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Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety / J. KLUSEK in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)
[article]
Titre : Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety Type de document : Texte imprimé et/ou numérique Auteurs : J. KLUSEK, Auteur ; G. LAFAUCI, Auteur ; T. ADAYEV, Auteur ; W. Ted BROWN, Auteur ; F. TASSONE, Auteur ; J. E. ROBERTS, Auteur Article en page(s) : p.16 Langues : Anglais (eng) Mots-clés : FMR1 mRNA Fmrp Fragile X carriers Heart rate Physiological arousal Vagal tone Index. décimale : PER Périodiques Résumé : BACKGROUND: Autonomic dysfunction is implicated in a range of psychological conditions, including depression and anxiety. The fragile X mental retardation-1 (FMR1) premutation is a common genetic mutation that affects ~1:150 women and is associated with psychological vulnerability. This study examined cardiac indicators of autonomic function among women with the FMR1 premutation and control women as potential biomarkers for psychological risk that may be linked to FMR1. METHODS: Baseline inter-beat interval and respiratory sinus arrhythmia (a measure of parasympathetic vagal tone) were measured in 35 women with the FMR1 premutation and 28 controls. The women completed anxiety and depression questionnaires. FMR1 genetic indices (i.e., CGG repeat, quantitative FMRP, FMR1 mRNA, activation ratio) were obtained for the premutation group. RESULTS: Respiratory sinus arrhythmia was reduced in the FMR1 premutation group relative to controls. While depression symptoms were associated with reduced respiratory sinus arrhythmia among control women, these variables were unrelated in the FMR1 premutation. Elevated FMR1 mRNA was associated with higher respiratory sinus arrhythmia. CONCLUSIONS: Women with the FMR1 premutation demonstrated autonomic dysregulation characterized by reduced vagal tone. Unlike patterns observed in the general population and in study controls, vagal activity and depression symptoms were decoupled in women with the FMR1 premutation, suggesting independence between autonomic regulation and psychopathological symptoms that is atypical and potentially specific to the FMR1 premutation. The association between vagal tone and mRNA suggests that molecular variation associated with FMR1 plays a role in autonomic regulation. En ligne : http://dx.doi.org/10.1186/s11689-017-9197-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350
in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.16[article] Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety [Texte imprimé et/ou numérique] / J. KLUSEK, Auteur ; G. LAFAUCI, Auteur ; T. ADAYEV, Auteur ; W. Ted BROWN, Auteur ; F. TASSONE, Auteur ; J. E. ROBERTS, Auteur . - p.16.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.16
Mots-clés : FMR1 mRNA Fmrp Fragile X carriers Heart rate Physiological arousal Vagal tone Index. décimale : PER Périodiques Résumé : BACKGROUND: Autonomic dysfunction is implicated in a range of psychological conditions, including depression and anxiety. The fragile X mental retardation-1 (FMR1) premutation is a common genetic mutation that affects ~1:150 women and is associated with psychological vulnerability. This study examined cardiac indicators of autonomic function among women with the FMR1 premutation and control women as potential biomarkers for psychological risk that may be linked to FMR1. METHODS: Baseline inter-beat interval and respiratory sinus arrhythmia (a measure of parasympathetic vagal tone) were measured in 35 women with the FMR1 premutation and 28 controls. The women completed anxiety and depression questionnaires. FMR1 genetic indices (i.e., CGG repeat, quantitative FMRP, FMR1 mRNA, activation ratio) were obtained for the premutation group. RESULTS: Respiratory sinus arrhythmia was reduced in the FMR1 premutation group relative to controls. While depression symptoms were associated with reduced respiratory sinus arrhythmia among control women, these variables were unrelated in the FMR1 premutation. Elevated FMR1 mRNA was associated with higher respiratory sinus arrhythmia. CONCLUSIONS: Women with the FMR1 premutation demonstrated autonomic dysregulation characterized by reduced vagal tone. Unlike patterns observed in the general population and in study controls, vagal activity and depression symptoms were decoupled in women with the FMR1 premutation, suggesting independence between autonomic regulation and psychopathological symptoms that is atypical and potentially specific to the FMR1 premutation. The association between vagal tone and mRNA suggests that molecular variation associated with FMR1 plays a role in autonomic regulation. En ligne : http://dx.doi.org/10.1186/s11689-017-9197-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 Preterm infants who are prone to distress: differential effects of parenting on 36-month behavioral and cognitive outcomes / Julie POEHLMANN in Journal of Child Psychology and Psychiatry, 53-10 (October 2012)
[article]
Titre : Preterm infants who are prone to distress: differential effects of parenting on 36-month behavioral and cognitive outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Julie POEHLMANN, Auteur ; Amanda HANE, Auteur ; Cynthia BURNSON, Auteur ; Sarah MALECK, Auteur ; Elizabeth HAMBURGER, Auteur ; Prachi E. SHAH, Auteur Année de publication : 2012 Article en page(s) : p.1018-25 Langues : Anglais (eng) Mots-clés : Behavior IQ vagal tone parenting preterm temperament Index. décimale : PER Périodiques Résumé : Background: The differential susceptibility (DS) model suggests that temperamentally prone-to-distress infants may exhibit adverse outcomes in negative environments but optimal outcomes in positive environments. This study explored temperament, parenting, and 36-month cognition and behavior in preterm infants using the DS model. We hypothesized that temperamentally prone to distress preterm infants would exhibit more optimal cognition and fewer behavior problems when early parenting was positive; and less optimal cognition and more behavior problems when early parenting was less positive. Methods: Participants included 109 preterm infants (gestation <37 weeks) and their mothers. We assessed neonatal risk and basal vagal tone in the neonatal intensive care unit; infant temperament and parenting interactions at 9 months post-term; and child behavior and cognitive skills at 36 months post-term. Hierarchical regression analyses tested study hypotheses. Results: Temperamentally prone-to-distress infants exhibited more externalizing problems if they experienced more critical parenting at 9 months (β = −.20, p < 0.05) but fewer externalizing problems with more positive parenting. Similarly, variations in maternal positive affect (β = .25, p < .01) and intrusive behaviors (β = .23, p < .05) at 9 months predicted 36-month cognition at high but not at low levels of infant temperamental distress. Higher basal vagal tone predicted fewer externalizing problems (β = −.19, p < .05). Conclusions: Early parenting behaviors relate to later behavior and development in preterm infants who are temperamentally prone to distress, and neonatal basal vagal tone predicts subsequent externalizing behaviors. These findings suggest that both biological reactivity and quality of caregiving are important predictors for later outcomes in preterm infants and may be considered as foci for developmental surveillance and interventions. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02564.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181
in Journal of Child Psychology and Psychiatry > 53-10 (October 2012) . - p.1018-25[article] Preterm infants who are prone to distress: differential effects of parenting on 36-month behavioral and cognitive outcomes [Texte imprimé et/ou numérique] / Julie POEHLMANN, Auteur ; Amanda HANE, Auteur ; Cynthia BURNSON, Auteur ; Sarah MALECK, Auteur ; Elizabeth HAMBURGER, Auteur ; Prachi E. SHAH, Auteur . - 2012 . - p.1018-25.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-10 (October 2012) . - p.1018-25
Mots-clés : Behavior IQ vagal tone parenting preterm temperament Index. décimale : PER Périodiques Résumé : Background: The differential susceptibility (DS) model suggests that temperamentally prone-to-distress infants may exhibit adverse outcomes in negative environments but optimal outcomes in positive environments. This study explored temperament, parenting, and 36-month cognition and behavior in preterm infants using the DS model. We hypothesized that temperamentally prone to distress preterm infants would exhibit more optimal cognition and fewer behavior problems when early parenting was positive; and less optimal cognition and more behavior problems when early parenting was less positive. Methods: Participants included 109 preterm infants (gestation <37 weeks) and their mothers. We assessed neonatal risk and basal vagal tone in the neonatal intensive care unit; infant temperament and parenting interactions at 9 months post-term; and child behavior and cognitive skills at 36 months post-term. Hierarchical regression analyses tested study hypotheses. Results: Temperamentally prone-to-distress infants exhibited more externalizing problems if they experienced more critical parenting at 9 months (β = −.20, p < 0.05) but fewer externalizing problems with more positive parenting. Similarly, variations in maternal positive affect (β = .25, p < .01) and intrusive behaviors (β = .23, p < .05) at 9 months predicted 36-month cognition at high but not at low levels of infant temperamental distress. Higher basal vagal tone predicted fewer externalizing problems (β = −.19, p < .05). Conclusions: Early parenting behaviors relate to later behavior and development in preterm infants who are temperamentally prone to distress, and neonatal basal vagal tone predicts subsequent externalizing behaviors. These findings suggest that both biological reactivity and quality of caregiving are important predictors for later outcomes in preterm infants and may be considered as foci for developmental surveillance and interventions. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02564.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=181 Sociodemographic risk, parenting, and inhibitory control in early childhood: the role of respiratory sinus arrhythmia / Steven J. HOLOCHWOST in Journal of Child Psychology and Psychiatry, 59-9 (September 2018)
[article]
Titre : Sociodemographic risk, parenting, and inhibitory control in early childhood: the role of respiratory sinus arrhythmia Type de document : Texte imprimé et/ou numérique Auteurs : Steven J. HOLOCHWOST, Auteur ; Vanessa V. VOLPE, Auteur ; Noa GUERON-SELA, Auteur ; Cathi B. PROPPER, Auteur ; W. Roger MILLS-KOONCE, Auteur Article en page(s) : p.973-981 Langues : Anglais (eng) Mots-clés : Risk factors parenting inhbitory control respiratory sinus arrhythmia vagal tone Index. décimale : PER Périodiques Résumé : Background Deficits of inhibitory control in early childhood are linked to externalizing behaviors and attention problems. While environmental factors and physiological processes are associated with its etiology, few studies have examined how these factors jointly predict inhibitory control. This study examined whether respiratory sinus arrhythmia (RSA) functioned as a mediator or moderator of both cumulative sociodemographic risk and parenting behaviors on inhibitory control during early childhood. Methods The sample included 206 children and their biological mothers. At 24, 30, and 36 months of child age dyads participated in a series of laboratory visits in which sociodemographic, parenting, and baseline RSA (RSAB) data were collected. Inhibitory control was assessed at 36 months using a gift-wrap delay task. Results A series of structural equation models yielded no evidence that RSAB mediated the relations of risk or parenting and inhibitory control. RSAB moderated the effects of risk, such that high-risk children with low RSAB performed more poorly on tasks of inhibitory control, while high-risk children with high RSAB did not. Conclusions These results suggest that higher levels of RSAB may mitigate the influence of environmental risk on the development of inhibitory control early childhood. En ligne : https://doi.org/10.1111/jcpp.12889 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.973-981[article] Sociodemographic risk, parenting, and inhibitory control in early childhood: the role of respiratory sinus arrhythmia [Texte imprimé et/ou numérique] / Steven J. HOLOCHWOST, Auteur ; Vanessa V. VOLPE, Auteur ; Noa GUERON-SELA, Auteur ; Cathi B. PROPPER, Auteur ; W. Roger MILLS-KOONCE, Auteur . - p.973-981.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.973-981
Mots-clés : Risk factors parenting inhbitory control respiratory sinus arrhythmia vagal tone Index. décimale : PER Périodiques Résumé : Background Deficits of inhibitory control in early childhood are linked to externalizing behaviors and attention problems. While environmental factors and physiological processes are associated with its etiology, few studies have examined how these factors jointly predict inhibitory control. This study examined whether respiratory sinus arrhythmia (RSA) functioned as a mediator or moderator of both cumulative sociodemographic risk and parenting behaviors on inhibitory control during early childhood. Methods The sample included 206 children and their biological mothers. At 24, 30, and 36 months of child age dyads participated in a series of laboratory visits in which sociodemographic, parenting, and baseline RSA (RSAB) data were collected. Inhibitory control was assessed at 36 months using a gift-wrap delay task. Results A series of structural equation models yielded no evidence that RSAB mediated the relations of risk or parenting and inhibitory control. RSAB moderated the effects of risk, such that high-risk children with low RSAB performed more poorly on tasks of inhibitory control, while high-risk children with high RSAB did not. Conclusions These results suggest that higher levels of RSAB may mitigate the influence of environmental risk on the development of inhibitory control early childhood. En ligne : https://doi.org/10.1111/jcpp.12889 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368