5 recherche sur le mot-clé 'Childhood Autism Rating Scale'

Development of the Childhood Autism Rating Scale-Brief Form for early detection of autism spectrum disorder in toddlers under three / Yuh-Ming HOU ; Lai-Sang IAO ; Chin-Chin WU in Research in Autism, 126 (August 2025)  

Public ISBD [article]  inResearch in Autism > 126 (August 2025) . - p.202645 Titre : Development of the Childhood Autism Rating Scale-Brief Form for early detection of autism spectrum disorder in toddlers under three Type de document : texte imprimé Auteurs : Yuh-Ming HOU, Auteur ; Lai-Sang IAO, Auteur ; Chin-Chin WU, Auteur Article en page(s) : p.202645 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Childhood Autism Rating Scale  Brief Form  Developmental delays  Sensitivity  Specificity Index. décimale : PER Périodiques Résumé : Background Early diagnosis and intervention could improve the prognosis of autism spectrum disorder (ASD). This study aimed to investigate the validity of the Childhood Autism Rating Scale (CARS) in toddlers with ASD under 3 years and develop an efficient abbreviated version for early diagnosis of ASD. Methods Two studies were conducted to evaluate the validity of the CARS for detecting ASD. Study 1 examined the differences between 30 toddlers with ASD and 30 toddlers with developmental delays (DD) and analyzed the area under the receiver operating characteristic (ROC) curve. Critical items were selected as the CARS-Brief Form (CARS-BF) and cutoff scores were determined. Study 2 involved 206 toddlers, including 115 with ASD, 34 with mild-ASD, and 57 with DD, to validate the utility of the CARS-BF. Results Study 1 identified 7 items for the CARS-BF and found the optimal cutoff scores to be 12.5 and 13. Study 2 confirmed the optimal cutoff score of 12.5 and 13 for the CARS-BF and demonstrated good accuracy. Besides, the cutoff score of 13 exhibited high sensitivity (88.7 %) and specificity (84.2 %). Conclusion The CARS-BF demonstrated a high level of accuracy. It can be utilized as an effective tool for identifying toddlers with ASD in clinical settings. En ligne : https://doi.org/10.1016/j.reia.2025.202645 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] Development of the Childhood Autism Rating Scale-Brief Form for early detection of autism spectrum disorder in toddlers under three [texte imprimé] / Yuh-Ming HOU, Auteur ; Lai-Sang IAO, Auteur ; Chin-Chin WU, Auteur . - p.202645. Langues : Anglais (eng) in Research in Autism > 126 (August 2025) . - p.202645 Mots-clés : Autism spectrum disorder  Childhood Autism Rating Scale  Brief Form  Developmental delays  Sensitivity  Specificity Index. décimale : PER Périodiques Résumé : Background Early diagnosis and intervention could improve the prognosis of autism spectrum disorder (ASD). This study aimed to investigate the validity of the Childhood Autism Rating Scale (CARS) in toddlers with ASD under 3 years and develop an efficient abbreviated version for early diagnosis of ASD. Methods Two studies were conducted to evaluate the validity of the CARS for detecting ASD. Study 1 examined the differences between 30 toddlers with ASD and 30 toddlers with developmental delays (DD) and analyzed the area under the receiver operating characteristic (ROC) curve. Critical items were selected as the CARS-Brief Form (CARS-BF) and cutoff scores were determined. Study 2 involved 206 toddlers, including 115 with ASD, 34 with mild-ASD, and 57 with DD, to validate the utility of the CARS-BF. Results Study 1 identified 7 items for the CARS-BF and found the optimal cutoff scores to be 12.5 and 13. Study 2 confirmed the optimal cutoff score of 12.5 and 13 for the CARS-BF and demonstrated good accuracy. Besides, the cutoff score of 13 exhibited high sensitivity (88.7 %) and specificity (84.2 %). Conclusion The CARS-BF demonstrated a high level of accuracy. It can be utilized as an effective tool for identifying toddlers with ASD in clinical settings. En ligne : https://doi.org/10.1016/j.reia.2025.202645 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

Differences Between the Childhood Autism Rating Scale and the Social Responsiveness Scale in Assessing Symptoms of Children with Autistic Spectrum Disorder / Kuan-Lin CHEN in Journal of Autism and Developmental Disorders, 48-9 (September 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3191-3198 Titre : Differences Between the Childhood Autism Rating Scale and the Social Responsiveness Scale in Assessing Symptoms of Children with Autistic Spectrum Disorder Type de document : texte imprimé Auteurs : Kuan-Lin CHEN, Auteur ; Chien-Ho LIN, Auteur ; Tzu-Ying YU, Auteur ; Chien-Yu HUANG, Auteur ; Ying-Dar CHEN, Auteur Article en page(s) : p.3191-3198 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Childhood Autism Rating Scale  Children  Social Responsiveness Scale Index. décimale : PER Périodiques Résumé : This study aimed to compare symptoms of autism spectrum disorder using the Childhood Autism Rating Scale (CARS) and the Social Responsiveness Scale (SRS-2) and to investigate their influencing factors. The diagnostic agreement was 92.7%, but with a fair Kappa value (0.247). Children's verbal comprehension was related to the CARS scores, and no variables were related to the SRS-2 scores. Generally, significant small correlations were found between the two measures in children with normal or borderline to below average verbal comprehension (rs = 0.32 ~ 0.49, p < .005), but not in those with impaired verbal comprehension. The CARS and the SRS-2 may contain different explicit behaviors and collect different perspectives (i.e., those of caregivers and professionals). Therefore, they appear to complement each other. En ligne : http://dx.doi.org/10.1007/s10803-018-3585-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Differences Between the Childhood Autism Rating Scale and the Social Responsiveness Scale in Assessing Symptoms of Children with Autistic Spectrum Disorder [texte imprimé] / Kuan-Lin CHEN, Auteur ; Chien-Ho LIN, Auteur ; Tzu-Ying YU, Auteur ; Chien-Yu HUANG, Auteur ; Ying-Dar CHEN, Auteur . - p.3191-3198. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-9 (September 2018) . - p.3191-3198 Mots-clés : Autism spectrum disorder  Childhood Autism Rating Scale  Children  Social Responsiveness Scale Index. décimale : PER Périodiques Résumé : This study aimed to compare symptoms of autism spectrum disorder using the Childhood Autism Rating Scale (CARS) and the Social Responsiveness Scale (SRS-2) and to investigate their influencing factors. The diagnostic agreement was 92.7%, but with a fair Kappa value (0.247). Children's verbal comprehension was related to the CARS scores, and no variables were related to the SRS-2 scores. Generally, significant small correlations were found between the two measures in children with normal or borderline to below average verbal comprehension (rs = 0.32 ~ 0.49, p < .005), but not in those with impaired verbal comprehension. The CARS and the SRS-2 may contain different explicit behaviors and collect different perspectives (i.e., those of caregivers and professionals). Therefore, they appear to complement each other. En ligne : http://dx.doi.org/10.1007/s10803-018-3585-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Final DSM-5 under-identifies mild Autism Spectrum Disorder: Agreement between the DSM-5, CARS, CASD, and clinical diagnoses / Susan DICKERSON MAYES in Research in Autism Spectrum Disorders, 8-2 (February 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-2 (February 2014) . - p.68-73 Titre : Final DSM-5 under-identifies mild Autism Spectrum Disorder: Agreement between the DSM-5, CARS, CASD, and clinical diagnoses Type de document : texte imprimé Auteurs : Susan DICKERSON MAYES, Auteur ; Susan L. CALHOUN, Auteur ; Michael J. MURRAY, Auteur ; Amanda M. PEARL, Auteur ; Amanda BLACK, Auteur ; Cheryl D. TIERNEY, Auteur Article en page(s) : p.68-73 Langues : Anglais (eng) Mots-clés : DSM-5  Checklist for Autism Spectrum Disorder  Childhood Autism Rating Scale Index. décimale : PER Périodiques Résumé : Abstract Agreement between the final DSM-5 ASD criteria, Childhood Autism Rating Scale (CARS), and Checklist for Autism Spectrum Disorder (CASD) was assessed in 143 children with ASD and other disorders (e.g., ADHD, intellectual disability, and oppositional defiant disorder). Diagnostic agreement between the CARS and CASD was high (94%), but their agreement with the DSM-5 was lower (84% and 88%). Agreement between the DSM-5 and both the CARS and CASD increased to 94% and diagnostic accuracy increased from 92% to 96% when one less DSM-5 social communication and interaction symptom was required for a diagnosis. Children with ASD not meeting DSM-5 criteria most often did not have criterion A2 (deficits in nonverbal social communication). Total scores on the DSM-5, CASD, and CARS were far higher for children with mild ASD (formerly PDDNOS) than no ASD, indicating that these children are clearly on the autism spectrum and are quite different from children with other disorders. However, only one child with mild ASD was identified by the DSM-5. This study and 11 others show that the DSM-5 under-identifies children with ASD, particularly children at the mild end of the spectrum. This can be rectified by requiring one less social communication and interaction symptom for a diagnosis. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.11.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Final DSM-5 under-identifies mild Autism Spectrum Disorder: Agreement between the DSM-5, CARS, CASD, and clinical diagnoses [texte imprimé] / Susan DICKERSON MAYES, Auteur ; Susan L. CALHOUN, Auteur ; Michael J. MURRAY, Auteur ; Amanda M. PEARL, Auteur ; Amanda BLACK, Auteur ; Cheryl D. TIERNEY, Auteur . - p.68-73. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-2 (February 2014) . - p.68-73 Mots-clés : DSM-5  Checklist for Autism Spectrum Disorder  Childhood Autism Rating Scale Index. décimale : PER Périodiques Résumé : Abstract Agreement between the final DSM-5 ASD criteria, Childhood Autism Rating Scale (CARS), and Checklist for Autism Spectrum Disorder (CASD) was assessed in 143 children with ASD and other disorders (e.g., ADHD, intellectual disability, and oppositional defiant disorder). Diagnostic agreement between the CARS and CASD was high (94%), but their agreement with the DSM-5 was lower (84% and 88%). Agreement between the DSM-5 and both the CARS and CASD increased to 94% and diagnostic accuracy increased from 92% to 96% when one less DSM-5 social communication and interaction symptom was required for a diagnosis. Children with ASD not meeting DSM-5 criteria most often did not have criterion A2 (deficits in nonverbal social communication). Total scores on the DSM-5, CASD, and CARS were far higher for children with mild ASD (formerly PDDNOS) than no ASD, indicating that these children are clearly on the autism spectrum and are quite different from children with other disorders. However, only one child with mild ASD was identified by the DSM-5. This study and 11 others show that the DSM-5 under-identifies children with ASD, particularly children at the mild end of the spectrum. This can be rectified by requiring one less social communication and interaction symptom for a diagnosis. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.11.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report / Alok SHARMA in Autism - Open Access, 6-2 ([01/03/2016])  

Public ISBD [article]  inAutism - Open Access > 6-2 [01/03/2016] . - 6 p. Titre : PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report Type de document : texte imprimé Auteurs : Alok SHARMA, Auteur ; Hemangi SANE, Auteur ; Nandini GOKULCHANDRAN, Auteur ; Prerna BADHE, Auteur ; Avantika PATIL, Auteur ; Pooja KULKARNI, Auteur ; Amruta PARANJAPE, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Mots-clés : Autism  Stem cell therapy  Bone marrow mononuclear cells  Autologous  Childhood autism Rating scale  Functional neuroimaging  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : PET - CT scan has been recently utilized to detect functional abnormalities in the brain. In autism, the MRI of brain is normal hence, functional neuroimaging techniques such as Positron Emission Tomography – Computer Tomography scan of the brain should be explored. Autism is a complex neurodevelopmental disorder affecting communication, behavior and socialization. Currently, available therapeutic approaches are aimed at symptomatic changes and do not target the core pathology in the brain of autism. Cell therapy has recently emerged as a promising treatment modality for autism. However, the effects of cell therapy need to be monitored by objective imaging. In this study, we present the case of a 6 year old boy with autism treated with intrathecal administration of autologous bone marrow mononuclear cells and monitored with Positron Emission Tomography – Computer Tomography scan. On regular follow up at 3 and 6 months, significant social, behavioral and communication improvements were observed. On outcome measures, the Indian Scale for Assessment of Autism score pre -intervention improved from 113 to 97, Functional Independence Measure improved significantly from 42 to 50 and Childhood Autism Rating Scale improved from 42.5 to 35.5. The severity of illness on Clinical Global Impression scale showed a change from a score of 5 (markedly ill) to 4 (moderately ill). Global improvement graded on the CGI scale was 2 (much improved). The efficacy index on Childhood Autism Rating Scale showed moderate therapeutic effect (score 5). Interestingly, Positron Emission Tomography - Computer Tomography comparisons at 6 months revealed improved metabolism of the previously hypometabolic areas of the brain which correlated well with clinical improvements. No adverse events were reported. En ligne : https://dx.doi.org/10.4172/2165-7890.1000169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] PET - CT Scan Shows Decreased Severity of Autism after Autologous Cellular Therapy: A Case Report [texte imprimé] / Alok SHARMA, Auteur ; Hemangi SANE, Auteur ; Nandini GOKULCHANDRAN, Auteur ; Prerna BADHE, Auteur ; Avantika PATIL, Auteur ; Pooja KULKARNI, Auteur ; Amruta PARANJAPE, Auteur . - 6 p. Langues : Anglais (eng) in Autism - Open Access > 6-2 [01/03/2016] . - 6 p. Mots-clés : Autism  Stem cell therapy  Bone marrow mononuclear cells  Autologous  Childhood autism Rating scale  Functional neuroimaging  Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : PET - CT scan has been recently utilized to detect functional abnormalities in the brain. In autism, the MRI of brain is normal hence, functional neuroimaging techniques such as Positron Emission Tomography – Computer Tomography scan of the brain should be explored. Autism is a complex neurodevelopmental disorder affecting communication, behavior and socialization. Currently, available therapeutic approaches are aimed at symptomatic changes and do not target the core pathology in the brain of autism. Cell therapy has recently emerged as a promising treatment modality for autism. However, the effects of cell therapy need to be monitored by objective imaging. In this study, we present the case of a 6 year old boy with autism treated with intrathecal administration of autologous bone marrow mononuclear cells and monitored with Positron Emission Tomography – Computer Tomography scan. On regular follow up at 3 and 6 months, significant social, behavioral and communication improvements were observed. On outcome measures, the Indian Scale for Assessment of Autism score pre -intervention improved from 113 to 97, Functional Independence Measure improved significantly from 42 to 50 and Childhood Autism Rating Scale improved from 42.5 to 35.5. The severity of illness on Clinical Global Impression scale showed a change from a score of 5 (markedly ill) to 4 (moderately ill). Global improvement graded on the CGI scale was 2 (much improved). The efficacy index on Childhood Autism Rating Scale showed moderate therapeutic effect (score 5). Interestingly, Positron Emission Tomography - Computer Tomography comparisons at 6 months revealed improved metabolism of the previously hypometabolic areas of the brain which correlated well with clinical improvements. No adverse events were reported. En ligne : https://dx.doi.org/10.4172/2165-7890.1000169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia / Subhashini JAYANATH in Research in Autism Spectrum Disorders, 84 (June 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 84 (June 2021) . - 101786 Titre : Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia Type de document : texte imprimé Auteurs : Subhashini JAYANATH, Auteur ; Choong Yi FONG, Auteur ; Rajini SARVANANTHAN, Auteur Article en page(s) : 101786 Langues : Anglais (eng) Mots-clés : Autism  Vitamin D  Children  Childhood Autism Rating Scale  Aberrant Behaviour Checklist Index. décimale : PER Périodiques Résumé : Background Determine the prevalence and risk factors of vitamin D deficiency (<35 nmol/L) in children with autism spectrum disorder (ASD); and explore the association between vitamin D deficiency with ASD severity and behavioural symptoms. Method Cross-sectional study of children with ASD at a tertiary hospital. Children with vitamin D deficiency (<35.0 nmol/L) were treated (1200IU cholecalciferol, daily for 3 months). ASD severity was determined via the Childhood Autism Rating Scale, 2nd Edition (CARS-2); and behavioural symptoms via the Aberrant Behaviour Checklist, 2nd Edition (ABC-2). Scores were compared between the vitamin D deficient and non-deficient groups. Results There were 103 participants (85.4 % male). Mean age: 6.2 years (SD = 2.4), 19 % were vitamin D deficient and 42 % were insufficient. Mean vitamin D concentration was 45.8 nmol/L (SD = 13.5). Female gender was significantly associated with vitamin D deficiency (OR 5.05, 95 % CI: 1.56, 16.31, p = 0.007). Post-vitamin D treatment, there was a significant reduction in CARS-2 scores (p < 0.05), but not ABC-2 scores. Conclusions Nearly two-thirds (61 %) of Malaysian children with ASD have vitamin D deficiency (19 %) and insufficiency (42 %). Vitamin D treatment among vitamin D deficient children with ASD resulted in improvement in ASD symptom severity but not behavioural symptoms. En ligne : https://doi.org/10.1016/j.rasd.2021.101786 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446 [article] Autism spectrum disorder and vitamin D status: A cross-sectional study of children in a developing country in Southeast Asia [texte imprimé] / Subhashini JAYANATH, Auteur ; Choong Yi FONG, Auteur ; Rajini SARVANANTHAN, Auteur . - 101786. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 84 (June 2021) . - 101786 Mots-clés : Autism  Vitamin D  Children  Childhood Autism Rating Scale  Aberrant Behaviour Checklist Index. décimale : PER Périodiques Résumé : Background Determine the prevalence and risk factors of vitamin D deficiency (<35 nmol/L) in children with autism spectrum disorder (ASD); and explore the association between vitamin D deficiency with ASD severity and behavioural symptoms. Method Cross-sectional study of children with ASD at a tertiary hospital. Children with vitamin D deficiency (<35.0 nmol/L) were treated (1200IU cholecalciferol, daily for 3 months). ASD severity was determined via the Childhood Autism Rating Scale, 2nd Edition (CARS-2); and behavioural symptoms via the Aberrant Behaviour Checklist, 2nd Edition (ABC-2). Scores were compared between the vitamin D deficient and non-deficient groups. Results There were 103 participants (85.4 % male). Mean age: 6.2 years (SD = 2.4), 19 % were vitamin D deficient and 42 % were insufficient. Mean vitamin D concentration was 45.8 nmol/L (SD = 13.5). Female gender was significantly associated with vitamin D deficiency (OR 5.05, 95 % CI: 1.56, 16.31, p = 0.007). Post-vitamin D treatment, there was a significant reduction in CARS-2 scores (p < 0.05), but not ABC-2 scores. Conclusions Nearly two-thirds (61 %) of Malaysian children with ASD have vitamin D deficiency (19 %) and insufficiency (42 %). Vitamin D treatment among vitamin D deficient children with ASD resulted in improvement in ASD symptom severity but not behavioural symptoms. En ligne : https://doi.org/10.1016/j.rasd.2021.101786 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446