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Auteur Nurit YIRMIYA |
Documents disponibles écrits par cet auteur (32)
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Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study / Elad LERER in Autism Research, 3-6 (December 2010)
[article]
Titre : Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study Type de document : Texte imprimé et/ou numérique Auteurs : Elad LERER, Auteur ; Shlomit LEVI, Auteur ; Salomon ISRAEL, Auteur ; Maya YAARI, Auteur ; Lubov NEMANOV, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2010 Article en page(s) : p.293-302 Langues : Anglais (eng) Mots-clés : autism spectrum disorder (ASD) CD38;polymorphism gene expression real time PCR haplotype Index. décimale : PER Périodiques Résumé : Background: Impairments in social processes characterize one of the core deficits in autism spectrum disorders (ASD) and accumulating evidence suggests that oxytocin neurotransmission is implicated in mediating social adaptation in ASD. Using a mouse model, CD38, a transmembrane protein expressed in immune cells but also in brain, was found to be critical for social behavior via regulation of oxytocin secretion. This prompted us to both examine CD38 expression in human lymphoblastoid cell lines (LBC) as well as to test association between SNPs across the CD38 gene and ASD. Methods: LBC's were derived from 44 ASD lines and 40 “unaffected” parents. Family-based association (UNPHASED) was examined by genotyping 11 tagging SNPs spanning the CD38 gene identified using HapMap data in 170 trios. An additional SNP (rs3796863) associated in a study by Munesue et al. with ASD was also genotyped. Results: A highly significant reduction in CD38 expression was observed in immortalized lymphocytes derived from ASD subjects compared to their “unaffected” parents (F = 17.2, P = 0.00024, df = 1). Haplotype analysis showed significant association (permutation corrected) between three and seven locus haplotypes and DSM IV ASD in low functioning (IQ<70) subjects. Conclusions: The current report supports a role for CD38 in conferring risk for ASD. Notably, our study shows that this gene is not only associated with low functioning ASD but that CD38 expression is markedly reduced in LBC derived from ASD subjects compared to “unaffected” parents, strengthening the connection between oxytocin and ASD. En ligne : http://dx.doi.org/10.1002/aur.156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Autism Research > 3-6 (December 2010) . - p.293-302[article] Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study [Texte imprimé et/ou numérique] / Elad LERER, Auteur ; Shlomit LEVI, Auteur ; Salomon ISRAEL, Auteur ; Maya YAARI, Auteur ; Lubov NEMANOV, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur ; Richard P. EBSTEIN, Auteur . - 2010 . - p.293-302.
Langues : Anglais (eng)
in Autism Research > 3-6 (December 2010) . - p.293-302
Mots-clés : autism spectrum disorder (ASD) CD38;polymorphism gene expression real time PCR haplotype Index. décimale : PER Périodiques Résumé : Background: Impairments in social processes characterize one of the core deficits in autism spectrum disorders (ASD) and accumulating evidence suggests that oxytocin neurotransmission is implicated in mediating social adaptation in ASD. Using a mouse model, CD38, a transmembrane protein expressed in immune cells but also in brain, was found to be critical for social behavior via regulation of oxytocin secretion. This prompted us to both examine CD38 expression in human lymphoblastoid cell lines (LBC) as well as to test association between SNPs across the CD38 gene and ASD. Methods: LBC's were derived from 44 ASD lines and 40 “unaffected” parents. Family-based association (UNPHASED) was examined by genotyping 11 tagging SNPs spanning the CD38 gene identified using HapMap data in 170 trios. An additional SNP (rs3796863) associated in a study by Munesue et al. with ASD was also genotyped. Results: A highly significant reduction in CD38 expression was observed in immortalized lymphocytes derived from ASD subjects compared to their “unaffected” parents (F = 17.2, P = 0.00024, df = 1). Haplotype analysis showed significant association (permutation corrected) between three and seven locus haplotypes and DSM IV ASD in low functioning (IQ<70) subjects. Conclusions: The current report supports a role for CD38 in conferring risk for ASD. Notably, our study shows that this gene is not only associated with low functioning ASD but that CD38 expression is markedly reduced in LBC derived from ASD subjects compared to “unaffected” parents, strengthening the connection between oxytocin and ASD. En ligne : http://dx.doi.org/10.1002/aur.156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Mothers of securely attached children with autism spectrum disorder are more sensitive than mothers of insecurely attached children / Nina KOREN-KARIE in Journal of Child Psychology and Psychiatry, 50-5 (May 2009)
[article]
Titre : Mothers of securely attached children with autism spectrum disorder are more sensitive than mothers of insecurely attached children Type de document : Texte imprimé et/ou numérique Auteurs : Nina KOREN-KARIE, Auteur ; Nurit YIRMIYA, Auteur ; David OPPENHEIM, Auteur ; Smadar DOLEV, Auteur Année de publication : 2009 Article en page(s) : p.643-650 Langues : Anglais (eng) Mots-clés : Attachment autistic-disorder maternal-sensitivity parent–child interaction parent–child-relationships Index. décimale : PER Périodiques Résumé : In the current study we examined the links between maternal sensitivity and children's secure attachment in a sample of 45 preschool-age boys with Autism Spectrum Disorders (ASD). We hypothesized that mothers of securely attached children would be more sensitive to their children than mothers of insecurely attached children. Children's attachment was assessed using Ainsworth's Strange Situation Procedure (SSP; Ainsworth, Blehar, Waters, & Wall, 1978). Mothers' sensitivity and children's responsiveness to their mothers were assessed using the Emotional Availability Scales (Biringen, Robinson, & Emde, 1993). The findings supported our hypothesis: mothers of securely attached children were more sensitive to their children even when controlling for the severity of children's diagnosis (Autism Disorder vs. Pervasive Developmental Disorder – Not Otherwise Specified (PDD-NOS)), children's level of functioning (high vs. low), and children's levels of responsiveness. The significance of sensitivity for security of attachment in ASD and the implications of these findings for the validity of the SSP in children with ASD are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02043.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732
in Journal of Child Psychology and Psychiatry > 50-5 (May 2009) . - p.643-650[article] Mothers of securely attached children with autism spectrum disorder are more sensitive than mothers of insecurely attached children [Texte imprimé et/ou numérique] / Nina KOREN-KARIE, Auteur ; Nurit YIRMIYA, Auteur ; David OPPENHEIM, Auteur ; Smadar DOLEV, Auteur . - 2009 . - p.643-650.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 50-5 (May 2009) . - p.643-650
Mots-clés : Attachment autistic-disorder maternal-sensitivity parent–child interaction parent–child-relationships Index. décimale : PER Périodiques Résumé : In the current study we examined the links between maternal sensitivity and children's secure attachment in a sample of 45 preschool-age boys with Autism Spectrum Disorders (ASD). We hypothesized that mothers of securely attached children would be more sensitive to their children than mothers of insecurely attached children. Children's attachment was assessed using Ainsworth's Strange Situation Procedure (SSP; Ainsworth, Blehar, Waters, & Wall, 1978). Mothers' sensitivity and children's responsiveness to their mothers were assessed using the Emotional Availability Scales (Biringen, Robinson, & Emde, 1993). The findings supported our hypothesis: mothers of securely attached children were more sensitive to their children even when controlling for the severity of children's diagnosis (Autism Disorder vs. Pervasive Developmental Disorder – Not Otherwise Specified (PDD-NOS)), children's level of functioning (high vs. low), and children's levels of responsiveness. The significance of sensitivity for security of attachment in ASD and the implications of these findings for the validity of the SSP in children with ASD are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02043.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732 Neuropsychological Functioning of Siblings of Children with Autism, Siblings of Children with Developmental language Delay, and Siblings of Children with Mental Retardation of Unknown Genetic Etiology / Tammy PILOWSKY in Journal of Autism and Developmental Disorders, 37-3 (March 2007)
[article]
Titre : Neuropsychological Functioning of Siblings of Children with Autism, Siblings of Children with Developmental language Delay, and Siblings of Children with Mental Retardation of Unknown Genetic Etiology Type de document : Texte imprimé et/ou numérique Auteurs : Tammy PILOWSKY, Auteur ; Nurit YIRMIYA, Auteur ; Varda GROSS-TSUR, Auteur ; Ruth S. SHALEV, Auteur Année de publication : 2007 Article en page(s) : p.537-552 Langues : Anglais (eng) Mots-clés : Behavioral-genetics Intelligence Neuropsychological-functioning Broad-phenotype Index. décimale : PER Périodiques Résumé : Neuropsychological functioning of 30 siblings of children with autism (AU-S), 28 siblings of children with mental retardation of (MR-S), and 30 siblings of children with developmental language delay (DLD-S) was compared. Two siblings, both AU-S, received diagnoses of pervasive developmental disorder (PDD). More siblings with cognitive disabilities were found in DLD-S than in AU-S. However, these differences disappeared after excluding diagnosed siblings or after accounting for family membership. In sum, despite the elevated incidence of PDD among AU-S, the neuropsychological functioning of the remaining siblings did not convey specific characteristics related to the genetic risk associated with autism, in contrast to the cognitive functioning of the DLD-S, which did reflect a genetic risk.
En ligne : http://dx.doi.org/10.1007/s10803-006-0185-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=657
in Journal of Autism and Developmental Disorders > 37-3 (March 2007) . - p.537-552[article] Neuropsychological Functioning of Siblings of Children with Autism, Siblings of Children with Developmental language Delay, and Siblings of Children with Mental Retardation of Unknown Genetic Etiology [Texte imprimé et/ou numérique] / Tammy PILOWSKY, Auteur ; Nurit YIRMIYA, Auteur ; Varda GROSS-TSUR, Auteur ; Ruth S. SHALEV, Auteur . - 2007 . - p.537-552.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 37-3 (March 2007) . - p.537-552
Mots-clés : Behavioral-genetics Intelligence Neuropsychological-functioning Broad-phenotype Index. décimale : PER Périodiques Résumé : Neuropsychological functioning of 30 siblings of children with autism (AU-S), 28 siblings of children with mental retardation of (MR-S), and 30 siblings of children with developmental language delay (DLD-S) was compared. Two siblings, both AU-S, received diagnoses of pervasive developmental disorder (PDD). More siblings with cognitive disabilities were found in DLD-S than in AU-S. However, these differences disappeared after excluding diagnosed siblings or after accounting for family membership. In sum, despite the elevated incidence of PDD among AU-S, the neuropsychological functioning of the remaining siblings did not convey specific characteristics related to the genetic risk associated with autism, in contrast to the cognitive functioning of the DLD-S, which did reflect a genetic risk.
En ligne : http://dx.doi.org/10.1007/s10803-006-0185-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=657 Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study / Tony CHARMAN in Autism Research, 10-1 (January 2017)
[article]
Titre : Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study Type de document : Texte imprimé et/ou numérique Auteurs : Tony CHARMAN, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Emily J. H. JONES, Auteur ; Rebecca LANDA, Auteur ; Suzanne MACARI, Auteur ; Daniel S. MESSINGER, Auteur ; Charles A. NELSON, Auteur ; Sally OZONOFF, Auteur ; Celine A. SAULNIER, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Sara Jane WEBB, Auteur ; Nurit YIRMIYA, Auteur ; Lonnie ZWAIGENBAUM, Auteur Article en page(s) : p.169-178 Langues : Anglais (eng) Mots-clés : autism spectrum disorder broader autism phenotype developmental outcomes high risk siblings adaptive functioning Index. décimale : PER Périodiques Résumé : We characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n?=?859), and low-risk controls with no family history of ASD (n?=?473). We report outcomes at age 3 years using the Mullen Scales of Early Learning, the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview—Revised (ADI-R) and adaptive functioning on the Vineland Adaptive Behavior Scales. Around 11% of high-risk siblings had mild-to-moderate levels of developmental delay, a rate higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. Thirty percent of high-risk siblings had elevated scores on the ADOS, double the rate seen in the low-risk controls. High-risk siblings also had higher parent reported levels of ASD symptoms on the ADI-R and lower adaptive functioning on the Vineland. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures but not mild-to-moderate language delay. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. These findings are evidence for early emerging characteristics related to the “broader autism phenotype” (BAP) previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not have an ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes. En ligne : http://dx.doi.org/10.1002/aur.1669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-1 (January 2017) . - p.169-178[article] Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study [Texte imprimé et/ou numérique] / Tony CHARMAN, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Emily J. H. JONES, Auteur ; Rebecca LANDA, Auteur ; Suzanne MACARI, Auteur ; Daniel S. MESSINGER, Auteur ; Charles A. NELSON, Auteur ; Sally OZONOFF, Auteur ; Celine A. SAULNIER, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Sara Jane WEBB, Auteur ; Nurit YIRMIYA, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - p.169-178.
Langues : Anglais (eng)
in Autism Research > 10-1 (January 2017) . - p.169-178
Mots-clés : autism spectrum disorder broader autism phenotype developmental outcomes high risk siblings adaptive functioning Index. décimale : PER Périodiques Résumé : We characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n?=?859), and low-risk controls with no family history of ASD (n?=?473). We report outcomes at age 3 years using the Mullen Scales of Early Learning, the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview—Revised (ADI-R) and adaptive functioning on the Vineland Adaptive Behavior Scales. Around 11% of high-risk siblings had mild-to-moderate levels of developmental delay, a rate higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. Thirty percent of high-risk siblings had elevated scores on the ADOS, double the rate seen in the low-risk controls. High-risk siblings also had higher parent reported levels of ASD symptoms on the ADI-R and lower adaptive functioning on the Vineland. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures but not mild-to-moderate language delay. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. These findings are evidence for early emerging characteristics related to the “broader autism phenotype” (BAP) previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not have an ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes. En ligne : http://dx.doi.org/10.1002/aur.1669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 Parental insightfulness is associated with mother-father-child interactions among families of preschoolers with an Autism Spectrum Disorder diagnosis / David OPPENHEIM in Journal of Child Psychology and Psychiatry, 64-9 (September 2023)
[article]
Titre : Parental insightfulness is associated with mother-father-child interactions among families of preschoolers with an Autism Spectrum Disorder diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : David OPPENHEIM, Auteur ; Nina KOREN-KARIE, Auteur ; Lior HAMBURGER, Auteur ; Yael MACCABI, Auteur ; Michal SLONIM, Auteur ; Nurit YIRMIYA, Auteur Article en page(s) : p.1359-1368 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Parental insightfulness underlies parental sensitive behavior and is associated with secure attachment among Typically Developing (TD) children and also among children with Autism Spectrum Disorder (ASD). Moving beyond the parent-child dyad, a study of TD children and their parents linked mothers' and fathers' combined insightfulness to triadic interactions. The goal of the current study was to examine this association in families with children with ASD. The hypothesis was that the interactions in families in which both parents are insightful will be more cooperative than in families in which only one or neither parent was insightful. Methods Eighty preschooler boys with ASD and both of their parents participated in the study. Parental insightfulness was assessed employing the Insightfulness Assessment (IA) and mother-father-child interactions were observed and coded employing the Lausanne Triadic Play (LTP) procedure. Results As expected, families in which both parents were insightful displayed higher parental coordinated support in the LTP than families in which one or neither parent was insightful, controlling for children's IQ and severity of symptoms. Children's engagement with their parents was associated with their IQ and severity of symptoms but not with parental insightfulness. Conclusions The importance of considering paternal, in addition to maternal insightfulness as a foundation for parental coordinated support in family interactions, is discussed, as well as the contribution of the LTP in assessing family interactions with children diagnosed with ASD. En ligne : https://doi.org/10.1111/jcpp.13788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512
in Journal of Child Psychology and Psychiatry > 64-9 (September 2023) . - p.1359-1368[article] Parental insightfulness is associated with mother-father-child interactions among families of preschoolers with an Autism Spectrum Disorder diagnosis [Texte imprimé et/ou numérique] / David OPPENHEIM, Auteur ; Nina KOREN-KARIE, Auteur ; Lior HAMBURGER, Auteur ; Yael MACCABI, Auteur ; Michal SLONIM, Auteur ; Nurit YIRMIYA, Auteur . - p.1359-1368.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 64-9 (September 2023) . - p.1359-1368
Index. décimale : PER Périodiques Résumé : Background Parental insightfulness underlies parental sensitive behavior and is associated with secure attachment among Typically Developing (TD) children and also among children with Autism Spectrum Disorder (ASD). Moving beyond the parent-child dyad, a study of TD children and their parents linked mothers' and fathers' combined insightfulness to triadic interactions. The goal of the current study was to examine this association in families with children with ASD. The hypothesis was that the interactions in families in which both parents are insightful will be more cooperative than in families in which only one or neither parent was insightful. Methods Eighty preschooler boys with ASD and both of their parents participated in the study. Parental insightfulness was assessed employing the Insightfulness Assessment (IA) and mother-father-child interactions were observed and coded employing the Lausanne Triadic Play (LTP) procedure. Results As expected, families in which both parents were insightful displayed higher parental coordinated support in the LTP than families in which one or neither parent was insightful, controlling for children's IQ and severity of symptoms. Children's engagement with their parents was associated with their IQ and severity of symptoms but not with parental insightfulness. Conclusions The importance of considering paternal, in addition to maternal insightfulness as a foundation for parental coordinated support in family interactions, is discussed, as well as the contribution of the LTP in assessing family interactions with children diagnosed with ASD. En ligne : https://doi.org/10.1111/jcpp.13788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 Positive and challenging themes in parents' perceptions of their relationships with their child with autism: Comparison between mothers and fathers / Shir MOSHE in Autism, 28-3 (March 2024)
PermalinkPragmatic Language and School Related Linguistic Abilities in Siblings of Children with Autism / Noa BEN-YIZHAK in Journal of Autism and Developmental Disorders, 41-6 (June 2011)
PermalinkResolution of the Diagnosis Among Parents of Children with Autism Spectrum Disorder: Associations with Child and Parent Characteristics / Shahaf MILSHTEIN in Journal of Autism and Developmental Disorders, 40-1 (January 2010)
PermalinkRisk for ASD in Preterm Infants: A Three-Year Follow-Up Study / Ayelet HAREL-GADASSI in Autism Research and Treatment, 2018 (2018)
PermalinkSocial and Cognitive Understanding in High-Functioning Children with Autism / Marian SIGMAN
PermalinkStability and change in resolution of diagnosis among parents of children with autism spectrum disorder: Child and parental contributions / Nurit YIRMIYA in Development and Psychopathology, 27-4 (Part 1) (November 2015)
PermalinkStability of early risk assessment for autism spectrum disorder in preterm infants / Maya YAARI in Autism, 20-7 (October 2016)
PermalinkThe Broad Autism Phenotype Questionnaire: Mothers Versus Fathers of Children with an Autism Spectrum Disorder / Ifat SEIDMAN in Journal of Autism and Developmental Disorders, 42-5 (May 2012)
PermalinkThe Development of Autism / Jacob A. BURACK
PermalinkThe development of siblings of children with autism at 4 and 14 months: social engagement, communication, and cognition / Nurit YIRMIYA in Journal of Child Psychology and Psychiatry, 47-5 (May 2006)
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