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Auteur Arun L. W. BOKDE |
Documents disponibles écrits par cet auteur (5)
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Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample / Argyris STRINGARIS in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)
[article]
Titre : Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample Type de document : Texte imprimé et/ou numérique Auteurs : Argyris STRINGARIS, Auteur ; Natalie CASTELLANOS-RYAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÜCHEL, Auteur ; Mira FAUTH-BÜHLER, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMAN, Auteur ; Claire LAWRENCE, Auteur ; Frauke NEES, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Tomas PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Marcella RIETSCHEL, Auteur ; Michael N. SMOLKA, Auteur ; Gunter SCHUMANN, Auteur ; Robert GOODMAN, Auteur ; Patricia CONROD, Auteur ; THE IMAGEN CONSORTIUM,, Auteur Article en page(s) : p.1380-1389 Langues : Anglais (eng) Mots-clés : Mania bipolar intelligence adolescents creativity Index. décimale : PER Périodiques Résumé : Background It has been reported that mania may be associated with superior cognitive performance. In this study, we test the hypothesis that manic symptoms in youth separate along two correlated dimensions and that a symptom constellation of high energy and cheerfulness is associated with superior cognitive performance. Method We studied 1755 participants of the IMAGEN study, of average age 14.4 years (SD = 0.43), 50.7% girls. Manic symptoms were assessed using the Development and Wellbeing Assessment by interviewing parents and young people. Cognition was assessed using the Wechsler Intelligence Scale For Children (WISC-IV) and a response inhibition task. Results Manic symptoms in youth formed two correlated dimensions: one termed exuberance, characterized by high energy and cheerfulness and one of undercontrol with distractibility, irritability and risk-taking behavior. Only the undercontrol, but not the exuberant dimension, was independently associated with measures of psychosocial impairment. In multivariate regression models, the exuberant, but not the undercontrolled, dimension was positively and significantly associated with verbal IQ by both parent- and self-report; conversely, the undercontrolled, but not the exuberant, dimension was associated with poor performance in a response inhibition task. Conclusions Our findings suggest that manic symptoms in youth may form dimensions with distinct correlates. The results are in keeping with previous findings about superior performance associated with mania. Further research is required to study etiological differences between these symptom dimensions and their implications for clinical practice. En ligne : http://dx.doi.org/10.1111/jcpp.12255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1380-1389[article] Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample [Texte imprimé et/ou numérique] / Argyris STRINGARIS, Auteur ; Natalie CASTELLANOS-RYAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÜCHEL, Auteur ; Mira FAUTH-BÜHLER, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMAN, Auteur ; Claire LAWRENCE, Auteur ; Frauke NEES, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Tomas PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Marcella RIETSCHEL, Auteur ; Michael N. SMOLKA, Auteur ; Gunter SCHUMANN, Auteur ; Robert GOODMAN, Auteur ; Patricia CONROD, Auteur ; THE IMAGEN CONSORTIUM,, Auteur . - p.1380-1389.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1380-1389
Mots-clés : Mania bipolar intelligence adolescents creativity Index. décimale : PER Périodiques Résumé : Background It has been reported that mania may be associated with superior cognitive performance. In this study, we test the hypothesis that manic symptoms in youth separate along two correlated dimensions and that a symptom constellation of high energy and cheerfulness is associated with superior cognitive performance. Method We studied 1755 participants of the IMAGEN study, of average age 14.4 years (SD = 0.43), 50.7% girls. Manic symptoms were assessed using the Development and Wellbeing Assessment by interviewing parents and young people. Cognition was assessed using the Wechsler Intelligence Scale For Children (WISC-IV) and a response inhibition task. Results Manic symptoms in youth formed two correlated dimensions: one termed exuberance, characterized by high energy and cheerfulness and one of undercontrol with distractibility, irritability and risk-taking behavior. Only the undercontrol, but not the exuberant dimension, was independently associated with measures of psychosocial impairment. In multivariate regression models, the exuberant, but not the undercontrolled, dimension was positively and significantly associated with verbal IQ by both parent- and self-report; conversely, the undercontrolled, but not the exuberant, dimension was associated with poor performance in a response inhibition task. Conclusions Our findings suggest that manic symptoms in youth may form dimensions with distinct correlates. The results are in keeping with previous findings about superior performance associated with mania. Further research is required to study etiological differences between these symptom dimensions and their implications for clinical practice. En ligne : http://dx.doi.org/10.1111/jcpp.12255 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 Disrupted Functional Connectivity in Dorsal and Ventral Attention Networks During Attention Orienting in Autism Spectrum Disorders / Jacqueline FITZGERALD in Autism Research, 8-2 (April 2015)
[article]
Titre : Disrupted Functional Connectivity in Dorsal and Ventral Attention Networks During Attention Orienting in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jacqueline FITZGERALD, Auteur ; Katherine JOHNSON, Auteur ; Elizabeth KEHOE, Auteur ; Arun L. W. BOKDE, Auteur ; Hugh GARAVAN, Auteur ; Louise GALLAGHER, Auteur ; Jane MCGRATH, Auteur Article en page(s) : p.136-152 Langues : Anglais (eng) Mots-clés : autism spectrum disorders functional connectivity attention orienting attention network neuroimaging Index. décimale : PER Périodiques Résumé : Background Attention orienting is a cognitive process that facilitates the movement of attention focus from one location to another: this may be impaired in autism spectrum disorder (ASD). Dorsal and ventral attention networks (DAN and VAN) sub-serve the process of attention orienting. This study investigated the functional connectivity of attention orienting in these networks in ASD using the Posner Cueing Task. Method Twenty-one adolescents with ASD and 21 age and IQ matched controls underwent functional magnetic resonance imaging. A psychophysical interaction (PPI) analysis was implemented to investigate task-dependent functional connectivity, measuring synchronicity of brain regions during the task. Regions of interest (ROI) were selected to explore functional connectivity in the DAN during cue-only conditions and in the VAN during invalid and valid trials. Results Behaviourally, the ASD and control groups performed the task in a similar manner. Functional MRI results indicated that the ASD and control groups activated similar brain regions. During invalid trials (VAN), the ASD group showed significant positive functional connectivity to multiple brain regions, whilst the control group demonstrated negative connectivity. During valid trials (VAN), the two groups also showed contrasting patterns of connectivity. In the cue-only conditions (DAN), the ASD group showed weaker functional connectivity. Conclusion The DAN analysis suggests that the ASD group has weaker coherence between brain areas involved in goal-driven, endogenous attention control. The strong positive functional connectivity exhibited by the ASD group in the VAN during the invalid trials suggests that individuals with ASD may generate compensatory mechanisms to achieve neurotypical behaviour. These results support the theory of abnormal cortical connectivity in autism. En ligne : http://dx.doi.org/10.1002/aur.1430 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256
in Autism Research > 8-2 (April 2015) . - p.136-152[article] Disrupted Functional Connectivity in Dorsal and Ventral Attention Networks During Attention Orienting in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Jacqueline FITZGERALD, Auteur ; Katherine JOHNSON, Auteur ; Elizabeth KEHOE, Auteur ; Arun L. W. BOKDE, Auteur ; Hugh GARAVAN, Auteur ; Louise GALLAGHER, Auteur ; Jane MCGRATH, Auteur . - p.136-152.
Langues : Anglais (eng)
in Autism Research > 8-2 (April 2015) . - p.136-152
Mots-clés : autism spectrum disorders functional connectivity attention orienting attention network neuroimaging Index. décimale : PER Périodiques Résumé : Background Attention orienting is a cognitive process that facilitates the movement of attention focus from one location to another: this may be impaired in autism spectrum disorder (ASD). Dorsal and ventral attention networks (DAN and VAN) sub-serve the process of attention orienting. This study investigated the functional connectivity of attention orienting in these networks in ASD using the Posner Cueing Task. Method Twenty-one adolescents with ASD and 21 age and IQ matched controls underwent functional magnetic resonance imaging. A psychophysical interaction (PPI) analysis was implemented to investigate task-dependent functional connectivity, measuring synchronicity of brain regions during the task. Regions of interest (ROI) were selected to explore functional connectivity in the DAN during cue-only conditions and in the VAN during invalid and valid trials. Results Behaviourally, the ASD and control groups performed the task in a similar manner. Functional MRI results indicated that the ASD and control groups activated similar brain regions. During invalid trials (VAN), the ASD group showed significant positive functional connectivity to multiple brain regions, whilst the control group demonstrated negative connectivity. During valid trials (VAN), the two groups also showed contrasting patterns of connectivity. In the cue-only conditions (DAN), the ASD group showed weaker functional connectivity. Conclusion The DAN analysis suggests that the ASD group has weaker coherence between brain areas involved in goal-driven, endogenous attention control. The strong positive functional connectivity exhibited by the ASD group in the VAN during the invalid trials suggests that individuals with ASD may generate compensatory mechanisms to achieve neurotypical behaviour. These results support the theory of abnormal cortical connectivity in autism. En ligne : http://dx.doi.org/10.1002/aur.1430 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents / B. RUGGERI in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)
[article]
Titre : Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents Type de document : Texte imprimé et/ou numérique Auteurs : B. RUGGERI, Auteur ; C. MACARE, Auteur ; S. STOPPONI, Auteur ; T. JIA, Auteur ; F. M. CARVALHO, Auteur ; G. ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; A. CATTRELL, Auteur ; P. J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; H. FLOR, Auteur ; V. FROUIN, Auteur ; J. GALLINAT, Auteur ; H. GARAVAN, Auteur ; P. GOWLAND, Auteur ; A. HEINZ, Auteur ; B. ITTERMANN, Auteur ; J. L. MARTINOT, Auteur ; M. P. MARTINOT, Auteur ; F. NEES, Auteur ; D. PAPADOPOULOS-ORFANOS, Auteur ; T. PAUS, Auteur ; L. POUSTKA, Auteur ; M. N. SMOLKA, Auteur ; N. C. VETTER, Auteur ; H. WALTER, Auteur ; R. WHELAN, Auteur ; W. H. SOMMER, Auteur ; G. BAKALKIN, Auteur ; R. CICCOCIOPPO, Auteur ; G. SCHUMANN, Auteur Article en page(s) : p.650-658 Langues : Anglais (eng) Mots-clés : OPRL1 methylation adolescence binge drinking nucleus accumbens stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363
in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658[article] Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents [Texte imprimé et/ou numérique] / B. RUGGERI, Auteur ; C. MACARE, Auteur ; S. STOPPONI, Auteur ; T. JIA, Auteur ; F. M. CARVALHO, Auteur ; G. ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; A. CATTRELL, Auteur ; P. J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; H. FLOR, Auteur ; V. FROUIN, Auteur ; J. GALLINAT, Auteur ; H. GARAVAN, Auteur ; P. GOWLAND, Auteur ; A. HEINZ, Auteur ; B. ITTERMANN, Auteur ; J. L. MARTINOT, Auteur ; M. P. MARTINOT, Auteur ; F. NEES, Auteur ; D. PAPADOPOULOS-ORFANOS, Auteur ; T. PAUS, Auteur ; L. POUSTKA, Auteur ; M. N. SMOLKA, Auteur ; N. C. VETTER, Auteur ; H. WALTER, Auteur ; R. WHELAN, Auteur ; W. H. SOMMER, Auteur ; G. BAKALKIN, Auteur ; R. CICCOCIOPPO, Auteur ; G. SCHUMANN, Auteur . - p.650-658.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658
Mots-clés : OPRL1 methylation adolescence binge drinking nucleus accumbens stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 Structural brain correlates of adolescent resilience / Keith B. BURT in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)
[article]
Titre : Structural brain correlates of adolescent resilience Type de document : Texte imprimé et/ou numérique Auteurs : Keith B. BURT, Auteur ; Robert WHELAN, Auteur ; Patricia J. CONROD, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÜCHEL, Auteur ; Mira FAUTH-BÜHLER, Auteur ; Herta FLOR, Auteur ; André GALINOWSKI, Auteur ; Juergen GALLINAT, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Karl MANN, Auteur ; Frauke NEES, Auteur ; Dimitrios PAPADOPOULOS, Auteur ; Tomas PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Luise POUSTKA, Auteur ; Marcella RIETSCHEL, Auteur ; Trevor W. ROBBINS, Auteur ; Michael N. SMOLKA, Auteur ; Andreas STRÖHLE, Auteur ; Gunter SCHUMANN, Auteur ; Hugh GARAVAN, Auteur ; Imagen Consortium THE, Auteur Article en page(s) : p.1287-1296 Langues : Anglais (eng) Mots-clés : Imaging resilience adolescence competence adversity IMAGEN study Index. décimale : PER Périodiques Résumé : Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. Methods 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. Results The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. Conclusions We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity. En ligne : http://dx.doi.org/10.1111/jcpp.12552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295
in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1287-1296[article] Structural brain correlates of adolescent resilience [Texte imprimé et/ou numérique] / Keith B. BURT, Auteur ; Robert WHELAN, Auteur ; Patricia J. CONROD, Auteur ; Tobias BANASCHEWSKI, Auteur ; Gareth J. BARKER, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; Christian BÜCHEL, Auteur ; Mira FAUTH-BÜHLER, Auteur ; Herta FLOR, Auteur ; André GALINOWSKI, Auteur ; Juergen GALLINAT, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Karl MANN, Auteur ; Frauke NEES, Auteur ; Dimitrios PAPADOPOULOS, Auteur ; Tomas PAUS, Auteur ; Zdenka PAUSOVA, Auteur ; Luise POUSTKA, Auteur ; Marcella RIETSCHEL, Auteur ; Trevor W. ROBBINS, Auteur ; Michael N. SMOLKA, Auteur ; Andreas STRÖHLE, Auteur ; Gunter SCHUMANN, Auteur ; Hugh GARAVAN, Auteur ; Imagen Consortium THE, Auteur . - p.1287-1296.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1287-1296
Mots-clés : Imaging resilience adolescence competence adversity IMAGEN study Index. décimale : PER Périodiques Résumé : Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. Methods 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. Results The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. Conclusions We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity. En ligne : http://dx.doi.org/10.1111/jcpp.12552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach / Tochukwu NWEZE in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)
[article]
Titre : Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach Type de document : Texte imprimé et/ou numérique Auteurs : Tochukwu NWEZE, Auteur ; Tobias BANASCHEWSKI, Auteur ; Cyracius AJAELU, Auteur ; Chukwuemeka OKOYE, Auteur ; Michael EZENWA, Auteur ; Robert WHELAN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Arun L. W. BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Antoine GRIGIS, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Rüdiger BRÜHL, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure Paillère MARTINOT, Auteur ; Éric ARTIGES, Auteur ; Frauke NEES, Auteur ; Tomá? PAUS, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Sabina MILLENET, Auteur ; Juliane H. FRÖHNER, Auteur ; Michael N. SMOLKA, Auteur ; Henrik WALTER, Auteur ; Gunter SCHUMANN, Auteur ; Jamie L. HANSON, Auteur ; Imagen CONSORTIUM, Auteur Article en page(s) : p.1159-1175 Langues : Anglais (eng) Mots-clés : Stress cortical development cognitive functioning longitudinal models bivariate latent change score model longitudinal mediation analysis Index. décimale : PER Périodiques Résumé : Background Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. Methods Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. Results Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. = .327, p = .042, 95% CI [ 0.643, 0.012]) and right anterior cingulate surface area (Std. = .274, p = .038, 95% CI [ 0.533, 0.015]) across ages 14 22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. Conclusion Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted. En ligne : https://doi.org/10.1111/jcpp.13793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508
in Journal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1159-1175[article] Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach [Texte imprimé et/ou numérique] / Tochukwu NWEZE, Auteur ; Tobias BANASCHEWSKI, Auteur ; Cyracius AJAELU, Auteur ; Chukwuemeka OKOYE, Auteur ; Michael EZENWA, Auteur ; Robert WHELAN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Arun L. W. BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Antoine GRIGIS, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Rüdiger BRÜHL, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure Paillère MARTINOT, Auteur ; Éric ARTIGES, Auteur ; Frauke NEES, Auteur ; Tomá? PAUS, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Sabina MILLENET, Auteur ; Juliane H. FRÖHNER, Auteur ; Michael N. SMOLKA, Auteur ; Henrik WALTER, Auteur ; Gunter SCHUMANN, Auteur ; Jamie L. HANSON, Auteur ; Imagen CONSORTIUM, Auteur . - p.1159-1175.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1159-1175
Mots-clés : Stress cortical development cognitive functioning longitudinal models bivariate latent change score model longitudinal mediation analysis Index. décimale : PER Périodiques Résumé : Background Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. Methods Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. Results Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. = .327, p = .042, 95% CI [ 0.643, 0.012]) and right anterior cingulate surface area (Std. = .274, p = .038, 95% CI [ 0.533, 0.015]) across ages 14 22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. Conclusion Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted. En ligne : https://doi.org/10.1111/jcpp.13793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508