1 recherche sur le mot-clé 'Autism Positron-emission-tomography Setoperone [18Fluoro]setoperone Serotonin Endophenotype'

Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders / Jeremy GOLDBERG in Journal of Autism and Developmental Disorders, 39-1 (January 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.97-104 Titre : Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jeremy GOLDBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; George M. ANDERSON, Auteur ; Claude NAHMIAS, Auteur ; Geoffrey B. C. HALL, Auteur ; Ann THOMPSON, Auteur Année de publication : 2009 Article en page(s) : p.97-104 Langues : Anglais (eng) Mots-clés : Autism Positron-emission-tomography Setoperone [18Fluoro]setoperone Serotonin Endophenotype Index. décimale : PER Périodiques Résumé : Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [18F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [18F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior. En ligne : http://dx.doi.org/10.1007/s10803-008-0604-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660 [article] Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Jeremy GOLDBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; George M. ANDERSON, Auteur ; Claude NAHMIAS, Auteur ; Geoffrey B. C. HALL, Auteur ; Ann THOMPSON, Auteur . - 2009 . - p.97-104. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.97-104 Mots-clés : Autism Positron-emission-tomography Setoperone [18Fluoro]setoperone Serotonin Endophenotype Index. décimale : PER Périodiques Résumé : Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [18F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [18F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior. En ligne : http://dx.doi.org/10.1007/s10803-008-0604-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660