Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
2 recherche sur le mot-clé '*sex'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain / C. M. SCHUMANN in Molecular Autism, 8 (2017)
[article]
Titre : Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain Type de document : Texte imprimé et/ou numérique Auteurs : C. M. SCHUMANN, Auteur ; F. R. SHARP, Auteur ; Bradley P. ANDER, Auteur ; B. STAMOVA, Auteur Article en page(s) : 4p. Langues : Anglais (eng) Mots-clés : Adolescent Adult Autism Spectrum Disorder/*genetics Child Child, Preschool Female Gene Expression Profiling/*methods Gene Expression Regulation Humans Male MicroRNAs/*genetics Middle Aged Oligonucleotide Array Sequence Analysis/*methods RNA, Small Untranslated/*genetics Sex Characteristics Young Adult *Auditory cortex *Autism *Myelin *Oligodendrocytes *Postmortem human brain *Sex *Sexual dimorphism *Superior Temporal Sulcus *miR-125 *miR-181 *miR-219 *miR-338 *miR-448 *microRNA *small noncoding RNA Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is sexually dimorphic in brain structure, genetics, and behaviors. In studies of brain tissue, the age of the population is clearly a factor in interpreting study outcome, yet sex is rarely considered. To begin to address this issue, we extend our previously published microarray analyses to examine expression of small noncoding RNAs (sncRNAs), including microRNAs (miRNAs), in ASD and in the control temporal cortex in males and females. Predicted miRNA targets were identified as well as the pathways they overpopulate. FINDINGS: After considering age, sexual dimorphism in ASD sncRNA expression persists in the temporal cortex and in the patterning that distinguishes regions. Among the sexually dimorphic miRNAs are miR-219 and miR-338, which promote oligodendrocyte differentiation, miR-125, implicated in neuronal differentiation, and miR-488, implicated in anxiety. Putative miRNA targets are significantly over-represented in immune and nervous system pathways in both sexes, consistent with previous mRNA studies. Even for common pathways, the specific target mRNAs are often sexually dimorphic. For example, both male and female target genes significantly populate the Axonal Guidance Signaling pathway, yet less than a third of the targets are common to both sexes. CONCLUSIONS: Our findings of sexual dimorphism in sncRNA levels underscore the importance of considering sex, in addition to age, when interpreting molecular findings on ASD brain. En ligne : http://dx.doi.org/10.1186/s13229-017-0117-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331
in Molecular Autism > 8 (2017) . - 4p.[article] Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain [Texte imprimé et/ou numérique] / C. M. SCHUMANN, Auteur ; F. R. SHARP, Auteur ; Bradley P. ANDER, Auteur ; B. STAMOVA, Auteur . - 4p.
Langues : Anglais (eng)
in Molecular Autism > 8 (2017) . - 4p.
Mots-clés : Adolescent Adult Autism Spectrum Disorder/*genetics Child Child, Preschool Female Gene Expression Profiling/*methods Gene Expression Regulation Humans Male MicroRNAs/*genetics Middle Aged Oligonucleotide Array Sequence Analysis/*methods RNA, Small Untranslated/*genetics Sex Characteristics Young Adult *Auditory cortex *Autism *Myelin *Oligodendrocytes *Postmortem human brain *Sex *Sexual dimorphism *Superior Temporal Sulcus *miR-125 *miR-181 *miR-219 *miR-338 *miR-448 *microRNA *small noncoding RNA Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is sexually dimorphic in brain structure, genetics, and behaviors. In studies of brain tissue, the age of the population is clearly a factor in interpreting study outcome, yet sex is rarely considered. To begin to address this issue, we extend our previously published microarray analyses to examine expression of small noncoding RNAs (sncRNAs), including microRNAs (miRNAs), in ASD and in the control temporal cortex in males and females. Predicted miRNA targets were identified as well as the pathways they overpopulate. FINDINGS: After considering age, sexual dimorphism in ASD sncRNA expression persists in the temporal cortex and in the patterning that distinguishes regions. Among the sexually dimorphic miRNAs are miR-219 and miR-338, which promote oligodendrocyte differentiation, miR-125, implicated in neuronal differentiation, and miR-488, implicated in anxiety. Putative miRNA targets are significantly over-represented in immune and nervous system pathways in both sexes, consistent with previous mRNA studies. Even for common pathways, the specific target mRNAs are often sexually dimorphic. For example, both male and female target genes significantly populate the Axonal Guidance Signaling pathway, yet less than a third of the targets are common to both sexes. CONCLUSIONS: Our findings of sexual dimorphism in sncRNA levels underscore the importance of considering sex, in addition to age, when interpreting molecular findings on ASD brain. En ligne : http://dx.doi.org/10.1186/s13229-017-0117-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 Head circumference trends in autism between 0 and 100 months / Joel CRUCITTI in Autism, 24-7 (October 2020)
[article]
Titre : Head circumference trends in autism between 0 and 100 months Type de document : Texte imprimé et/ou numérique Auteurs : Joel CRUCITTI, Auteur ; Christian HYDE, Auteur ; Peter G. ENTICOTT, Auteur ; Mark A. STOKES, Auteur Article en page(s) : p.1726-1739 Langues : Anglais (eng) Mots-clés : *age *autism *head circumference *sex Index. décimale : PER Périodiques Résumé : Summaries of studies that have measured head size in those with autism, known as meta-analyses, currently exist. However, this approach does not adequately explain extreme cases (such as those with extremely small, or extremely large, head size). Because of this, we obtained all available published data measuring head size (12 studies). The data from each study were then combined to make a larger dataset. We found that females with autism aged 12-17?months had, on average, smaller head sizes. Otherwise, average head size was not atypical in autism. However, we found that males with autism were more likely to have extreme head sizes at birth and between 60 and 100?months, a small head between 6 and 11?months, and a large head between 12 and 17?months. Females with autism were more likely to have extreme head sizes between 36 and 59?months and were less likely at birth. Our approach was able to measure the influence of age and biological sex on head size in autism, as well as the frequency of extreme cases of head size in autism. These results add to what we already know about head size in autism. En ligne : http://dx.doi.org/10.1177/1362361320921037 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431
in Autism > 24-7 (October 2020) . - p.1726-1739[article] Head circumference trends in autism between 0 and 100 months [Texte imprimé et/ou numérique] / Joel CRUCITTI, Auteur ; Christian HYDE, Auteur ; Peter G. ENTICOTT, Auteur ; Mark A. STOKES, Auteur . - p.1726-1739.
Langues : Anglais (eng)
in Autism > 24-7 (October 2020) . - p.1726-1739
Mots-clés : *age *autism *head circumference *sex Index. décimale : PER Périodiques Résumé : Summaries of studies that have measured head size in those with autism, known as meta-analyses, currently exist. However, this approach does not adequately explain extreme cases (such as those with extremely small, or extremely large, head size). Because of this, we obtained all available published data measuring head size (12 studies). The data from each study were then combined to make a larger dataset. We found that females with autism aged 12-17?months had, on average, smaller head sizes. Otherwise, average head size was not atypical in autism. However, we found that males with autism were more likely to have extreme head sizes at birth and between 60 and 100?months, a small head between 6 and 11?months, and a large head between 12 and 17?months. Females with autism were more likely to have extreme head sizes between 36 and 59?months and were less likely at birth. Our approach was able to measure the influence of age and biological sex on head size in autism, as well as the frequency of extreme cases of head size in autism. These results add to what we already know about head size in autism. En ligne : http://dx.doi.org/10.1177/1362361320921037 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431