[article] 
inDevelopment and Psychopathology > 35-2 (May 2023) . - p.791-799

Titre :	Sensation-seeking-related DNA methylation and the development of delinquency: A longitudinal epigenome-wide study
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Jacintha M. TIESKENS, Auteur ; Pol A. C. VAN LIER, Auteur ; J. Marieke BUIL, Auteur ; Edward D. BARKER, Auteur
Article en page(s) :	p.791-799
Langues :	Anglais (eng)
Mots-clés :	ALSPAC  childhood victimization  delinquency  DNA methylation  sensation-seeking
Index. décimale :	PER Périodiques
Résumé :	Heightened sensation-seeking is related to the development of delinquency. Moreover, sensation-seeking, or biological correlates of sensation-seeking, are suggested as factors linking victimization to delinquency. Here, we focused on epigenetic correlates of sensation-seeking. First, we identified DNA methylation (DNAm) patterns related to sensation-seeking. Second, we investigated the association between sensation-seeking related DNAm and the development of delinquency. Third, we examined whether victimization was related to sensation-seeking related DNAm and the development of delinquency. Participants (N = 905; 49% boys) came from the Avon Longitudinal Study of Parents and Children. DNAm was assessed at birth, age 7 and age 15-17. Sensation-seeking (self-reports) was assessed at age 11 and 14. Delinquency (self-reports) was assessed at age 17-19. Sensation-seeking epigenome-wide association study revealed that no probes reached the critical significance level. However, 20 differential methylated probes reached marginal significance. With these 20 suggestive sites, a sensation-seeking cumulative DNAm risk score was created. Results showed that this DNAm risk score at age 15-17 was related to delinquency at age 17-19. Moreover, an indirect effect of victimization to delinquency via DNAm was found. Sensation-seeking related DNAm is a potential biological correlate that can help to understand the development of delinquency, including how victimization might be associated with adolescent delinquency.
En ligne :	http://dx.doi.org/10.1017/S0954579422000049
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

[article] Sensation-seeking-related DNA methylation and the development of delinquency: A longitudinal epigenome-wide study [Texte imprimé et/ou numérique] / Jacintha M. TIESKENS, Auteur ; Pol A. C. VAN LIER, Auteur ; J. Marieke BUIL, Auteur ; Edward D. BARKER, Auteur . - p.791-799.
Langues : Anglais (eng)
in Development and Psychopathology > 35-2 (May 2023) . - p.791-799

Mots-clés :	ALSPAC  childhood victimization  delinquency  DNA methylation  sensation-seeking
Index. décimale :	PER Périodiques
Résumé :	Heightened sensation-seeking is related to the development of delinquency. Moreover, sensation-seeking, or biological correlates of sensation-seeking, are suggested as factors linking victimization to delinquency. Here, we focused on epigenetic correlates of sensation-seeking. First, we identified DNA methylation (DNAm) patterns related to sensation-seeking. Second, we investigated the association between sensation-seeking related DNAm and the development of delinquency. Third, we examined whether victimization was related to sensation-seeking related DNAm and the development of delinquency. Participants (N = 905; 49% boys) came from the Avon Longitudinal Study of Parents and Children. DNAm was assessed at birth, age 7 and age 15-17. Sensation-seeking (self-reports) was assessed at age 11 and 14. Delinquency (self-reports) was assessed at age 17-19. Sensation-seeking epigenome-wide association study revealed that no probes reached the critical significance level. However, 20 differential methylated probes reached marginal significance. With these 20 suggestive sites, a sensation-seeking cumulative DNAm risk score was created. Results showed that this DNAm risk score at age 15-17 was related to delinquency at age 17-19. Moreover, an indirect effect of victimization to delinquency via DNAm was found. Sensation-seeking related DNAm is a potential biological correlate that can help to understand the development of delinquency, including how victimization might be associated with adolescent delinquency.
En ligne :	http://dx.doi.org/10.1017/S0954579422000049
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504