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Auteur Lonnie ZWAIGENBAUM |
Documents disponibles écrits par cet auteur (138)
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Language delay aggregates in toddler siblings of children with autism spectrum disorder / N. MARRUS in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)
[article]
Titre : Language delay aggregates in toddler siblings of children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : N. MARRUS, Auteur ; L. P. HALL, Auteur ; Sarah J. PATERSON, Auteur ; J. T. ELISON, Auteur ; J. J. WOLFF, Auteur ; M. R. SWANSON, Auteur ; Julia PARISH-MORRIS, Auteur ; A. T. EGGEBRECHT, Auteur ; J. R. PRUETT, Auteur ; Heather C. HAZLETT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Robert T. SCHULTZ, Auteur ; Kelly N. BOTTERON, Auteur ; J. PIVEN, Auteur ; John N. CONSTANTINO, Auteur Année de publication : 2018 Article en page(s) : 29 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Development Endophenotype Infant sibling Language Index. décimale : PER Périodiques Résumé : BACKGROUND: Language delay is extremely common in children with autism spectrum disorder (ASD), yet it is unclear whether measurable variation in early language is associated with genetic liability for ASD. Assessment of language development in unaffected siblings of children with ASD can inform whether decreased early language ability aggregates with inherited risk for ASD and serves as an ASD endophenotype. METHODS: We implemented two approaches: (1) a meta-analysis of studies comparing language delay, a categorical indicator of language function, and language scores, a continuous metric, in unaffected toddlers at high and low familial risk for ASD, and (2) a parallel analysis of 350 unaffected 24-month-olds in the Infant Brain Imaging Study (IBIS), a prospective study of infants at high and low familial risk for ASD. An advantage of the former was its detection of group differences from pooled data across unique samples; an advantage of the latter was its sensitivity in quantifying early manifestations of language delay while accounting for covariates within a single large sample. RESULTS: Meta-analysis showed that high-risk siblings without ASD (HR-noASD) were three to four times more likely to exhibit language delay versus low-risk siblings without ASD (LR-noASD) and had lower mean receptive and expressive language scores. Analyses of IBIS data corroborated that language delay, specifically receptive language delay, was more frequent in the HR-noASD (n = 235) versus LR-noASD group (n = 115). IBIS language scores were continuously and unimodally distributed, with a pathological shift towards decreased language function in HR-noASD siblings. The elevated inherited risk for ASD was associated with lower receptive and expressive language scores when controlling for sociodemographic factors. For receptive but not expressive language, the effect of risk group remained significant even when controlling for nonverbal cognition. CONCLUSIONS: Greater frequency of language delay and a lower distribution of language scores in high-risk, unaffected toddler-aged siblings support decreased early language ability as an endophenotype for ASD, with a more pronounced effect for receptive versus expressive language. Further characterization of language development is warranted to refine genetic investigations of ASD and to elucidate factors influencing the progression of core autistic traits and related symptoms. En ligne : http://dx.doi.org/10.1186/s11689-018-9247-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386
in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 29 p.[article] Language delay aggregates in toddler siblings of children with autism spectrum disorder [Texte imprimé et/ou numérique] / N. MARRUS, Auteur ; L. P. HALL, Auteur ; Sarah J. PATERSON, Auteur ; J. T. ELISON, Auteur ; J. J. WOLFF, Auteur ; M. R. SWANSON, Auteur ; Julia PARISH-MORRIS, Auteur ; A. T. EGGEBRECHT, Auteur ; J. R. PRUETT, Auteur ; Heather C. HAZLETT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Stephen R. DAGER, Auteur ; A. M. ESTES, Auteur ; Robert T. SCHULTZ, Auteur ; Kelly N. BOTTERON, Auteur ; J. PIVEN, Auteur ; John N. CONSTANTINO, Auteur . - 2018 . - 29 p.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 29 p.
Mots-clés : Autism spectrum disorder Development Endophenotype Infant sibling Language Index. décimale : PER Périodiques Résumé : BACKGROUND: Language delay is extremely common in children with autism spectrum disorder (ASD), yet it is unclear whether measurable variation in early language is associated with genetic liability for ASD. Assessment of language development in unaffected siblings of children with ASD can inform whether decreased early language ability aggregates with inherited risk for ASD and serves as an ASD endophenotype. METHODS: We implemented two approaches: (1) a meta-analysis of studies comparing language delay, a categorical indicator of language function, and language scores, a continuous metric, in unaffected toddlers at high and low familial risk for ASD, and (2) a parallel analysis of 350 unaffected 24-month-olds in the Infant Brain Imaging Study (IBIS), a prospective study of infants at high and low familial risk for ASD. An advantage of the former was its detection of group differences from pooled data across unique samples; an advantage of the latter was its sensitivity in quantifying early manifestations of language delay while accounting for covariates within a single large sample. RESULTS: Meta-analysis showed that high-risk siblings without ASD (HR-noASD) were three to four times more likely to exhibit language delay versus low-risk siblings without ASD (LR-noASD) and had lower mean receptive and expressive language scores. Analyses of IBIS data corroborated that language delay, specifically receptive language delay, was more frequent in the HR-noASD (n = 235) versus LR-noASD group (n = 115). IBIS language scores were continuously and unimodally distributed, with a pathological shift towards decreased language function in HR-noASD siblings. The elevated inherited risk for ASD was associated with lower receptive and expressive language scores when controlling for sociodemographic factors. For receptive but not expressive language, the effect of risk group remained significant even when controlling for nonverbal cognition. CONCLUSIONS: Greater frequency of language delay and a lower distribution of language scores in high-risk, unaffected toddler-aged siblings support decreased early language ability as an endophenotype for ASD, with a more pronounced effect for receptive versus expressive language. Further characterization of language development is warranted to refine genetic investigations of ASD and to elucidate factors influencing the progression of core autistic traits and related symptoms. En ligne : http://dx.doi.org/10.1186/s11689-018-9247-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 Language Impairment and Early Social Competence in Preschoolers with Autism Spectrum Disorders: A Comparison of DSM-5 Profiles / Teresa BENNETT in Journal of Autism and Developmental Disorders, 44-11 (November 2014)
[article]
Titre : Language Impairment and Early Social Competence in Preschoolers with Autism Spectrum Disorders: A Comparison of DSM-5 Profiles Type de document : Texte imprimé et/ou numérique Auteurs : Teresa BENNETT, Auteur ; P. SZATMARI, Auteur ; K. GEORGIADES, Auteur ; S. HANNA, Auteur ; M. JANUS, Auteur ; S. GEORGIADES, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; E. FOMBONNE, Auteur ; I. M. SMITH, Auteur ; P. MIRENDA, Auteur ; J. VOLDEN, Auteur ; C. WADDELL, Auteur ; W. ROBERTS, Auteur ; T. VAILLANCOURT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; M. ELSABBAGH, Auteur ; A. THOMPSON, Auteur Article en page(s) : p.2797-2808 Langues : Anglais (eng) Mots-clés : Social competence Language impairment DSM-5 Autism spectrum disorders Longitudinal epidemiology Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) and structural language impairment (LI) may be at risk of more adverse social-developmental outcomes. We examined trajectories of early social competence (using the Vineland-II) in 330 children aged 2–4 years recently diagnosed with ASD, and compared 3 subgroups classified by: language impairment (ASD/LI); intellectual disability (ASD/ID) and ASD without LI or ID (ASD/alone). Children with ASD/LI were significantly more socially impaired at baseline than the ASD/alone subgroup, and less impaired than those with ASD/ID. Growth in social competence was significantly slower for the ASD/ID group. Many preschool-aged children with ASD/LI at time of diagnosis resembled “late talkers” who appeared to catch up linguistically. Children with ASD/ID were more severely impaired and continued to lag further behind. En ligne : http://dx.doi.org/10.1007/s10803-014-2138-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241
in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2797-2808[article] Language Impairment and Early Social Competence in Preschoolers with Autism Spectrum Disorders: A Comparison of DSM-5 Profiles [Texte imprimé et/ou numérique] / Teresa BENNETT, Auteur ; P. SZATMARI, Auteur ; K. GEORGIADES, Auteur ; S. HANNA, Auteur ; M. JANUS, Auteur ; S. GEORGIADES, Auteur ; E. DUKU, Auteur ; Susan E. BRYSON, Auteur ; E. FOMBONNE, Auteur ; I. M. SMITH, Auteur ; P. MIRENDA, Auteur ; J. VOLDEN, Auteur ; C. WADDELL, Auteur ; W. ROBERTS, Auteur ; T. VAILLANCOURT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; M. ELSABBAGH, Auteur ; A. THOMPSON, Auteur . - p.2797-2808.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-11 (November 2014) . - p.2797-2808
Mots-clés : Social competence Language impairment DSM-5 Autism spectrum disorders Longitudinal epidemiology Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) and structural language impairment (LI) may be at risk of more adverse social-developmental outcomes. We examined trajectories of early social competence (using the Vineland-II) in 330 children aged 2–4 years recently diagnosed with ASD, and compared 3 subgroups classified by: language impairment (ASD/LI); intellectual disability (ASD/ID) and ASD without LI or ID (ASD/alone). Children with ASD/LI were significantly more socially impaired at baseline than the ASD/alone subgroup, and less impaired than those with ASD/ID. Growth in social competence was significantly slower for the ASD/ID group. Many preschool-aged children with ASD/LI at time of diagnosis resembled “late talkers” who appeared to catch up linguistically. Children with ASD/ID were more severely impaired and continued to lag further behind. En ligne : http://dx.doi.org/10.1007/s10803-014-2138-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 Language-related abilities in ‘unaffected’ school-aged siblings of children with ASD / Ellen DRUMM in Research in Autism Spectrum Disorders, 18 (October 2015)
[article]
Titre : Language-related abilities in ‘unaffected’ school-aged siblings of children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Ellen DRUMM, Auteur ; Susan E. BRYSON, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur Article en page(s) : p.83-96 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder High-risk siblings Language Pragmatics Phonological processing Reading Index. décimale : PER Périodiques Résumé : Abstract Siblings of children with autism spectrum disorder (ASD) who do not have ASD outcomes are more likely than their peers to experience delays in language acquisition as preschoolers. However, less is known about how these siblings are faring when they are school-aged. We examined language-related abilities of 18 siblings with non-ASD outcomes, aged 8–11. On average, siblings performed more poorly than the normative sample in phonological memory and phonological awareness. In contrast, word-level reading was unimpaired. No deficits relative to norms were found on a direct child assessment and parent-report measure of pragmatic language; however, recommendations for further research in this area are made. Comparing two direct child assessments, this sample performed more poorly in pragmatics than receptive/expressive language. Language abilities in siblings of children with ASD is an area ripe for further investigation with larger sample sizes and appropriate comparison groups. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268
in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.83-96[article] Language-related abilities in ‘unaffected’ school-aged siblings of children with ASD [Texte imprimé et/ou numérique] / Ellen DRUMM, Auteur ; Susan E. BRYSON, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur . - p.83-96.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.83-96
Mots-clés : Autism spectrum disorder High-risk siblings Language Pragmatics Phonological processing Reading Index. décimale : PER Périodiques Résumé : Abstract Siblings of children with autism spectrum disorder (ASD) who do not have ASD outcomes are more likely than their peers to experience delays in language acquisition as preschoolers. However, less is known about how these siblings are faring when they are school-aged. We examined language-related abilities of 18 siblings with non-ASD outcomes, aged 8–11. On average, siblings performed more poorly than the normative sample in phonological memory and phonological awareness. In contrast, word-level reading was unimpaired. No deficits relative to norms were found on a direct child assessment and parent-report measure of pragmatic language; however, recommendations for further research in this area are made. Comparing two direct child assessments, this sample performed more poorly in pragmatics than receptive/expressive language. Language abilities in siblings of children with ASD is an area ripe for further investigation with larger sample sizes and appropriate comparison groups. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 Lie-Telling Behavior in Children With Autism and Its Relation to False-Belief Understanding / Victoria TALWAR in Focus on Autism and Other Developmental Disabilities, 27-2 (June 2012)
[article]
Titre : Lie-Telling Behavior in Children With Autism and Its Relation to False-Belief Understanding Type de document : Texte imprimé et/ou numérique Auteurs : Victoria TALWAR, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Keith GOULDEN, Auteur ; Shazeen MANJI, Auteur ; Carly LOOMES, Auteur ; Carmen RASMUSSEN, Auteur Année de publication : 2012 Article en page(s) : p.122-129 Langues : Anglais (eng) Mots-clés : lying deception theory of mind autism spectrum disorders Index. décimale : PER Périodiques Résumé : Children’s lie-telling behavior and its relation to false-belief understanding was examined in children with autism spectrum disorders (ASD; n = 26) and a comparison group of typically developing children (n = 27). Participants were assessed using a temptation resistance paradigm, in which children were told not to peek at a forbidden toy while left alone in a room and were later asked if they peeked. Overall, 77% of the total sample peeked at the toy, with no significant difference between the ASD and typically developing groups. Whereas 96% of the typically developing control children lied about peeking, significantly fewer children with ASD (72%) lied. Children with ASD were poorer at maintaining their lies than the control group. Liars had higher false-belief scores than truth-tellers. These findings have implications for understanding how theory of mind deficits may limit the ability of children with ASD to purposefully deceive others. En ligne : http://dx.doi.org/10.1177/1088357612441828 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166
in Focus on Autism and Other Developmental Disabilities > 27-2 (June 2012) . - p.122-129[article] Lie-Telling Behavior in Children With Autism and Its Relation to False-Belief Understanding [Texte imprimé et/ou numérique] / Victoria TALWAR, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Keith GOULDEN, Auteur ; Shazeen MANJI, Auteur ; Carly LOOMES, Auteur ; Carmen RASMUSSEN, Auteur . - 2012 . - p.122-129.
Langues : Anglais (eng)
in Focus on Autism and Other Developmental Disabilities > 27-2 (June 2012) . - p.122-129
Mots-clés : lying deception theory of mind autism spectrum disorders Index. décimale : PER Périodiques Résumé : Children’s lie-telling behavior and its relation to false-belief understanding was examined in children with autism spectrum disorders (ASD; n = 26) and a comparison group of typically developing children (n = 27). Participants were assessed using a temptation resistance paradigm, in which children were told not to peek at a forbidden toy while left alone in a room and were later asked if they peeked. Overall, 77% of the total sample peeked at the toy, with no significant difference between the ASD and typically developing groups. Whereas 96% of the typically developing control children lied about peeking, significantly fewer children with ASD (72%) lied. Children with ASD were poorer at maintaining their lies than the control group. Liars had higher false-belief scores than truth-tellers. These findings have implications for understanding how theory of mind deficits may limit the ability of children with ASD to purposefully deceive others. En ligne : http://dx.doi.org/10.1177/1088357612441828 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 Longitudinal associations between early childhood irritability and adolescent depression symptoms in autistic children are mediated by peer relationships but not educational engagement / Virginia CARTER LENO in Development and Psychopathology, 36-1 (February 2024)
[article]
Titre : Longitudinal associations between early childhood irritability and adolescent depression symptoms in autistic children are mediated by peer relationships but not educational engagement Type de document : Texte imprimé et/ou numérique Auteurs : Virginia CARTER LENO, Auteur ; Nicola WRIGHT, Auteur ; Andrew PICKLES, Auteur ; Rachael BEDFORD, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Connor KERNS, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Eric DUKU, Auteur ; Teresa BENNETT, Auteur ; Stelios GEORGIADES, Auteur ; Isabel M. SMITH, Auteur ; Annie RICHARDS, Auteur ; Tracy VAILLANCOURT, Auteur ; Peter SZATMARI, Auteur ; Mayada ELSABBAGH, Auteur Article en page(s) : p.443-453 Langues : Anglais (eng) Mots-clés : autism depression educational achievement failure model irritability peer relationships Index. décimale : PER Périodiques Résumé : In the general population, irritability is associated with later depression. Despite irritability being more prevalent in autistic children, the long-term sequelae are not well explored. We tested whether irritability in early childhood predicted depression symptoms in autistic adolescents, and whether associations could be explained by difficulties in peer relationships and lower educational engagement. Analyses tested the longitudinal associations between early childhood irritability (ages 3-5) and adolescent depression symptoms (age 14) in a prospective inception cohort of autistic children (N = 390), followed from early in development shortly after they received a clinical diagnosis. Mediators were measured in mid-childhood (age 10) by a combination of measures, from which latent factors for peer relationships and educational engagement were estimated. Results showed early childhood irritability was positively associated with adolescent depression symptoms, and this association remained when adjusting for baseline depression. A significant indirect pathway through peer relationships was found, which accounted for around 13% of the association between early childhood irritability and adolescent depression, suggesting peer problems may partially mediate the association between irritability and later depression. No mediation effects were found for education engagement. Results highlight the importance of early screening and intervention for co-occurring irritability and peer problems in young autistic children. En ligne : https://dx.doi.org/10.1017/S0954579422001316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523
in Development and Psychopathology > 36-1 (February 2024) . - p.443-453[article] Longitudinal associations between early childhood irritability and adolescent depression symptoms in autistic children are mediated by peer relationships but not educational engagement [Texte imprimé et/ou numérique] / Virginia CARTER LENO, Auteur ; Nicola WRIGHT, Auteur ; Andrew PICKLES, Auteur ; Rachael BEDFORD, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Connor KERNS, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Eric DUKU, Auteur ; Teresa BENNETT, Auteur ; Stelios GEORGIADES, Auteur ; Isabel M. SMITH, Auteur ; Annie RICHARDS, Auteur ; Tracy VAILLANCOURT, Auteur ; Peter SZATMARI, Auteur ; Mayada ELSABBAGH, Auteur . - p.443-453.
Langues : Anglais (eng)
in Development and Psychopathology > 36-1 (February 2024) . - p.443-453
Mots-clés : autism depression educational achievement failure model irritability peer relationships Index. décimale : PER Périodiques Résumé : In the general population, irritability is associated with later depression. Despite irritability being more prevalent in autistic children, the long-term sequelae are not well explored. We tested whether irritability in early childhood predicted depression symptoms in autistic adolescents, and whether associations could be explained by difficulties in peer relationships and lower educational engagement. Analyses tested the longitudinal associations between early childhood irritability (ages 3-5) and adolescent depression symptoms (age 14) in a prospective inception cohort of autistic children (N = 390), followed from early in development shortly after they received a clinical diagnosis. Mediators were measured in mid-childhood (age 10) by a combination of measures, from which latent factors for peer relationships and educational engagement were estimated. Results showed early childhood irritability was positively associated with adolescent depression symptoms, and this association remained when adjusting for baseline depression. A significant indirect pathway through peer relationships was found, which accounted for around 13% of the association between early childhood irritability and adolescent depression, suggesting peer problems may partially mediate the association between irritability and later depression. No mediation effects were found for education engagement. Results highlight the importance of early screening and intervention for co-occurring irritability and peer problems in young autistic children. En ligne : https://dx.doi.org/10.1017/S0954579422001316 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 Longitudinal patterns of repetitive behavior in toddlers with autism / Jason J. WOLFF in Journal of Child Psychology and Psychiatry, 55-8 (August 2014)
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