Dépouillements

Annotation: Tourette syndrome: a relentless drumbeat – driven by misguided brain oscillations / James F. LECKMAN in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.537–550 Titre : Annotation: Tourette syndrome: a relentless drumbeat – driven by misguided brain oscillations Type de document : Texte imprimé et/ou numérique Auteurs : James F. LECKMAN, Auteur ; Flora M. VACCARINO, Auteur ; Paul S.A. KALANITHI, Auteur ; Aribert ROTHENBERGER, Auteur Année de publication : 2006 Article en page(s) : p.537–550 Langues : Anglais (eng) Mots-clés : Tourette-syndrome oscillations basal-ganglia fast-spiking-GABAergic-interneurons thalamocortical-dysrhythmia habit-reversal-training Index. décimale : PER Périodiques Résumé : Objective: This annotation reviews recent evidence that points to the likely role of aberrant neural oscillations in the pathogenesis of Tourette syndrome (TS). Methods: The available anatomic and electrophysiological findings in TS are reviewed in the context of an emerging picture of the crucial role that neural oscillations play in maintaining normal central nervous system (CNS) function. Results: Neurons form behavior-dependent oscillating networks of various sizes and frequencies that bias input selection and facilitate synaptic plasticity, mechanisms that cooperatively support temporal representation as well as the transfer and long-term consolidation of information. Coherent network activity is likely to modulate sensorimotor gating as well as focused motor actions. When these networks are dysrhythmic, there may be a loss of control of sensory information and motor action. The known electrophysiological effects of medications and surgical interventions used to treat TS likely have an ameliorative effect on these aberrant oscillations. Similarly, a strong case can be made that successful behavioral treatments involve the willful training regions of the prefrontal cortex to engage in tic suppression and the performance of competing motor responses to unwanted sensory urges such that these prefrontal regions become effective modulators of aberrant thalamocortical rhythms. Conclusions: A deeper understanding of neural oscillations may illuminate the complex, challenging, enigmatic, internal world that is TS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01620.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=738 [article] Annotation: Tourette syndrome: a relentless drumbeat – driven by misguided brain oscillations [Texte imprimé et/ou numérique] / James F. LECKMAN, Auteur ; Flora M. VACCARINO, Auteur ; Paul S.A. KALANITHI, Auteur ; Aribert ROTHENBERGER, Auteur . - 2006 . - p.537–550. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.537–550 Mots-clés : Tourette-syndrome oscillations basal-ganglia fast-spiking-GABAergic-interneurons thalamocortical-dysrhythmia habit-reversal-training Index. décimale : PER Périodiques Résumé : Objective: This annotation reviews recent evidence that points to the likely role of aberrant neural oscillations in the pathogenesis of Tourette syndrome (TS). Methods: The available anatomic and electrophysiological findings in TS are reviewed in the context of an emerging picture of the crucial role that neural oscillations play in maintaining normal central nervous system (CNS) function. Results: Neurons form behavior-dependent oscillating networks of various sizes and frequencies that bias input selection and facilitate synaptic plasticity, mechanisms that cooperatively support temporal representation as well as the transfer and long-term consolidation of information. Coherent network activity is likely to modulate sensorimotor gating as well as focused motor actions. When these networks are dysrhythmic, there may be a loss of control of sensory information and motor action. The known electrophysiological effects of medications and surgical interventions used to treat TS likely have an ameliorative effect on these aberrant oscillations. Similarly, a strong case can be made that successful behavioral treatments involve the willful training regions of the prefrontal cortex to engage in tic suppression and the performance of competing motor responses to unwanted sensory urges such that these prefrontal regions become effective modulators of aberrant thalamocortical rhythms. Conclusions: A deeper understanding of neural oscillations may illuminate the complex, challenging, enigmatic, internal world that is TS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01620.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=738

Fine-motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome / Michael H. BLOCH in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.551–559 Titre : Fine-motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Michael H. BLOCH, Auteur ; James F. LECKMAN, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Robert T. SCHULTZ, Auteur Année de publication : 2006 Article en page(s) : p.551–559 Langues : Anglais (eng) Mots-clés : Tourette's-syndrome obsessive-compulsive-disorder motor-skills neuropsychology Index. décimale : PER Périodiques Résumé : Background: Most children with Tourette's syndrome (TS) experience a significant decline in tic symptoms during adolescence. Currently no clinical measures have been identified that can predict whose tic symptoms will persist into adulthood. Patients with TS have deficits on neuropsychological tests involving fine-motor coordination and visual-motor integration. We seek to determine if these neuropsychological tests are useful in predicting future symptom severity. Methods: Thirty-two children, aged 8–14, with TS underwent clinical evaluation and a focused neuropsychological testing battery consisting of the Purdue Pegboard, Beery Visual-Motor Integration (VMI) Test and the Rey-Osterreith Complex Figure Task (RCFT). A follow-up clinical assessment was performed on these children an average of 7.5 years later. Ordinal logistic regression analysis was used to correlate neuropsychological testing at Time 1 with tic severity, OCD severity and global psychosocial functioning at Time 2. Results: Poor performance with the dominant hand on the Purdue Pegboard test predicted worse adulthood tic severity and correlated with tic severity at the time of childhood assessment. Poor performance on the VMI and Purdue Pegboard tests (both dominant and non-dominant hand) also predicted worse adulthood global psychosocial functioning. None of the neuropsychological tests were useful in predicting the future course of OCD symptoms in TS patients. Conclusion: Fine motor skill deficits may be a predictor of future tic severity and global psychosocial function in children with TS. We hypothesize that performance on the Purdue Pegboard test may serve as a useful endophenotype in the study of TS and provide a rough measure of the degree of basal ganglia dysfunction present in TS patients. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01561.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=739 [article] Fine-motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome [Texte imprimé et/ou numérique] / Michael H. BLOCH, Auteur ; James F. LECKMAN, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Robert T. SCHULTZ, Auteur . - 2006 . - p.551–559. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.551–559 Mots-clés : Tourette's-syndrome obsessive-compulsive-disorder motor-skills neuropsychology Index. décimale : PER Périodiques Résumé : Background: Most children with Tourette's syndrome (TS) experience a significant decline in tic symptoms during adolescence. Currently no clinical measures have been identified that can predict whose tic symptoms will persist into adulthood. Patients with TS have deficits on neuropsychological tests involving fine-motor coordination and visual-motor integration. We seek to determine if these neuropsychological tests are useful in predicting future symptom severity. Methods: Thirty-two children, aged 8–14, with TS underwent clinical evaluation and a focused neuropsychological testing battery consisting of the Purdue Pegboard, Beery Visual-Motor Integration (VMI) Test and the Rey-Osterreith Complex Figure Task (RCFT). A follow-up clinical assessment was performed on these children an average of 7.5 years later. Ordinal logistic regression analysis was used to correlate neuropsychological testing at Time 1 with tic severity, OCD severity and global psychosocial functioning at Time 2. Results: Poor performance with the dominant hand on the Purdue Pegboard test predicted worse adulthood tic severity and correlated with tic severity at the time of childhood assessment. Poor performance on the VMI and Purdue Pegboard tests (both dominant and non-dominant hand) also predicted worse adulthood global psychosocial functioning. None of the neuropsychological tests were useful in predicting the future course of OCD symptoms in TS patients. Conclusion: Fine motor skill deficits may be a predictor of future tic severity and global psychosocial function in children with TS. We hypothesize that performance on the Purdue Pegboard test may serve as a useful endophenotype in the study of TS and provide a rough measure of the degree of basal ganglia dysfunction present in TS patients. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01561.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=739

Event rate and event-related potentials in ADHD / Jan R. WIERSEMA in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.560–567 Titre : Event rate and event-related potentials in ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Jan R. WIERSEMA, Auteur ; Herbert ROEYERS, Auteur ; Jaap VAN DER MEERE, Auteur ; Rudy VAN COSTER, Auteur ; Dieter BAEYENS, Auteur Année de publication : 2006 Article en page(s) : p.560–567 Langues : Anglais (eng) Mots-clés : ADHD ODD/CD ERP event-rate effort state-regulation Index. décimale : PER Périodiques Résumé : Background: It has been repeatedly found that performance of children with attention deficit hyperactivity disorder (ADHD) is more impaired when a long inter-stimulus interval (ISI) is used than when a short ISI is used. According to the cognitive-energetic model, this may reflect difficulty in remaining in an optimal motor activation state because of insufficient effort allocation. Method: Event-related potentials (ERPs) were evaluated during a Go/No-Go task that incorporates a condition with a fast and a slow presentation rate. Results: ADHD, whether or not comorbid with oppositional defiant/conduct disorder (ODD/CD), was associated with a steeper increase in reaction time (RT) from the fast to the slow condition accompanied by a missing increment of the parietal P3. Speed of responding was found to be correlated with P3 amplitude. In the fast condition, children with ADHD made more errors of commission, accompanied by a smaller No-Go N2, a component thought to be related to inhibition; however, after controlling for ODD/CD these differences disappeared. Conclusions: The association between the steeper increase in RT and reduced parietal P3s may indicate that the children with ADHD did not allocate enough extra effort to adjust to a potentially under-activated state. However, the event rate effects could not account for all of the differences between groups and also early automatic information processing stages seem disturbed in this disorder as indexed by larger P2 amplitudes. Alternative explanations are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01592.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=740 [article] Event rate and event-related potentials in ADHD [Texte imprimé et/ou numérique] / Jan R. WIERSEMA, Auteur ; Herbert ROEYERS, Auteur ; Jaap VAN DER MEERE, Auteur ; Rudy VAN COSTER, Auteur ; Dieter BAEYENS, Auteur . - 2006 . - p.560–567. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.560–567 Mots-clés : ADHD ODD/CD ERP event-rate effort state-regulation Index. décimale : PER Périodiques Résumé : Background: It has been repeatedly found that performance of children with attention deficit hyperactivity disorder (ADHD) is more impaired when a long inter-stimulus interval (ISI) is used than when a short ISI is used. According to the cognitive-energetic model, this may reflect difficulty in remaining in an optimal motor activation state because of insufficient effort allocation. Method: Event-related potentials (ERPs) were evaluated during a Go/No-Go task that incorporates a condition with a fast and a slow presentation rate. Results: ADHD, whether or not comorbid with oppositional defiant/conduct disorder (ODD/CD), was associated with a steeper increase in reaction time (RT) from the fast to the slow condition accompanied by a missing increment of the parietal P3. Speed of responding was found to be correlated with P3 amplitude. In the fast condition, children with ADHD made more errors of commission, accompanied by a smaller No-Go N2, a component thought to be related to inhibition; however, after controlling for ODD/CD these differences disappeared. Conclusions: The association between the steeper increase in RT and reduced parietal P3s may indicate that the children with ADHD did not allocate enough extra effort to adjust to a potentially under-activated state. However, the event rate effects could not account for all of the differences between groups and also early automatic information processing stages seem disturbed in this disorder as indexed by larger P2 amplitudes. Alternative explanations are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01592.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=740

Colour perception in ADHD / Tobias BANASCHEWSKI in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.568–572 Titre : Colour perception in ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Tobias BANASCHEWSKI, Auteur ; Aribert ROTHENBERGER, Auteur ; Sinje RUPPERT, Auteur ; Rosemary TANNOCK, Auteur ; Björn ALBRECHT, Auteur ; Andreas BECKER, Auteur ; Henrik UEBEL, Auteur ; Joseph A. SERGEANT, Auteur Année de publication : 2006 Article en page(s) : p.568–572 Langues : Anglais (eng) Mots-clés : Colour-vision attention-deficit-hyperactivity-disorder dopamine Stroop-Colour-Word-test Index. décimale : PER Périodiques Résumé : Attention-deficit/hyperactivity disorder (ADHD) is associated with unexplained impairments on speeded naming of coloured stimuli. These deficits may reflect hypofunctioning retinal dopaminergic mechanisms impairing particularly blue–yellow colour discrimination. Colour perception and rapid colour naming ability were investigated in 14 children with ADHD and 13 healthy peers matched for age, gender, and IQ, using the Farnsworth–Munsell 100 Hue Test (FMT) and the Stroop-Colour-Word test. Children with ADHD committed more errors on the FMT, particularly on discrimination of colours along the blue–yellow axis, and were slower on Stroop subtests involving colour naming. However, the latter deficit was accounted for similarly by blue–yellow and red–green discrimination abilities. Blue–yellow colour perception problems in ADHD contribute to but do not fully explain the observed slowed colour naming. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01540.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=741 [article] Colour perception in ADHD [Texte imprimé et/ou numérique] / Tobias BANASCHEWSKI, Auteur ; Aribert ROTHENBERGER, Auteur ; Sinje RUPPERT, Auteur ; Rosemary TANNOCK, Auteur ; Björn ALBRECHT, Auteur ; Andreas BECKER, Auteur ; Henrik UEBEL, Auteur ; Joseph A. SERGEANT, Auteur . - 2006 . - p.568–572. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.568–572 Mots-clés : Colour-vision attention-deficit-hyperactivity-disorder dopamine Stroop-Colour-Word-test Index. décimale : PER Périodiques Résumé : Attention-deficit/hyperactivity disorder (ADHD) is associated with unexplained impairments on speeded naming of coloured stimuli. These deficits may reflect hypofunctioning retinal dopaminergic mechanisms impairing particularly blue–yellow colour discrimination. Colour perception and rapid colour naming ability were investigated in 14 children with ADHD and 13 healthy peers matched for age, gender, and IQ, using the Farnsworth–Munsell 100 Hue Test (FMT) and the Stroop-Colour-Word test. Children with ADHD committed more errors on the FMT, particularly on discrimination of colours along the blue–yellow axis, and were slower on Stroop subtests involving colour naming. However, the latter deficit was accounted for similarly by blue–yellow and red–green discrimination abilities. Blue–yellow colour perception problems in ADHD contribute to but do not fully explain the observed slowed colour naming. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01540.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=741

Repetitive and stereotyped behaviours in pervasive developmental disorders / Iris CARCANI-RATHWELL in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.573–581 Titre : Repetitive and stereotyped behaviours in pervasive developmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : Iris CARCANI-RATHWELL, Auteur ; Sophia RABE-HESKETH, Auteur ; Paramala J. SANTOSH, Auteur Année de publication : 2006 Article en page(s) : p.573–581 Langues : Anglais (eng) Mots-clés : Repetitive-and-stereotyped-behaviours sensory-and-motor-stereotypies cognitive-rigidity pervasive-developmental-disorders autism mental-retardation Index. décimale : PER Périodiques Résumé : Background: Repetitive and stereotyped behaviours are a heterogeneous group of behaviours present in many neuropsychiatric disorders. Despite their core significance in PDD, it is not clear whether there are distinct groups of these behaviours with different specificity to autism. Methods: A two-factor model of the repetitive behaviours, namely sensory/motor (lower-order) and cognitive rigidity (higher-order), was conceptualised. The model's goodness of fit to the data was examined in a clinic population of children with PDD, with and without mental retardation, and of those with only mental retardation (MR). Results: Subjects with PDD had higher rates of all repetitive behaviours compared to those with MR only. The existence of two independent 'lower-order' and 'higher-order' sub-groups of the repetitive behaviours was confirmed only in the MR group. The lower-order behaviours appear to be associated more with global developmental problems, whereas the higher-order behaviours were significantly associated with ruminations in the PDD group. Conclusions: This study suggests that there may be two distinct sub-groups of repetitive behaviours whereby the sensory and motor repetitive behaviours are generally associated with lower developmental age and less specific to the autistic syndrome whereas the 'higher-order' behaviours may be a more 'autism specific' feature. The co-occurrence of the lower- and higher-order behaviours in PDD might reflect the end result of diffuse altered neural networks in these disorders thus being a specific feature of PDD. There is a need for more systematic studies of these behaviours not only in autistic disorders but also in other neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01565.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=742 [article] Repetitive and stereotyped behaviours in pervasive developmental disorders [Texte imprimé et/ou numérique] / Iris CARCANI-RATHWELL, Auteur ; Sophia RABE-HESKETH, Auteur ; Paramala J. SANTOSH, Auteur . - 2006 . - p.573–581. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.573–581 Mots-clés : Repetitive-and-stereotyped-behaviours sensory-and-motor-stereotypies cognitive-rigidity pervasive-developmental-disorders autism mental-retardation Index. décimale : PER Périodiques Résumé : Background: Repetitive and stereotyped behaviours are a heterogeneous group of behaviours present in many neuropsychiatric disorders. Despite their core significance in PDD, it is not clear whether there are distinct groups of these behaviours with different specificity to autism. Methods: A two-factor model of the repetitive behaviours, namely sensory/motor (lower-order) and cognitive rigidity (higher-order), was conceptualised. The model's goodness of fit to the data was examined in a clinic population of children with PDD, with and without mental retardation, and of those with only mental retardation (MR). Results: Subjects with PDD had higher rates of all repetitive behaviours compared to those with MR only. The existence of two independent 'lower-order' and 'higher-order' sub-groups of the repetitive behaviours was confirmed only in the MR group. The lower-order behaviours appear to be associated more with global developmental problems, whereas the higher-order behaviours were significantly associated with ruminations in the PDD group. Conclusions: This study suggests that there may be two distinct sub-groups of repetitive behaviours whereby the sensory and motor repetitive behaviours are generally associated with lower developmental age and less specific to the autistic syndrome whereas the 'higher-order' behaviours may be a more 'autism specific' feature. The co-occurrence of the lower- and higher-order behaviours in PDD might reflect the end result of diffuse altered neural networks in these disorders thus being a specific feature of PDD. There is a need for more systematic studies of these behaviours not only in autistic disorders but also in other neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01565.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=742

Investigating the structure of the restricted, repetitive behaviours and interests domain of autism / Peter SZATMARI in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.582–590 Titre : Investigating the structure of the restricted, repetitive behaviours and interests domain of autism Type de document : Texte imprimé et/ou numérique Auteurs : Peter SZATMARI, Auteur ; Susan E. BRYSON, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Wendy ROBERTS, Auteur ; Stelios GEORGIADES, Auteur ; William MAHONEY, Auteur ; Jeremy GOLDBERG, Auteur ; Lawrence TUFF, Auteur Année de publication : 2006 Article en page(s) : p.582–590 Langues : Anglais (eng) Mots-clés : Pervasive-developmental-disorders autism restricted-repetitive-behaviours-and-interests principal-components-analysis structure-of-autism-domains genetic studies Index. décimale : PER Périodiques Résumé : Background: The Restricted, Repetitive Behaviours and Interests (RRBIs) are represented in the DSM-IV and measured by the Autism Diagnostic Interview-Revised (ADI-R) as one of the three homogeneous symptom categories of Pervasive Developmental Disorders. Although this conceptualisation is well accepted in the field, the grouping of symptoms is based primarily on clinical judgment rather than on empirical evidence. Methods: The objective of this study was to examine the factor structure of the RRBI domain of autism. Eleven items from this domain of the ADI-R were used in a Principal Components Analysis (PCA). Our sample consisted of 339 individuals with a Best Estimate diagnosis of Pervasive Developmental Disorder (PDD). Results: Findings indicate that the RRBI domain is composed of two distinct factors or dimensions: Insistence on Sameness (IS) and Repetitive Sensory and Motor Behaviours (RSMB). RSMB is negatively correlated with adaptive skills; that is, lower functioning individuals tend to have higher levels of repetitive sensory and motor behaviours. On the other hand, IS is positively correlated with autistic symptoms in the communication and language domain. Further analyses suggest moderate familial aggregation among affected sibling pairs within the IS but not the RSMB factor. Conclusions: These results provide evidence for the heterogeneity of the RRBI domain of the ADI-R in terms of both clinical presentation and other correlates. In addition, the IS factor seems to be under familial (presumably genetic) control, while RSMB appears to simply reflect variation in developmental level. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01537.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=743 [article] Investigating the structure of the restricted, repetitive behaviours and interests domain of autism [Texte imprimé et/ou numérique] / Peter SZATMARI, Auteur ; Susan E. BRYSON, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Wendy ROBERTS, Auteur ; Stelios GEORGIADES, Auteur ; William MAHONEY, Auteur ; Jeremy GOLDBERG, Auteur ; Lawrence TUFF, Auteur . - 2006 . - p.582–590. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.582–590 Mots-clés : Pervasive-developmental-disorders autism restricted-repetitive-behaviours-and-interests principal-components-analysis structure-of-autism-domains genetic studies Index. décimale : PER Périodiques Résumé : Background: The Restricted, Repetitive Behaviours and Interests (RRBIs) are represented in the DSM-IV and measured by the Autism Diagnostic Interview-Revised (ADI-R) as one of the three homogeneous symptom categories of Pervasive Developmental Disorders. Although this conceptualisation is well accepted in the field, the grouping of symptoms is based primarily on clinical judgment rather than on empirical evidence. Methods: The objective of this study was to examine the factor structure of the RRBI domain of autism. Eleven items from this domain of the ADI-R were used in a Principal Components Analysis (PCA). Our sample consisted of 339 individuals with a Best Estimate diagnosis of Pervasive Developmental Disorder (PDD). Results: Findings indicate that the RRBI domain is composed of two distinct factors or dimensions: Insistence on Sameness (IS) and Repetitive Sensory and Motor Behaviours (RSMB). RSMB is negatively correlated with adaptive skills; that is, lower functioning individuals tend to have higher levels of repetitive sensory and motor behaviours. On the other hand, IS is positively correlated with autistic symptoms in the communication and language domain. Further analyses suggest moderate familial aggregation among affected sibling pairs within the IS but not the RSMB factor. Conclusions: These results provide evidence for the heterogeneity of the RRBI domain of the ADI-R in terms of both clinical presentation and other correlates. In addition, the IS factor seems to be under familial (presumably genetic) control, while RSMB appears to simply reflect variation in developmental level. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01537.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=743

Sensory Experiences Questionnaire: discriminating sensory features in young children with autism, developmental delays, and typical development / Grace T. BARANEK in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.591–601 Titre : Sensory Experiences Questionnaire: discriminating sensory features in young children with autism, developmental delays, and typical development Type de document : Texte imprimé et/ou numérique Auteurs : Grace T. BARANEK, Auteur ; Linda R. WATSON, Auteur ; Fabian J. DAVID, Auteur ; Michele D. POE, Auteur ; Wendy L. STONE, Auteur Année de publication : 2006 Article en page(s) : p.591–601 Langues : Anglais (eng) Mots-clés : Sensory-modulation/processing hyper/hyporesponsiveness autism developmental-disabilities Index. décimale : PER Périodiques Résumé : Background: This study describes a new caregiver-report assessment, the Sensory Experiences Questionnaire (SEQ), and explicates the nature of sensory patterns of hyper- and hyporesponsiveness, their prevalence, and developmental correlates in autism relative to comparison groups. Method: Caregivers of 258 children in five diagnostic groups (Autism, PDD, DD/MR, Other DD, Typical) ages 5–80 months completed the SEQ. Results: The SEQ's internal consistency was α' = .80. Prevalence of overall sensory symptoms for the Autism group was 69%. Sensory symptoms were inversely related to mental age. The Autism group had significantly higher symptoms than either the Typical or DD groups and presented with a unique pattern of response to sensory stimuli –hyporesponsiveness in both social and nonsocial contexts. A pattern of hyperresponsiveness was similar in the Autism and DD groups, but significantly greater in both clinical groups than in the Typical group. Conclusion: The SEQ was able to characterize sensory features in young children with autism, and differentiate their sensory patterns from comparison groups. These unique sensory patterns have etiological implications, as well as relevance for assessment and intervention practices. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01546.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=744 [article] Sensory Experiences Questionnaire: discriminating sensory features in young children with autism, developmental delays, and typical development [Texte imprimé et/ou numérique] / Grace T. BARANEK, Auteur ; Linda R. WATSON, Auteur ; Fabian J. DAVID, Auteur ; Michele D. POE, Auteur ; Wendy L. STONE, Auteur . - 2006 . - p.591–601. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.591–601 Mots-clés : Sensory-modulation/processing hyper/hyporesponsiveness autism developmental-disabilities Index. décimale : PER Périodiques Résumé : Background: This study describes a new caregiver-report assessment, the Sensory Experiences Questionnaire (SEQ), and explicates the nature of sensory patterns of hyper- and hyporesponsiveness, their prevalence, and developmental correlates in autism relative to comparison groups. Method: Caregivers of 258 children in five diagnostic groups (Autism, PDD, DD/MR, Other DD, Typical) ages 5–80 months completed the SEQ. Results: The SEQ's internal consistency was α' = .80. Prevalence of overall sensory symptoms for the Autism group was 69%. Sensory symptoms were inversely related to mental age. The Autism group had significantly higher symptoms than either the Typical or DD groups and presented with a unique pattern of response to sensory stimuli –hyporesponsiveness in both social and nonsocial contexts. A pattern of hyperresponsiveness was similar in the Autism and DD groups, but significantly greater in both clinical groups than in the Typical group. Conclusion: The SEQ was able to characterize sensory features in young children with autism, and differentiate their sensory patterns from comparison groups. These unique sensory patterns have etiological implications, as well as relevance for assessment and intervention practices. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01546.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=744

Social behavior and cortisol reactivity in children with fragile X syndrome / David HESSL in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.602–610 Titre : Social behavior and cortisol reactivity in children with fragile X syndrome Type de document : Texte imprimé et/ou numérique Auteurs : David HESSL, Auteur ; Bronwyn GLASER, Auteur ; Jennifer DYER-FRIEDMAN, Auteur ; Allan L. REISS, Auteur Année de publication : 2006 Article en page(s) : p.602–610 Langues : Anglais (eng) Mots-clés : Fragile-X-syndrome cortisol anxiety social-phobia FMR1-gene gaze autism Index. décimale : PER Périodiques Résumé : Objective: To examine the association between limbic-hypothalamic-pituitary-adrenal (L-HPA) axis reactivity and social behavior in children with fragile X syndrome (FXS). Method: Salivary cortisol changes and concurrent anxiety-related behaviors consistent with the behavioral phenotype of FXS were measured in 90 children with the fragile X full mutation and their 90 unaffected siblings during a social challenge task in the home. Results: Boys and girls with FXS demonstrated more gaze aversion, task avoidance, behavioral signs of distress, and poorer vocal quality than the unaffected siblings. Multiple regression analyses showed that after accounting for effects of IQ, gender, age, quality of the home environment, and basal cortisol level, cortisol reactivity to the task was significantly associated with social gaze in children with FXS. The most gaze-aversive children with FXS had cortisol reductions, whereas those with more eye contact demonstrated the most cortisol reactivity. Unaffected siblings demonstrated an opposite pattern in which less eye contact was associated with increased cortisol reactivity. Conclusions: Results of the study suggest a unique relation between abnormal gaze behavior and L-HPA mediated stress reactivity in FXS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01556.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=745 [article] Social behavior and cortisol reactivity in children with fragile X syndrome [Texte imprimé et/ou numérique] / David HESSL, Auteur ; Bronwyn GLASER, Auteur ; Jennifer DYER-FRIEDMAN, Auteur ; Allan L. REISS, Auteur . - 2006 . - p.602–610. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.602–610 Mots-clés : Fragile-X-syndrome cortisol anxiety social-phobia FMR1-gene gaze autism Index. décimale : PER Périodiques Résumé : Objective: To examine the association between limbic-hypothalamic-pituitary-adrenal (L-HPA) axis reactivity and social behavior in children with fragile X syndrome (FXS). Method: Salivary cortisol changes and concurrent anxiety-related behaviors consistent with the behavioral phenotype of FXS were measured in 90 children with the fragile X full mutation and their 90 unaffected siblings during a social challenge task in the home. Results: Boys and girls with FXS demonstrated more gaze aversion, task avoidance, behavioral signs of distress, and poorer vocal quality than the unaffected siblings. Multiple regression analyses showed that after accounting for effects of IQ, gender, age, quality of the home environment, and basal cortisol level, cortisol reactivity to the task was significantly associated with social gaze in children with FXS. The most gaze-aversive children with FXS had cortisol reductions, whereas those with more eye contact demonstrated the most cortisol reactivity. Unaffected siblings demonstrated an opposite pattern in which less eye contact was associated with increased cortisol reactivity. Conclusions: Results of the study suggest a unique relation between abnormal gaze behavior and L-HPA mediated stress reactivity in FXS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01556.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=745

Joint attention and symbolic play in young children with autism: a randomized controlled intervention study / Connie KASARI in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.611–620 Titre : Joint attention and symbolic play in young children with autism: a randomized controlled intervention study Type de document : Texte imprimé et/ou numérique Auteurs : Connie KASARI, Auteur ; Stephanny FREEMAN, Auteur ; Tanya PAPARELLA, Auteur Année de publication : 2006 Article en page(s) : p.611–620 Langues : Anglais (eng) Mots-clés : Intervention joint-attention symbolic-play autism Index. décimale : PER Périodiques Résumé : Background: Delays and deficits in joint attention and symbolic play constitute two important developmental problems in young children with autism. These areas of deficit have been well studied in autism but have rarely been the focus of treatment efforts (see Kasari, Freeman, & Paparella, 2001). In this study, we examine the efficacy of targeted interventions of joint attention and symbolic play. Methods: Participants were 58 children with autism aged 3 and 4 years (46 boys). Children were randomized to a joint attention intervention, a symbolic play intervention, or control group. Interventions were conducted 30 minutes daily for 5–6 weeks. Both structured assessments of joint attention and play skills and mother–child interactions were collected pre and post intervention by independent assessors. Results: Results indicate that both intervention groups improved significantly over the control group on certain behaviors. Children in the joint attention intervention initiated significantly more showing and responsiveness to joint attention on the structured joint attention assessment and more child-initiated joint attention in the mother–child interaction. The children in the play group showed more diverse types of symbolic play in interaction with their mothers and higher play levels on both the play assessment and in interaction with their mothers. Conclusions: This randomized controlled trial provides promising data on the specificity and generalizability of joint attention and play interventions for young children with autism. Future studies need to examine the long-term effects of these early interventions on children's development. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01567.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=746 [article] Joint attention and symbolic play in young children with autism: a randomized controlled intervention study [Texte imprimé et/ou numérique] / Connie KASARI, Auteur ; Stephanny FREEMAN, Auteur ; Tanya PAPARELLA, Auteur . - 2006 . - p.611–620. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.611–620 Mots-clés : Intervention joint-attention symbolic-play autism Index. décimale : PER Périodiques Résumé : Background: Delays and deficits in joint attention and symbolic play constitute two important developmental problems in young children with autism. These areas of deficit have been well studied in autism but have rarely been the focus of treatment efforts (see Kasari, Freeman, & Paparella, 2001). In this study, we examine the efficacy of targeted interventions of joint attention and symbolic play. Methods: Participants were 58 children with autism aged 3 and 4 years (46 boys). Children were randomized to a joint attention intervention, a symbolic play intervention, or control group. Interventions were conducted 30 minutes daily for 5–6 weeks. Both structured assessments of joint attention and play skills and mother–child interactions were collected pre and post intervention by independent assessors. Results: Results indicate that both intervention groups improved significantly over the control group on certain behaviors. Children in the joint attention intervention initiated significantly more showing and responsiveness to joint attention on the structured joint attention assessment and more child-initiated joint attention in the mother–child interaction. The children in the play group showed more diverse types of symbolic play in interaction with their mothers and higher play levels on both the play assessment and in interaction with their mothers. Conclusions: This randomized controlled trial provides promising data on the specificity and generalizability of joint attention and play interventions for young children with autism. Future studies need to examine the long-term effects of these early interventions on children's development. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01567.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=746

The prevalence of autistic spectrum disorders in adolescents with a history of specific language impairment (SLI) / Gina CONTI-RAMSDEN in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.621–628 Titre : The prevalence of autistic spectrum disorders in adolescents with a history of specific language impairment (SLI) Type de document : Texte imprimé et/ou numérique Auteurs : Gina CONTI-RAMSDEN, Auteur ; Zoë SIMKIN, Auteur ; Nicola BOTTING, Auteur Année de publication : 2006 Article en page(s) : p.621–628 Langues : Anglais (eng) Mots-clés : Specific-language-impairment-(SLI) autism prevalence diagnosis Index. décimale : PER Périodiques Résumé : Background: Traditionally, autism and specific language impairment (SLI) have been regarded as distinct disorders but, more recently, evidence has been put forward for a closer link between them: a common set of language problems, in particular receptive language difficulties and the existence of intermediate cases including pragmatic language impairment. The present study aimed to examine the prevalence of autism spectrum disorders in a large sample of adolescents with a history of SLI. Method: The presence of autism spectrum disorders was examined in seventy-six 14-year-olds with a confirmed history of SLI. A variety of instruments were employed, including the Autism Diagnostic Interview-Revised (ADI-R), the Autism Diagnostic Observation Schedule (ADOS) and the Family History Interview (FHI). Results: The prevalence of autism spectrum disorders in young people with SLI was found to be 3.9%, about 10 times what would be expected from the general population. In addition, a much larger number of young people with a history of SLI showed only some autism spectrum symptoms or showed them in a mild form. Conclusions: Young people with SLI have an increased risk of autism. The magnitude of this risk is considerable. In addition, a larger proportion (a quarter of individuals) present with a number of behaviours consistent with autism spectrum disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01584.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=747 [article] The prevalence of autistic spectrum disorders in adolescents with a history of specific language impairment (SLI) [Texte imprimé et/ou numérique] / Gina CONTI-RAMSDEN, Auteur ; Zoë SIMKIN, Auteur ; Nicola BOTTING, Auteur . - 2006 . - p.621–628. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.621–628 Mots-clés : Specific-language-impairment-(SLI) autism prevalence diagnosis Index. décimale : PER Périodiques Résumé : Background: Traditionally, autism and specific language impairment (SLI) have been regarded as distinct disorders but, more recently, evidence has been put forward for a closer link between them: a common set of language problems, in particular receptive language difficulties and the existence of intermediate cases including pragmatic language impairment. The present study aimed to examine the prevalence of autism spectrum disorders in a large sample of adolescents with a history of SLI. Method: The presence of autism spectrum disorders was examined in seventy-six 14-year-olds with a confirmed history of SLI. A variety of instruments were employed, including the Autism Diagnostic Interview-Revised (ADI-R), the Autism Diagnostic Observation Schedule (ADOS) and the Family History Interview (FHI). Results: The prevalence of autism spectrum disorders in young people with SLI was found to be 3.9%, about 10 times what would be expected from the general population. In addition, a much larger number of young people with a history of SLI showed only some autism spectrum symptoms or showed them in a mild form. Conclusions: Young people with SLI have an increased risk of autism. The magnitude of this risk is considerable. In addition, a larger proportion (a quarter of individuals) present with a number of behaviours consistent with autism spectrum disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2005.01584.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=747

Development in infants with autism spectrum disorders: a prospective study / Rebecca LANDA in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.629–638 Titre : Development in infants with autism spectrum disorders: a prospective study Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca LANDA, Auteur ; Elizabeth GARRETT-MAYER, Auteur Année de publication : 2006 Article en page(s) : p.629–638 Langues : Anglais (eng) Mots-clés : Autism autism-spectrum-disorder autistic-disorder language-impairment language-delay language-disorder motor-skills pervasive-developmental-disorder siblings Index. décimale : PER Périodiques Résumé : Background: Autism is rarely diagnosed before three years of age despite evidence suggesting prenatal abnormalities in neurobiological processes. Little is known about when or how development becomes disrupted in the first two years of life in autism. Such information is needed to facilitate early detection and early intervention. Methods: This prospective study of autism spectrum disorders (ASD) examined development using the Mullen Scales of Early Learning (MSEL) in 87 infants tested at target ages 6, 14, and 24 months. Participants came from infants at high risk (siblings of children with autism) and low risk (no family history of autism) groups. Based on language test scores, Autism Diagnostic Observation Schedule, and clinical judgment at 24 months of age, participants were categorized as: unaffected, ASD, or language delayed (LD). Longitudinal linear regression and ANOVA models were applied to MSEL raw scores, and estimates were compared between the three diagnostic groups. Results: No statistically significant group differences were detected at 6 months. By 14 months of age, the ASD group performed significantly worse than the unaffected group on all scales except Visual Reception. By 24 months of age, the ASD group performed significantly worse than the unaffected group in all domains, and worse than the language delayed group in Gross Motor, Fine Motor, and Receptive Language. The developmental trajectory of the ASD group was slower than the other groups', and showed a significant decrease in development between the first and second birthdays. Conclusions: Variations from typical and language delayed development are detectable in many children with ASD using a measure of general development by 24 months of age. Unusual slowing in performance occurred between 14 and 24 months of age in ASD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01531.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=748 [article] Development in infants with autism spectrum disorders: a prospective study [Texte imprimé et/ou numérique] / Rebecca LANDA, Auteur ; Elizabeth GARRETT-MAYER, Auteur . - 2006 . - p.629–638. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.629–638 Mots-clés : Autism autism-spectrum-disorder autistic-disorder language-impairment language-delay language-disorder motor-skills pervasive-developmental-disorder siblings Index. décimale : PER Périodiques Résumé : Background: Autism is rarely diagnosed before three years of age despite evidence suggesting prenatal abnormalities in neurobiological processes. Little is known about when or how development becomes disrupted in the first two years of life in autism. Such information is needed to facilitate early detection and early intervention. Methods: This prospective study of autism spectrum disorders (ASD) examined development using the Mullen Scales of Early Learning (MSEL) in 87 infants tested at target ages 6, 14, and 24 months. Participants came from infants at high risk (siblings of children with autism) and low risk (no family history of autism) groups. Based on language test scores, Autism Diagnostic Observation Schedule, and clinical judgment at 24 months of age, participants were categorized as: unaffected, ASD, or language delayed (LD). Longitudinal linear regression and ANOVA models were applied to MSEL raw scores, and estimates were compared between the three diagnostic groups. Results: No statistically significant group differences were detected at 6 months. By 14 months of age, the ASD group performed significantly worse than the unaffected group on all scales except Visual Reception. By 24 months of age, the ASD group performed significantly worse than the unaffected group in all domains, and worse than the language delayed group in Gross Motor, Fine Motor, and Receptive Language. The developmental trajectory of the ASD group was slower than the other groups', and showed a significant decrease in development between the first and second birthdays. Conclusions: Variations from typical and language delayed development are detectable in many children with ASD using a measure of general development by 24 months of age. Unusual slowing in performance occurred between 14 and 24 months of age in ASD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01531.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=748

The broader cognitive phenotype of autism in parents: how specific is the tendency for local processing and executive dysfunction? / Sven BÖLTE in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.639–645 Titre : The broader cognitive phenotype of autism in parents: how specific is the tendency for local processing and executive dysfunction? Type de document : Texte imprimé et/ou numérique Auteurs : Sven BÖLTE, Auteur ; Fritz POUSTKA, Auteur Année de publication : 2006 Article en page(s) : p.639–645 Langues : Anglais (eng) Mots-clés : Autism phenotype executive-function local-processing genetics Index. décimale : PER Périodiques Résumé : Background: The objective of this study was to investigate the tendency for local processing style ('weak central coherence') and executive dysfunction in parents of subjects with an autism spectrum disorder (ASD) compared with parents of individuals with early onset schizophrenia (EOS) and mental retardation (MR). Method: Sixty-two parents of subjects with ASD, 36 parents of subjects with EOS and 30 parents of subjects with MR were examined. Data on two scales indicative of local visual processing (Embedded Figures Test, Block Design) and on three executive function tests (Wisconsin Card Sorting Test, Tower of Hanoi, Trailmaking Test) were collected for all participants. Results: Parents of subjects with ASD performed significantly faster on the Embedded Figures Test compared with both control samples. No other substantial group differences were observed. Conclusions: The findings indicate that an increased tendency for local processing in terms of visual disembedding could be a relatively specific core feature of the broader cognitive phenotype of autism in parents. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01603.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=749 [article] The broader cognitive phenotype of autism in parents: how specific is the tendency for local processing and executive dysfunction? [Texte imprimé et/ou numérique] / Sven BÖLTE, Auteur ; Fritz POUSTKA, Auteur . - 2006 . - p.639–645. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.639–645 Mots-clés : Autism phenotype executive-function local-processing genetics Index. décimale : PER Périodiques Résumé : Background: The objective of this study was to investigate the tendency for local processing style ('weak central coherence') and executive dysfunction in parents of subjects with an autism spectrum disorder (ASD) compared with parents of individuals with early onset schizophrenia (EOS) and mental retardation (MR). Method: Sixty-two parents of subjects with ASD, 36 parents of subjects with EOS and 30 parents of subjects with MR were examined. Data on two scales indicative of local visual processing (Embedded Figures Test, Block Design) and on three executive function tests (Wisconsin Card Sorting Test, Tower of Hanoi, Trailmaking Test) were collected for all participants. Results: Parents of subjects with ASD performed significantly faster on the Embedded Figures Test compared with both control samples. No other substantial group differences were observed. Conclusions: The findings indicate that an increased tendency for local processing in terms of visual disembedding could be a relatively specific core feature of the broader cognitive phenotype of autism in parents. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01603.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=749

Elucidating brain-behaviour relationship in child psychiatric disorders and its clinical impact / Aribert ROTHENBERGER in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.535–536 Titre : Elucidating brain-behaviour relationship in child psychiatric disorders and its clinical impact Type de document : Texte imprimé et/ou numérique Auteurs : Aribert ROTHENBERGER, Auteur Année de publication : 2006 Article en page(s) : p.535–536 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01642.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Elucidating brain-behaviour relationship in child psychiatric disorders and its clinical impact [Texte imprimé et/ou numérique] / Aribert ROTHENBERGER, Auteur . - 2006 . - p.535–536. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.535–536 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01642.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422