Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing / V. B. PUETZ in Development and Psychopathology, 35-3 (August 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-3 (August 2023) . - p.1382-1389 Titre : Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing Type de document : Texte imprimé et/ou numérique Auteurs : V. B. PUETZ, Auteur ; E. VIDING, Auteur ; E. A. MAGUIRE, Auteur ; A. MECHELLI, Auteur ; D. ARMBRUSTER-GENÇ, Auteur ; M. SHARP, Auteur ; G. RANKIN, Auteur ; M. I. GERIN, Auteur ; E. J. MCCRORY, Auteur Article en page(s) : p.1382-1389 Langues : Anglais (eng) Mots-clés : autobiographical memory  brain plasticity  childhood maltreatment  fMRI  longitudinal study Index. décimale : PER Périodiques Résumé : Altered autobiographical memory (ABM) processing characterizes some individuals with experiences of childhood maltreatment. This fMRI study of ABM processing evaluated potential developmental plasticity in neural functioning following maltreatment. Adolescents with (N = 19; MT group) and without (N = 18; Non-MT group) documented childhood maltreatment recalled specific ABMs in response to emotionally valenced cue words during fMRI at baseline (age 12.71 + 1.48) and follow-up (14.88 + 1.53 years). Psychological assessments were collected at both timepoints. Longitudinal analyses were carried out with BOLD signal changes during ABM recall and psychopathology to investigate change over time. In both groups there was relative stability of the ABM brain network, with some developmental maturational changes observed in cortical midline structures (ventromedial PFC (vmPFC), posterior cingulate cortex (pCC), and retrosplenial cortex (rSC). Significantly increased activation of the right rSC was observed only in the MT group, which was associated with improved psychological functioning. Baseline group differences in relation to hippocampal functioning, were not detected at follow-up. This study provides preliminary empirical evidence of functional developmental plasticity in children with documented maltreatment experience using fMRI. This suggests that altered patterns of brain function, associated with maltreatment experience, are not fixed and may reflect the potential to track a neural basis of resilience. En ligne : http://dx.doi.org/10.1017/S0954579421001292 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Functional brain plasticity following childhood maltreatment: A longitudinal fMRI investigation of autobiographical memory processing [Texte imprimé et/ou numérique] / V. B. PUETZ, Auteur ; E. VIDING, Auteur ; E. A. MAGUIRE, Auteur ; A. MECHELLI, Auteur ; D. ARMBRUSTER-GENÇ, Auteur ; M. SHARP, Auteur ; G. RANKIN, Auteur ; M. I. GERIN, Auteur ; E. J. MCCRORY, Auteur . - p.1382-1389. Langues : Anglais (eng) in Development and Psychopathology > 35-3 (August 2023) . - p.1382-1389 Mots-clés : autobiographical memory  brain plasticity  childhood maltreatment  fMRI  longitudinal study Index. décimale : PER Périodiques Résumé : Altered autobiographical memory (ABM) processing characterizes some individuals with experiences of childhood maltreatment. This fMRI study of ABM processing evaluated potential developmental plasticity in neural functioning following maltreatment. Adolescents with (N = 19; MT group) and without (N = 18; Non-MT group) documented childhood maltreatment recalled specific ABMs in response to emotionally valenced cue words during fMRI at baseline (age 12.71 + 1.48) and follow-up (14.88 + 1.53 years). Psychological assessments were collected at both timepoints. Longitudinal analyses were carried out with BOLD signal changes during ABM recall and psychopathology to investigate change over time. In both groups there was relative stability of the ABM brain network, with some developmental maturational changes observed in cortical midline structures (ventromedial PFC (vmPFC), posterior cingulate cortex (pCC), and retrosplenial cortex (rSC). Significantly increased activation of the right rSC was observed only in the MT group, which was associated with improved psychological functioning. Baseline group differences in relation to hippocampal functioning, were not detected at follow-up. This study provides preliminary empirical evidence of functional developmental plasticity in children with documented maltreatment experience using fMRI. This suggests that altered patterns of brain function, associated with maltreatment experience, are not fixed and may reflect the potential to track a neural basis of resilience. En ligne : http://dx.doi.org/10.1017/S0954579421001292 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment / M. I. GERIN in Journal of Child Psychology and Psychiatry, 60-7 (July 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.752-761 Titre : Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment Type de document : Texte imprimé et/ou numérique Auteurs : M. I. GERIN, Auteur ; E. VIDING, Auteur ; J. B. PINGAULT, Auteur ; V. B. PUETZ, Auteur ; A. R. KNODT, Auteur ; S. R. RADTKE, Auteur ; Bartholomew D. BRIGIDI, Auteur ; J. R. SWARTZ, Auteur ; A. R. HARIRI, Auteur ; E. J. MCCRORY, Auteur Article en page(s) : p.752-761 Langues : Anglais (eng) Mots-clés : Maltreatment  amygdala  child abuse  internalizing disorder  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood maltreatment is one of the most potent predictors of future psychopathology, including internalizing disorders. It remains unclear whether heightened amygdala reactivity to threat and elevated stress exposure may be implicated in the pathogenesis and maintenance of internalizing disorders among individuals with a history of childhood maltreatment. METHODS: Using data from a sample of 1,144 young adults, we investigated the contribution of baseline threat-related amygdala reactivity and prospective major stressful life events to internalizing symptoms severity 1 year later (on average) in individuals with a history of maltreatment (n = 100) and propensity score matched nonmaltreated peers (n = 96). RESULTS: Even after stringently matching for several potentially confounding variables - including baseline internalizing symptoms, socioeconomic status and IQ - childhood maltreatment status predicted increased amygdala reactivity at baseline, elevated post-baseline exposure to major stressful life events and internalizing symptoms at follow-up. We also showed, for the first time, that amygdala reactivity at baseline and also post-baseline exposure to major stressful life events mediated the association between a history of maltreatment and future internalizing symptoms. CONCLUSIONS: These findings provide support for the view that maltreatment is a potent developmental insult leading to long-lasting neurocognitive recalibrations of the threat processing system. It is possible that such alterations, over time, may impact mental health functioning by compromising the ability to effectively negotiate everyday challenges (stress susceptibility). These alterations were not, however, found to sensitize an individual to the impact of major stressful life events. The results of this study also lend compelling support to the view that increased psychiatric risk, in the context of childhood maltreatment, follows from an increased propensity to experience major stressful life events (stress generation). En ligne : http://dx.doi.org/10.1111/jcpp.13041 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment [Texte imprimé et/ou numérique] / M. I. GERIN, Auteur ; E. VIDING, Auteur ; J. B. PINGAULT, Auteur ; V. B. PUETZ, Auteur ; A. R. KNODT, Auteur ; S. R. RADTKE, Auteur ; Bartholomew D. BRIGIDI, Auteur ; J. R. SWARTZ, Auteur ; A. R. HARIRI, Auteur ; E. J. MCCRORY, Auteur . - p.752-761. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.752-761 Mots-clés : Maltreatment  amygdala  child abuse  internalizing disorder  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood maltreatment is one of the most potent predictors of future psychopathology, including internalizing disorders. It remains unclear whether heightened amygdala reactivity to threat and elevated stress exposure may be implicated in the pathogenesis and maintenance of internalizing disorders among individuals with a history of childhood maltreatment. METHODS: Using data from a sample of 1,144 young adults, we investigated the contribution of baseline threat-related amygdala reactivity and prospective major stressful life events to internalizing symptoms severity 1 year later (on average) in individuals with a history of maltreatment (n = 100) and propensity score matched nonmaltreated peers (n = 96). RESULTS: Even after stringently matching for several potentially confounding variables - including baseline internalizing symptoms, socioeconomic status and IQ - childhood maltreatment status predicted increased amygdala reactivity at baseline, elevated post-baseline exposure to major stressful life events and internalizing symptoms at follow-up. We also showed, for the first time, that amygdala reactivity at baseline and also post-baseline exposure to major stressful life events mediated the association between a history of maltreatment and future internalizing symptoms. CONCLUSIONS: These findings provide support for the view that maltreatment is a potent developmental insult leading to long-lasting neurocognitive recalibrations of the threat processing system. It is possible that such alterations, over time, may impact mental health functioning by compromising the ability to effectively negotiate everyday challenges (stress susceptibility). These alterations were not, however, found to sensitize an individual to the impact of major stressful life events. The results of this study also lend compelling support to the view that increased psychiatric risk, in the context of childhood maltreatment, follows from an increased propensity to experience major stressful life events (stress generation). En ligne : http://dx.doi.org/10.1111/jcpp.13041 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

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