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Auteur Stelios GEORGIADES |
Documents disponibles écrits par cet auteur (50)
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Longitudinal associations between early childhood irritability and adolescent depression symptoms in autistic children are mediated by peer relationships but not educational engagement / Virginia CARTER LENO in Development and Psychopathology, 36-1 (February 2024)
[article]
Titre : Longitudinal associations between early childhood irritability and adolescent depression symptoms in autistic children are mediated by peer relationships but not educational engagement Type de document : Texte imprimé et/ou numérique Auteurs : Virginia CARTER LENO, Auteur ; Nicola WRIGHT, Auteur ; Andrew PICKLES, Auteur ; Rachael BEDFORD, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Connor KERNS, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Eric DUKU, Auteur ; Teresa BENNETT, Auteur ; Stelios GEORGIADES, Auteur ; Isabel M. SMITH, Auteur ; Annie RICHARDS, Auteur ; Tracy VAILLANCOURT, Auteur ; Peter SZATMARI, Auteur ; Mayada ELSABBAGH, Auteur Article en page(s) : p.443-453 Langues : Anglais (eng) Mots-clés : autism depression educational achievement failure model irritability peer relationships Index. décimale : PER Périodiques Résumé : In the general population, irritability is associated with later depression. Despite irritability being more prevalent in autistic children, the long-term sequelae are not well explored. We tested whether irritability in early childhood predicted depression symptoms in autistic adolescents, and whether associations could be explained by difficulties in peer relationships and lower educational engagement. Analyses tested the longitudinal associations between early childhood irritability (ages 3-5) and adolescent depression symptoms (age 14) in a prospective inception cohort of autistic children (N = 390), followed from early in development shortly after they received a clinical diagnosis. Mediators were measured in mid-childhood (age 10) by a combination of measures, from which latent factors for peer relationships and educational engagement were estimated. Results showed early childhood irritability was positively associated with adolescent depression symptoms, and this association remained when adjusting for baseline depression. A significant indirect pathway through peer relationships was found, which accounted for around 13% of the association between early childhood irritability and adolescent depression, suggesting peer problems may partially mediate the association between irritability and later depression. No mediation effects were found for education engagement. Results highlight the importance of early screening and intervention for co-occurring irritability and peer problems in young autistic children. En ligne : https://dx.doi.org/10.1017/S0954579422001316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523
in Development and Psychopathology > 36-1 (February 2024) . - p.443-453[article] Longitudinal associations between early childhood irritability and adolescent depression symptoms in autistic children are mediated by peer relationships but not educational engagement [Texte imprimé et/ou numérique] / Virginia CARTER LENO, Auteur ; Nicola WRIGHT, Auteur ; Andrew PICKLES, Auteur ; Rachael BEDFORD, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Connor KERNS, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Eric DUKU, Auteur ; Teresa BENNETT, Auteur ; Stelios GEORGIADES, Auteur ; Isabel M. SMITH, Auteur ; Annie RICHARDS, Auteur ; Tracy VAILLANCOURT, Auteur ; Peter SZATMARI, Auteur ; Mayada ELSABBAGH, Auteur . - p.443-453.
Langues : Anglais (eng)
in Development and Psychopathology > 36-1 (February 2024) . - p.443-453
Mots-clés : autism depression educational achievement failure model irritability peer relationships Index. décimale : PER Périodiques Résumé : In the general population, irritability is associated with later depression. Despite irritability being more prevalent in autistic children, the long-term sequelae are not well explored. We tested whether irritability in early childhood predicted depression symptoms in autistic adolescents, and whether associations could be explained by difficulties in peer relationships and lower educational engagement. Analyses tested the longitudinal associations between early childhood irritability (ages 3-5) and adolescent depression symptoms (age 14) in a prospective inception cohort of autistic children (N = 390), followed from early in development shortly after they received a clinical diagnosis. Mediators were measured in mid-childhood (age 10) by a combination of measures, from which latent factors for peer relationships and educational engagement were estimated. Results showed early childhood irritability was positively associated with adolescent depression symptoms, and this association remained when adjusting for baseline depression. A significant indirect pathway through peer relationships was found, which accounted for around 13% of the association between early childhood irritability and adolescent depression, suggesting peer problems may partially mediate the association between irritability and later depression. No mediation effects were found for education engagement. Results highlight the importance of early screening and intervention for co-occurring irritability and peer problems in young autistic children. En ligne : https://dx.doi.org/10.1017/S0954579422001316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 Measurement equivalence of the autism symptom phenotype in children and youth / Eric DUKU in Journal of Child Psychology and Psychiatry, 54-12 (December 2013)
[article]
Titre : Measurement equivalence of the autism symptom phenotype in children and youth Type de document : Texte imprimé et/ou numérique Auteurs : Eric DUKU, Auteur ; Peter SZATMARI, Auteur ; Tracy VAILLANCOURT, Auteur ; Stelios GEORGIADES, Auteur ; Ann THOMPSON, Auteur ; Xiao-Qing LIU, Auteur ; Andrew D. PATERSON, Auteur ; Terry BENNETT, Auteur Article en page(s) : p.1346-1355 Langues : Anglais (eng) Mots-clés : Autism Diagnostic Interview-Revised measurement equivalence autism spectrum disorder confirmatory factor analysis structural equation modelling Index. décimale : PER Périodiques Résumé : Background The Autism Diagnostic Interview-Revised (ADI-R) is a gold standard assessment of Autism Spectrum Disorder (ASD) symptoms and behaviours. A key underlying assumption of studies using the ADI-R is that it measures the same phenotypic constructs across different populations (i.e. males/females, younger/older, verbal/nonverbal). The objectives of this study were to evaluate alternative measurement models for the autism symptom phenotype based on the ADI-R algorithm items and to examine the measurement equivalence of the most parsimonious and best fitting model across subgroups of interest. Methods Data came from the Autism Genome Project consortium and consisted of 3,628 children aged 4–18 years (84.2% boys and 75% verbal). Twenty-eight algorithm items applicable to both verbal and nonverbal participants were used in the analysis. Measurement equivalence of the autism phenotype was examined using categorical confirmatory factor analysis. Results A second-order model resembling the proposed DSM-5 two-factor structure of the phenotype showed good overall fit, but not for all the subgroups. The autism symptom phenotype was best indexed by the first-order, six-factor measurement model proposed by Liu et al. (2011). This model was well fitting and measurement equivalent across subgroups of participants (age, verbal ability and sex). Conclusions The autism symptom phenotype is adequately characterized by a six-factor measurement model; this model appears to be measurement equivalent across subgroups of children and youth with ASD that differ in age, sex and verbal ability. The two-factor model provides equally good fit for the sample as a whole, but comparison of these two dimensions between subgroups that might differ in terms of age, sex or verbal ability is challenged by lack of measurement equivalence. En ligne : http://dx.doi.org/10.1111/jcpp.12103 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219
in Journal of Child Psychology and Psychiatry > 54-12 (December 2013) . - p.1346-1355[article] Measurement equivalence of the autism symptom phenotype in children and youth [Texte imprimé et/ou numérique] / Eric DUKU, Auteur ; Peter SZATMARI, Auteur ; Tracy VAILLANCOURT, Auteur ; Stelios GEORGIADES, Auteur ; Ann THOMPSON, Auteur ; Xiao-Qing LIU, Auteur ; Andrew D. PATERSON, Auteur ; Terry BENNETT, Auteur . - p.1346-1355.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-12 (December 2013) . - p.1346-1355
Mots-clés : Autism Diagnostic Interview-Revised measurement equivalence autism spectrum disorder confirmatory factor analysis structural equation modelling Index. décimale : PER Périodiques Résumé : Background The Autism Diagnostic Interview-Revised (ADI-R) is a gold standard assessment of Autism Spectrum Disorder (ASD) symptoms and behaviours. A key underlying assumption of studies using the ADI-R is that it measures the same phenotypic constructs across different populations (i.e. males/females, younger/older, verbal/nonverbal). The objectives of this study were to evaluate alternative measurement models for the autism symptom phenotype based on the ADI-R algorithm items and to examine the measurement equivalence of the most parsimonious and best fitting model across subgroups of interest. Methods Data came from the Autism Genome Project consortium and consisted of 3,628 children aged 4–18 years (84.2% boys and 75% verbal). Twenty-eight algorithm items applicable to both verbal and nonverbal participants were used in the analysis. Measurement equivalence of the autism phenotype was examined using categorical confirmatory factor analysis. Results A second-order model resembling the proposed DSM-5 two-factor structure of the phenotype showed good overall fit, but not for all the subgroups. The autism symptom phenotype was best indexed by the first-order, six-factor measurement model proposed by Liu et al. (2011). This model was well fitting and measurement equivalent across subgroups of participants (age, verbal ability and sex). Conclusions The autism symptom phenotype is adequately characterized by a six-factor measurement model; this model appears to be measurement equivalent across subgroups of children and youth with ASD that differ in age, sex and verbal ability. The two-factor model provides equally good fit for the sample as a whole, but comparison of these two dimensions between subgroups that might differ in terms of age, sex or verbal ability is challenged by lack of measurement equivalence. En ligne : http://dx.doi.org/10.1111/jcpp.12103 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 Middle-childhood executive functioning mediates associations between early-childhood autism symptoms and adolescent mental health, academic and functional outcomes in autistic children / Stephanie H. AMEIS in Journal of Child Psychology and Psychiatry, 63-5 (May 2022)
[article]
Titre : Middle-childhood executive functioning mediates associations between early-childhood autism symptoms and adolescent mental health, academic and functional outcomes in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Stephanie H. AMEIS, Auteur ; John D. HALTIGAN, Auteur ; Rachael E. LYON, Auteur ; Amanda SAWYER, Auteur ; Pat MIRENDA, Auteur ; Connor M. KERNS, Auteur ; Isabel M. SMITH, Auteur ; Tracy VAILLANCOURT, Auteur ; Joanne VOLDEN, Auteur ; Charlotte WADDELL, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Teresa BENNETT, Auteur ; Eric DUKU, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Wendy J. UNGAR, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Meng-Chuan LAI, Auteur ; Peter SZATMARI, Auteur Article en page(s) : p.553-562 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder Autistic Disorder/complications Child Executive Function Humans Mental Health Parents academic performance adaptive functioning internalizing/externalizing behavior longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Executive functioning (EF) varies in children with autism spectrum disorder (ASD) and is associated with clinical symptoms, academic, and adaptive functioning. Here, we examined whether middle-childhood EF mediates associations between early-childhood autism symptoms and adolescent outcomes in children with ASD. METHODS: The Pathways in ASD Cohort comprising children recruited at the time of ASD diagnosis (at 2-4?years-of-age) and followed prospectively across eight subsequent timepoints over ~10?years was used. A subset of Pathways participants (n=250) with Behavior Rating Inventory of Executive Function (BRIEF)-Parent Form data from at least one timepoint when participants were school-aged was analyzed. A mediation framework was used to examine whether BRIEF-measured EF across age 7-10?years (middle-childhood) mediated associations between early-childhood autism symptoms (measured using the parent-report Social Responsiveness Scale across age 2-6?years) and clinical, academic, and functional outcomes, indexed at age >10-11.8?years (early-adolescence) using the Child Behavior Checklist (CBCL)-Internalizing and Externalizing Scales, Academic Performance from the Teacher's Report Form, and Vineland Adaptive Behavior Scales. Models were rerun substituting clinician-rated and teacher-rated measures, where possible. RESULTS: Mediation models indicated a significant indirect effect of middle-childhood EF on associations between early-childhood autism symptoms and externalizing behavior, academic performance, or adaptive functioning in early adolescence; kappa squared (?(2) ) effect sizes ranged from large to small. Model findings were stable across raters. Middle-childhood EF did not mediate associations between early-childhood autism symptoms and adolescent internalizing behavior. CONCLUSIONS: Among children with an ASD diagnosis, middle-childhood EF may be one pathway through which early-childhood autism symptoms influence a variety of outcomes in early-adolescence. An experimental study targeting middle-childhood EF to improve adolescent academic, emotional/behavioral, and adaptive functioning is needed to evaluate the clinical meaningfulness of these findings. En ligne : http://dx.doi.org/10.1111/jcpp.13493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Journal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.553-562[article] Middle-childhood executive functioning mediates associations between early-childhood autism symptoms and adolescent mental health, academic and functional outcomes in autistic children [Texte imprimé et/ou numérique] / Stephanie H. AMEIS, Auteur ; John D. HALTIGAN, Auteur ; Rachael E. LYON, Auteur ; Amanda SAWYER, Auteur ; Pat MIRENDA, Auteur ; Connor M. KERNS, Auteur ; Isabel M. SMITH, Auteur ; Tracy VAILLANCOURT, Auteur ; Joanne VOLDEN, Auteur ; Charlotte WADDELL, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Teresa BENNETT, Auteur ; Eric DUKU, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Wendy J. UNGAR, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Meng-Chuan LAI, Auteur ; Peter SZATMARI, Auteur . - p.553-562.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.553-562
Mots-clés : Adolescent Autism Spectrum Disorder Autistic Disorder/complications Child Executive Function Humans Mental Health Parents academic performance adaptive functioning internalizing/externalizing behavior longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Executive functioning (EF) varies in children with autism spectrum disorder (ASD) and is associated with clinical symptoms, academic, and adaptive functioning. Here, we examined whether middle-childhood EF mediates associations between early-childhood autism symptoms and adolescent outcomes in children with ASD. METHODS: The Pathways in ASD Cohort comprising children recruited at the time of ASD diagnosis (at 2-4?years-of-age) and followed prospectively across eight subsequent timepoints over ~10?years was used. A subset of Pathways participants (n=250) with Behavior Rating Inventory of Executive Function (BRIEF)-Parent Form data from at least one timepoint when participants were school-aged was analyzed. A mediation framework was used to examine whether BRIEF-measured EF across age 7-10?years (middle-childhood) mediated associations between early-childhood autism symptoms (measured using the parent-report Social Responsiveness Scale across age 2-6?years) and clinical, academic, and functional outcomes, indexed at age >10-11.8?years (early-adolescence) using the Child Behavior Checklist (CBCL)-Internalizing and Externalizing Scales, Academic Performance from the Teacher's Report Form, and Vineland Adaptive Behavior Scales. Models were rerun substituting clinician-rated and teacher-rated measures, where possible. RESULTS: Mediation models indicated a significant indirect effect of middle-childhood EF on associations between early-childhood autism symptoms and externalizing behavior, academic performance, or adaptive functioning in early adolescence; kappa squared (?(2) ) effect sizes ranged from large to small. Model findings were stable across raters. Middle-childhood EF did not mediate associations between early-childhood autism symptoms and adolescent internalizing behavior. CONCLUSIONS: Among children with an ASD diagnosis, middle-childhood EF may be one pathway through which early-childhood autism symptoms influence a variety of outcomes in early-adolescence. An experimental study targeting middle-childhood EF to improve adolescent academic, emotional/behavioral, and adaptive functioning is needed to evaluate the clinical meaningfulness of these findings. En ligne : http://dx.doi.org/10.1111/jcpp.13493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 Modeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6 / Stelios GEORGIADES in Journal of Autism and Developmental Disorders, 44-12 (December 2014)
[article]
Titre : Modeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6 Type de document : Texte imprimé et/ou numérique Auteurs : Stelios GEORGIADES, Auteur ; Michael H. BOYLE, Auteur ; Peter SZATMARI, Auteur ; Steven HANNA, Auteur ; Eric DUKU, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Joanne VOLDEN, Auteur ; Pat MIRENDA, Auteur ; Isabel SMITH, Auteur ; Wendy ROBERTS, Auteur ; Tracy VAILLANCOURT, Auteur ; Charlotte WADDELL, Auteur ; Teresa BENNETT, Auteur ; Mayada ELSABBAGH, Auteur ; Ann THOMPSON, Auteur Article en page(s) : p.3045-3055 Langues : Anglais (eng) Mots-clés : Autism symptoms Classification Phenotypic heterogeneity Index. décimale : PER Périodiques Résumé : The latent class structure of autism symptoms from the time of diagnosis to age 6 years was examined in a sample of 280 children with autism spectrum disorder. Factor mixture modeling was performed on 26 algorithm items from the Autism Diagnostic Interview - Revised at diagnosis (Time 1) and again at age 6 (Time 2). At Time 1, a “2-factor/3-class” model provided the best fit to the data. At Time 2, a “2-factor/2-class” model provided the best fit to the data. Longitudinal (repeated measures) analysis of variance showed that the “2-factor/3-class” model derived at the time of diagnosis allows for the identification of a subgroup of children (9 % of sample) who exhibit notable reduction in symptom severity. En ligne : http://dx.doi.org/10.1007/s10803-014-2167-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Journal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.3045-3055[article] Modeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6 [Texte imprimé et/ou numérique] / Stelios GEORGIADES, Auteur ; Michael H. BOYLE, Auteur ; Peter SZATMARI, Auteur ; Steven HANNA, Auteur ; Eric DUKU, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Joanne VOLDEN, Auteur ; Pat MIRENDA, Auteur ; Isabel SMITH, Auteur ; Wendy ROBERTS, Auteur ; Tracy VAILLANCOURT, Auteur ; Charlotte WADDELL, Auteur ; Teresa BENNETT, Auteur ; Mayada ELSABBAGH, Auteur ; Ann THOMPSON, Auteur . - p.3045-3055.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.3045-3055
Mots-clés : Autism symptoms Classification Phenotypic heterogeneity Index. décimale : PER Périodiques Résumé : The latent class structure of autism symptoms from the time of diagnosis to age 6 years was examined in a sample of 280 children with autism spectrum disorder. Factor mixture modeling was performed on 26 algorithm items from the Autism Diagnostic Interview - Revised at diagnosis (Time 1) and again at age 6 (Time 2). At Time 1, a “2-factor/3-class” model provided the best fit to the data. At Time 2, a “2-factor/2-class” model provided the best fit to the data. Longitudinal (repeated measures) analysis of variance showed that the “2-factor/3-class” model derived at the time of diagnosis allows for the identification of a subgroup of children (9 % of sample) who exhibit notable reduction in symptom severity. En ligne : http://dx.doi.org/10.1007/s10803-014-2167-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study / Tony CHARMAN in Autism Research, 10-1 (January 2017)
[article]
Titre : Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study Type de document : Texte imprimé et/ou numérique Auteurs : Tony CHARMAN, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Emily J. H. JONES, Auteur ; Rebecca LANDA, Auteur ; Suzanne MACARI, Auteur ; Daniel S. MESSINGER, Auteur ; Charles A. NELSON, Auteur ; Sally OZONOFF, Auteur ; Celine A. SAULNIER, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Sara Jane WEBB, Auteur ; Nurit YIRMIYA, Auteur ; Lonnie ZWAIGENBAUM, Auteur Article en page(s) : p.169-178 Langues : Anglais (eng) Mots-clés : autism spectrum disorder broader autism phenotype developmental outcomes high risk siblings adaptive functioning Index. décimale : PER Périodiques Résumé : We characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n?=?859), and low-risk controls with no family history of ASD (n?=?473). We report outcomes at age 3 years using the Mullen Scales of Early Learning, the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview—Revised (ADI-R) and adaptive functioning on the Vineland Adaptive Behavior Scales. Around 11% of high-risk siblings had mild-to-moderate levels of developmental delay, a rate higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. Thirty percent of high-risk siblings had elevated scores on the ADOS, double the rate seen in the low-risk controls. High-risk siblings also had higher parent reported levels of ASD symptoms on the ADI-R and lower adaptive functioning on the Vineland. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures but not mild-to-moderate language delay. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. These findings are evidence for early emerging characteristics related to the “broader autism phenotype” (BAP) previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not have an ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes. En ligne : http://dx.doi.org/10.1002/aur.1669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-1 (January 2017) . - p.169-178[article] Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study [Texte imprimé et/ou numérique] / Tony CHARMAN, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Emily J. H. JONES, Auteur ; Rebecca LANDA, Auteur ; Suzanne MACARI, Auteur ; Daniel S. MESSINGER, Auteur ; Charles A. NELSON, Auteur ; Sally OZONOFF, Auteur ; Celine A. SAULNIER, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Sara Jane WEBB, Auteur ; Nurit YIRMIYA, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - p.169-178.
Langues : Anglais (eng)
in Autism Research > 10-1 (January 2017) . - p.169-178
Mots-clés : autism spectrum disorder broader autism phenotype developmental outcomes high risk siblings adaptive functioning Index. décimale : PER Périodiques Résumé : We characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n?=?859), and low-risk controls with no family history of ASD (n?=?473). We report outcomes at age 3 years using the Mullen Scales of Early Learning, the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview—Revised (ADI-R) and adaptive functioning on the Vineland Adaptive Behavior Scales. Around 11% of high-risk siblings had mild-to-moderate levels of developmental delay, a rate higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. Thirty percent of high-risk siblings had elevated scores on the ADOS, double the rate seen in the low-risk controls. High-risk siblings also had higher parent reported levels of ASD symptoms on the ADI-R and lower adaptive functioning on the Vineland. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures but not mild-to-moderate language delay. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. These findings are evidence for early emerging characteristics related to the “broader autism phenotype” (BAP) previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not have an ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes. En ligne : http://dx.doi.org/10.1002/aur.1669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 Obsessive-compulsive disorder in children and youth: neurocognitive function in clinic and community samples / Russell SCHACHAR in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)
PermalinkParent-Reported Rates and Clinical Correlates of Suicidality in Children with Autism Spectrum Disorder: A Longitudinal Study / Michelle C. HUNSCHE in Journal of Autism and Developmental Disorders, 50-10 (October 2020)
PermalinkPhenotypic Overlap Between Core Diagnostic Features and Emotional/Behavioral Problems in Preschool Children with Autism Spectrum Disorder / Stelios GEORGIADES in Journal of Autism and Developmental Disorders, 41-10 (October 2011)
PermalinkPilot randomized controlled trial of a Functional Behavior Skills Training program for young children with Autism Spectrum Disorder who have significant early learning skill impairments and their families / J. REITZEL in Research in Autism Spectrum Disorders, 7-11 (November 2013)
PermalinkPredictors of language regression and its association with subsequent communication development in children with autism / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)
PermalinkPredictors of longer-term development of expressive language in two independent longitudinal cohorts of language-delayed preschoolers with Autism Spectrum Disorder / Vanessa H. BAL in Journal of Child Psychology and Psychiatry, 61-7 (July 2020)
PermalinkQuantitative autism symptom patterns recapitulate differential mechanisms of genetic transmission in single and multiple incidence families / Thomas W. FRAZIER in Molecular Autism, (October 2015)
PermalinkSex differences in scores on standardized measures of autism symptoms: a multisite integrative data analysis / Aaron J. KAAT in Journal of Child Psychology and Psychiatry, 62-1 (January 2021)
PermalinkStability and Change in the Cognitive and Adaptive Behaviour Scores of Preschoolers with Autism Spectrum Disorder / Helen E. FLANAGAN in Journal of Autism and Developmental Disorders, 45-9 (September 2015)
PermalinkTeacher-Reported Prevalence of FASD in Kindergarten in Canada: Association with Child Development and Problems at Home / Jacqueline PEI in Journal of Autism and Developmental Disorders, 51-2 (February 2021)
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