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Treatment of Adults with Autism and Major Depressive Disorder Using Transcranial Magnetic Stimulation: An Open Label Pilot Study / McLeod Frampton GWYNETTE in Autism Research, 13-3 (March 2020)
[article]
Titre : Treatment of Adults with Autism and Major Depressive Disorder Using Transcranial Magnetic Stimulation: An Open Label Pilot Study Type de document : Texte imprimé et/ou numérique Auteurs : McLeod Frampton GWYNETTE, Auteur ; Danielle W. LOWE, Auteur ; Erin A. HENNEBERRY, Auteur ; Gregory L. SAHLEM, Auteur ; Melanie Gail WILEY, Auteur ; Hussam ALSARRAF, Auteur ; Sarah Brice RUSSO, Auteur ; Jane E. JOSEPH, Auteur ; Philipp M. SUMMERS, Auteur ; Laura LOHNES, Auteur ; Mark S. GEORGE, Auteur Article en page(s) : p.346-351 Langues : Anglais (eng) Mots-clés : adults with autism spectrum disorder autism spectrum disorder major depressive disorder mood psychiatric comorbidity transcranial stimulation treatment research Index. décimale : PER Périodiques Résumé : Patients with autism spectrum disorder (ASD) are at high risk for comorbid major depressive disorder (MDD), which can severely impair functioning and quality of life. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique, which is Food and Drug Administration (FDA) cleared for the treatment of MDD in adults. Despite demonstrated efficacy in the treatment of depression, there are limited data on the use of rTMS in patients with ASD and comorbid MDD. We hypothesized that a standard rTMS protocol for MDD would reduce depressive symptoms for adults with ASD and MDD. Secondarily, we investigated whether this treatment would also reduce core ASD symptoms. Participants of 18-65 years old with ASD and MDD without any medication changes in the last month were eligible for this open-label trial. Participants underwent 25 sessions of rTMS (figure-of-eight coil, 100-120% resting motor threshold, 10 Hz, 3,000 pulses per session) applied to the left dorsolateral prefrontal cortex. Thirteen participants enrolled in the study, with two withdrawing due to tolerability, and one excluded from analysis. Overall, side effects were mild and rTMS was well tolerated. The Hamilton rating scale for depression (HAM-D17 ) improved 13.5 points (IQR 5-15), and 40% of participants achieved remission (HAM-D17 = 7) after rTMS treatment. Informant clinical scales of core symptoms of autism also suggested improvement with rTMS, though no change was observed by the participants themselves. Thus, this open-label trial suggests that high-frequency rTMS is well tolerated by adults with autism and MDD, with improvement in depressive symptoms and possible effects on core autism symptoms. Autism Res 2020, 13: 346-351. (c) 2020 International Society for Autism Research,Wiley Periodicals, Inc. LAY SUMMARY: This study evaluated the safety and effects of repetitive transcranial magnetic stimulation (rTMS) on depression and autism symptoms in individuals with both major depressive disorder and autism spectrum disorder. rTMS was well tolerated by the participants, depression improved with treatment, and family members' assessment of autism symptoms improved as well. This study supports the need for further work to evaluate rTMS in individuals who have both autism and depression. En ligne : http://dx.doi.org/10.1002/aur.2266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421
in Autism Research > 13-3 (March 2020) . - p.346-351[article] Treatment of Adults with Autism and Major Depressive Disorder Using Transcranial Magnetic Stimulation: An Open Label Pilot Study [Texte imprimé et/ou numérique] / McLeod Frampton GWYNETTE, Auteur ; Danielle W. LOWE, Auteur ; Erin A. HENNEBERRY, Auteur ; Gregory L. SAHLEM, Auteur ; Melanie Gail WILEY, Auteur ; Hussam ALSARRAF, Auteur ; Sarah Brice RUSSO, Auteur ; Jane E. JOSEPH, Auteur ; Philipp M. SUMMERS, Auteur ; Laura LOHNES, Auteur ; Mark S. GEORGE, Auteur . - p.346-351.
Langues : Anglais (eng)
in Autism Research > 13-3 (March 2020) . - p.346-351
Mots-clés : adults with autism spectrum disorder autism spectrum disorder major depressive disorder mood psychiatric comorbidity transcranial stimulation treatment research Index. décimale : PER Périodiques Résumé : Patients with autism spectrum disorder (ASD) are at high risk for comorbid major depressive disorder (MDD), which can severely impair functioning and quality of life. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique, which is Food and Drug Administration (FDA) cleared for the treatment of MDD in adults. Despite demonstrated efficacy in the treatment of depression, there are limited data on the use of rTMS in patients with ASD and comorbid MDD. We hypothesized that a standard rTMS protocol for MDD would reduce depressive symptoms for adults with ASD and MDD. Secondarily, we investigated whether this treatment would also reduce core ASD symptoms. Participants of 18-65 years old with ASD and MDD without any medication changes in the last month were eligible for this open-label trial. Participants underwent 25 sessions of rTMS (figure-of-eight coil, 100-120% resting motor threshold, 10 Hz, 3,000 pulses per session) applied to the left dorsolateral prefrontal cortex. Thirteen participants enrolled in the study, with two withdrawing due to tolerability, and one excluded from analysis. Overall, side effects were mild and rTMS was well tolerated. The Hamilton rating scale for depression (HAM-D17 ) improved 13.5 points (IQR 5-15), and 40% of participants achieved remission (HAM-D17 = 7) after rTMS treatment. Informant clinical scales of core symptoms of autism also suggested improvement with rTMS, though no change was observed by the participants themselves. Thus, this open-label trial suggests that high-frequency rTMS is well tolerated by adults with autism and MDD, with improvement in depressive symptoms and possible effects on core autism symptoms. Autism Res 2020, 13: 346-351. (c) 2020 International Society for Autism Research,Wiley Periodicals, Inc. LAY SUMMARY: This study evaluated the safety and effects of repetitive transcranial magnetic stimulation (rTMS) on depression and autism symptoms in individuals with both major depressive disorder and autism spectrum disorder. rTMS was well tolerated by the participants, depression improved with treatment, and family members' assessment of autism symptoms improved as well. This study supports the need for further work to evaluate rTMS in individuals who have both autism and depression. En ligne : http://dx.doi.org/10.1002/aur.2266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 Relationship Between Symptom Severity and Caregiver Burden Experienced by Parents of Adults With Autism / Christina N. MARSACK-TOPOLEWSKI in Focus on Autism and Other Developmental Disabilities, 36-1 (March 2021)
[article]
Titre : Relationship Between Symptom Severity and Caregiver Burden Experienced by Parents of Adults With Autism Type de document : Texte imprimé et/ou numérique Auteurs : Christina N. MARSACK-TOPOLEWSKI, Auteur ; Alexandros MARAGAKIS, Auteur Article en page(s) : p.57-65 Langues : Anglais (eng) Mots-clés : caregiver burden severity aging caregivers adults with autism spectrum disorder activities of daily living Index. décimale : PER Périodiques Résumé : This study examined the relationship between the severity of autism spectrum disorder (ASD) and caregiver burden among parents of adult children with ASD. Using a mixed-methods study, 320 parents of adults with ASD participated in the web-based survey, with 51 parents participating in follow-up interviews. The quantitative analysis was used to determine whether caregiver burden could be predicted from the severity of ASD factors (communication, behavior, and socialization) and basic and instrumental activities of daily living (BADLs and IADLs). Results indicated that caregiver burden was predicted from BADLs, IADLs, and adult child behavior. Interview themes that emerged from qualitative analyses supported quantitative findings. Behavior was the strongest predictor of caregiver burden and discussed by parents during interviews. Professionals should develop behavioral support programs for adults with ASD to continue to reinforce positive behavior and support parents who are managing their adult child’s difficult behaviors. En ligne : http://dx.doi.org/10.1177/1088357620956927 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441
in Focus on Autism and Other Developmental Disabilities > 36-1 (March 2021) . - p.57-65[article] Relationship Between Symptom Severity and Caregiver Burden Experienced by Parents of Adults With Autism [Texte imprimé et/ou numérique] / Christina N. MARSACK-TOPOLEWSKI, Auteur ; Alexandros MARAGAKIS, Auteur . - p.57-65.
Langues : Anglais (eng)
in Focus on Autism and Other Developmental Disabilities > 36-1 (March 2021) . - p.57-65
Mots-clés : caregiver burden severity aging caregivers adults with autism spectrum disorder activities of daily living Index. décimale : PER Périodiques Résumé : This study examined the relationship between the severity of autism spectrum disorder (ASD) and caregiver burden among parents of adult children with ASD. Using a mixed-methods study, 320 parents of adults with ASD participated in the web-based survey, with 51 parents participating in follow-up interviews. The quantitative analysis was used to determine whether caregiver burden could be predicted from the severity of ASD factors (communication, behavior, and socialization) and basic and instrumental activities of daily living (BADLs and IADLs). Results indicated that caregiver burden was predicted from BADLs, IADLs, and adult child behavior. Interview themes that emerged from qualitative analyses supported quantitative findings. Behavior was the strongest predictor of caregiver burden and discussed by parents during interviews. Professionals should develop behavioral support programs for adults with ASD to continue to reinforce positive behavior and support parents who are managing their adult child’s difficult behaviors. En ligne : http://dx.doi.org/10.1177/1088357620956927 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 Targeting Question-Asking Initiations in College Students With ASD Using a Video-Feedback Intervention / Whitney J. DETAR in Focus on Autism and Other Developmental Disabilities, 35-4 (December 2020)
[article]
Titre : Targeting Question-Asking Initiations in College Students With ASD Using a Video-Feedback Intervention Type de document : Texte imprimé et/ou numérique Auteurs : Whitney J. DETAR, Auteur ; Ty W. VERNON, Auteur Article en page(s) : p.208-220 Langues : Anglais (eng) Mots-clés : Adults with autism spectrum disorder video modeling video feedback question-asking social initiations social skills Index. décimale : PER Périodiques Résumé : Social conversational vulnerabilities associated with autism spectrum disorders (ASDs) generally persist into young adulthood and have a detrimental impact on short- and long-term academic, vocational, and interpersonal success. In light of these challenges, there is a growing need for targeted interventions to improve the social competencies of this population. The current study examined the effects of a video-feedback intervention that targeted a key social conversational skill—making social initiations to one’s conversational partner. A multiple-baseline research design across three college students with ASD indicated that the use of video feedback to target question-asking initiations was associated with improvements in (a) total questions asked, (b) conversational pauses, (c) nonperseverative discussion, (d) conversational reciprocity, and (e) perceived confidence. These findings generalized across contexts and conversation partners, suggesting that this intervention strategy may hold promise for promoting key social competencies in young adults with ASD. En ligne : http://dx.doi.org/10.1177/1088357620943506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Focus on Autism and Other Developmental Disabilities > 35-4 (December 2020) . - p.208-220[article] Targeting Question-Asking Initiations in College Students With ASD Using a Video-Feedback Intervention [Texte imprimé et/ou numérique] / Whitney J. DETAR, Auteur ; Ty W. VERNON, Auteur . - p.208-220.
Langues : Anglais (eng)
in Focus on Autism and Other Developmental Disabilities > 35-4 (December 2020) . - p.208-220
Mots-clés : Adults with autism spectrum disorder video modeling video feedback question-asking social initiations social skills Index. décimale : PER Périodiques Résumé : Social conversational vulnerabilities associated with autism spectrum disorders (ASDs) generally persist into young adulthood and have a detrimental impact on short- and long-term academic, vocational, and interpersonal success. In light of these challenges, there is a growing need for targeted interventions to improve the social competencies of this population. The current study examined the effects of a video-feedback intervention that targeted a key social conversational skill—making social initiations to one’s conversational partner. A multiple-baseline research design across three college students with ASD indicated that the use of video feedback to target question-asking initiations was associated with improvements in (a) total questions asked, (b) conversational pauses, (c) nonperseverative discussion, (d) conversational reciprocity, and (e) perceived confidence. These findings generalized across contexts and conversation partners, suggesting that this intervention strategy may hold promise for promoting key social competencies in young adults with ASD. En ligne : http://dx.doi.org/10.1177/1088357620943506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434