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Assessment of medical morbidities in a rhesus monkey model of naturally occurring low sociality / A. K. MYERS in Autism Research, 14-7 (July 2021)
[article]
Titre : Assessment of medical morbidities in a rhesus monkey model of naturally occurring low sociality Type de document : Texte imprimé et/ou numérique Auteurs : A. K. MYERS, Auteur ; Catherine F. TALBOT, Auteur ; L. A. DEL ROSSO, Auteur ; A. C. MANESS, Auteur ; S. M. V. SIMMONS, Auteur ; J. P. GARNER, Auteur ; John P. CAPITANIO, Auteur ; Karen J. PARKER, Auteur Article en page(s) : p.1332-1346 Langues : Anglais (eng) Mots-clés : Animals Autism Spectrum Disorder/epidemiology Autistic Disorder Humans Macaca mulatta Morbidity Social Behavior Social Responsiveness Scale animal model autism spectrum disorder medical morbidities rhesus macaque social behavior Index. décimale : PER Périodiques Résumé : People with autism spectrum disorder (ASD) exhibit a variety of medical morbidities at significantly higher rates than the general population. Using an established monkey model of naturally occurring low sociality, we investigated whether low-social monkeys show an increased burden of medical morbidities compared to their high-social counterparts. We systematically reviewed the medical records of N = 152 (n = 73 low-social; n = 79 high-social) rhesus macaques (Macaca mulatta) to assess the number of traumatic injury, gastrointestinal, and inflammatory events, as well as the presence of rare medical conditions. Subjects' nonsocial scores, determined by the frequency they were observed in a nonsocial state (i.e., alone), and macaque Social Responsiveness Scale-Revised (mSRS-R) scores were also used to test whether individual differences in social functioning were related to medical morbidity burden. Medical morbidity type significantly differed by group, such that low-social monkeys incurred higher rates of traumatic injury compared to high-social monkeys. Nonsocial scores and mSRS-R scores also significantly and positively predicted traumatic injury rates, indicating that monkeys with the greatest social impairment were most impacted on this health measure. These findings from low-social monkeys are consistent with well-documented evidence that people with ASD incur a greater number of traumatic injuries and receive more peer bullying than their neurotypical peers, and add to growing evidence for the face validity of this primate model. LAY SUMMARY: People with autism exhibit multiple medical problems at higher rates than the general population. We conducted a comprehensive medical record review of monkeys that naturally exhibit differences in sociality and found that low-social monkeys are more susceptible to traumatic injuries than high-social monkeys. These results are consistent with reports that people with autism also incur greater traumatic injury and peer bullying and add to growing evidence for the validity of this monkey model. En ligne : http://dx.doi.org/10.1002/aur.2512 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-7 (July 2021) . - p.1332-1346[article] Assessment of medical morbidities in a rhesus monkey model of naturally occurring low sociality [Texte imprimé et/ou numérique] / A. K. MYERS, Auteur ; Catherine F. TALBOT, Auteur ; L. A. DEL ROSSO, Auteur ; A. C. MANESS, Auteur ; S. M. V. SIMMONS, Auteur ; J. P. GARNER, Auteur ; John P. CAPITANIO, Auteur ; Karen J. PARKER, Auteur . - p.1332-1346.
Langues : Anglais (eng)
in Autism Research > 14-7 (July 2021) . - p.1332-1346
Mots-clés : Animals Autism Spectrum Disorder/epidemiology Autistic Disorder Humans Macaca mulatta Morbidity Social Behavior Social Responsiveness Scale animal model autism spectrum disorder medical morbidities rhesus macaque social behavior Index. décimale : PER Périodiques Résumé : People with autism spectrum disorder (ASD) exhibit a variety of medical morbidities at significantly higher rates than the general population. Using an established monkey model of naturally occurring low sociality, we investigated whether low-social monkeys show an increased burden of medical morbidities compared to their high-social counterparts. We systematically reviewed the medical records of N = 152 (n = 73 low-social; n = 79 high-social) rhesus macaques (Macaca mulatta) to assess the number of traumatic injury, gastrointestinal, and inflammatory events, as well as the presence of rare medical conditions. Subjects' nonsocial scores, determined by the frequency they were observed in a nonsocial state (i.e., alone), and macaque Social Responsiveness Scale-Revised (mSRS-R) scores were also used to test whether individual differences in social functioning were related to medical morbidity burden. Medical morbidity type significantly differed by group, such that low-social monkeys incurred higher rates of traumatic injury compared to high-social monkeys. Nonsocial scores and mSRS-R scores also significantly and positively predicted traumatic injury rates, indicating that monkeys with the greatest social impairment were most impacted on this health measure. These findings from low-social monkeys are consistent with well-documented evidence that people with ASD incur a greater number of traumatic injuries and receive more peer bullying than their neurotypical peers, and add to growing evidence for the face validity of this primate model. LAY SUMMARY: People with autism exhibit multiple medical problems at higher rates than the general population. We conducted a comprehensive medical record review of monkeys that naturally exhibit differences in sociality and found that low-social monkeys are more susceptible to traumatic injuries than high-social monkeys. These results are consistent with reports that people with autism also incur greater traumatic injury and peer bullying and add to growing evidence for the validity of this monkey model. En ligne : http://dx.doi.org/10.1002/aur.2512 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 A Scoping Review of Health Disparities in Autism Spectrum Disorder / Lauren BISHOP-FITZPATRICK in Journal of Autism and Developmental Disorders, 47-11 (November 2017)
[article]
Titre : A Scoping Review of Health Disparities in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lauren BISHOP-FITZPATRICK, Auteur ; A. J. H. KIND, Auteur Article en page(s) : p.3380-3391 Langues : Anglais (eng) Mots-clés : Costs Disparities Ethnicity Health Morbidity Race Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) experience increased morbidity and decreased life expectancy compared to the general population, and these disparities are likely exacerbated for those individuals who are otherwise disadvantaged. We conducted a review to ascertain what is known about health and health system quality (e.g., high quality care delivery, adequate care access) disparities in ASD. Nine studies met final inclusion criteria. Seven studies identified racial disparities in access to general medical services for children with ASD. No studies examined disparities in health outcomes or included older adults. We present a model of health disparities (Fundamental Causes Model) that guides future research. Additional work should examine health disparities, and their causal pathways, in ASD, particularly for older adults. En ligne : http://dx.doi.org/10.1007/s10803-017-3251-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324
in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3380-3391[article] A Scoping Review of Health Disparities in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lauren BISHOP-FITZPATRICK, Auteur ; A. J. H. KIND, Auteur . - p.3380-3391.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3380-3391
Mots-clés : Costs Disparities Ethnicity Health Morbidity Race Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) experience increased morbidity and decreased life expectancy compared to the general population, and these disparities are likely exacerbated for those individuals who are otherwise disadvantaged. We conducted a review to ascertain what is known about health and health system quality (e.g., high quality care delivery, adequate care access) disparities in ASD. Nine studies met final inclusion criteria. Seven studies identified racial disparities in access to general medical services for children with ASD. No studies examined disparities in health outcomes or included older adults. We present a model of health disparities (Fundamental Causes Model) that guides future research. Additional work should examine health disparities, and their causal pathways, in ASD, particularly for older adults. En ligne : http://dx.doi.org/10.1007/s10803-017-3251-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324