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Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain / C. M. SCHUMANN in Molecular Autism, 8 (2017)
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Titre : Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain Type de document : Texte imprimé et/ou numérique Auteurs : C. M. SCHUMANN, Auteur ; F. R. SHARP, Auteur ; Bradley P. ANDER, Auteur ; B. STAMOVA, Auteur Article en page(s) : 4p. Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/*genetics Child Child, Preschool Female Gene Expression Profiling/*methods Gene Expression Regulation Humans Male MicroRNAs/*genetics Middle Aged Oligonucleotide Array Sequence Analysis/*methods RNA, Small Untranslated/*genetics Sex Characteristics Young Adult *Auditory cortex *Autism *Myelin *Oligodendrocytes *Postmortem human brain *Sex *Sexual dimorphism *Superior Temporal Sulcus *miR-125 *miR-181 *miR-219 *miR-338 *miR-448 *microRNA *small noncoding RNA Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is sexually dimorphic in brain structure, genetics, and behaviors. In studies of brain tissue, the age of the population is clearly a factor in interpreting study outcome, yet sex is rarely considered. To begin to address this issue, we extend our previously published microarray analyses to examine expression of small noncoding RNAs (sncRNAs), including microRNAs (miRNAs), in ASD and in the control temporal cortex in males and females. Predicted miRNA targets were identified as well as the pathways they overpopulate. FINDINGS: After considering age, sexual dimorphism in ASD sncRNA expression persists in the temporal cortex and in the patterning that distinguishes regions. Among the sexually dimorphic miRNAs are miR-219 and miR-338, which promote oligodendrocyte differentiation, miR-125, implicated in neuronal differentiation, and miR-488, implicated in anxiety. Putative miRNA targets are significantly over-represented in immune and nervous system pathways in both sexes, consistent with previous mRNA studies. Even for common pathways, the specific target mRNAs are often sexually dimorphic. For example, both male and female target genes significantly populate the Axonal Guidance Signaling pathway, yet less than a third of the targets are common to both sexes. CONCLUSIONS: Our findings of sexual dimorphism in sncRNA levels underscore the importance of considering sex, in addition to age, when interpreting molecular findings on ASD brain. En ligne : http://dx.doi.org/10.1186/s13229-017-0117-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331
in Molecular Autism > 8 (2017) . - 4p.[article] Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain [Texte imprimé et/ou numérique] / C. M. SCHUMANN, Auteur ; F. R. SHARP, Auteur ; Bradley P. ANDER, Auteur ; B. STAMOVA, Auteur . - 4p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 4p.
Mots-clés : Adolescent Adult Autism Spectrum Disorder/*genetics Child Child, Preschool Female Gene Expression Profiling/*methods Gene Expression Regulation Humans Male MicroRNAs/*genetics Middle Aged Oligonucleotide Array Sequence Analysis/*methods RNA, Small Untranslated/*genetics Sex Characteristics Young Adult *Auditory cortex *Autism *Myelin *Oligodendrocytes *Postmortem human brain *Sex *Sexual dimorphism *Superior Temporal Sulcus *miR-125 *miR-181 *miR-219 *miR-338 *miR-448 *microRNA *small noncoding RNA Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is sexually dimorphic in brain structure, genetics, and behaviors. In studies of brain tissue, the age of the population is clearly a factor in interpreting study outcome, yet sex is rarely considered. To begin to address this issue, we extend our previously published microarray analyses to examine expression of small noncoding RNAs (sncRNAs), including microRNAs (miRNAs), in ASD and in the control temporal cortex in males and females. Predicted miRNA targets were identified as well as the pathways they overpopulate. FINDINGS: After considering age, sexual dimorphism in ASD sncRNA expression persists in the temporal cortex and in the patterning that distinguishes regions. Among the sexually dimorphic miRNAs are miR-219 and miR-338, which promote oligodendrocyte differentiation, miR-125, implicated in neuronal differentiation, and miR-488, implicated in anxiety. Putative miRNA targets are significantly over-represented in immune and nervous system pathways in both sexes, consistent with previous mRNA studies. Even for common pathways, the specific target mRNAs are often sexually dimorphic. For example, both male and female target genes significantly populate the Axonal Guidance Signaling pathway, yet less than a third of the targets are common to both sexes. CONCLUSIONS: Our findings of sexual dimorphism in sncRNA levels underscore the importance of considering sex, in addition to age, when interpreting molecular findings on ASD brain. En ligne : http://dx.doi.org/10.1186/s13229-017-0117-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331