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A Novel Approach to Dysmorphology to Enhance the Phenotypic Classification of Autism Spectrum Disorder in the Study to Explore Early Development / S. K. SHAPIRA in Journal of Autism and Developmental Disorders, 49-5 (May 2019)
[article]
Titre : A Novel Approach to Dysmorphology to Enhance the Phenotypic Classification of Autism Spectrum Disorder in the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : S. K. SHAPIRA, Auteur ; L. H. TIAN, Auteur ; Arthur S. AYLSWORTH, Auteur ; E. R. ELIAS, Auteur ; J. E. HOOVER-FONG, Auteur ; N. J. L. MEEKS, Auteur ; M. C. SOUDERS, Auteur ; A. C. TSAI, Auteur ; E. H. ZACKAI, Auteur ; A. A. ALEXANDER, Auteur ; M. YEARGIN-ALLSOPP, Auteur ; Laura A. SCHIEVE, Auteur Article en page(s) : p.2184-2202 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Birth defects Dysmorphic features Dysmorphology Genetic disorders Morphologic anomalies Phenotypic classification Race/ethnicity Index. décimale : PER Périodiques Résumé : The presence of multiple dysmorphic features in some children with autism spectrum disorder (ASD) might identify distinct ASD phenotypes and serve as potential markers for understanding causes and prognoses. To evaluate dysmorphology in ASD, children aged 3-6 years with ASD and non-ASD population controls (POP) from the Study to Explore Early Development were evaluated using a novel, systematic dysmorphology review approach. Separate analyses were conducted for non-Hispanic White, non-Hispanic Black, and Hispanic children. In each racial/ethnic group, ~ 17% of ASD cases were Dysmorphic compared with ~ 5% of POP controls. The ASD-POP differential was not explained by known genetic disorders or birth defects. In future epidemiologic studies, subgrouping ASD cases as Dysmorphic vs. Non-dysmorphic might help delineate risk factors for ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-03899-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393
in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.2184-2202[article] A Novel Approach to Dysmorphology to Enhance the Phenotypic Classification of Autism Spectrum Disorder in the Study to Explore Early Development [Texte imprimé et/ou numérique] / S. K. SHAPIRA, Auteur ; L. H. TIAN, Auteur ; Arthur S. AYLSWORTH, Auteur ; E. R. ELIAS, Auteur ; J. E. HOOVER-FONG, Auteur ; N. J. L. MEEKS, Auteur ; M. C. SOUDERS, Auteur ; A. C. TSAI, Auteur ; E. H. ZACKAI, Auteur ; A. A. ALEXANDER, Auteur ; M. YEARGIN-ALLSOPP, Auteur ; Laura A. SCHIEVE, Auteur . - p.2184-2202.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.2184-2202
Mots-clés : Autism spectrum disorder Birth defects Dysmorphic features Dysmorphology Genetic disorders Morphologic anomalies Phenotypic classification Race/ethnicity Index. décimale : PER Périodiques Résumé : The presence of multiple dysmorphic features in some children with autism spectrum disorder (ASD) might identify distinct ASD phenotypes and serve as potential markers for understanding causes and prognoses. To evaluate dysmorphology in ASD, children aged 3-6 years with ASD and non-ASD population controls (POP) from the Study to Explore Early Development were evaluated using a novel, systematic dysmorphology review approach. Separate analyses were conducted for non-Hispanic White, non-Hispanic Black, and Hispanic children. In each racial/ethnic group, ~ 17% of ASD cases were Dysmorphic compared with ~ 5% of POP controls. The ASD-POP differential was not explained by known genetic disorders or birth defects. In future epidemiologic studies, subgrouping ASD cases as Dysmorphic vs. Non-dysmorphic might help delineate risk factors for ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-03899-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393