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Cross-sectional associations between adaptive functioning and social cognitive and neurocognitive functions in adolescents with first-episode, early-onset schizophrenia spectrum disorders / J. R. M. JEPSEN in Development and Psychopathology, 36-1 (February 2024)
[article]
Titre : Cross-sectional associations between adaptive functioning and social cognitive and neurocognitive functions in adolescents with first-episode, early-onset schizophrenia spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : J. R. M. JEPSEN, Auteur ; J. RYDKJAER, Auteur ; B. FAGERLUND, Auteur ; Cecilie K. LEMVIGH, Auteur ; A. K. PAGSBERG, Auteur ; B. Y. GLENTHØJ, Auteur ; B. ORANJE, Auteur Article en page(s) : p.208-218 Langues : Anglais (eng) Mots-clés : adaptive functioning cognition early-onset schizophrenia first-episode Index. décimale : PER Périodiques Résumé : Background:Few studies have explored associations between adaptive functioning and cognition in adolescents with early-onset schizophrenia spectrum disorders (EOS).Methods:Adaptive functioning, cognition, positive, negative, and general symptoms were characterized in adolescents with EOS and healthy controls. A modified scale of negative, respectively, general symptoms was used. Bivariate analyses identified correlates of adaptive functioning to be included in multivariate analysis.Results:Adolescents with EOS showed significant impairments of social- and neurocognitive functions (?0.86 < Cohen´s ds < ?0.58) and adaptive functioning (Cohen´s d = ?2.23). Visual memory, verbal working memory, processing speed, reaction time, social cognition, and modified negative and general symptoms correlated significantly with adaptive functioning. The multiple regression analysis revealed only verbal working memory as uniquely associated with adaptive functioning (explaining 22.7 % of its variance). Verbal working memory also associated significantly with adaptive functioning in the context of the nonsignificant modified negative and the significant modified general symptoms dimension.Conclusions:Adolescents with first-episode EOS had large impairments in adaptive functioning and moderate to large cognitive deficits. Verbal working memory was an important associate to concurrent adaptive functioning and may be a treatment target for trials to improve cognitive and adaptive functioning in adolescents with EOS. En ligne : https://dx.doi.org/10.1017/S0954579422001110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523
in Development and Psychopathology > 36-1 (February 2024) . - p.208-218[article] Cross-sectional associations between adaptive functioning and social cognitive and neurocognitive functions in adolescents with first-episode, early-onset schizophrenia spectrum disorders [Texte imprimé et/ou numérique] / J. R. M. JEPSEN, Auteur ; J. RYDKJAER, Auteur ; B. FAGERLUND, Auteur ; Cecilie K. LEMVIGH, Auteur ; A. K. PAGSBERG, Auteur ; B. Y. GLENTHØJ, Auteur ; B. ORANJE, Auteur . - p.208-218.
Langues : Anglais (eng)
in Development and Psychopathology > 36-1 (February 2024) . - p.208-218
Mots-clés : adaptive functioning cognition early-onset schizophrenia first-episode Index. décimale : PER Périodiques Résumé : Background:Few studies have explored associations between adaptive functioning and cognition in adolescents with early-onset schizophrenia spectrum disorders (EOS).Methods:Adaptive functioning, cognition, positive, negative, and general symptoms were characterized in adolescents with EOS and healthy controls. A modified scale of negative, respectively, general symptoms was used. Bivariate analyses identified correlates of adaptive functioning to be included in multivariate analysis.Results:Adolescents with EOS showed significant impairments of social- and neurocognitive functions (?0.86 < Cohen´s ds < ?0.58) and adaptive functioning (Cohen´s d = ?2.23). Visual memory, verbal working memory, processing speed, reaction time, social cognition, and modified negative and general symptoms correlated significantly with adaptive functioning. The multiple regression analysis revealed only verbal working memory as uniquely associated with adaptive functioning (explaining 22.7 % of its variance). Verbal working memory also associated significantly with adaptive functioning in the context of the nonsignificant modified negative and the significant modified general symptoms dimension.Conclusions:Adolescents with first-episode EOS had large impairments in adaptive functioning and moderate to large cognitive deficits. Verbal working memory was an important associate to concurrent adaptive functioning and may be a treatment target for trials to improve cognitive and adaptive functioning in adolescents with EOS. En ligne : https://dx.doi.org/10.1017/S0954579422001110 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 Annual Research Review: Prevention of psychosis in adolescents - systematic review and meta-analysis of advances in detection, prognosis and intervention / Ana CATALAN in Journal of Child Psychology and Psychiatry, 62-5 (May 2021)
[article]
Titre : Annual Research Review: Prevention of psychosis in adolescents - systematic review and meta-analysis of advances in detection, prognosis and intervention Type de document : Texte imprimé et/ou numérique Auteurs : Ana CATALAN, Auteur ; Gonzalo SALAZAR DE PABLO, Auteur ; Julio VAQUERIZO SERRANO, Auteur ; Pierluca MOSILLO, Auteur ; Helen BALDWIN, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Carmen MORENO, Auteur ; Celso ARANGO, Auteur ; Christoph U CORRELL, Auteur ; Ilaria BONOLDI, Auteur ; Paolo FUSAR-POLI, Auteur Article en page(s) : p.657-673 Langues : Anglais (eng) Mots-clés : Psychosis adolescence childhood clinical high-risk state for psychosis evidence first-episode meta-analysis prediction prevention psychosis risk schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: The clinical high-risk state for psychosis (CHR-P) paradigm has facilitated the implementation of psychosis prevention into clinical practice; however, advancements in adolescent CHR-P populations are less established. METHODS: We performed a PRISMA/MOOSE-compliant systematic review of the Web of Science database, from inception until 7 October 2019, to identify original studies conducted in CHR-P children and adolescents (mean age <18 years). Findings were systematically appraised around core themes: detection, prognosis and intervention. We performed meta-analyses (employing Q statistics and I (2) test) regarding the proportion of CHR-P subgroups, the prevalence of baseline comorbid mental disorders, the risk of psychosis onset and the type of interventions received at baseline. Quality assessment and publication bias were also analysed. RESULTS: Eighty-seven articles were included (n = 4,667 CHR-P individuals). Quality of studies ranged from 3.5 to 8 (median 5.5) on a modified Newcastle-Ottawa scale. Detection: Individuals were aged 15.6 ± 1.2 years (51.5% males), mostly (83%) presenting with attenuated positive psychotic symptoms. CHR-P psychometric accuracy improved when caregivers served as additional informants. Comorbid mood (46.4%) and anxiety (31.4%) disorders were highly prevalent. Functioning and cognition were impaired. Neurobiological studies were inconclusive. PROGNOSIS: Risk for psychosis was 10.4% (95%CI: 5.8%-18.1%) at 6 months, 20% (95%CI: 15%-26%) at 12 months, 23% (95%CI: 18%-29%) at 24 months and 23.3% (95%CI: 17.3%-30.7%) at ?36 months. INTERVENTIONS: There was not enough evidence to recommend one specific treatment (including cognitive behavioural therapy) over the others (including control conditions) to prevent the transition to psychosis in this population. Randomised controlled trials suggested that family interventions, cognitive remediation and fish oil supplementation may improve cognition, symptoms and functioning. At baseline, 30% of CHR-P adolescents were prescribed antipsychotics and 60% received psychotherapy. CONCLUSIONS: It is possible to detect and formulate a group-level prognosis in adolescents at risk for psychosis. Future interventional research is required. En ligne : http://dx.doi.org/10.1111/jcpp.13322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445
in Journal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.657-673[article] Annual Research Review: Prevention of psychosis in adolescents - systematic review and meta-analysis of advances in detection, prognosis and intervention [Texte imprimé et/ou numérique] / Ana CATALAN, Auteur ; Gonzalo SALAZAR DE PABLO, Auteur ; Julio VAQUERIZO SERRANO, Auteur ; Pierluca MOSILLO, Auteur ; Helen BALDWIN, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Carmen MORENO, Auteur ; Celso ARANGO, Auteur ; Christoph U CORRELL, Auteur ; Ilaria BONOLDI, Auteur ; Paolo FUSAR-POLI, Auteur . - p.657-673.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.657-673
Mots-clés : Psychosis adolescence childhood clinical high-risk state for psychosis evidence first-episode meta-analysis prediction prevention psychosis risk schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: The clinical high-risk state for psychosis (CHR-P) paradigm has facilitated the implementation of psychosis prevention into clinical practice; however, advancements in adolescent CHR-P populations are less established. METHODS: We performed a PRISMA/MOOSE-compliant systematic review of the Web of Science database, from inception until 7 October 2019, to identify original studies conducted in CHR-P children and adolescents (mean age <18 years). Findings were systematically appraised around core themes: detection, prognosis and intervention. We performed meta-analyses (employing Q statistics and I (2) test) regarding the proportion of CHR-P subgroups, the prevalence of baseline comorbid mental disorders, the risk of psychosis onset and the type of interventions received at baseline. Quality assessment and publication bias were also analysed. RESULTS: Eighty-seven articles were included (n = 4,667 CHR-P individuals). Quality of studies ranged from 3.5 to 8 (median 5.5) on a modified Newcastle-Ottawa scale. Detection: Individuals were aged 15.6 ± 1.2 years (51.5% males), mostly (83%) presenting with attenuated positive psychotic symptoms. CHR-P psychometric accuracy improved when caregivers served as additional informants. Comorbid mood (46.4%) and anxiety (31.4%) disorders were highly prevalent. Functioning and cognition were impaired. Neurobiological studies were inconclusive. PROGNOSIS: Risk for psychosis was 10.4% (95%CI: 5.8%-18.1%) at 6 months, 20% (95%CI: 15%-26%) at 12 months, 23% (95%CI: 18%-29%) at 24 months and 23.3% (95%CI: 17.3%-30.7%) at ?36 months. INTERVENTIONS: There was not enough evidence to recommend one specific treatment (including cognitive behavioural therapy) over the others (including control conditions) to prevent the transition to psychosis in this population. Randomised controlled trials suggested that family interventions, cognitive remediation and fish oil supplementation may improve cognition, symptoms and functioning. At baseline, 30% of CHR-P adolescents were prescribed antipsychotics and 60% received psychotherapy. CONCLUSIONS: It is possible to detect and formulate a group-level prognosis in adolescents at risk for psychosis. Future interventional research is required. En ligne : http://dx.doi.org/10.1111/jcpp.13322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 Editorial Perspective: Psychosis risk in adolescence - outcomes, comorbidity, and antipsychotics / A. RABALLO in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)
[article]
Titre : Editorial Perspective: Psychosis risk in adolescence - outcomes, comorbidity, and antipsychotics Type de document : Texte imprimé et/ou numérique Auteurs : A. RABALLO, Auteur ; M. POLETTI, Auteur ; A. PRETI, Auteur Article en page(s) : p.241-244 Langues : Anglais (eng) Mots-clés : Psychosis adolescence childhood clinical high-risk state for psychosis evidence first-episode prediction prevention psychosis risk schizophrenia Index. décimale : PER Périodiques Résumé : Research on Clinical High-Risk for Psychosis (CHR-P) has led to a vigorous change in the field of early detection in psychiatry and is gradually expanding its focus toward early development. The Annual Research Review on psychosis risk in adolescents (Journal of Child Psychology and Psychiatry, 62, 2020 and 657) offers a wide-angle meta-analytical picture of such emerging trends in all areas relevant to CHR-P Research, that is, detection, prognosis, and intervention. This editorial perspective is meant to expand the clinical and conceptual reach of these meta-analytic findings in relation to (a) the influence of age on transition rate and scalability of the early detection model across the child-adolescent vs adult periods; (b) potential latent heterogeneity of the pathogenetic trajectories leading to CHR-P as suggested by comorbid psychopathologies; (c) controversial (or at least problematic) prognostic significance of antipsychotic exposure in CHR-P subjects, especially in children and adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.13438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457
in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.241-244[article] Editorial Perspective: Psychosis risk in adolescence - outcomes, comorbidity, and antipsychotics [Texte imprimé et/ou numérique] / A. RABALLO, Auteur ; M. POLETTI, Auteur ; A. PRETI, Auteur . - p.241-244.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.241-244
Mots-clés : Psychosis adolescence childhood clinical high-risk state for psychosis evidence first-episode prediction prevention psychosis risk schizophrenia Index. décimale : PER Périodiques Résumé : Research on Clinical High-Risk for Psychosis (CHR-P) has led to a vigorous change in the field of early detection in psychiatry and is gradually expanding its focus toward early development. The Annual Research Review on psychosis risk in adolescents (Journal of Child Psychology and Psychiatry, 62, 2020 and 657) offers a wide-angle meta-analytical picture of such emerging trends in all areas relevant to CHR-P Research, that is, detection, prognosis, and intervention. This editorial perspective is meant to expand the clinical and conceptual reach of these meta-analytic findings in relation to (a) the influence of age on transition rate and scalability of the early detection model across the child-adolescent vs adult periods; (b) potential latent heterogeneity of the pathogenetic trajectories leading to CHR-P as suggested by comorbid psychopathologies; (c) controversial (or at least problematic) prognostic significance of antipsychotic exposure in CHR-P subjects, especially in children and adolescents. En ligne : http://dx.doi.org/10.1111/jcpp.13438 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457