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A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder / Stephen BENT in Journal of Autism and Developmental Disorders, 41-5 (May 2011)
[article]
Titre : A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Stephen BENT, Auteur ; Kiah BERTOGLIO, Auteur ; Paul ASHWOOD, Auteur ; Alan BOSTROM, Auteur ; Robert L. HENDREN, Auteur Année de publication : 2011 Article en page(s) : p.545-554 Langues : Anglais (eng) Mots-clés : Autism Omega-3 fatty acids Complementary and alternative medicine Clinical trial Index. décimale : PER Périodiques Résumé : We conducted a pilot randomized controlled trial to determine the feasibility and initial safety and efficacy of omega-3 fatty acids (1.3 g/day) for the treatment of hyperactivity in 27 children ages 3–8 with autism spectrum disorder (ASD). After 12 weeks, hyperactivity, as measured by the Aberrant Behavior Checklist, improved 2.7 (±4.8) points in the omega-3 group compared to 0.3 (±7.2) points in the placebo group (p = 0.40; effect size = 0.38). Correlations were found between decreases in five fatty acid levels and decreases in hyperactivity, and the treatment was well tolerated. Although this pilot study did not find a statistically significant benefit from omega-3 fatty acids, the small sample size does not rule out small to moderate beneficial effects. En ligne : http://dx.doi.org/10.1007/s10803-010-1078-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Journal of Autism and Developmental Disorders > 41-5 (May 2011) . - p.545-554[article] A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Stephen BENT, Auteur ; Kiah BERTOGLIO, Auteur ; Paul ASHWOOD, Auteur ; Alan BOSTROM, Auteur ; Robert L. HENDREN, Auteur . - 2011 . - p.545-554.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 41-5 (May 2011) . - p.545-554
Mots-clés : Autism Omega-3 fatty acids Complementary and alternative medicine Clinical trial Index. décimale : PER Périodiques Résumé : We conducted a pilot randomized controlled trial to determine the feasibility and initial safety and efficacy of omega-3 fatty acids (1.3 g/day) for the treatment of hyperactivity in 27 children ages 3–8 with autism spectrum disorder (ASD). After 12 weeks, hyperactivity, as measured by the Aberrant Behavior Checklist, improved 2.7 (±4.8) points in the omega-3 group compared to 0.3 (±7.2) points in the placebo group (p = 0.40; effect size = 0.38). Correlations were found between decreases in five fatty acid levels and decreases in hyperactivity, and the treatment was well tolerated. Although this pilot study did not find a statistically significant benefit from omega-3 fatty acids, the small sample size does not rule out small to moderate beneficial effects. En ligne : http://dx.doi.org/10.1007/s10803-010-1078-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder / Sarah A. KEIM in Journal of Autism and Developmental Disorders, 52-12 (December 2022)
[article]
Titre : Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sarah A. KEIM, Auteur ; Abigail JUDE, Auteur ; Katie SMITH, Auteur ; Aiman Q. KHAN, Auteur ; Daniel L. COURY, Auteur ; Joseph RAUSCH, Auteur ; Shivika UDAIPURIA, Auteur ; Megan NORRIS, Auteur ; Lindsay R. BARTRAM, Auteur ; Anita R. NARAYANAN, Auteur ; Lynette K. ROGERS, Auteur Année de publication : 2022 Article en page(s) : p.5342-5355 Langues : Anglais (eng) Mots-clés : Child Child, Preschool Humans Autism Spectrum Disorder/drug therapy Biomarkers Dietary Supplements Double-Blind Method Fatty Acids, Omega-3/therapeutic use Fatty Acids, Omega-6/therapeutic use Interleukin-2/metabolism Autism spectrum disorder Il-2 Inflammation Omega-3 fatty acids Omega-6 fatty acids Young child the content of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Nordic Naturals provided the investigational product at no cost and Welsh, Holme, & Clark Co., Inc. provided canola oil at no cost. Neither the study sponsors nor product providers had a role in the study design the collection, analysis, and interpretation of data writing of this report or the decision to submit the manuscript for publication. Index. décimale : PER Périodiques Résumé : This double-blind, randomized controlled trial, tested fatty acid (FA) supplementation in children (ages 2- < 6Â years) recently diagnosed with Autism Spectrum Disorder (ASD). Participants received daily oral FA supplement containing omega-3 and omega-6 FA, or a placebo for 90Â days based on participant weight. Erythrocyte FAs and the cytokines, IL-1Î2, IL-2, IFNÎ3, were measured in plasma obtained from serial blood collections. Treatment increased omega-3 and omega-6 FA levels (1.40Â mol% for EPA and 1.62Â mol% for DHA) and reduced IL-2 levels compared to placebo (-Â 0.17Â pg/mL, 95% CI -Â 0.31, -Â 0.02, d=-Â 0.62). Omega 3-6 treatment was tolerable and adherence was greater than 70%. Future research will assess the effects of Omega 3-6 treatment on ASD symptoms. Registered on 06/08/2018 with ClinicalTrials.gov: NCT03550209. En ligne : http://dx.doi.org/10.1007/s10803-021-05396-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Journal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5342-5355[article] Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Sarah A. KEIM, Auteur ; Abigail JUDE, Auteur ; Katie SMITH, Auteur ; Aiman Q. KHAN, Auteur ; Daniel L. COURY, Auteur ; Joseph RAUSCH, Auteur ; Shivika UDAIPURIA, Auteur ; Megan NORRIS, Auteur ; Lindsay R. BARTRAM, Auteur ; Anita R. NARAYANAN, Auteur ; Lynette K. ROGERS, Auteur . - 2022 . - p.5342-5355.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5342-5355
Mots-clés : Child Child, Preschool Humans Autism Spectrum Disorder/drug therapy Biomarkers Dietary Supplements Double-Blind Method Fatty Acids, Omega-3/therapeutic use Fatty Acids, Omega-6/therapeutic use Interleukin-2/metabolism Autism spectrum disorder Il-2 Inflammation Omega-3 fatty acids Omega-6 fatty acids Young child the content of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Nordic Naturals provided the investigational product at no cost and Welsh, Holme, & Clark Co., Inc. provided canola oil at no cost. Neither the study sponsors nor product providers had a role in the study design the collection, analysis, and interpretation of data writing of this report or the decision to submit the manuscript for publication. Index. décimale : PER Périodiques Résumé : This double-blind, randomized controlled trial, tested fatty acid (FA) supplementation in children (ages 2- < 6Â years) recently diagnosed with Autism Spectrum Disorder (ASD). Participants received daily oral FA supplement containing omega-3 and omega-6 FA, or a placebo for 90Â days based on participant weight. Erythrocyte FAs and the cytokines, IL-1Î2, IL-2, IFNÎ3, were measured in plasma obtained from serial blood collections. Treatment increased omega-3 and omega-6 FA levels (1.40Â mol% for EPA and 1.62Â mol% for DHA) and reduced IL-2 levels compared to placebo (-Â 0.17Â pg/mL, 95% CI -Â 0.31, -Â 0.02, d=-Â 0.62). Omega 3-6 treatment was tolerable and adherence was greater than 70%. Future research will assess the effects of Omega 3-6 treatment on ASD symptoms. Registered on 06/08/2018 with ClinicalTrials.gov: NCT03550209. En ligne : http://dx.doi.org/10.1007/s10803-021-05396-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 Effect of Omega-3 and -6 Supplementation on Language in Preterm Toddlers Exhibiting Autism Spectrum Disorder Symptoms / K. W. SHEPPARD in Journal of Autism and Developmental Disorders, 47-11 (November 2017)
[article]
Titre : Effect of Omega-3 and -6 Supplementation on Language in Preterm Toddlers Exhibiting Autism Spectrum Disorder Symptoms Type de document : Texte imprimé et/ou numérique Auteurs : K. W. SHEPPARD, Auteur ; K. M. BOONE, Auteur ; B. GRACIOUS, Auteur ; M. A. KLEBANOFF, Auteur ; L. K. ROGERS, Auteur ; J. RAUSCH, Auteur ; C. BARTLETT, Auteur ; D. L. COURY, Auteur ; S. A. KEIM, Auteur Article en page(s) : p.3358-3369 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Children born preterm Language development MacArthur Bates communicative development inventory Omega-3 fatty acids Omega-6 fatty acids Index. décimale : PER Périodiques Résumé : Delayed language development may be an early indicator of autism spectrum disorder (ASD). Early intervention is critical for children with ASD, and the present study presents pilot data on a clinical trial of omega-3 and -6 fatty acid supplementation and language development, a secondary trial outcome, in children at risk for ASD. We randomized 31 children to receive an omega-3 and -6 supplement or a placebo for 3 months, and measured their language abilities at baseline and after supplementation. Gesture use, but not word production, increased for children in the treatment group more than children in the placebo group. These results suggest possible effectiveness of omega-3 and -6 supplementation for language development in children at risk for ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3249-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324
in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3358-3369[article] Effect of Omega-3 and -6 Supplementation on Language in Preterm Toddlers Exhibiting Autism Spectrum Disorder Symptoms [Texte imprimé et/ou numérique] / K. W. SHEPPARD, Auteur ; K. M. BOONE, Auteur ; B. GRACIOUS, Auteur ; M. A. KLEBANOFF, Auteur ; L. K. ROGERS, Auteur ; J. RAUSCH, Auteur ; C. BARTLETT, Auteur ; D. L. COURY, Auteur ; S. A. KEIM, Auteur . - p.3358-3369.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3358-3369
Mots-clés : Autism spectrum disorder Children born preterm Language development MacArthur Bates communicative development inventory Omega-3 fatty acids Omega-6 fatty acids Index. décimale : PER Périodiques Résumé : Delayed language development may be an early indicator of autism spectrum disorder (ASD). Early intervention is critical for children with ASD, and the present study presents pilot data on a clinical trial of omega-3 and -6 fatty acid supplementation and language development, a secondary trial outcome, in children at risk for ASD. We randomized 31 children to receive an omega-3 and -6 supplement or a placebo for 3 months, and measured their language abilities at baseline and after supplementation. Gesture use, but not word production, increased for children in the treatment group more than children in the placebo group. These results suggest possible effectiveness of omega-3 and -6 supplementation for language development in children at risk for ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3249-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 Therapeutic diets and supplementation: exploring their impact on autism spectrum disorders in childhood - A narrative review of recent clinical trials / Ruzha PANCHEVA in Research in Autism Spectrum Disorders, 112 (April 2024)
[article]
Titre : Therapeutic diets and supplementation: exploring their impact on autism spectrum disorders in childhood - A narrative review of recent clinical trials Type de document : Texte imprimé et/ou numérique Auteurs : Ruzha PANCHEVA, Auteur ; Rositsa CHAMOVA, Auteur ; Dimitar MARINOV, Auteur ; Albena TONEVA, Auteur ; Mariya DZHOGOVA, Auteur ; Sevdzhihan EYUBOVA, Auteur ; Natalya USHEVA, Auteur Article en page(s) : p.102352 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Nutritional interventions Clinical trials Gluten-free diet Omega-3 fatty acids Vitamins Probiotics Developmental disabilities Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits, restricted interests, and repetitive behaviors. Nutritional interventions have gained attention as potential therapeutic strategies for individuals with ASD. This review aims to provide a comprehensive summary of recent clinical trials investigating the effects of various nutritional interventions on ASD symptoms. Methods A systematic search was conducted in multiple databases to identify clinical trials published between 2018 and 2023. Studies focusing on children with ASD and evaluating the impact of nutritional interventions were included. The selected articles were analyzed for study design, intervention type, outcome measures, and results. Results A total of 26 studies were included in the review, covering a range of nutritional interventions including gluten-free and casein-free diets, omega-3 fatty acid supplementation, vitamin and mineral supplementation, probiotics, prebiotics, and others. The studies varied in design, sample size, and outcome measures. Overall, the findings revealed some positive effects of specific nutritional interventions on ASD symptoms, such as improvements in social responsiveness, communication, hyperactivity, and stereotypical behaviors. However, discrepancies and limitations were noted across the studies, highlighting the need for further research. Conclusion This comprehensive review provides insights into the potential therapeutic effects of nutritional interventions for individuals with ASD. While some interventions showed promising results, further research with larger sample sizes, standardized methodologies, and longer-term follow-ups is needed to establish their efficacy. Personalized approaches, considering the heterogeneity of ASD, and strategies to enhance adherence to dietary interventions are also crucial in developing effective treatment plans. Overall, nutritional interventions hold promise as adjunctive therapies for individuals with ASD, warranting continued investigation in this field of research. En ligne : https://doi.org/10.1016/j.rasd.2024.102352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524
in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102352[article] Therapeutic diets and supplementation: exploring their impact on autism spectrum disorders in childhood - A narrative review of recent clinical trials [Texte imprimé et/ou numérique] / Ruzha PANCHEVA, Auteur ; Rositsa CHAMOVA, Auteur ; Dimitar MARINOV, Auteur ; Albena TONEVA, Auteur ; Mariya DZHOGOVA, Auteur ; Sevdzhihan EYUBOVA, Auteur ; Natalya USHEVA, Auteur . - p.102352.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102352
Mots-clés : Autism Spectrum Disorder Nutritional interventions Clinical trials Gluten-free diet Omega-3 fatty acids Vitamins Probiotics Developmental disabilities Index. décimale : PER Périodiques Résumé : Background Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits, restricted interests, and repetitive behaviors. Nutritional interventions have gained attention as potential therapeutic strategies for individuals with ASD. This review aims to provide a comprehensive summary of recent clinical trials investigating the effects of various nutritional interventions on ASD symptoms. Methods A systematic search was conducted in multiple databases to identify clinical trials published between 2018 and 2023. Studies focusing on children with ASD and evaluating the impact of nutritional interventions were included. The selected articles were analyzed for study design, intervention type, outcome measures, and results. Results A total of 26 studies were included in the review, covering a range of nutritional interventions including gluten-free and casein-free diets, omega-3 fatty acid supplementation, vitamin and mineral supplementation, probiotics, prebiotics, and others. The studies varied in design, sample size, and outcome measures. Overall, the findings revealed some positive effects of specific nutritional interventions on ASD symptoms, such as improvements in social responsiveness, communication, hyperactivity, and stereotypical behaviors. However, discrepancies and limitations were noted across the studies, highlighting the need for further research. Conclusion This comprehensive review provides insights into the potential therapeutic effects of nutritional interventions for individuals with ASD. While some interventions showed promising results, further research with larger sample sizes, standardized methodologies, and longer-term follow-ups is needed to establish their efficacy. Personalized approaches, considering the heterogeneity of ASD, and strategies to enhance adherence to dietary interventions are also crucial in developing effective treatment plans. Overall, nutritional interventions hold promise as adjunctive therapies for individuals with ASD, warranting continued investigation in this field of research. En ligne : https://doi.org/10.1016/j.rasd.2024.102352 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524