[article]
| Titre : |
Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Léa C. PERRET, Auteur ; Michel BOIVIN, Auteur ; Geneviève MORNEAU-VAILLANCOURT, Auteur ; Till F. M. ANDLAUER, Auteur ; Stéphane PAQUIN, Auteur ; Stéphanie LANGEVIN, Auteur ; Alain GIRARD, Auteur ; Gustavo TURECKI, Auteur ; Kieran J. O'DONNELL, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Jean-Philippe GOUIN, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Marie-Claude GEOFFROY, Auteur |
| Article en page(s) : |
p.388-396 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Peer victimisation has been associated with depressive symptoms during adolescence, however not all peer victimised adolescents will exhibit such symptoms. This study tested whether having a genetic predisposition to developing depression increased the risk of experiencing depressive symptoms in peer victimised youth. To date, no study has explored such gene-environment interaction using a polygenic risk score for depression (PRS-depression) in the context of peer victimisation and depressive symptoms in adolescence. Methods The sample included 748 participants born in 1997/98 from the Quebec Longitudinal Study of Child Development with genotype data and prospectively collected information on peer victimisation (12-13 years) obtained from both self- and teacher-reports, as well as self-reported depressive symptoms (15-17 years). The PRS-depression was based on the genome-wide association meta-analysis of broad depression by Howard et al. (2019). Results Self- and teacher-reported peer victimisation in early adolescence were both associated with depressive symptoms in adolescence (Î2=0.34, p < .001; Î2=0.14, p=.001 respectively), and this association remained significant when accounting for PRS-depression (Î2=0.33, p < .001; Î2=0.13, p=.002 respectively). PRS-depression was independently associated with depressive symptoms, but there was no significant PRS-depression by peer victimisation interaction (self-reported and teacher-reported). PRS-depression was correlated with self-reported, but not teacher-reported, peer victimisation. Conclusions Our findings suggested that a partial measure of an individual's genetic predisposition to depression, as measured by PRS-depression, and being exposed to peer victimisation (self- and teacher-reported) were independently associated with depressive symptoms in adolescence. Furthermore, PRS-depression did not exacerbate the risk of depressive symptoms among adolescents who had been peer victimised. Lastly, we found evidence of a gene-environment correlation between PRS-depression and self-reported peer victimisation. Future studies are needed to replicate this finding and to further understand the role of genetic predispositions in experiencing depressive symptoms following peer victimisation. |
| En ligne : |
https://doi.org/10.1111/jcpp.13706 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 |
in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.388-396
[article] Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development [Texte imprimé et/ou numérique] / Léa C. PERRET, Auteur ; Michel BOIVIN, Auteur ; Geneviève MORNEAU-VAILLANCOURT, Auteur ; Till F. M. ANDLAUER, Auteur ; Stéphane PAQUIN, Auteur ; Stéphanie LANGEVIN, Auteur ; Alain GIRARD, Auteur ; Gustavo TURECKI, Auteur ; Kieran J. O'DONNELL, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Jean-Philippe GOUIN, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Marie-Claude GEOFFROY, Auteur . - p.388-396. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.388-396
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Peer victimisation has been associated with depressive symptoms during adolescence, however not all peer victimised adolescents will exhibit such symptoms. This study tested whether having a genetic predisposition to developing depression increased the risk of experiencing depressive symptoms in peer victimised youth. To date, no study has explored such gene-environment interaction using a polygenic risk score for depression (PRS-depression) in the context of peer victimisation and depressive symptoms in adolescence. Methods The sample included 748 participants born in 1997/98 from the Quebec Longitudinal Study of Child Development with genotype data and prospectively collected information on peer victimisation (12-13 years) obtained from both self- and teacher-reports, as well as self-reported depressive symptoms (15-17 years). The PRS-depression was based on the genome-wide association meta-analysis of broad depression by Howard et al. (2019). Results Self- and teacher-reported peer victimisation in early adolescence were both associated with depressive symptoms in adolescence (Î2=0.34, p < .001; Î2=0.14, p=.001 respectively), and this association remained significant when accounting for PRS-depression (Î2=0.33, p < .001; Î2=0.13, p=.002 respectively). PRS-depression was independently associated with depressive symptoms, but there was no significant PRS-depression by peer victimisation interaction (self-reported and teacher-reported). PRS-depression was correlated with self-reported, but not teacher-reported, peer victimisation. Conclusions Our findings suggested that a partial measure of an individual's genetic predisposition to depression, as measured by PRS-depression, and being exposed to peer victimisation (self- and teacher-reported) were independently associated with depressive symptoms in adolescence. Furthermore, PRS-depression did not exacerbate the risk of depressive symptoms among adolescents who had been peer victimised. Lastly, we found evidence of a gene-environment correlation between PRS-depression and self-reported peer victimisation. Future studies are needed to replicate this finding and to further understand the role of genetic predispositions in experiencing depressive symptoms following peer victimisation. |
| En ligne : |
https://doi.org/10.1111/jcpp.13706 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 |
|
Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)
