Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
4 recherche sur le mot-clé 'high risk siblings'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study / Tony CHARMAN in Autism Research, 10-1 (January 2017)
[article]
Titre : Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study Type de document : Texte imprimé et/ou numérique Auteurs : Tony CHARMAN, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Emily J. H. JONES, Auteur ; Rebecca LANDA, Auteur ; Suzanne MACARI, Auteur ; Daniel S. MESSINGER, Auteur ; Charles A. NELSON, Auteur ; Sally OZONOFF, Auteur ; Celine A. SAULNIER, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Sara Jane WEBB, Auteur ; Nurit YIRMIYA, Auteur ; Lonnie ZWAIGENBAUM, Auteur Article en page(s) : p.169-178 Langues : Anglais (eng) Mots-clés : autism spectrum disorder broader autism phenotype developmental outcomes high risk siblings adaptive functioning Index. décimale : PER Périodiques Résumé : We characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n?=?859), and low-risk controls with no family history of ASD (n?=?473). We report outcomes at age 3 years using the Mullen Scales of Early Learning, the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview—Revised (ADI-R) and adaptive functioning on the Vineland Adaptive Behavior Scales. Around 11% of high-risk siblings had mild-to-moderate levels of developmental delay, a rate higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. Thirty percent of high-risk siblings had elevated scores on the ADOS, double the rate seen in the low-risk controls. High-risk siblings also had higher parent reported levels of ASD symptoms on the ADI-R and lower adaptive functioning on the Vineland. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures but not mild-to-moderate language delay. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. These findings are evidence for early emerging characteristics related to the “broader autism phenotype” (BAP) previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not have an ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes. En ligne : http://dx.doi.org/10.1002/aur.1669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-1 (January 2017) . - p.169-178[article] Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study [Texte imprimé et/ou numérique] / Tony CHARMAN, Auteur ; Gregory S. YOUNG, Auteur ; Jessica BRIAN, Auteur ; Alice S. CARTER, Auteur ; Leslie J. CARVER, Auteur ; Katarzyna CHAWARSKA, Auteur ; Suzanne CURTIN, Auteur ; Karen DOBKINS, Auteur ; Mayada ELSABBAGH, Auteur ; Stelios GEORGIADES, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Ted HUTMAN, Auteur ; Jana M. IVERSON, Auteur ; Emily J. H. JONES, Auteur ; Rebecca LANDA, Auteur ; Suzanne MACARI, Auteur ; Daniel S. MESSINGER, Auteur ; Charles A. NELSON, Auteur ; Sally OZONOFF, Auteur ; Celine A. SAULNIER, Auteur ; Wendy L. STONE, Auteur ; Helen TAGER-FLUSBERG, Auteur ; Sara Jane WEBB, Auteur ; Nurit YIRMIYA, Auteur ; Lonnie ZWAIGENBAUM, Auteur . - p.169-178.
Langues : Anglais (eng)
in Autism Research > 10-1 (January 2017) . - p.169-178
Mots-clés : autism spectrum disorder broader autism phenotype developmental outcomes high risk siblings adaptive functioning Index. décimale : PER Périodiques Résumé : We characterized developmental outcomes of a large sample of siblings at familial high-risk of autism spectrum disorder (ASD), who themselves did not have ASD (n?=?859), and low-risk controls with no family history of ASD (n?=?473). We report outcomes at age 3 years using the Mullen Scales of Early Learning, the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview—Revised (ADI-R) and adaptive functioning on the Vineland Adaptive Behavior Scales. Around 11% of high-risk siblings had mild-to-moderate levels of developmental delay, a rate higher than the low-risk controls. The groups did not differ in the proportion of toddlers with mild-to-moderate language delay. Thirty percent of high-risk siblings had elevated scores on the ADOS, double the rate seen in the low-risk controls. High-risk siblings also had higher parent reported levels of ASD symptoms on the ADI-R and lower adaptive functioning on the Vineland. Males were more likely to show higher levels of ASD symptoms and lower levels of developmental ability and adaptive behavior than females across most measures but not mild-to-moderate language delay. Lower maternal education was associated with lower developmental and adaptive behavior outcomes. These findings are evidence for early emerging characteristics related to the “broader autism phenotype” (BAP) previously described in older family members of individuals with ASD. There is a need for ongoing clinical monitoring of high-risk siblings who do not have an ASD by age 3 years, as well as continued follow-up into school age to determine their developmental and behavioral outcomes. En ligne : http://dx.doi.org/10.1002/aur.1669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 Parents' Use of Internal State Language with Toddlers at High and Low Genetic Risk for Autism Spectrum Disorder / S. B. CAMPBELL in Journal of Autism and Developmental Disorders, 49-4 (April 2019)
[article]
Titre : Parents' Use of Internal State Language with Toddlers at High and Low Genetic Risk for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. B. CAMPBELL, Auteur ; A. S. MAHONEY, Auteur ; Celia A. BROWNELL, Auteur ; E. L. MOORE, Auteur ; A. B. TAVARES, Auteur Article en page(s) : p.1366-1377 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Children's state words High risk siblings Parents' internal state language Index. décimale : PER Périodiques Résumé : Parents of toddlers with an older sibling with autism spectrum disorder (ASD; high risk, HR) and parents of low risk (LR) toddlers with typically-developing older siblings read a wordless picture book to their child at 22 and 28 months. Parents' and toddlers' internal state language (ISL) was coded; parents reported on toddlers' use of ISL. Diagnostic assessments conducted at 36 months identified three groups: ASD, HR-noASD, LR. Parents did not differ in overall ISL, but parents of toddlers with later ASD attempted to elicit ISL from their children less than parents of LR toddlers. Toddlers increased their use of ISL with age, but those with ASD had lower scores and less age-related improvement than children in the other two groups. En ligne : https://dx.doi.org/10.1007/s10803-018-3839-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388
in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1366-1377[article] Parents' Use of Internal State Language with Toddlers at High and Low Genetic Risk for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / S. B. CAMPBELL, Auteur ; A. S. MAHONEY, Auteur ; Celia A. BROWNELL, Auteur ; E. L. MOORE, Auteur ; A. B. TAVARES, Auteur . - p.1366-1377.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1366-1377
Mots-clés : Autism spectrum disorder Children's state words High risk siblings Parents' internal state language Index. décimale : PER Périodiques Résumé : Parents of toddlers with an older sibling with autism spectrum disorder (ASD; high risk, HR) and parents of low risk (LR) toddlers with typically-developing older siblings read a wordless picture book to their child at 22 and 28 months. Parents' and toddlers' internal state language (ISL) was coded; parents reported on toddlers' use of ISL. Diagnostic assessments conducted at 36 months identified three groups: ASD, HR-noASD, LR. Parents did not differ in overall ISL, but parents of toddlers with later ASD attempted to elicit ISL from their children less than parents of LR toddlers. Toddlers increased their use of ISL with age, but those with ASD had lower scores and less age-related improvement than children in the other two groups. En ligne : https://dx.doi.org/10.1007/s10803-018-3839-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 Predictors of Pragmatic Communication in School-Age Siblings of Children with ASD and Low-Risk Controls / K. J. GREENSLADE in Journal of Autism and Developmental Disorders, 49-4 (April 2019)
[article]
Titre : Predictors of Pragmatic Communication in School-Age Siblings of Children with ASD and Low-Risk Controls Type de document : Texte imprimé et/ou numérique Auteurs : K. J. GREENSLADE, Auteur ; E. A. UTTER, Auteur ; R. J. LANDA, Auteur Article en page(s) : p.1352-1365 Langues : Anglais (eng) Mots-clés : Autism Broad autism phenotype High risk siblings Joint attention Pragmatic language Social-communication Index. décimale : PER Périodiques Résumé : Little empirical evidence exists about school-age pragmatic communication or predictors in siblings at heightened familial risk for ASD (HR) and low-risk (LR) controls. The Pragmatic Rating Scale-School-Age (Landa unpublished) was scored for 49 HR siblings and 18 LR controls at 8-12 years. Social-communication and language measures were collected between 14 and 36 months. At 36-months, siblings were classified as ASD (HR-ASD, n = 15), broad autism phenotype (HR-BAP, n = 19), or typically developing (HR-TD, n = 15). Results revealed a pragmatic continuum with significantly better scores for HR-TD than HR-BAP or HR-ASD, and HR-BAP than HR-ASD. Per regression models including all participants, 14-month joint attention initiations predicted school-age pragmatic communication, as did 24-month social-communication and expressive language scores. Early joint attention, social-communication, and language abilities contribute to later pragmatic functioning. En ligne : https://dx.doi.org/10.1007/s10803-018-3837-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388
in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1352-1365[article] Predictors of Pragmatic Communication in School-Age Siblings of Children with ASD and Low-Risk Controls [Texte imprimé et/ou numérique] / K. J. GREENSLADE, Auteur ; E. A. UTTER, Auteur ; R. J. LANDA, Auteur . - p.1352-1365.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1352-1365
Mots-clés : Autism Broad autism phenotype High risk siblings Joint attention Pragmatic language Social-communication Index. décimale : PER Périodiques Résumé : Little empirical evidence exists about school-age pragmatic communication or predictors in siblings at heightened familial risk for ASD (HR) and low-risk (LR) controls. The Pragmatic Rating Scale-School-Age (Landa unpublished) was scored for 49 HR siblings and 18 LR controls at 8-12 years. Social-communication and language measures were collected between 14 and 36 months. At 36-months, siblings were classified as ASD (HR-ASD, n = 15), broad autism phenotype (HR-BAP, n = 19), or typically developing (HR-TD, n = 15). Results revealed a pragmatic continuum with significantly better scores for HR-TD than HR-BAP or HR-ASD, and HR-BAP than HR-ASD. Per regression models including all participants, 14-month joint attention initiations predicted school-age pragmatic communication, as did 24-month social-communication and expressive language scores. Early joint attention, social-communication, and language abilities contribute to later pragmatic functioning. En ligne : https://dx.doi.org/10.1007/s10803-018-3837-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 Resistance to temptation in toddlers at genetic risk for autism spectrum disorder / S. B. CAMPBELL in Autism, 23-4 (May 2019)
[article]
Titre : Resistance to temptation in toddlers at genetic risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. B. CAMPBELL, Auteur ; Jessie B. NORTHRUP, Auteur ; A. B. TAVARES, Auteur Article en page(s) : p.1018-1027 Langues : Anglais (eng) Mots-clés : autism spectrum disorder high risk siblings resistance to temptation Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder often demonstrate difficulties with self-regulation, although studies of this construct in young children with autism spectrum disorder are limited. In this study, developmental changes were examined using a measure of self-regulation appropriate for young children, resistance to temptation. At 22, 28, and 34 months, toddlers with an older sibling with autism spectrum disorder (high risk) and toddlers with typically developing older siblings (low risk) were presented with an appealing toy and instructed not to touch it. Observers coded whether or not children touched the toy and the strategies they used to resist touching it. At 36 months, children were assessed for autism spectrum disorder, yielding three groups: high risk children with autism spectrum disorder, high risk children without autism spectrum disorder, and low risk children. At 22 months, most children, regardless of group, touched the forbidden toy; at 28 and 34 months, many high risk children without autism spectrum disorder and low risk children resisted the temptation to touch the toy, whereas most of the children with autism spectrum disorder did not. Differences in delay strategies were also evident. Some, but not all group differences, were accounted for by differences in language ability. Results highlight one early index of impulse control that differentiates children with emerging autism spectrum disorder from age-mates prior to the third birthday. En ligne : http://dx.doi.org/10.1177/1362361318797264 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397
in Autism > 23-4 (May 2019) . - p.1018-1027[article] Resistance to temptation in toddlers at genetic risk for autism spectrum disorder [Texte imprimé et/ou numérique] / S. B. CAMPBELL, Auteur ; Jessie B. NORTHRUP, Auteur ; A. B. TAVARES, Auteur . - p.1018-1027.
Langues : Anglais (eng)
in Autism > 23-4 (May 2019) . - p.1018-1027
Mots-clés : autism spectrum disorder high risk siblings resistance to temptation Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder often demonstrate difficulties with self-regulation, although studies of this construct in young children with autism spectrum disorder are limited. In this study, developmental changes were examined using a measure of self-regulation appropriate for young children, resistance to temptation. At 22, 28, and 34 months, toddlers with an older sibling with autism spectrum disorder (high risk) and toddlers with typically developing older siblings (low risk) were presented with an appealing toy and instructed not to touch it. Observers coded whether or not children touched the toy and the strategies they used to resist touching it. At 36 months, children were assessed for autism spectrum disorder, yielding three groups: high risk children with autism spectrum disorder, high risk children without autism spectrum disorder, and low risk children. At 22 months, most children, regardless of group, touched the forbidden toy; at 28 and 34 months, many high risk children without autism spectrum disorder and low risk children resisted the temptation to touch the toy, whereas most of the children with autism spectrum disorder did not. Differences in delay strategies were also evident. Some, but not all group differences, were accounted for by differences in language ability. Results highlight one early index of impulse control that differentiates children with emerging autism spectrum disorder from age-mates prior to the third birthday. En ligne : http://dx.doi.org/10.1177/1362361318797264 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397