1325 recherche sur le mot-clé 'behavior'

Advances in Our Understanding of Behavioral Intervention: 1980 to 2020 for Individuals Diagnosed with Autism Spectrum Disorder / Justin B. LEAF in Journal of Autism and Developmental Disorders, 51-12 (December 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4395-4410 Titre : Advances in Our Understanding of Behavioral Intervention: 1980 to 2020 for Individuals Diagnosed with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Justin B. LEAF, Auteur ; Joseph H. CIHON, Auteur ; Julia L. FERGUSON, Auteur ; Christine M. MILNE, Auteur ; Ron LEAF, Auteur ; John MCEACHIN, Auteur Article en page(s) : p.4395-4410 Langues : Anglais (eng) Mots-clés : Applied Behavior Analysis  Autism Spectrum Disorder/diagnosis/therapy  Behavior Therapy  Humans  Applied behavior analysis  Behavior analysis  Behavioral intervention  Certification  Intensive behavioral intervention Index. décimale : PER Périodiques Résumé : There are three branches of science of behavior analysis [i.e., experimental analysis of behavior, behavior analysis, and applied behavior analysis (ABA)]. ABA can be defined as a systematic approach to understanding behavior of social interest. For the past 40 plus years, researchers have evaluated ABA and ABA based procedures (e.g., behavioral intervention) as they relate to individuals diagnosed with autism spectrum disorder (ASD) and have implemented behavioral intervention in clinical settings for individuals diagnosed with ASD. In this paper, we discuss some of the pivotal contributions in the field of ABA in research and clinical practice. Additionally, we provide recommendations for the science and clinical practice of behavioral intervention in the next 40 years. En ligne : http://dx.doi.org/10.1007/s10803-020-04481-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Advances in Our Understanding of Behavioral Intervention: 1980 to 2020 for Individuals Diagnosed with Autism Spectrum Disorder [texte imprimé] / Justin B. LEAF, Auteur ; Joseph H. CIHON, Auteur ; Julia L. FERGUSON, Auteur ; Christine M. MILNE, Auteur ; Ron LEAF, Auteur ; John MCEACHIN, Auteur . - p.4395-4410. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4395-4410 Mots-clés : Applied Behavior Analysis  Autism Spectrum Disorder/diagnosis/therapy  Behavior Therapy  Humans  Applied behavior analysis  Behavior analysis  Behavioral intervention  Certification  Intensive behavioral intervention Index. décimale : PER Périodiques Résumé : There are three branches of science of behavior analysis [i.e., experimental analysis of behavior, behavior analysis, and applied behavior analysis (ABA)]. ABA can be defined as a systematic approach to understanding behavior of social interest. For the past 40 plus years, researchers have evaluated ABA and ABA based procedures (e.g., behavioral intervention) as they relate to individuals diagnosed with autism spectrum disorder (ASD) and have implemented behavioral intervention in clinical settings for individuals diagnosed with ASD. In this paper, we discuss some of the pivotal contributions in the field of ABA in research and clinical practice. Additionally, we provide recommendations for the science and clinical practice of behavioral intervention in the next 40 years. En ligne : http://dx.doi.org/10.1007/s10803-020-04481-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

Keeping up with the evidence base: Survey of behavior professionals about Naturalistic Developmental Behavioral Interventions / Lauren H. HAMPTON in Autism, 26-4 (May 2022)  

Public ISBD [article]  inAutism > 26-4 (May 2022) . - p.875-888 Titre : Keeping up with the evidence base: Survey of behavior professionals about Naturalistic Developmental Behavioral Interventions Type de document : texte imprimé Auteurs : Lauren H. HAMPTON, Auteur ; Micheal SANDBANK, Auteur Article en page(s) : p.875-888 Langues : Anglais (eng) Mots-clés : Applied Behavior Analysis  Autism Spectrum Disorder/therapy  Behavior Therapy  Child  Child Development Disorders, Pervasive  Child, Preschool  Humans  Surveys and Questionnaires  Behavior Analyst Certification Board  Board Certified Behavior Analyst  Naturalistic Developmental Behavior Intervention  autism  behavior analysis  naturalistic  survey Index. décimale : PER Périodiques Résumé : Primary service providers for young children on the autism spectrum and developmentally delayed children use many strategies under the umbrella of applied behavior analysis therapy. The evidence supporting interventions for children on the autism spectrum has changed last decade, and powerful research supports the relative effectiveness of Naturalistic Developmental Behavior Interventions, yet a few professionals serving young children on the autism spectrum receive training in this category of interventions. Board Certified Behavior Analysts and related professionals are the primary service providers for this population. The purpose of this survey study is to describe and understand the knowledge and beliefs that Behavior Analyst Certification Board certificants have around Naturalistic Developmental Behavior Interventions. The survey was completed by 901 respondents. Respondents indicated, on average, little to no knowledge of Naturalistic Developmental Behavior Intervention practices and few believe that these practices are effective or appropriate for the field. Recommendations include increasing training opportunities for related professionals, and changing certification requirements to match the current evidence. En ligne : https://dx.doi.org/10.1177/13623613211035233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Keeping up with the evidence base: Survey of behavior professionals about Naturalistic Developmental Behavioral Interventions [texte imprimé] / Lauren H. HAMPTON, Auteur ; Micheal SANDBANK, Auteur . - p.875-888. Langues : Anglais (eng) in Autism > 26-4 (May 2022) . - p.875-888 Mots-clés : Applied Behavior Analysis  Autism Spectrum Disorder/therapy  Behavior Therapy  Child  Child Development Disorders, Pervasive  Child, Preschool  Humans  Surveys and Questionnaires  Behavior Analyst Certification Board  Board Certified Behavior Analyst  Naturalistic Developmental Behavior Intervention  autism  behavior analysis  naturalistic  survey Index. décimale : PER Périodiques Résumé : Primary service providers for young children on the autism spectrum and developmentally delayed children use many strategies under the umbrella of applied behavior analysis therapy. The evidence supporting interventions for children on the autism spectrum has changed last decade, and powerful research supports the relative effectiveness of Naturalistic Developmental Behavior Interventions, yet a few professionals serving young children on the autism spectrum receive training in this category of interventions. Board Certified Behavior Analysts and related professionals are the primary service providers for this population. The purpose of this survey study is to describe and understand the knowledge and beliefs that Behavior Analyst Certification Board certificants have around Naturalistic Developmental Behavior Interventions. The survey was completed by 901 respondents. Respondents indicated, on average, little to no knowledge of Naturalistic Developmental Behavior Intervention practices and few believe that these practices are effective or appropriate for the field. Recommendations include increasing training opportunities for related professionals, and changing certification requirements to match the current evidence. En ligne : https://dx.doi.org/10.1177/13623613211035233 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome / Timothy A. FENTON in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome Type de document : texte imprimé Auteurs : Timothy A. FENTON, Auteur ; Stela P. PETKOVA, Auteur ; Anna ADHIKARI, Auteur ; Jill L. SILVERMAN, Auteur Langues : Anglais (eng) Mots-clés : Animals  Lovastatin/pharmacology/administration & dosage  Angelman Syndrome/drug therapy/physiopathology/genetics  Disease Models, Animal  Mice  Gait/drug effects  Male  Cognition/drug effects  Female  Behavior, Animal/drug effects  Mice, Inbred C57BL  Ubiquitin-Protein Ligases/genetics  Motor Activity/drug effects  Angelman syndrome  Behavior  Gait  Lovastatin  Neurodevelopmental disorder  UBE3A  reviewed and approved by the UC Davis IACUC on April 20, 2023. Active protocols  are reviewed annually. Title: Novel Testing of Therapeutics for Angelman  Syndrome. Principal Investigator: Jill L. Silverman Protocol #: 23384  Institution: University of California, Davis This institution is accredited by  the Association for Assessment and Accreditation of Laboratory Animal Care,  International (AAALAC). This institution has an Animal Welfare Assurance on file  with the Office of Laboratory Animal Welfare (OLAW). The Assurance Number is  D16-00272 (A3433-01). The IACUC is constituted in accordance with U.S. Public  Health Service (PHS) Animal Welfare Policy and includes a member of the public  and a non-scientist. Consent for publication: FAST, the MIND Institute and the  NIH/NICHD IDDRC consent for the data presented herein to be publishable.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : Translational research is needed to discover pharmacological targets and treatments for the diagnostic behavioral domains of neurodevelopmental disorders (NDDs), including autism spectrum disorders (ASDs) and intellectual disabilities (IDs). One NDD, associated with ASD and ID, is Angelman Syndrome (AS). AS is a rare genetic NDD for which there is currently no cure nor effective therapeutics. The genetic cause is known to be the loss of expression from the maternal allele of ubiquitin protein ligase E3A (UBE3A). The Ube3a maternal deletion mouse model of AS reliably demonstrates behavioral phenotypes of relevance to AS and therefore offers a suitable in vivo system in which to test potential therapeutics, with construct and face validity. Successes in reducing hyperexcitability and epileptogenesis have been reported in an AS model following acute treatment with lovastatin, an ERK inhibitor by reducing seizure threshold and percentage of mice exhibiting seizures. Since there has been literature reporting disruption of the ERK signaling pathway in AS, we chose to evaluate the effects of acute lovastatin administration in a tailored set of translationally relevant behavioral assays in a mouse model of AS. Unexpectedly, deleterious effects of sedation were observed in wildtype (WT), age matched littermate control mice and despite a baseline hypolocomotive phenotype in AS mice, even further reductions in exploratory activity, were observed post-acute lovastatin treatment. Limitations of this work include that chronic lower dose regimens, more akin to drug administration in humans were beyond the scope of this work, and may have produced a more favorable impact of lovastatin administration over single acute high doses. In addition, lovastatin's effects were not assessed in younger subjects, since our study focused exclusively on adult functional outcomes. Metrics of gait, as well as motor coordination and motor learning in rotarod, previously observed to be impaired in AS mice, were not improved by lovastatin treatment. Finally, cognition by novel object recognition task was worsened in WT controls and not improved in AS, following lovastatin administration. In conclusion, lovastatin did not indicate any major improvement to AS symptoms, and in fact, worsened behavioral outcomes in the WT control groups. Therefore, despite its attractive low toxicity, immediate availability, and low cost of the drug, further investigation for clinical study is unwarranted given the results presented herein. En ligne : https://dx.doi.org/10.1186/s11689-025-09616-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome [texte imprimé] / Timothy A. FENTON, Auteur ; Stela P. PETKOVA, Auteur ; Anna ADHIKARI, Auteur ; Jill L. SILVERMAN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Animals  Lovastatin/pharmacology/administration & dosage  Angelman Syndrome/drug therapy/physiopathology/genetics  Disease Models, Animal  Mice  Gait/drug effects  Male  Cognition/drug effects  Female  Behavior, Animal/drug effects  Mice, Inbred C57BL  Ubiquitin-Protein Ligases/genetics  Motor Activity/drug effects  Angelman syndrome  Behavior  Gait  Lovastatin  Neurodevelopmental disorder  UBE3A  reviewed and approved by the UC Davis IACUC on April 20, 2023. Active protocols  are reviewed annually. Title: Novel Testing of Therapeutics for Angelman  Syndrome. Principal Investigator: Jill L. Silverman Protocol #: 23384  Institution: University of California, Davis This institution is accredited by  the Association for Assessment and Accreditation of Laboratory Animal Care,  International (AAALAC). This institution has an Animal Welfare Assurance on file  with the Office of Laboratory Animal Welfare (OLAW). The Assurance Number is  D16-00272 (A3433-01). The IACUC is constituted in accordance with U.S. Public  Health Service (PHS) Animal Welfare Policy and includes a member of the public  and a non-scientist. Consent for publication: FAST, the MIND Institute and the  NIH/NICHD IDDRC consent for the data presented herein to be publishable.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : Translational research is needed to discover pharmacological targets and treatments for the diagnostic behavioral domains of neurodevelopmental disorders (NDDs), including autism spectrum disorders (ASDs) and intellectual disabilities (IDs). One NDD, associated with ASD and ID, is Angelman Syndrome (AS). AS is a rare genetic NDD for which there is currently no cure nor effective therapeutics. The genetic cause is known to be the loss of expression from the maternal allele of ubiquitin protein ligase E3A (UBE3A). The Ube3a maternal deletion mouse model of AS reliably demonstrates behavioral phenotypes of relevance to AS and therefore offers a suitable in vivo system in which to test potential therapeutics, with construct and face validity. Successes in reducing hyperexcitability and epileptogenesis have been reported in an AS model following acute treatment with lovastatin, an ERK inhibitor by reducing seizure threshold and percentage of mice exhibiting seizures. Since there has been literature reporting disruption of the ERK signaling pathway in AS, we chose to evaluate the effects of acute lovastatin administration in a tailored set of translationally relevant behavioral assays in a mouse model of AS. Unexpectedly, deleterious effects of sedation were observed in wildtype (WT), age matched littermate control mice and despite a baseline hypolocomotive phenotype in AS mice, even further reductions in exploratory activity, were observed post-acute lovastatin treatment. Limitations of this work include that chronic lower dose regimens, more akin to drug administration in humans were beyond the scope of this work, and may have produced a more favorable impact of lovastatin administration over single acute high doses. In addition, lovastatin's effects were not assessed in younger subjects, since our study focused exclusively on adult functional outcomes. Metrics of gait, as well as motor coordination and motor learning in rotarod, previously observed to be impaired in AS mice, were not improved by lovastatin treatment. Finally, cognition by novel object recognition task was worsened in WT controls and not improved in AS, following lovastatin administration. In conclusion, lovastatin did not indicate any major improvement to AS symptoms, and in fact, worsened behavioral outcomes in the WT control groups. Therefore, despite its attractive low toxicity, immediate availability, and low cost of the drug, further investigation for clinical study is unwarranted given the results presented herein. En ligne : https://dx.doi.org/10.1186/s11689-025-09616-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents / Renad JABARIN in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 41 p. Titre : Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents Type de document : texte imprimé Auteurs : Renad JABARIN, Auteur ; Shai NETSER, Auteur ; Shlomo WAGNER, Auteur Article en page(s) : 41 p. Langues : Anglais (eng) Mots-clés : Animals  Humans  Rodentia  Autism Spectrum Disorder  Social Behavior  Behavior, Animal  Emotions  Animal models  Autism spectrum disorder  Behavioral phenotyping  Emotional states  Social vocalizations  Three-chamber test Index. décimale : PER Périodiques Résumé : MAIN: In recent years, substantial advances in social neuroscience have been realized, including the generation of numerous rodent models of autism spectrum disorder. Still, it can be argued that those methods currently being used to analyze animal social behavior create a bottleneck that significantly slows down progress in this field. Indeed, the bulk of research still relies on a small number of simple behavioral paradigms, the results of which are assessed without considering behavioral dynamics. Moreover, only few variables are examined in each paradigm, thus overlooking a significant portion of the complexity that characterizes social interaction between two conspecifics, subsequently hindering our understanding of the neural mechanisms governing different aspects of social behavior. We further demonstrate these constraints by discussing the most commonly used paradigm for assessing rodent social behavior, the three-chamber test. We also point to the fact that although emotions greatly influence human social behavior, we lack reliable means for assessing the emotional state of animals during social tasks. As such, we also discuss current evidence supporting the existence of pro-social emotions and emotional cognition in animal models. We further suggest that adequate social behavior analysis requires a novel multimodal approach that employs automated and simultaneous measurements of multiple behavioral and physiological variables at high temporal resolution in socially interacting animals. We accordingly describe several computerized systems and computational tools for acquiring and analyzing such measurements. Finally, we address several behavioral and physiological variables that can be used to assess socio-emotional states in animal models and thus elucidate intricacies of social behavior so as to attain deeper insight into the brain mechanisms that mediate such behaviors. CONCLUSIONS: In summary, we suggest that combining automated multimodal measurements with machine-learning algorithms will help define socio-emotional states and determine their dynamics during various types of social tasks, thus enabling a more thorough understanding of the complexity of social behavior. En ligne : http://dx.doi.org/10.1186/s13229-022-00521-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents [texte imprimé] / Renad JABARIN, Auteur ; Shai NETSER, Auteur ; Shlomo WAGNER, Auteur . - 41 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 41 p. Mots-clés : Animals  Humans  Rodentia  Autism Spectrum Disorder  Social Behavior  Behavior, Animal  Emotions  Animal models  Autism spectrum disorder  Behavioral phenotyping  Emotional states  Social vocalizations  Three-chamber test Index. décimale : PER Périodiques Résumé : MAIN: In recent years, substantial advances in social neuroscience have been realized, including the generation of numerous rodent models of autism spectrum disorder. Still, it can be argued that those methods currently being used to analyze animal social behavior create a bottleneck that significantly slows down progress in this field. Indeed, the bulk of research still relies on a small number of simple behavioral paradigms, the results of which are assessed without considering behavioral dynamics. Moreover, only few variables are examined in each paradigm, thus overlooking a significant portion of the complexity that characterizes social interaction between two conspecifics, subsequently hindering our understanding of the neural mechanisms governing different aspects of social behavior. We further demonstrate these constraints by discussing the most commonly used paradigm for assessing rodent social behavior, the three-chamber test. We also point to the fact that although emotions greatly influence human social behavior, we lack reliable means for assessing the emotional state of animals during social tasks. As such, we also discuss current evidence supporting the existence of pro-social emotions and emotional cognition in animal models. We further suggest that adequate social behavior analysis requires a novel multimodal approach that employs automated and simultaneous measurements of multiple behavioral and physiological variables at high temporal resolution in socially interacting animals. We accordingly describe several computerized systems and computational tools for acquiring and analyzing such measurements. Finally, we address several behavioral and physiological variables that can be used to assess socio-emotional states in animal models and thus elucidate intricacies of social behavior so as to attain deeper insight into the brain mechanisms that mediate such behaviors. CONCLUSIONS: In summary, we suggest that combining automated multimodal measurements with machine-learning algorithms will help define socio-emotional states and determine their dynamics during various types of social tasks, thus enabling a more thorough understanding of the complexity of social behavior. En ligne : http://dx.doi.org/10.1186/s13229-022-00521-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Brief Report: A Longitudinal Study of Excessive Smiling and Laughing in Children with Angelman Syndrome / Dawn ADAMS in Journal of Autism and Developmental Disorders, 45-8 (August 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2624-2627 Titre : Brief Report: A Longitudinal Study of Excessive Smiling and Laughing in Children with Angelman Syndrome Type de document : texte imprimé Auteurs : Dawn ADAMS, Auteur ; Kate HORSLER, Auteur ; Rebecca MOUNT, Auteur ; Chris OLIVER, Auteur Année de publication : 2015 Article en page(s) : p.2624-2627 Langues : Anglais (eng) Mots-clés : Angelman syndrome  Behavioral phenotype  Intellectual disability  Aging  Behavior Index. décimale : PER Périodiques Résumé : Elevated laughing and smiling is a key characteristic of the Angelman syndrome behavioral phenotype, with cross-sectional studies reporting changes with environment and age. This study compares levels of laughing and smiling in 12 participants across three experimental conditions [full social interaction (with eye contact), social interaction with no eye contact, proximity only] at two data points. No differences were noted in frequency of laughing and smiling over time in any condition. However, with age as a covariate, the frequency of laughing and smiling decreased over time in the full social interaction (with eye contact) condition only. As this is the first longitudinal study to explore these behaviors in Angelman syndrome, the results suggest a gene–environment–time interaction within the behavioral phenotype. En ligne : http://dx.doi.org/10.1007/s10803-015-2404-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Brief Report: A Longitudinal Study of Excessive Smiling and Laughing in Children with Angelman Syndrome [texte imprimé] / Dawn ADAMS, Auteur ; Kate HORSLER, Auteur ; Rebecca MOUNT, Auteur ; Chris OLIVER, Auteur . - 2015 . - p.2624-2627. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-8 (August 2015) . - p.2624-2627 Mots-clés : Angelman syndrome  Behavioral phenotype  Intellectual disability  Aging  Behavior Index. décimale : PER Périodiques Résumé : Elevated laughing and smiling is a key characteristic of the Angelman syndrome behavioral phenotype, with cross-sectional studies reporting changes with environment and age. This study compares levels of laughing and smiling in 12 participants across three experimental conditions [full social interaction (with eye contact), social interaction with no eye contact, proximity only] at two data points. No differences were noted in frequency of laughing and smiling over time in any condition. However, with age as a covariate, the frequency of laughing and smiling decreased over time in the full social interaction (with eye contact) condition only. As this is the first longitudinal study to explore these behaviors in Angelman syndrome, the results suggest a gene–environment–time interaction within the behavioral phenotype. En ligne : http://dx.doi.org/10.1007/s10803-015-2404-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Brief Report: Mobile Technology to Support Parents in Reducing Stereotypy / Lydia TRUDEL in Journal of Autism and Developmental Disorders, 51-7 (July 2021)  

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Clinical Outcomes of Behavioral Treatments for Pica in Children with Developmental Disabilities / Nathan A. CALL in Journal of Autism and Developmental Disorders, 45-7 (July 2015)  

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Integrating parent report, observed behavior, and physiological measures to identify biomarkers of sensory over-responsivity in autism / Apurva CHATURVEDI in Journal of Neurodevelopmental Disorders, 17 (2025)  

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Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development / Jacob ELLEGOOD in Molecular Autism, 12 (2021)  

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Parent Reports of Executive Function Associated with Functional Communication and Conversational Skills Among School Age Children With and Without Autism Spectrum Disorder / Sarah M. HUTCHISON in Journal of Autism and Developmental Disorders, 50-6 (June 2020)  

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