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Single Nucleotide Polymorphisms Predict Symptom Severity of Autism Spectrum Disorder / Yun JIAO in Journal of Autism and Developmental Disorders, 42-6 (June 2012)
[article]
Titre : Single Nucleotide Polymorphisms Predict Symptom Severity of Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yun JIAO, Auteur ; Rong CHEN, Auteur ; Xiaoyan KE, Auteur ; Lu CHENG, Auteur ; Kangkang CHU, Auteur ; Zuhong LU, Auteur ; Edward H. HERSKOVITS, Auteur Année de publication : 2012 Article en page(s) : p.971-983 Langues : Anglais (eng) Mots-clés : Autism-spectrum disorder Single-nucleotide polymorphisms Diagnostic model Genotype-phenotype analysis Data mining Index. décimale : PER Périodiques Résumé : Autism is widely believed to be a heterogeneous disorder; diagnosis is currently based solely on clinical criteria, although genetic, as well as environmental, influences are thought to be prominent factors in the etiology of most forms of autism. Our goal is to determine whether a predictive model based on single-nucleotide polymorphisms (SNPs) can predict symptom severity of autism spectrum disorder (ASD). We divided 118 ASD children into a mild/moderate autism group (n = 65) and a severe autism group (n = 53), based on the Childhood Autism Rating Scale (CARS). For each child, we obtained 29 SNPs of 9 ASD-related genes. To generate predictive models, we employed three machine-learning techniques: decision stumps (DSs), alternating decision trees (ADTrees), and FlexTrees. DS and FlexTree generated modestly better classifiers, with accuracy = 67%, sensitivity = 0.88 and specificity = 0.42. The SNP rs878960 in GABRB3 was selected by all models, and was related associated with CARS assessment. Our results suggest that SNPs have the potential to offer accurate classification of ASD symptom severity. En ligne : http://dx.doi.org/10.1007/s10803-011-1327-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.971-983[article] Single Nucleotide Polymorphisms Predict Symptom Severity of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Yun JIAO, Auteur ; Rong CHEN, Auteur ; Xiaoyan KE, Auteur ; Lu CHENG, Auteur ; Kangkang CHU, Auteur ; Zuhong LU, Auteur ; Edward H. HERSKOVITS, Auteur . - 2012 . - p.971-983.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.971-983
Mots-clés : Autism-spectrum disorder Single-nucleotide polymorphisms Diagnostic model Genotype-phenotype analysis Data mining Index. décimale : PER Périodiques Résumé : Autism is widely believed to be a heterogeneous disorder; diagnosis is currently based solely on clinical criteria, although genetic, as well as environmental, influences are thought to be prominent factors in the etiology of most forms of autism. Our goal is to determine whether a predictive model based on single-nucleotide polymorphisms (SNPs) can predict symptom severity of autism spectrum disorder (ASD). We divided 118 ASD children into a mild/moderate autism group (n = 65) and a severe autism group (n = 53), based on the Childhood Autism Rating Scale (CARS). For each child, we obtained 29 SNPs of 9 ASD-related genes. To generate predictive models, we employed three machine-learning techniques: decision stumps (DSs), alternating decision trees (ADTrees), and FlexTrees. DS and FlexTree generated modestly better classifiers, with accuracy = 67%, sensitivity = 0.88 and specificity = 0.42. The SNP rs878960 in GABRB3 was selected by all models, and was related associated with CARS assessment. Our results suggest that SNPs have the potential to offer accurate classification of ASD symptom severity. En ligne : http://dx.doi.org/10.1007/s10803-011-1327-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156 The "Reading the Mind in the Eyes" Test in Autism-Spectrum Disorders Comparison with Healthy Controls: A Systematic Review and Meta-analysis / I. PENUELAS-CALVO in Journal of Autism and Developmental Disorders, 49-3 (March 2019)
[article]
Titre : The "Reading the Mind in the Eyes" Test in Autism-Spectrum Disorders Comparison with Healthy Controls: A Systematic Review and Meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : I. PENUELAS-CALVO, Auteur ; A. SAREEN, Auteur ; J. SEVILLA-LLEWELLYN-JONES, Auteur ; P. FERNANDEZ-BERROCAL, Auteur Article en page(s) : p.1048-1061 Langues : Anglais (eng) Mots-clés : Autism-spectrum disorder Intelligence quotient Performance intelligence Reading the Mind in the Eye Test Verbal intelligence Index. décimale : PER Périodiques Résumé : We conducted a meta-analysis of 18 studies to establish whether a relation exists between Reading the Mind in the Eye Test (RMET) performance and intelligence quotient (IQ) in individuals diagnosed with autism-spectrum disorders (ASD) and controls, taking into account relevant characteristics such as age, gender, and autism quotient. Our findings indicate that RMET performance was better in controls compared with those diagnosed with ASD. We found that RMET performance is dependent on full and verbal IQ and age in controls. However, RMET performance is negatively correlated with performance IQ in individuals diagnosed with ASD. These results suggest that the methodology applied by ASD when taking the RMET is different from control individuals and might depend less on verbal abilities. En ligne : http://dx.doi.org/10.1007/s10803-018-3814-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386
in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1048-1061[article] The "Reading the Mind in the Eyes" Test in Autism-Spectrum Disorders Comparison with Healthy Controls: A Systematic Review and Meta-analysis [Texte imprimé et/ou numérique] / I. PENUELAS-CALVO, Auteur ; A. SAREEN, Auteur ; J. SEVILLA-LLEWELLYN-JONES, Auteur ; P. FERNANDEZ-BERROCAL, Auteur . - p.1048-1061.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1048-1061
Mots-clés : Autism-spectrum disorder Intelligence quotient Performance intelligence Reading the Mind in the Eye Test Verbal intelligence Index. décimale : PER Périodiques Résumé : We conducted a meta-analysis of 18 studies to establish whether a relation exists between Reading the Mind in the Eye Test (RMET) performance and intelligence quotient (IQ) in individuals diagnosed with autism-spectrum disorders (ASD) and controls, taking into account relevant characteristics such as age, gender, and autism quotient. Our findings indicate that RMET performance was better in controls compared with those diagnosed with ASD. We found that RMET performance is dependent on full and verbal IQ and age in controls. However, RMET performance is negatively correlated with performance IQ in individuals diagnosed with ASD. These results suggest that the methodology applied by ASD when taking the RMET is different from control individuals and might depend less on verbal abilities. En ligne : http://dx.doi.org/10.1007/s10803-018-3814-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 Mothers' Reactions to Their Child's ASD Diagnosis: Predictors That Discriminate Grief from Distress / H. A. WAYMENT in Journal of Autism and Developmental Disorders, 48-4 (April 2018)
[article]
Titre : Mothers' Reactions to Their Child's ASD Diagnosis: Predictors That Discriminate Grief from Distress Type de document : Texte imprimé et/ou numérique Auteurs : H. A. WAYMENT, Auteur ; K. A. BROOKSHIRE, Auteur Article en page(s) : p.1147-1158 Langues : Anglais (eng) Mots-clés : Autism-Spectrum Disorder Distress Grief Identity ambiguity Perceptions of loss Index. décimale : PER Périodiques Résumé : We examined whether grief and general distress reactions characterized mothers' reactions to their child's ASD diagnosis, and whether these two types of reactions had unique predictors. Hierarchical regression analyses were conducted on data collected from 362 mothers recruited from the Interactive Autism Network (IAN). The mothers were predominantly white, highly educated, and married. Grief reactions were positively associated with perceiving ASD as a loss and as unjust. Distress was positively associated with previous mental health issues, mothers' reports of their child's aggressive behavior, identity ambiguity, and less social support. Internal attributions were positively related to grief and distress. Discussion focuses on why the distinction between these two types of affective reactions may be useful for parents and professionals. En ligne : http://dx.doi.org/10.1007/s10803-017-3266-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=351
in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1147-1158[article] Mothers' Reactions to Their Child's ASD Diagnosis: Predictors That Discriminate Grief from Distress [Texte imprimé et/ou numérique] / H. A. WAYMENT, Auteur ; K. A. BROOKSHIRE, Auteur . - p.1147-1158.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1147-1158
Mots-clés : Autism-Spectrum Disorder Distress Grief Identity ambiguity Perceptions of loss Index. décimale : PER Périodiques Résumé : We examined whether grief and general distress reactions characterized mothers' reactions to their child's ASD diagnosis, and whether these two types of reactions had unique predictors. Hierarchical regression analyses were conducted on data collected from 362 mothers recruited from the Interactive Autism Network (IAN). The mothers were predominantly white, highly educated, and married. Grief reactions were positively associated with perceiving ASD as a loss and as unjust. Distress was positively associated with previous mental health issues, mothers' reports of their child's aggressive behavior, identity ambiguity, and less social support. Internal attributions were positively related to grief and distress. Discussion focuses on why the distinction between these two types of affective reactions may be useful for parents and professionals. En ligne : http://dx.doi.org/10.1007/s10803-017-3266-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=351