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Fetal and Infancy Growth Pattern, Cord and Early Childhood Plasma Leptin, and Development of Autism Spectrum Disorder in the Boston Birth Cohort / R. RAGHAVAN in Autism Research, 11-10 (October 2018)
[article]
Titre : Fetal and Infancy Growth Pattern, Cord and Early Childhood Plasma Leptin, and Development of Autism Spectrum Disorder in the Boston Birth Cohort Type de document : Texte imprimé et/ou numérique Auteurs : R. RAGHAVAN, Auteur ; Barry S. ZUCKERMAN, Auteur ; X. HONG, Auteur ; G. WANG, Auteur ; Y. JI, Auteur ; D. PAIGE, Auteur ; J. DIBARI, Auteur ; C. ZHANG, Auteur ; M. D. FALLIN, Auteur ; X. WANG, Auteur Article en page(s) : p.1416-1431 Langues : Anglais (eng) Mots-clés : autism birth weight for gestational age leptin rapid weight gain in infancy Index. décimale : PER Périodiques Résumé : Leptin is a proinflammatory cytokine that plays an important role in energy homeostasis. Emerging evidence suggests that leptin levels are altered in children with autism spectrum disorder (ASD); however, this has not been studied prospectively. Rapid growth during infancy and early childhood has been implicated in ASD, but the evidence is inconsistent. As leptin is involved in growth and is a potential risk factor for ASD, we explored the associations between (a) cord, early childhood leptin and ASD; and (b) birth weight for gestational age, early childhood weight gain, and ASD. We also assessed the mediating role of leptin in the relationship between weight gain during infancy and ASD. This study was conducted in a sample of 822 subjects from the Boston Birth Cohort. ASD was defined from diagnostic codes in electronic medical records. Extremely rapid weight gain during infancy was associated with a greater ASD risk and this persisted after adjusting for potential confounders (aOR: 3.11; 95% CI: 1.37, 7.07). Similarly, children that had higher plasma leptin levels, prior to ASD diagnosis, had an increased ASD risk in both unadjusted and adjusted models (aOR: 7.87; 95% CI: 2.06, 30.04). Further, early childhood leptin indirectly mediated the relationship between rapid weight gain and ASD. No associations were found between birth weight for gestational age, cord leptin and risk of ASD. Our findings provide a basis to further explore whether the combination of early life growth pattern and a biomarker such as leptin can predict ASD earlier. Autism Res 2018, 11: 1416-1431. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Is early life growth and a biomarker leptin related to ASD risk? To answer this question, we followed 822 children from birth and found that those who gained weight very quickly in infancy, had higher leptin levels in early childhood, had a greater chance of later ASD diagnosis. More research is needed to see if infant's weight gain pattern along with a biomarker (such as leptin) can be used to identify children with ASD sooner. En ligne : http://dx.doi.org/10.1002/aur.2011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369
in Autism Research > 11-10 (October 2018) . - p.1416-1431[article] Fetal and Infancy Growth Pattern, Cord and Early Childhood Plasma Leptin, and Development of Autism Spectrum Disorder in the Boston Birth Cohort [Texte imprimé et/ou numérique] / R. RAGHAVAN, Auteur ; Barry S. ZUCKERMAN, Auteur ; X. HONG, Auteur ; G. WANG, Auteur ; Y. JI, Auteur ; D. PAIGE, Auteur ; J. DIBARI, Auteur ; C. ZHANG, Auteur ; M. D. FALLIN, Auteur ; X. WANG, Auteur . - p.1416-1431.
Langues : Anglais (eng)
in Autism Research > 11-10 (October 2018) . - p.1416-1431
Mots-clés : autism birth weight for gestational age leptin rapid weight gain in infancy Index. décimale : PER Périodiques Résumé : Leptin is a proinflammatory cytokine that plays an important role in energy homeostasis. Emerging evidence suggests that leptin levels are altered in children with autism spectrum disorder (ASD); however, this has not been studied prospectively. Rapid growth during infancy and early childhood has been implicated in ASD, but the evidence is inconsistent. As leptin is involved in growth and is a potential risk factor for ASD, we explored the associations between (a) cord, early childhood leptin and ASD; and (b) birth weight for gestational age, early childhood weight gain, and ASD. We also assessed the mediating role of leptin in the relationship between weight gain during infancy and ASD. This study was conducted in a sample of 822 subjects from the Boston Birth Cohort. ASD was defined from diagnostic codes in electronic medical records. Extremely rapid weight gain during infancy was associated with a greater ASD risk and this persisted after adjusting for potential confounders (aOR: 3.11; 95% CI: 1.37, 7.07). Similarly, children that had higher plasma leptin levels, prior to ASD diagnosis, had an increased ASD risk in both unadjusted and adjusted models (aOR: 7.87; 95% CI: 2.06, 30.04). Further, early childhood leptin indirectly mediated the relationship between rapid weight gain and ASD. No associations were found between birth weight for gestational age, cord leptin and risk of ASD. Our findings provide a basis to further explore whether the combination of early life growth pattern and a biomarker such as leptin can predict ASD earlier. Autism Res 2018, 11: 1416-1431. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Is early life growth and a biomarker leptin related to ASD risk? To answer this question, we followed 822 children from birth and found that those who gained weight very quickly in infancy, had higher leptin levels in early childhood, had a greater chance of later ASD diagnosis. More research is needed to see if infant's weight gain pattern along with a biomarker (such as leptin) can be used to identify children with ASD sooner. En ligne : http://dx.doi.org/10.1002/aur.2011 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 Evaluation of Appetite-Regulating Hormones ?n Young Children with Autism Spectrum Disorder / Ça?la ÇELIKKOL SADIÇ in Journal of Autism and Developmental Disorders, 51-2 (February 2021)
[article]
Titre : Evaluation of Appetite-Regulating Hormones ?n Young Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ça?la ÇELIKKOL SADIÇ, Auteur ; Ayhan BILGIC, Auteur ; ?brahim KILINÇ, Auteur ; Mehmet Burhan OFLAZ, Auteur ; Tamer BAYSAL, Auteur Article en page(s) : p.632-643 Langues : Anglais (eng) Mots-clés : Autism Early childhood Ghrelin Leptin Nesfatin-1 Neuropeptide Y Index. décimale : PER Périodiques Résumé : This study aimed to investigate the role of leptin, ghrelin, neuropeptide Y, and nesfatin-1 in young children with autism spectrum disorder (ASD). A total of 44 children with ASD and 44 healthy controls aged 18-60 months were included. Plasma levels of hormones were measured using commercial enzyme-linked immunosorbent assay kits. Plasma leptin and ghrelin levels were significantly higher in the ASD group than in the control group. However, no significant difference for plasma neuropeptide Y and nesfatin-1 levels was detected between the groups. No relation was found between the severity of ASD symptoms, severity of eating problems, and plasma levels of hormones. Leptin and ghrelin may play a potential role in the pathogenesis of ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04579-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440
in Journal of Autism and Developmental Disorders > 51-2 (February 2021) . - p.632-643[article] Evaluation of Appetite-Regulating Hormones ?n Young Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Ça?la ÇELIKKOL SADIÇ, Auteur ; Ayhan BILGIC, Auteur ; ?brahim KILINÇ, Auteur ; Mehmet Burhan OFLAZ, Auteur ; Tamer BAYSAL, Auteur . - p.632-643.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-2 (February 2021) . - p.632-643
Mots-clés : Autism Early childhood Ghrelin Leptin Nesfatin-1 Neuropeptide Y Index. décimale : PER Périodiques Résumé : This study aimed to investigate the role of leptin, ghrelin, neuropeptide Y, and nesfatin-1 in young children with autism spectrum disorder (ASD). A total of 44 children with ASD and 44 healthy controls aged 18-60 months were included. Plasma levels of hormones were measured using commercial enzyme-linked immunosorbent assay kits. Plasma leptin and ghrelin levels were significantly higher in the ASD group than in the control group. However, no significant difference for plasma neuropeptide Y and nesfatin-1 levels was detected between the groups. No relation was found between the severity of ASD symptoms, severity of eating problems, and plasma levels of hormones. Leptin and ghrelin may play a potential role in the pathogenesis of ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04579-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440