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Genetic Causes of Intellectual Disability: The Genes Controlling Cortical Development / Yoann SAILLOUR
in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Titre : Genetic Causes of Intellectual Disability: The Genes Controlling Cortical Development Type de document : Texte imprimé et/ou numérique Auteurs : Yoann SAILLOUR, Auteur ; Jamel CHELLY, Auteur Année de publication : 2016 Importance : p.43-64 Langues : Anglais (eng) Mots-clés : Brain cortex Cortical development Epilepsy Intellectual disability Malformations of cortical development (MCD) Neuronal migration disorders Tubulinopathies Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The cerebral cortex has a key role in cognitive and intellectual processes. Its development results from careful orchestrated developmental interactions, most of which are unknown. In recent years, substantial insights have been gained through the rapid evolution of imaging techniques, large-scale genomic sequencing approaches, and the delineation of genes and mutations underlying neurodevelopmental disorders, including malformations of cortical development (MCDs), which are increasingly recognized as causes of intellectual disability conditions and epilepsy. Combined with investigation into cellular and animal models, genetic studies have identified genes, complexes, and pathways that might disrupt each of the main stages of cell proliferation, neuronal migration, and late cortical organization and lead to MCDs. This review summarizes most of the major MCDs from genetic and neurodevelopmental perspectives and highlights how understanding key molecular pathways can also lead to development of strategies aimed at reversing disrupted cellular and biological processes. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00004-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Genetic Causes of Intellectual Disability: The Genes Controlling Cortical Development [Texte imprimé et/ou numérique] / Yoann SAILLOUR, Auteur ; Jamel CHELLY, Auteur . - 2016 . - p.43-64.
in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Langues : Anglais (eng)
Mots-clés : Brain cortex Cortical development Epilepsy Intellectual disability Malformations of cortical development (MCD) Neuronal migration disorders Tubulinopathies Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The cerebral cortex has a key role in cognitive and intellectual processes. Its development results from careful orchestrated developmental interactions, most of which are unknown. In recent years, substantial insights have been gained through the rapid evolution of imaging techniques, large-scale genomic sequencing approaches, and the delineation of genes and mutations underlying neurodevelopmental disorders, including malformations of cortical development (MCDs), which are increasingly recognized as causes of intellectual disability conditions and epilepsy. Combined with investigation into cellular and animal models, genetic studies have identified genes, complexes, and pathways that might disrupt each of the main stages of cell proliferation, neuronal migration, and late cortical organization and lead to MCDs. This review summarizes most of the major MCDs from genetic and neurodevelopmental perspectives and highlights how understanding key molecular pathways can also lead to development of strategies aimed at reversing disrupted cellular and biological processes. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00004-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach / Tochukwu NWEZE in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)
[article]
Titre : Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach Type de document : Texte imprimé et/ou numérique Auteurs : Tochukwu NWEZE, Auteur ; Tobias BANASCHEWSKI, Auteur ; Cyracius AJAELU, Auteur ; Chukwuemeka OKOYE, Auteur ; Michael EZENWA, Auteur ; Robert WHELAN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Arun L. W. BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Antoine GRIGIS, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Rüdiger BRÜHL, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure Paillère MARTINOT, Auteur ; Éric ARTIGES, Auteur ; Frauke NEES, Auteur ; Tomá? PAUS, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Sabina MILLENET, Auteur ; Juliane H. FRÖHNER, Auteur ; Michael N. SMOLKA, Auteur ; Henrik WALTER, Auteur ; Gunter SCHUMANN, Auteur ; Jamie L. HANSON, Auteur ; Imagen CONSORTIUM, Auteur Article en page(s) : p.1159-1175 Langues : Anglais (eng) Mots-clés : Stress cortical development cognitive functioning longitudinal models bivariate latent change score model longitudinal mediation analysis Index. décimale : PER Périodiques Résumé : Background Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. Methods Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. Results Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. = .327, p = .042, 95% CI [ 0.643, 0.012]) and right anterior cingulate surface area (Std. = .274, p = .038, 95% CI [ 0.533, 0.015]) across ages 14 22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. Conclusion Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted. En ligne : https://doi.org/10.1111/jcpp.13793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508
in Journal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1159-1175[article] Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach [Texte imprimé et/ou numérique] / Tochukwu NWEZE, Auteur ; Tobias BANASCHEWSKI, Auteur ; Cyracius AJAELU, Auteur ; Chukwuemeka OKOYE, Auteur ; Michael EZENWA, Auteur ; Robert WHELAN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Arun L. W. BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Antoine GRIGIS, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Rüdiger BRÜHL, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure Paillère MARTINOT, Auteur ; Éric ARTIGES, Auteur ; Frauke NEES, Auteur ; Tomá? PAUS, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Sabina MILLENET, Auteur ; Juliane H. FRÖHNER, Auteur ; Michael N. SMOLKA, Auteur ; Henrik WALTER, Auteur ; Gunter SCHUMANN, Auteur ; Jamie L. HANSON, Auteur ; Imagen CONSORTIUM, Auteur . - p.1159-1175.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1159-1175
Mots-clés : Stress cortical development cognitive functioning longitudinal models bivariate latent change score model longitudinal mediation analysis Index. décimale : PER Périodiques Résumé : Background Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. Methods Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. Results Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. = .327, p = .042, 95% CI [ 0.643, 0.012]) and right anterior cingulate surface area (Std. = .274, p = .038, 95% CI [ 0.533, 0.015]) across ages 14 22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. Conclusion Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted. En ligne : https://doi.org/10.1111/jcpp.13793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508