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Cross-sectional associations between adaptive functioning and social cognitive and neurocognitive functions in adolescents with first-episode, early-onset schizophrenia spectrum disorders / J. R. M. JEPSEN in Development and Psychopathology, 36-1 (February 2024)
[article]
Titre : Cross-sectional associations between adaptive functioning and social cognitive and neurocognitive functions in adolescents with first-episode, early-onset schizophrenia spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : J. R. M. JEPSEN, Auteur ; J. RYDKJAER, Auteur ; B. FAGERLUND, Auteur ; Cecilie K. LEMVIGH, Auteur ; A. K. PAGSBERG, Auteur ; B. Y. GLENTHØJ, Auteur ; B. ORANJE, Auteur Article en page(s) : p.208-218 Langues : Anglais (eng) Mots-clés : adaptive functioning cognition early-onset schizophrenia first-episode Index. décimale : PER Périodiques Résumé : Background:Few studies have explored associations between adaptive functioning and cognition in adolescents with early-onset schizophrenia spectrum disorders (EOS).Methods:Adaptive functioning, cognition, positive, negative, and general symptoms were characterized in adolescents with EOS and healthy controls. A modified scale of negative, respectively, general symptoms was used. Bivariate analyses identified correlates of adaptive functioning to be included in multivariate analysis.Results:Adolescents with EOS showed significant impairments of social- and neurocognitive functions (?0.86 < Cohen´s ds < ?0.58) and adaptive functioning (Cohen´s d = ?2.23). Visual memory, verbal working memory, processing speed, reaction time, social cognition, and modified negative and general symptoms correlated significantly with adaptive functioning. The multiple regression analysis revealed only verbal working memory as uniquely associated with adaptive functioning (explaining 22.7 % of its variance). Verbal working memory also associated significantly with adaptive functioning in the context of the nonsignificant modified negative and the significant modified general symptoms dimension.Conclusions:Adolescents with first-episode EOS had large impairments in adaptive functioning and moderate to large cognitive deficits. Verbal working memory was an important associate to concurrent adaptive functioning and may be a treatment target for trials to improve cognitive and adaptive functioning in adolescents with EOS. En ligne : https://dx.doi.org/10.1017/S0954579422001110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523
in Development and Psychopathology > 36-1 (February 2024) . - p.208-218[article] Cross-sectional associations between adaptive functioning and social cognitive and neurocognitive functions in adolescents with first-episode, early-onset schizophrenia spectrum disorders [Texte imprimé et/ou numérique] / J. R. M. JEPSEN, Auteur ; J. RYDKJAER, Auteur ; B. FAGERLUND, Auteur ; Cecilie K. LEMVIGH, Auteur ; A. K. PAGSBERG, Auteur ; B. Y. GLENTHØJ, Auteur ; B. ORANJE, Auteur . - p.208-218.
Langues : Anglais (eng)
in Development and Psychopathology > 36-1 (February 2024) . - p.208-218
Mots-clés : adaptive functioning cognition early-onset schizophrenia first-episode Index. décimale : PER Périodiques Résumé : Background:Few studies have explored associations between adaptive functioning and cognition in adolescents with early-onset schizophrenia spectrum disorders (EOS).Methods:Adaptive functioning, cognition, positive, negative, and general symptoms were characterized in adolescents with EOS and healthy controls. A modified scale of negative, respectively, general symptoms was used. Bivariate analyses identified correlates of adaptive functioning to be included in multivariate analysis.Results:Adolescents with EOS showed significant impairments of social- and neurocognitive functions (?0.86 < Cohen´s ds < ?0.58) and adaptive functioning (Cohen´s d = ?2.23). Visual memory, verbal working memory, processing speed, reaction time, social cognition, and modified negative and general symptoms correlated significantly with adaptive functioning. The multiple regression analysis revealed only verbal working memory as uniquely associated with adaptive functioning (explaining 22.7 % of its variance). Verbal working memory also associated significantly with adaptive functioning in the context of the nonsignificant modified negative and the significant modified general symptoms dimension.Conclusions:Adolescents with first-episode EOS had large impairments in adaptive functioning and moderate to large cognitive deficits. Verbal working memory was an important associate to concurrent adaptive functioning and may be a treatment target for trials to improve cognitive and adaptive functioning in adolescents with EOS. En ligne : https://dx.doi.org/10.1017/S0954579422001110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 Do clinical characteristics predict the cognitive course in early-onset schizophrenia-spectrum disorders? / Charlotte M. TEIGSET in Journal of Child Psychology and Psychiatry, 59-9 (September 2018)
[article]
Titre : Do clinical characteristics predict the cognitive course in early-onset schizophrenia-spectrum disorders? Type de document : Texte imprimé et/ou numérique Auteurs : Charlotte M. TEIGSET, Auteur ; Christine MOHN, Auteur ; Cathrine BRUNBORG, Auteur ; Monica JUUHL-LANGSETH, Auteur ; Aina HOLMÉN, Auteur ; Bjørn Rishovd RUND, Auteur Article en page(s) : p.1012-1023 Langues : Anglais (eng) Mots-clés : Cognition early-onset schizophrenia suicide attempts general symptoms Index. décimale : PER Périodiques Résumé : Background Being in a period with extensive brain maturation, adolescents with early-onset schizophrenia-spectrum disorders (EOS) provide unique neurodevelopmental data that may contribute to a better understanding of schizophrenia at all ages. Cognitive dysfunction is a central feature of schizophrenia and is more pronounced in EOS than in later onset illness. However, there is limited research on both the long-term course of global cognition in EOS, and how cognition over time is influenced by clinical characteristics during the early illness period. Methods Thirty-one EOS patients and 73 controls (age 12?18) were assessed on clinical variables at baseline (PANSS, duration of untreated psychosis [DUP], hospitalizations, suicide attempts, and remission). Neuropsychological assessments with the MATRICS Consensus Cognitive Battery (MCCB) were conducted at baseline and after both 1 and 2 years, and composite scores of total performances were calculated. The analyses were performed with a linear mixed model. Results The present study found that global cognition followed a stable course over the first years of the disease in EOS, though at a significantly lower level in EOS compared with the controls. We did not detect a relationship between DUP, remission, positive/negative symptoms, and hospitalizations on one hand, and long-term cognition on the other hand, but PANSS-general and suicide attempt history at baseline were identified as risk factors of longitudinal cognitive function. Conclusions Though at different levels, the EOS group and the controls had a similar cognitive course over 2 years. Some baseline characteristics (psychotic symptoms, DUP, remission, and hospitalization) had no influence on cognition within the first 2 years of illness. In contrast, general symptoms and a history of suicide attempts at baseline were more potent risk factors of the cognitive course than the psychotic-specific symptoms, and should, therefore, be subject to specific attention in the evaluation and treatment of patients with early-onset psychosis. En ligne : https://doi.org/10.1111/jcpp.12896 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.1012-1023[article] Do clinical characteristics predict the cognitive course in early-onset schizophrenia-spectrum disorders? [Texte imprimé et/ou numérique] / Charlotte M. TEIGSET, Auteur ; Christine MOHN, Auteur ; Cathrine BRUNBORG, Auteur ; Monica JUUHL-LANGSETH, Auteur ; Aina HOLMÉN, Auteur ; Bjørn Rishovd RUND, Auteur . - p.1012-1023.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.1012-1023
Mots-clés : Cognition early-onset schizophrenia suicide attempts general symptoms Index. décimale : PER Périodiques Résumé : Background Being in a period with extensive brain maturation, adolescents with early-onset schizophrenia-spectrum disorders (EOS) provide unique neurodevelopmental data that may contribute to a better understanding of schizophrenia at all ages. Cognitive dysfunction is a central feature of schizophrenia and is more pronounced in EOS than in later onset illness. However, there is limited research on both the long-term course of global cognition in EOS, and how cognition over time is influenced by clinical characteristics during the early illness period. Methods Thirty-one EOS patients and 73 controls (age 12?18) were assessed on clinical variables at baseline (PANSS, duration of untreated psychosis [DUP], hospitalizations, suicide attempts, and remission). Neuropsychological assessments with the MATRICS Consensus Cognitive Battery (MCCB) were conducted at baseline and after both 1 and 2 years, and composite scores of total performances were calculated. The analyses were performed with a linear mixed model. Results The present study found that global cognition followed a stable course over the first years of the disease in EOS, though at a significantly lower level in EOS compared with the controls. We did not detect a relationship between DUP, remission, positive/negative symptoms, and hospitalizations on one hand, and long-term cognition on the other hand, but PANSS-general and suicide attempt history at baseline were identified as risk factors of longitudinal cognitive function. Conclusions Though at different levels, the EOS group and the controls had a similar cognitive course over 2 years. Some baseline characteristics (psychotic symptoms, DUP, remission, and hospitalization) had no influence on cognition within the first 2 years of illness. In contrast, general symptoms and a history of suicide attempts at baseline were more potent risk factors of the cognitive course than the psychotic-specific symptoms, and should, therefore, be subject to specific attention in the evaluation and treatment of patients with early-onset psychosis. En ligne : https://doi.org/10.1111/jcpp.12896 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 Homotopic connectivity in drug-naïve, first-episode, early-onset schizophrenia / Hui-Jie LI in Journal of Child Psychology and Psychiatry, 56-4 (April 2015)
[article]
Titre : Homotopic connectivity in drug-naïve, first-episode, early-onset schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Hui-Jie LI, Auteur ; Yong XU, Auteur ; Ke-Rang ZHANG, Auteur ; Matthew J. HOPTMAN, Auteur ; Xi-Nian ZUO, Auteur Article en page(s) : p.432-443 Langues : Anglais (eng) Mots-clés : Resting-state fMRI early-onset schizophrenia functional connectivity interhemispheric connectivity Index. décimale : PER Périodiques Résumé : Background The disconnection hypothesis of schizophrenia has been extensively tested in adults. Recent studies have reported the presence of brain disconnection in younger patients, adding evidence to support the neurodevelopmental hypothesis of schizophrenia. Because of drug confounds in chronic and medicated patients, it has been extremely challenging for researchers to directly investigate abnormalities in the development of connectivity and their role in the pathophysiology of schizophrenia. The present study aimed to examine functional homotopy – a measure of interhemispheric connection – and its relevance to clinical symptoms in first-episode drug-naïve early-onset schizophrenia (EOS) patients. Methods Resting-state functional magnetic resonance imaging was performed in 26 first-episode drug-naïve EOS patients (age: 14.5 ± 1.94, 13 males) and 25 matched typically developing controls (TDCs) (age: 14.4 ± 2.97, 13 males). We were mainly concerned with the functional connectivity between any pair of symmetric interhemispheric voxels (i.e., functional homotopy) measured by voxel-mirrored homotopic connectivity (VMHC). Results Early-onset schizophrenia patients exhibited both global and regional VMHC reductions in comparison with TDCs. Reduced VMHC values were observed within the superior temporal cortex and postcentral gyrus. These interhemispheric synchronization deficits were negatively correlated with negative symptom of the Positive and Negative Syndrome Scale. Moreover, regions of interest analyses based on left and right clusters of temporal cortex and postcentral gyrus revealed abnormal heterotopic connectivity in EOS patients. Conclusions Our findings provide novel neurodevelopmental evidence for the disconnection hypothesis of schizophrenia and suggest that these alterations occur early in the course of the disease and are independent of medication status. En ligne : http://dx.doi.org/10.1111/jcpp.12307 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Journal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.432-443[article] Homotopic connectivity in drug-naïve, first-episode, early-onset schizophrenia [Texte imprimé et/ou numérique] / Hui-Jie LI, Auteur ; Yong XU, Auteur ; Ke-Rang ZHANG, Auteur ; Matthew J. HOPTMAN, Auteur ; Xi-Nian ZUO, Auteur . - p.432-443.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.432-443
Mots-clés : Resting-state fMRI early-onset schizophrenia functional connectivity interhemispheric connectivity Index. décimale : PER Périodiques Résumé : Background The disconnection hypothesis of schizophrenia has been extensively tested in adults. Recent studies have reported the presence of brain disconnection in younger patients, adding evidence to support the neurodevelopmental hypothesis of schizophrenia. Because of drug confounds in chronic and medicated patients, it has been extremely challenging for researchers to directly investigate abnormalities in the development of connectivity and their role in the pathophysiology of schizophrenia. The present study aimed to examine functional homotopy – a measure of interhemispheric connection – and its relevance to clinical symptoms in first-episode drug-naïve early-onset schizophrenia (EOS) patients. Methods Resting-state functional magnetic resonance imaging was performed in 26 first-episode drug-naïve EOS patients (age: 14.5 ± 1.94, 13 males) and 25 matched typically developing controls (TDCs) (age: 14.4 ± 2.97, 13 males). We were mainly concerned with the functional connectivity between any pair of symmetric interhemispheric voxels (i.e., functional homotopy) measured by voxel-mirrored homotopic connectivity (VMHC). Results Early-onset schizophrenia patients exhibited both global and regional VMHC reductions in comparison with TDCs. Reduced VMHC values were observed within the superior temporal cortex and postcentral gyrus. These interhemispheric synchronization deficits were negatively correlated with negative symptom of the Positive and Negative Syndrome Scale. Moreover, regions of interest analyses based on left and right clusters of temporal cortex and postcentral gyrus revealed abnormal heterotopic connectivity in EOS patients. Conclusions Our findings provide novel neurodevelopmental evidence for the disconnection hypothesis of schizophrenia and suggest that these alterations occur early in the course of the disease and are independent of medication status. En ligne : http://dx.doi.org/10.1111/jcpp.12307 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260