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Auteur Nancy Raitano LEE |
Documents disponibles écrits par cet auteur (6)
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Cardiovascular disease risk factors in autistic adults: The impact of sleep quality and antipsychotic medication use / Lauren BISHOP in Autism Research, 16-3 (March 2023)
[article]
Titre : Cardiovascular disease risk factors in autistic adults: The impact of sleep quality and antipsychotic medication use Type de document : Texte imprimé et/ou numérique Auteurs : Lauren BISHOP, Auteur ; Rebecca A. CHARLTON, Auteur ; Kiley J. MCLEAN, Auteur ; Goldie A. MCQUAID, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.569-579 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Approximately 40% of American adults are affected by cardiovascular disease (CVD) risk factors (e.g., high blood pressure, high cholesterol, diabetes, and overweight or obesity), and risk among autistic adults may be even higher. Mechanisms underlying the high prevalence of CVD risk factors in autistic people may include known correlates of CVD risk factors in other groups, including high levels of perceived stress, poor sleep quality, and antipsychotic medication use. A sample of 545 autistic adults without intellectual disability aged 18+ were recruited through the Simons Foundation Powering Autism Research, Research Match. Multiple linear regression models examined the association between key independent variables (self-reported perceived stress, sleep quality, and antipsychotic medication use) and CVD risk factors, controlling for demographic variables (age, sex assigned at birth, race, low-income status, autistic traits). Overall, 73.2% of autistic adults in our sample had an overweight/obesity classification, 45.3% had high cholesterol, 39.4% had high blood pressure, and 10.3% had diabetes. Older age, male sex assigned at birth, and poorer sleep quality were associated with a higher number of CVD risk factors. Using antipsychotic medications was associated with an increased likelihood of having diabetes. Poorer sleep quality was associated with an increased likelihood of having an overweight/obesity classification. Self-reported CVD risk factors are highly prevalent among autistic adults. Both improving sleep quality and closely monitoring CVD risk factors among autistic adults who use antipsychotic medications have the potential to reduce risk for CVD. En ligne : https://doi.org/10.1002/aur.2872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498
in Autism Research > 16-3 (March 2023) . - p.569-579[article] Cardiovascular disease risk factors in autistic adults: The impact of sleep quality and antipsychotic medication use [Texte imprimé et/ou numérique] / Lauren BISHOP, Auteur ; Rebecca A. CHARLTON, Auteur ; Kiley J. MCLEAN, Auteur ; Goldie A. MCQUAID, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur . - p.569-579.
Langues : Anglais (eng)
in Autism Research > 16-3 (March 2023) . - p.569-579
Index. décimale : PER Périodiques Résumé : Abstract Approximately 40% of American adults are affected by cardiovascular disease (CVD) risk factors (e.g., high blood pressure, high cholesterol, diabetes, and overweight or obesity), and risk among autistic adults may be even higher. Mechanisms underlying the high prevalence of CVD risk factors in autistic people may include known correlates of CVD risk factors in other groups, including high levels of perceived stress, poor sleep quality, and antipsychotic medication use. A sample of 545 autistic adults without intellectual disability aged 18+ were recruited through the Simons Foundation Powering Autism Research, Research Match. Multiple linear regression models examined the association between key independent variables (self-reported perceived stress, sleep quality, and antipsychotic medication use) and CVD risk factors, controlling for demographic variables (age, sex assigned at birth, race, low-income status, autistic traits). Overall, 73.2% of autistic adults in our sample had an overweight/obesity classification, 45.3% had high cholesterol, 39.4% had high blood pressure, and 10.3% had diabetes. Older age, male sex assigned at birth, and poorer sleep quality were associated with a higher number of CVD risk factors. Using antipsychotic medications was associated with an increased likelihood of having diabetes. Poorer sleep quality was associated with an increased likelihood of having an overweight/obesity classification. Self-reported CVD risk factors are highly prevalent among autistic adults. Both improving sleep quality and closely monitoring CVD risk factors among autistic adults who use antipsychotic medications have the potential to reduce risk for CVD. En ligne : https://doi.org/10.1002/aur.2872 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=498 Co-occurring ADHD symptoms in autistic adults are associated with less independence in daily living activities and lower subjective quality of life / Benjamin E. YERYS in Autism, 26-8 (November 2022)
[article]
Titre : Co-occurring ADHD symptoms in autistic adults are associated with less independence in daily living activities and lower subjective quality of life Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin E. YERYS, Auteur ; Goldie A. MCQUAID, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.2188-2195 Langues : Anglais (eng) Mots-clés : Adult Humans Female Male Attention Deficit Disorder with Hyperactivity/complications/epidemiology/diagnosis Autistic Disorder/complications/epidemiology/diagnosis Activities of Daily Living/psychology Quality of Life Autism Spectrum Disorder/complications/epidemiology/diagnosis attention-deficit/hyperactivity disorder autism daily living skills Index. décimale : PER Périodiques Résumé : Outcomes for autistic adults are generally poor, including activities of daily living and self-ratings of quality of life. Co-occurring psychiatric conditions contribute to these poor outcomes. Attention-deficit/hyperactivity disorder is one of the most common co-occurring conditions in autistic individuals. However, we know little about the association between attention-deficit/hyperactivity disorder symptoms and outcomes in autistic adults. A total of 724 autistic adults (18-83 years; 58% female) recruited from the Simons Foundation Powering Autism Research participant registry completed questionnaires on demographics, co-occurring psychiatric conditions, activities of daily living, and subjective quality of life. Autistic adults who rated themselves as having more attention-deficit/hyperactivity disorder symptoms also rated themselves as having less independence in activities of daily living and a lower quality of life. This is the first study to show these relationships in autistic adults. These findings highlight that additional research and better supports for co-occurring attention-deficit/hyperactivity disorder symptoms may be critical to improving independence and quality of life for autistic adults. En ligne : http://dx.doi.org/10.1177/13623613221112198 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism > 26-8 (November 2022) . - p.2188-2195[article] Co-occurring ADHD symptoms in autistic adults are associated with less independence in daily living activities and lower subjective quality of life [Texte imprimé et/ou numérique] / Benjamin E. YERYS, Auteur ; Goldie A. MCQUAID, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur . - p.2188-2195.
Langues : Anglais (eng)
in Autism > 26-8 (November 2022) . - p.2188-2195
Mots-clés : Adult Humans Female Male Attention Deficit Disorder with Hyperactivity/complications/epidemiology/diagnosis Autistic Disorder/complications/epidemiology/diagnosis Activities of Daily Living/psychology Quality of Life Autism Spectrum Disorder/complications/epidemiology/diagnosis attention-deficit/hyperactivity disorder autism daily living skills Index. décimale : PER Périodiques Résumé : Outcomes for autistic adults are generally poor, including activities of daily living and self-ratings of quality of life. Co-occurring psychiatric conditions contribute to these poor outcomes. Attention-deficit/hyperactivity disorder is one of the most common co-occurring conditions in autistic individuals. However, we know little about the association between attention-deficit/hyperactivity disorder symptoms and outcomes in autistic adults. A total of 724 autistic adults (18-83 years; 58% female) recruited from the Simons Foundation Powering Autism Research participant registry completed questionnaires on demographics, co-occurring psychiatric conditions, activities of daily living, and subjective quality of life. Autistic adults who rated themselves as having more attention-deficit/hyperactivity disorder symptoms also rated themselves as having less independence in activities of daily living and a lower quality of life. This is the first study to show these relationships in autistic adults. These findings highlight that additional research and better supports for co-occurring attention-deficit/hyperactivity disorder symptoms may be critical to improving independence and quality of life for autistic adults. En ligne : http://dx.doi.org/10.1177/13623613221112198 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Increased anticholinergic medication use in middle-aged and older autistic adults and its associations with self-reported memory difficulties and cognitive decline / Goldie A. MCQUAID in Autism Research, 17-4 (April 2024)
[article]
Titre : Increased anticholinergic medication use in middle-aged and older autistic adults and its associations with self-reported memory difficulties and cognitive decline Type de document : Texte imprimé et/ou numérique Auteurs : Goldie A. MCQUAID, Auteur ; Sean C. DUANE, Auteur ; Neha AHMED, Auteur ; Nancy Raitano LEE, Auteur ; Rebecca CHARLTON, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.852-867 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Many commonly used prescription and over-the-counter medicines have potent anticholinergic (AC) effects. Among older adults, AC medications are associated with cognitive impairment and risk for cognitive disorders, including Alzheimer's disease. Collectively, the impact of AC medications is known as anticholinergic cognitive burden (ACB). Because of the high rates of co-occurring medical and psychiatric conditions, autistic adults may have high AC exposure and, thus, may experience elevated ACB. However, no research has characterized AC exposure or examined its associations with cognitive outcomes in autistic adults. Autistic adults (40-83?years) recruited via Simons Powering Autism Research's (SPARK) Research Match service self-reported their medication use (N = 415) and memory complaints (N = 382) at Time (T)1. At T2, 2?years later, a subset of T1 participants (N = 197) self-reported on decline in cognition. Medications were coded using two scales of AC potency. A high proportion (48.2%-62.9%, depending upon the AC potency scale) of autistic adults reported taking at least one medication with AC effects, and 20.5% to 26.5% of autistic adults reported clinically-relevant levels of AC medication (potency ?3). After controlling for birth-sex, and age, hierarchical linear regression models showed total ACB scores and AC potency values of ?3 predicted greater memory complaints. Logistic regression models showed that AC medicines at T1 were associated with self-reported cognitive decline at follow-up 2?years later. Understanding AC medications-including potentially earlier AC polypharmacy-and their impacts on cognition (e.g., dementia risk) in autistic adults is warranted. En ligne : https://doi.org/10.1002/aur.3076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526
in Autism Research > 17-4 (April 2024) . - p.852-867[article] Increased anticholinergic medication use in middle-aged and older autistic adults and its associations with self-reported memory difficulties and cognitive decline [Texte imprimé et/ou numérique] / Goldie A. MCQUAID, Auteur ; Sean C. DUANE, Auteur ; Neha AHMED, Auteur ; Nancy Raitano LEE, Auteur ; Rebecca CHARLTON, Auteur ; Gregory L. WALLACE, Auteur . - p.852-867.
Langues : Anglais (eng)
in Autism Research > 17-4 (April 2024) . - p.852-867
Index. décimale : PER Périodiques Résumé : Abstract Many commonly used prescription and over-the-counter medicines have potent anticholinergic (AC) effects. Among older adults, AC medications are associated with cognitive impairment and risk for cognitive disorders, including Alzheimer's disease. Collectively, the impact of AC medications is known as anticholinergic cognitive burden (ACB). Because of the high rates of co-occurring medical and psychiatric conditions, autistic adults may have high AC exposure and, thus, may experience elevated ACB. However, no research has characterized AC exposure or examined its associations with cognitive outcomes in autistic adults. Autistic adults (40-83?years) recruited via Simons Powering Autism Research's (SPARK) Research Match service self-reported their medication use (N = 415) and memory complaints (N = 382) at Time (T)1. At T2, 2?years later, a subset of T1 participants (N = 197) self-reported on decline in cognition. Medications were coded using two scales of AC potency. A high proportion (48.2%-62.9%, depending upon the AC potency scale) of autistic adults reported taking at least one medication with AC effects, and 20.5% to 26.5% of autistic adults reported clinically-relevant levels of AC medication (potency ?3). After controlling for birth-sex, and age, hierarchical linear regression models showed total ACB scores and AC potency values of ?3 predicted greater memory complaints. Logistic regression models showed that AC medicines at T1 were associated with self-reported cognitive decline at follow-up 2?years later. Understanding AC medications-including potentially earlier AC polypharmacy-and their impacts on cognition (e.g., dementia risk) in autistic adults is warranted. En ligne : https://doi.org/10.1002/aur.3076 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 Increased perceived stress is negatively associated with activities of daily living and subjective quality of life in younger, middle, and older autistic adults / Goldie A. MCQUAID in Autism Research, 15-8 (August 2022)
[article]
Titre : Increased perceived stress is negatively associated with activities of daily living and subjective quality of life in younger, middle, and older autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : Goldie A. MCQUAID, Auteur ; Colin H. WEISS, Auteur ; Alex Job SAID, Auteur ; Kevin A. PELPHREY, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.1535-1549 Langues : Anglais (eng) Mots-clés : Activities of Daily Living Adult Aged Autism Spectrum Disorder/psychology Autistic Disorder/psychology Female Humans Infant, Newborn Male Quality of Life/psychology Stress, Psychological/complications/epidemiology/psychology adulthood autism perceived stress subjective quality of life Index. décimale : PER Périodiques Résumé : Few studies have examined self-reported perceived stress in autistic adults. Existing studies have included relatively small, predominantly male samples and have not included older autistic adults. Using a large autistic sample (NÂ =Â 713), enriched for individuals designated female at birth (59.3%), and spanning younger, middle, and older adulthood, we examined perceived stress and its associations with independence in activities of daily living and subjective quality of life (QoL). Perceived stress for autistic adults designated male or female at birth was compared to their same birth-sex counterparts in a general population sample. In addition, within the autistic sample, effects of sex designated at birth, age, and their interaction were examined. Regression modeling examined associations between perceived stress and independence in activities of daily living and domains of subjective QoL in autistic adults, after controlling for age, sex designated at birth, and household income. Autistic adults reported significantly greater perceived stress than a general population comparison sample. Relative to autistic adults designated male at birth, those designated female at birth demonstrated significantly elevated perceived stress. Perceived stress contributed significantly to all regression models, with greater perceived stress associated with less independence in activities of daily living, and poorer subjective QoL across all domains-Physical, Psychological, Social, Environment, and Autism-related QoL. Findings are contextualized within the literature documenting that autistic individuals experience elevated underemployment and unemployment, heightened rates of adverse life events, and increased exposure to minority stress. LAY SUMMARY: This study looked at self-reported perceived stress in a large sample of autistic adults. Autistic adults reported more perceived stress than non-autistic adults. Autistic individuals designated female at birth reported higher stress than autistic individuals designated male at birth. In autistic adults, greater perceived stress is related to less independence in activities of daily living and poorer subjective quality of life. En ligne : http://dx.doi.org/10.1002/aur.2779 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483
in Autism Research > 15-8 (August 2022) . - p.1535-1549[article] Increased perceived stress is negatively associated with activities of daily living and subjective quality of life in younger, middle, and older autistic adults [Texte imprimé et/ou numérique] / Goldie A. MCQUAID, Auteur ; Colin H. WEISS, Auteur ; Alex Job SAID, Auteur ; Kevin A. PELPHREY, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur . - p.1535-1549.
Langues : Anglais (eng)
in Autism Research > 15-8 (August 2022) . - p.1535-1549
Mots-clés : Activities of Daily Living Adult Aged Autism Spectrum Disorder/psychology Autistic Disorder/psychology Female Humans Infant, Newborn Male Quality of Life/psychology Stress, Psychological/complications/epidemiology/psychology adulthood autism perceived stress subjective quality of life Index. décimale : PER Périodiques Résumé : Few studies have examined self-reported perceived stress in autistic adults. Existing studies have included relatively small, predominantly male samples and have not included older autistic adults. Using a large autistic sample (NÂ =Â 713), enriched for individuals designated female at birth (59.3%), and spanning younger, middle, and older adulthood, we examined perceived stress and its associations with independence in activities of daily living and subjective quality of life (QoL). Perceived stress for autistic adults designated male or female at birth was compared to their same birth-sex counterparts in a general population sample. In addition, within the autistic sample, effects of sex designated at birth, age, and their interaction were examined. Regression modeling examined associations between perceived stress and independence in activities of daily living and domains of subjective QoL in autistic adults, after controlling for age, sex designated at birth, and household income. Autistic adults reported significantly greater perceived stress than a general population comparison sample. Relative to autistic adults designated male at birth, those designated female at birth demonstrated significantly elevated perceived stress. Perceived stress contributed significantly to all regression models, with greater perceived stress associated with less independence in activities of daily living, and poorer subjective QoL across all domains-Physical, Psychological, Social, Environment, and Autism-related QoL. Findings are contextualized within the literature documenting that autistic individuals experience elevated underemployment and unemployment, heightened rates of adverse life events, and increased exposure to minority stress. LAY SUMMARY: This study looked at self-reported perceived stress in a large sample of autistic adults. Autistic adults reported more perceived stress than non-autistic adults. Autistic individuals designated female at birth reported higher stress than autistic individuals designated male at birth. In autistic adults, greater perceived stress is related to less independence in activities of daily living and poorer subjective quality of life. En ligne : http://dx.doi.org/10.1002/aur.2779 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 Predictors of sleep quality for autistic people across adulthood / Rebecca A. CHARLTON in Autism Research, 16-4 (April 2023)
[article]
Titre : Predictors of sleep quality for autistic people across adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca A. CHARLTON, Auteur ; Goldie A. MCQUAID, Auteur ; Lauren BISHOP, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur Article en page(s) : p.757-771 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Poor sleep can have a significant impact on physical health and well-being. Sleep problems are common among autistic children, but less is known about sleep across the autistic adult lifespan. Autistic adults (n = 730, aged 18-78?years) were recruited via Simons Powering Autism Research for Knowledge Research Match. Participants completed online surveys asking about demographics, health problems, social support, symptoms of anxiety and depression, and overall and specific aspects of sleep quality. Regression analyses explored the variables associated with sleep quality. Physical health, assigned female sex at birth and self-reported anxiety symptoms significantly contributed to models for all aspects of sleep. Perceived stress contributed to models of overall and subjective sleep quality, and daytime dysfunction. Depression symptoms did not contribute significantly to any of the models of sleep quality. However, utilizing government support mechanisms (such as social security) contributed to the model of sleep efficiency. Age contributed little to models of sleep quality, whereas perceived stress and psychotropic medication use contributed to some but not all aspects of sleep. Sleep quality is poor for autistic people across the adult lifespan. Given known impacts of poor sleep on health, cognition and quality of life, attention should be paid to sleep and its possible everyday effects for autistic people of all ages. En ligne : https://doi.org/10.1002/aur.2891 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499
in Autism Research > 16-4 (April 2023) . - p.757-771[article] Predictors of sleep quality for autistic people across adulthood [Texte imprimé et/ou numérique] / Rebecca A. CHARLTON, Auteur ; Goldie A. MCQUAID, Auteur ; Lauren BISHOP, Auteur ; Nancy Raitano LEE, Auteur ; Gregory L. WALLACE, Auteur . - p.757-771.
Langues : Anglais (eng)
in Autism Research > 16-4 (April 2023) . - p.757-771
Index. décimale : PER Périodiques Résumé : Abstract Poor sleep can have a significant impact on physical health and well-being. Sleep problems are common among autistic children, but less is known about sleep across the autistic adult lifespan. Autistic adults (n = 730, aged 18-78?years) were recruited via Simons Powering Autism Research for Knowledge Research Match. Participants completed online surveys asking about demographics, health problems, social support, symptoms of anxiety and depression, and overall and specific aspects of sleep quality. Regression analyses explored the variables associated with sleep quality. Physical health, assigned female sex at birth and self-reported anxiety symptoms significantly contributed to models for all aspects of sleep. Perceived stress contributed to models of overall and subjective sleep quality, and daytime dysfunction. Depression symptoms did not contribute significantly to any of the models of sleep quality. However, utilizing government support mechanisms (such as social security) contributed to the model of sleep efficiency. Age contributed little to models of sleep quality, whereas perceived stress and psychotropic medication use contributed to some but not all aspects of sleep. Sleep quality is poor for autistic people across the adult lifespan. Given known impacts of poor sleep on health, cognition and quality of life, attention should be paid to sleep and its possible everyday effects for autistic people of all ages. En ligne : https://doi.org/10.1002/aur.2891 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 Self-reported memory of autistic young adults and associated real-world outcomes / Goldie A. MCQUAID ; Gregory L. WALLACE ; Nancy Raitano LEE in Research in Autism Spectrum Disorders, 109 (November 2023)
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