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Auteur Claus VOGELE |
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Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity / André SCHULZ in Development and Psychopathology, 34-3 (August 2022)
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Titre : Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity Type de document : Texte imprimé et/ou numérique Auteurs : André SCHULZ, Auteur ; Christian E. DEUTER, Auteur ; Ion-Hideo BREDEN, Auteur ; Claus VOGELE, Auteur ; Katja WINGENFELD, Auteur ; Christian OTTE, Auteur ; Linn K. KUEHL, Auteur Article en page(s) : p.1013-1024 Langues : Anglais (eng) Mots-clés : alpha2-adrenergic receptors childhood trauma interoception major depressive disorder stress Index. décimale : PER Périodiques Résumé : Acute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamic “pituitary “adrenocortical axis. This study aimed to investigate the effect of SAM axis activation on interoceptive accuracy (IAcc). Central alpha2-adrenergic receptors represent a negative feedback mechanism of the SAM axis. Major depressive disorder and adverse childhood experiences (ACE) are associated with alterations in the biological stress systems, including central alpha2-adrenergic receptors. Here, healthy individuals with and without ACE as well as depressive patients with and without ACE (n = 114; all without antidepressant medication) were tested after yohimbine (alpha2-adrenergic antagonist) and placebo. We assessed IAcc and sensibility in a heartbeat counting task. Increases in systolic and diastolic blood pressure after yohimbine confirmed successful SAM axis activation. IAcc decreased after yohimbine only in the healthy group with ACE, but remained unchanged in all other groups (Group × Drug interaction). This effect may be due to selective upregulation of alpha2-adrenergic receptors after childhood trauma, which reduces capacity for attention focus on heartbeats. The sympathetic neural pathway including alpha2-adrenergic circuitries may be essential for mediating interoceptive signal transmission. Suppressed processing of physical sensations in stressful situations may represent an adaptive response in healthy individuals who experienced ACE. En ligne : http://dx.doi.org/10.1017/S0954579420001613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485
in Development and Psychopathology > 34-3 (August 2022) . - p.1013-1024[article] Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity [Texte imprimé et/ou numérique] / André SCHULZ, Auteur ; Christian E. DEUTER, Auteur ; Ion-Hideo BREDEN, Auteur ; Claus VOGELE, Auteur ; Katja WINGENFELD, Auteur ; Christian OTTE, Auteur ; Linn K. KUEHL, Auteur . - p.1013-1024.
Langues : Anglais (eng)
in Development and Psychopathology > 34-3 (August 2022) . - p.1013-1024
Mots-clés : alpha2-adrenergic receptors childhood trauma interoception major depressive disorder stress Index. décimale : PER Périodiques Résumé : Acute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamic “pituitary “adrenocortical axis. This study aimed to investigate the effect of SAM axis activation on interoceptive accuracy (IAcc). Central alpha2-adrenergic receptors represent a negative feedback mechanism of the SAM axis. Major depressive disorder and adverse childhood experiences (ACE) are associated with alterations in the biological stress systems, including central alpha2-adrenergic receptors. Here, healthy individuals with and without ACE as well as depressive patients with and without ACE (n = 114; all without antidepressant medication) were tested after yohimbine (alpha2-adrenergic antagonist) and placebo. We assessed IAcc and sensibility in a heartbeat counting task. Increases in systolic and diastolic blood pressure after yohimbine confirmed successful SAM axis activation. IAcc decreased after yohimbine only in the healthy group with ACE, but remained unchanged in all other groups (Group × Drug interaction). This effect may be due to selective upregulation of alpha2-adrenergic receptors after childhood trauma, which reduces capacity for attention focus on heartbeats. The sympathetic neural pathway including alpha2-adrenergic circuitries may be essential for mediating interoceptive signal transmission. Suppressed processing of physical sensations in stressful situations may represent an adaptive response in healthy individuals who experienced ACE. En ligne : http://dx.doi.org/10.1017/S0954579420001613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485