Sensation-seeking-related DNA methylation and the development of delinquency: A longitudinal epigenome-wide study / Jacintha M. TIESKENS in Development and Psychopathology, 35-2 (May 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-2 (May 2023) . - p.791-799 Titre : Sensation-seeking-related DNA methylation and the development of delinquency: A longitudinal epigenome-wide study Type de document : Texte imprimé et/ou numérique Auteurs : Jacintha M. TIESKENS, Auteur ; Pol A. C. VAN LIER, Auteur ; J. Marieke BUIL, Auteur ; Edward D. BARKER, Auteur Article en page(s) : p.791-799 Langues : Anglais (eng) Mots-clés : ALSPAC  childhood victimization  delinquency  DNA methylation  sensation-seeking Index. décimale : PER Périodiques Résumé : Heightened sensation-seeking is related to the development of delinquency. Moreover, sensation-seeking, or biological correlates of sensation-seeking, are suggested as factors linking victimization to delinquency. Here, we focused on epigenetic correlates of sensation-seeking. First, we identified DNA methylation (DNAm) patterns related to sensation-seeking. Second, we investigated the association between sensation-seeking related DNAm and the development of delinquency. Third, we examined whether victimization was related to sensation-seeking related DNAm and the development of delinquency. Participants (N = 905; 49% boys) came from the Avon Longitudinal Study of Parents and Children. DNAm was assessed at birth, age 7 and age 15-17. Sensation-seeking (self-reports) was assessed at age 11 and 14. Delinquency (self-reports) was assessed at age 17-19. Sensation-seeking epigenome-wide association study revealed that no probes reached the critical significance level. However, 20 differential methylated probes reached marginal significance. With these 20 suggestive sites, a sensation-seeking cumulative DNAm risk score was created. Results showed that this DNAm risk score at age 15-17 was related to delinquency at age 17-19. Moreover, an indirect effect of victimization to delinquency via DNAm was found. Sensation-seeking related DNAm is a potential biological correlate that can help to understand the development of delinquency, including how victimization might be associated with adolescent delinquency. En ligne : http://dx.doi.org/10.1017/S0954579422000049 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Sensation-seeking-related DNA methylation and the development of delinquency: A longitudinal epigenome-wide study [Texte imprimé et/ou numérique] / Jacintha M. TIESKENS, Auteur ; Pol A. C. VAN LIER, Auteur ; J. Marieke BUIL, Auteur ; Edward D. BARKER, Auteur . - p.791-799. Langues : Anglais (eng) in Development and Psychopathology > 35-2 (May 2023) . - p.791-799 Mots-clés : ALSPAC  childhood victimization  delinquency  DNA methylation  sensation-seeking Index. décimale : PER Périodiques Résumé : Heightened sensation-seeking is related to the development of delinquency. Moreover, sensation-seeking, or biological correlates of sensation-seeking, are suggested as factors linking victimization to delinquency. Here, we focused on epigenetic correlates of sensation-seeking. First, we identified DNA methylation (DNAm) patterns related to sensation-seeking. Second, we investigated the association between sensation-seeking related DNAm and the development of delinquency. Third, we examined whether victimization was related to sensation-seeking related DNAm and the development of delinquency. Participants (N = 905; 49% boys) came from the Avon Longitudinal Study of Parents and Children. DNAm was assessed at birth, age 7 and age 15-17. Sensation-seeking (self-reports) was assessed at age 11 and 14. Delinquency (self-reports) was assessed at age 17-19. Sensation-seeking epigenome-wide association study revealed that no probes reached the critical significance level. However, 20 differential methylated probes reached marginal significance. With these 20 suggestive sites, a sensation-seeking cumulative DNAm risk score was created. Results showed that this DNAm risk score at age 15-17 was related to delinquency at age 17-19. Moreover, an indirect effect of victimization to delinquency via DNAm was found. Sensation-seeking related DNAm is a potential biological correlate that can help to understand the development of delinquency, including how victimization might be associated with adolescent delinquency. En ligne : http://dx.doi.org/10.1017/S0954579422000049 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

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