUDSON, Auteur . - 2018 . - p.763-772. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.763-772 Mots-clés : Anxiety  cognitive therapy  treatment trials Index. décimale : PER Périodiques Résumé : BACKGROUND: Several delivery formats of cognitive behaviour therapy (CBT) for child anxiety have been proposed, however, there is little consensus on the optimal delivery format. The primary goal of this study was to investigate the impact of the child's primary anxiety diagnosis on changes in clinical severity (of the primary problem) during individual CBT, group CBT and guided parent-led CBT. The secondary goal was to investigate the impact of the child's primary anxiety diagnosis on rates of remission for the three treatment formats. METHODS: A sample of 1,253 children (5-12 years; Mage = 9.3, SD = 1.7) was pooled from CBT trials carried out at 10 sites. Children had a primary diagnosis of generalised anxiety disorder (GAD), social anxiety disorder (SoAD), specific phobia (SP) or separation anxiety disorder (SAD). Children and parents completed a semistructured clinical interview to assess the presence and severity of DSM-IV psychiatric disorders at preintervention, postintervention and follow-up. Linear mixture modelling was used to evaluate the primary research question and logistic modelling was used to investigate the secondary research question. RESULTS: In children with primary GAD, SAD or SoAD, there were no significant differences between delivery formats. However, children with primary SP showed significantly larger reductions in clinical severity following individual CBT compared to group CBT and guided parent-led CBT. The results were mirrored in the analysis of remission responses with the exception that individual CBT was no longer superior to group CBT for children with a primary SP. The difference between individual and group was not significant when follow-up data were examined separately. CONCLUSIONS: Data show there may be greater clinical benefit by allocating children with a primary SP to individual CBT, although future research on cost-effectiveness is needed to determine whether the additional clinical benefits justify the additional resources required. En ligne : http://dx.doi.org/10.1111/jcpp.12872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Toward a Better Understanding of Self Injurious Behaviors in Children and Adolescents with Autism Spectrum Disorders / Emma G. DUERDEN in Journal of Autism and Developmental Disorders, 42-11 (November 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2515-2518 Titre : Toward a Better Understanding of Self Injurious Behaviors in Children and Adolescents with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Emma G. DUERDEN, Auteur ; Peter SZATMARI, Auteur ; S. ROBERTS, Auteur Article en page(s) : p.2515-2518 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-012-1600-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 [article] Toward a Better Understanding of Self Injurious Behaviors in Children and Adolescents with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Emma G. DUERDEN, Auteur ; Peter SZATMARI, Auteur ; S. ROBERTS, Auteur . - p.2515-2518. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-11 (November 2012) . - p.2515-2518 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-012-1600-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183

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