15 recherche sur le mot-clé '*autism spectrum disorders'

Sex-related patterns of intrinsic functional connectivity in children and adolescents with autism spectrum disorders / Lindsay A. OLSON in Autism, 24-8 (November 2020)  

Public ISBD [article]  inAutism > 24-8 (November 2020) . - p.2190-2201 Titre : Sex-related patterns of intrinsic functional connectivity in children and adolescents with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay A. OLSON, Auteur ; Lisa E. MASH, Auteur ; Annika LINKE, Auteur ; Christopher H. FONG, Auteur ; Ralph-Axel MULLER, Auteur ; Inna FISHMAN, Auteur Article en page(s) : p.2190-2201 Langues : Anglais (eng) Mots-clés : *autism spectrum disorders  *brain function  *school-age children  interest to report. Index. décimale : PER Périodiques Résumé : We investigated whether children and adolescents with autism spectrum disorders show sex-specific patterns of brain function (using functional magnetic resonance imaging) that are well documented in typically developing males and females. We found, unexpectedly, that boys and girls with autism do not differ in their brain functional connectivity, whereas typically developing boys and girls showed differences in a brain network involved in thinking about self and others (the default mode network). Results suggest that autism may be characterized by a lack of brain sex differentiation. En ligne : http://dx.doi.org/10.1177/1362361320938194 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4319 [article] Sex-related patterns of intrinsic functional connectivity in children and adolescents with autism spectrum disorders [Texte imprimé et/ou numérique] / Lindsay A. OLSON, Auteur ; Lisa E. MASH, Auteur ; Annika LINKE, Auteur ; Christopher H. FONG, Auteur ; Ralph-Axel MULLER, Auteur ; Inna FISHMAN, Auteur . - p.2190-2201. Langues : Anglais (eng) in Autism > 24-8 (November 2020) . - p.2190-2201 Mots-clés : *autism spectrum disorders  *brain function  *school-age children  interest to report. Index. décimale : PER Périodiques Résumé : We investigated whether children and adolescents with autism spectrum disorders show sex-specific patterns of brain function (using functional magnetic resonance imaging) that are well documented in typically developing males and females. We found, unexpectedly, that boys and girls with autism do not differ in their brain functional connectivity, whereas typically developing boys and girls showed differences in a brain network involved in thinking about self and others (the default mode network). Results suggest that autism may be characterized by a lack of brain sex differentiation. En ligne : http://dx.doi.org/10.1177/1362361320938194 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4319

Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice / T. N. HUANG in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 5 p. Titre : Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice Type de document : Texte imprimé et/ou numérique Auteurs : T. N. HUANG, Auteur ; T. L. YEN, Auteur ; L. R. QIU, Auteur ; H. C. CHUANG, Auteur ; J. P. LERCH, Auteur ; Y. P. HSUEH, Auteur Article en page(s) : 5 p. Langues : Anglais (eng) Mots-clés : *Autism spectrum disorders  *c-fos  *D-cycloserine  *Neuronal activation  *Olfactory bulb  *Olfactory discrimination  *T-brain-1  interests.Springer Nature remains neutral with regard to jurisdictional claims in  published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) exhibit two clusters of core symptoms, i.e., social and communication impairment, and repetitive behaviors and sensory abnormalities. Our previous study demonstrated that TBR1, a causative gene of ASD, controls axonal projection and neuronal activation of amygdala and regulates social interaction and vocal communication in a mouse model. Behavioral defects caused by Tbr1 haploinsufficiency can be ameliorated by increasing neural activity via D-cycloserine treatment, an N-methyl-D-aspartate receptor (NMDAR) coagonist. In this report, we investigate the role of TBR1 in regulating olfaction and test whether D-cycloserine can also improve olfactory defects in Tbr1 mutant mice. Methods: We used Tbr1 (+/-) mice as a model to investigate the function of TBR1 in olfactory sensation and discrimination of non-social odors. We employed a behavioral assay to characterize the olfactory defects of Tbr1 (+/-) mice. Magnetic resonance imaging (MRI) and histological analysis were applied to characterize anatomical features. Immunostaining was performed to further analyze differences in expression of TBR1 subfamily members (namely TBR1, TBR2, and TBX21), interneuron populations, and dendritic abnormalities in olfactory bulbs. Finally, C-FOS staining was used to monitor neuronal activation of the olfactory system upon odor stimulation. Results: Tbr1 (+/-) mice exhibited smaller olfactory bulbs and anterior commissures, reduced interneuron populations, and an abnormal dendritic morphology of mitral cells in the olfactory bulbs. Tbr1 haploinsufficiency specifically impaired olfactory discrimination but not olfactory sensation. Neuronal activation upon odorant stimulation was reduced in the glomerular layer of Tbr1 (+/-) olfactory bulbs. Furthermore, although the sizes of piriform and perirhinal cortices were not affected by Tbr1 deficiency, neuronal activation was reduced in these two cortical regions in response to odorant stimulation. These results suggest an impairment of neuronal activation in olfactory bulbs and defective connectivity from olfactory bulbs to the upper olfactory system in Tbr1 (+/-) mice. Systemic administration of D-cycloserine, an NMDAR co-agonist, ameliorated olfactory discrimination in Tbr1 (+/-) mice, suggesting that increased neuronal activity has a beneficial effect on Tbr1 deficiency. Conclusions: Tbr1 regulates neural circuits and activity in the olfactory system to control olfaction. Tbr1 (+/-) mice can serve as a suitable model for revealing how an autism causative gene controls neuronal circuits, neural activity, and autism-related behaviors. En ligne : https://dx.doi.org/10.1186/s13229-019-0257-5 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3893 [article] Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice [Texte imprimé et/ou numérique] / T. N. HUANG, Auteur ; T. L. YEN, Auteur ; L. R. QIU, Auteur ; H. C. CHUANG, Auteur ; J. P. LERCH, Auteur ; Y. P. HSUEH, Auteur . - 5 p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 5 p. Mots-clés : *Autism spectrum disorders  *c-fos  *D-cycloserine  *Neuronal activation  *Olfactory bulb  *Olfactory discrimination  *T-brain-1  interests.Springer Nature remains neutral with regard to jurisdictional claims in  published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASD) exhibit two clusters of core symptoms, i.e., social and communication impairment, and repetitive behaviors and sensory abnormalities. Our previous study demonstrated that TBR1, a causative gene of ASD, controls axonal projection and neuronal activation of amygdala and regulates social interaction and vocal communication in a mouse model. Behavioral defects caused by Tbr1 haploinsufficiency can be ameliorated by increasing neural activity via D-cycloserine treatment, an N-methyl-D-aspartate receptor (NMDAR) coagonist. In this report, we investigate the role of TBR1 in regulating olfaction and test whether D-cycloserine can also improve olfactory defects in Tbr1 mutant mice. Methods: We used Tbr1 (+/-) mice as a model to investigate the function of TBR1 in olfactory sensation and discrimination of non-social odors. We employed a behavioral assay to characterize the olfactory defects of Tbr1 (+/-) mice. Magnetic resonance imaging (MRI) and histological analysis were applied to characterize anatomical features. Immunostaining was performed to further analyze differences in expression of TBR1 subfamily members (namely TBR1, TBR2, and TBX21), interneuron populations, and dendritic abnormalities in olfactory bulbs. Finally, C-FOS staining was used to monitor neuronal activation of the olfactory system upon odor stimulation. Results: Tbr1 (+/-) mice exhibited smaller olfactory bulbs and anterior commissures, reduced interneuron populations, and an abnormal dendritic morphology of mitral cells in the olfactory bulbs. Tbr1 haploinsufficiency specifically impaired olfactory discrimination but not olfactory sensation. Neuronal activation upon odorant stimulation was reduced in the glomerular layer of Tbr1 (+/-) olfactory bulbs. Furthermore, although the sizes of piriform and perirhinal cortices were not affected by Tbr1 deficiency, neuronal activation was reduced in these two cortical regions in response to odorant stimulation. These results suggest an impairment of neuronal activation in olfactory bulbs and defective connectivity from olfactory bulbs to the upper olfactory system in Tbr1 (+/-) mice. Systemic administration of D-cycloserine, an NMDAR co-agonist, ameliorated olfactory discrimination in Tbr1 (+/-) mice, suggesting that increased neuronal activity has a beneficial effect on Tbr1 deficiency. Conclusions: Tbr1 regulates neural circuits and activity in the olfactory system to control olfaction. Tbr1 (+/-) mice can serve as a suitable model for revealing how an autism causative gene controls neuronal circuits, neural activity, and autism-related behaviors. En ligne : https://dx.doi.org/10.1186/s13229-019-0257-5 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3893

Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder / Jessica BRADSHAW in Autism, 24-7 (October 2020)  

Public ISBD [article]  inAutism > 24-7 (October 2020) . - p.1874-1884 Titre : Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BRADSHAW, Auteur ; Ashley TRUMBULL, Auteur ; Jennifer STAPEL-WAX, Auteur ; Scott GILLESPIE, Auteur ; Nisha GEORGE, Auteur ; Celine A. SAULNIER, Auteur ; Cheryl KLAIMAN, Auteur ; Juliann WOODS, Auteur ; Nathan A. CALL, Auteur ; Ami KLIN, Auteur ; Amy M. WETHERBY, Auteur Article en page(s) : p.1874-1884 Langues : Anglais (eng) Mots-clés : *autism spectrum disorders  *clinical trial  *communication and language  *infant  *interventions—psychosocial/behavioral Index. décimale : PER Périodiques Résumé : Early intervention helps to address developmental delays in young children with autism spectrum disorder. Yet, research suggests there are barriers to enrollment into research studies that test the effectiveness of these interventions for infants at risk. This study identifies family characteristics that were associated with agreement to enroll in a clinical trial of early intervention for 12-month-old infants at risk for autism spectrum disorder. As part of a large longitudinal study, infants were evaluated for early signs of autism spectrum disorder at 1?year of age. Of the fifty-seven infants who were showing signs of autism and deemed eligible for the early intervention trial, 44% declined enrollment. Results suggest that families were more likely to decline enrolling into the intervention study if the mother was working full time, the total household income was between US$60,000 and US$100,000, and they lived further from the clinic. In contrast, infant autism symptoms and parental concern at 12?months were not significantly associated with enrollment. These findings highlight the need for intervention studies that are more accessible to parents, for example, intervention that takes place in the home, in addition to more research on how parental understanding of, and willingness to act on, early social-communication delays impact intervention study enrollment. Future research can then examine how to address these barriers to enrollment in early intervention studies. Such findings will shed light on best practices for dissemination of early identification and intervention strategies. En ligne : http://dx.doi.org/10.1177/1362361320928829 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4316 [article] Factors associated with enrollment into a clinical trial of caregiver-implemented intervention for infants at risk for autism spectrum disorder [Texte imprimé et/ou numérique] / Jessica BRADSHAW, Auteur ; Ashley TRUMBULL, Auteur ; Jennifer STAPEL-WAX, Auteur ; Scott GILLESPIE, Auteur ; Nisha GEORGE, Auteur ; Celine A. SAULNIER, Auteur ; Cheryl KLAIMAN, Auteur ; Juliann WOODS, Auteur ; Nathan A. CALL, Auteur ; Ami KLIN, Auteur ; Amy M. WETHERBY, Auteur . - p.1874-1884. Langues : Anglais (eng) in Autism > 24-7 (October 2020) . - p.1874-1884 Mots-clés : *autism spectrum disorders  *clinical trial  *communication and language  *infant  *interventions—psychosocial/behavioral Index. décimale : PER Périodiques Résumé : Early intervention helps to address developmental delays in young children with autism spectrum disorder. Yet, research suggests there are barriers to enrollment into research studies that test the effectiveness of these interventions for infants at risk. This study identifies family characteristics that were associated with agreement to enroll in a clinical trial of early intervention for 12-month-old infants at risk for autism spectrum disorder. As part of a large longitudinal study, infants were evaluated for early signs of autism spectrum disorder at 1?year of age. Of the fifty-seven infants who were showing signs of autism and deemed eligible for the early intervention trial, 44% declined enrollment. Results suggest that families were more likely to decline enrolling into the intervention study if the mother was working full time, the total household income was between US$60,000 and US$100,000, and they lived further from the clinic. In contrast, infant autism symptoms and parental concern at 12?months were not significantly associated with enrollment. These findings highlight the need for intervention studies that are more accessible to parents, for example, intervention that takes place in the home, in addition to more research on how parental understanding of, and willingness to act on, early social-communication delays impact intervention study enrollment. Future research can then examine how to address these barriers to enrollment in early intervention studies. Such findings will shed light on best practices for dissemination of early identification and intervention strategies. En ligne : http://dx.doi.org/10.1177/1362361320928829 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4316

Identifying and measuring the common elements of naturalistic developmental behavioral interventions for autism spectrum disorder: Development of the NDBI-Fi / Kyle M. FROST in Autism, 24-8 (November 2020)  

Public ISBD [article]  inAutism > 24-8 (November 2020) . - p.2285-2297 Titre : Identifying and measuring the common elements of naturalistic developmental behavioral interventions for autism spectrum disorder: Development of the NDBI-Fi Type de document : Texte imprimé et/ou numérique Auteurs : Kyle M. FROST, Auteur ; Jessica BRIAN, Auteur ; Grace W. GENGOUX, Auteur ; Antonio HARDAN, Auteur ; Sarah R. RIETH, Auteur ; Aubyn STAHMER, Auteur ; Brooke R. INGERSOLL, Auteur Année de publication : 2020 Article en page(s) : p.2285-2297 Langues : Anglais (eng) Mots-clés : *autism spectrum disorders  *common elements  *interventions—psychosocial/behavioral  *measure development  conflicts of interest to declare. Author B.I. receives royalties from the sale of  one of the manuals used in the research. Royalties are donated to the research. Index. décimale : PER Périodiques Résumé : Naturalistic developmental behavioral interventions for young children with autism spectrum disorder share key elements. However, the extent of similarity between programs within this class of evidence-based interventions is unknown. There is also currently no tool that can be used to measure the implementation of their common elements. This article presents a multi-stage process which began with defining all intervention elements of naturalistic developmental behavioral interventions. Next, intervention experts identified the common elements of naturalistic developmental behavioral interventions using a survey. An observational rating scheme of those common elements, the eight-item NDBI-Fi, was developed. We evaluated the quality of the NDBI-Fi using videos from completed trials of caregiver-implemented naturalistic developmental behavioral interventions. Results showed that the NDBI-Fi measure has promise; it was sensitive to change, related to other similar measures, and demonstrated adequate agreement between raters. This unique measure has the potential to advance intervention science in autism spectrum disorder by providing a tool to measure the implementation of common elements across naturalistic developmental behavioral intervention models. Given that naturalistic developmental behavioral interventions have numerous shared strategies, this may ease clinicians' uncertainty about choosing the "right" intervention package. It also suggests that there may not be a need for extensive training in more than one naturalistic developmental behavioral intervention. Future research should determine whether these common elements are part of other treatment approaches to better understand the quality of services children and families receive as part of usual care. En ligne : http://dx.doi.org/10.1177/1362361320944011 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4320 [article] Identifying and measuring the common elements of naturalistic developmental behavioral interventions for autism spectrum disorder: Development of the NDBI-Fi [Texte imprimé et/ou numérique] / Kyle M. FROST, Auteur ; Jessica BRIAN, Auteur ; Grace W. GENGOUX, Auteur ; Antonio HARDAN, Auteur ; Sarah R. RIETH, Auteur ; Aubyn STAHMER, Auteur ; Brooke R. INGERSOLL, Auteur . - 2020 . - p.2285-2297. Langues : Anglais (eng) in Autism > 24-8 (November 2020) . - p.2285-2297 Mots-clés : *autism spectrum disorders  *common elements  *interventions—psychosocial/behavioral  *measure development  conflicts of interest to declare. Author B.I. receives royalties from the sale of  one of the manuals used in the research. Royalties are donated to the research. Index. décimale : PER Périodiques Résumé : Naturalistic developmental behavioral interventions for young children with autism spectrum disorder share key elements. However, the extent of similarity between programs within this class of evidence-based interventions is unknown. There is also currently no tool that can be used to measure the implementation of their common elements. This article presents a multi-stage process which began with defining all intervention elements of naturalistic developmental behavioral interventions. Next, intervention experts identified the common elements of naturalistic developmental behavioral interventions using a survey. An observational rating scheme of those common elements, the eight-item NDBI-Fi, was developed. We evaluated the quality of the NDBI-Fi using videos from completed trials of caregiver-implemented naturalistic developmental behavioral interventions. Results showed that the NDBI-Fi measure has promise; it was sensitive to change, related to other similar measures, and demonstrated adequate agreement between raters. This unique measure has the potential to advance intervention science in autism spectrum disorder by providing a tool to measure the implementation of common elements across naturalistic developmental behavioral intervention models. Given that naturalistic developmental behavioral interventions have numerous shared strategies, this may ease clinicians' uncertainty about choosing the "right" intervention package. It also suggests that there may not be a need for extensive training in more than one naturalistic developmental behavioral intervention. Future research should determine whether these common elements are part of other treatment approaches to better understand the quality of services children and families receive as part of usual care. En ligne : http://dx.doi.org/10.1177/1362361320944011 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4320

Moral foundations theory in autism spectrum disorder: A qualitative investigation / Erin E. DEMPSEY in Autism, 24-8 (November 2020)  

Public ISBD [article]  inAutism > 24-8 (November 2020) . - p.2202-2212 Titre : Moral foundations theory in autism spectrum disorder: A qualitative investigation Type de document : Texte imprimé et/ou numérique Auteurs : Erin E. DEMPSEY, Auteur ; Chris MOORE, Auteur ; Annie E. RICHARD, Auteur ; Isabel M SMITH, Auteur Article en page(s) : p.2202-2212 Langues : Anglais (eng) Mots-clés : *autism spectrum disorders  *commonsense psychology  *ethics  *moral emotion  *moral foundations theory  *morality  *social cognition and social behaviour Index. décimale : PER Périodiques Résumé : Morality is important for how humans treat each other and non-human animals. Differences in moral thinking have been found between autistic and neurotypical individuals. This research has relied on ways of thinking about moral psychology that suggest that mature morals develop as individuals learn to take the perspectives of others. Yet, even autistic individuals, who sometimes differ in their ability to take others' perspectives, make moral judgements that are similar to neurotypical individuals. Moral foundations theory suggests that moral psychology is not hierarchical but differs depending on culture. This theory could therefore help make sense of similarities and differences in autistic and neurotypical moral thinking. Moral foundations theory has not yet been investigated among autistic individuals. In this study, we interviewed autistic adults as a first attempt at understanding how moral foundations theory fits with autistic moral thinking. We found that all five moral foundations of moral foundations theory were represented in the interviews, yet certain foundations appeared more prominent than others. The autistic adults interviewed in our study discussed issues of care and fairness more than of loyalty, authority or purity when prompted to discuss moral transgressions. Future research should use quantitative methods to compare groups of autistic and neurotypical individuals to clarify similarities and differences in moral thinking between the groups. En ligne : http://dx.doi.org/10.1177/1362361320939331 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4319 [article] Moral foundations theory in autism spectrum disorder: A qualitative investigation [Texte imprimé et/ou numérique] / Erin E. DEMPSEY, Auteur ; Chris MOORE, Auteur ; Annie E. RICHARD, Auteur ; Isabel M SMITH, Auteur . - p.2202-2212. Langues : Anglais (eng) in Autism > 24-8 (November 2020) . - p.2202-2212 Mots-clés : *autism spectrum disorders  *commonsense psychology  *ethics  *moral emotion  *moral foundations theory  *morality  *social cognition and social behaviour Index. décimale : PER Périodiques Résumé : Morality is important for how humans treat each other and non-human animals. Differences in moral thinking have been found between autistic and neurotypical individuals. This research has relied on ways of thinking about moral psychology that suggest that mature morals develop as individuals learn to take the perspectives of others. Yet, even autistic individuals, who sometimes differ in their ability to take others' perspectives, make moral judgements that are similar to neurotypical individuals. Moral foundations theory suggests that moral psychology is not hierarchical but differs depending on culture. This theory could therefore help make sense of similarities and differences in autistic and neurotypical moral thinking. Moral foundations theory has not yet been investigated among autistic individuals. In this study, we interviewed autistic adults as a first attempt at understanding how moral foundations theory fits with autistic moral thinking. We found that all five moral foundations of moral foundations theory were represented in the interviews, yet certain foundations appeared more prominent than others. The autistic adults interviewed in our study discussed issues of care and fairness more than of loyalty, authority or purity when prompted to discuss moral transgressions. Future research should use quantitative methods to compare groups of autistic and neurotypical individuals to clarify similarities and differences in moral thinking between the groups. En ligne : http://dx.doi.org/10.1177/1362361320939331 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4319

Parent perceptions of participation in a parent-mediated communication-focussed intervention with their young child with autism spectrum disorder / Kathy LEADBITTER in Autism, 24-8 (November 2020)  

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Short report: Social communication difficulties and restricted repetitive behaviors as predictors of anxiety in adults with autism spectrum disorder / Erika KUZMINSKAITE in Autism, 24-7 (October 2020)  

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Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses / A. MODABBERNIA in Molecular Autism, 8 (2017)  

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Facial emotion recognition in autistic adult females correlates with alexithymia, not autism / Louise OLA in Autism, 24-8 (November 2020)  

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Self-initiations in young children with autism during Pivotal Response Treatment with and without robot assistance / Manon DE KORTE in Autism, 24-8 (November 2020)  

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