An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior / Elisabeth CONRADT in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.881-890 Titre : An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior Type de document : texte imprimé Auteurs : Elisabeth CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; Sheila E. CROWELL, Auteur ; Catherine MONK, Auteur ; Michael S. KOBOR, Auteur Année de publication : 2018 Article en page(s) : p.881-890 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Following recent advances in behavioral and psychiatric epigenetics, researchers are increasingly using epigenetic methods to study prenatal exposure to maternal mood disorder and its effects on fetal and newborn neurobehavior. Despite notable progress, various methodological limitations continue to obscure our understanding of the epigenetic mechanisms underpinning prenatal exposure to maternal mood disorder on newborn neurobehavioral development. Here we detail this problem, discussing limitations of the currently dominant analytical approaches (i.e., candidate epigenetic and epigenome-wide association studies), then present a solution that retains many benefits of existing methods while minimizing their shortcomings: epigenetic pathway analysis. We argue that the application of pathway-based epigenetic approaches that target DNA methylation at transcription factor binding sites could substantially deepen our mechanistic understanding of how prenatal exposures influence newborn neurobehavior. En ligne : http://dx.doi.org/10.1017/s0954579418000688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior [texte imprimé] / Elisabeth CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; Sheila E. CROWELL, Auteur ; Catherine MONK, Auteur ; Michael S. KOBOR, Auteur . - 2018 . - p.881-890. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.881-890 Index. décimale : PER Périodiques Résumé : Following recent advances in behavioral and psychiatric epigenetics, researchers are increasingly using epigenetic methods to study prenatal exposure to maternal mood disorder and its effects on fetal and newborn neurobehavior. Despite notable progress, various methodological limitations continue to obscure our understanding of the epigenetic mechanisms underpinning prenatal exposure to maternal mood disorder on newborn neurobehavioral development. Here we detail this problem, discussing limitations of the currently dominant analytical approaches (i.e., candidate epigenetic and epigenome-wide association studies), then present a solution that retains many benefits of existing methods while minimizing their shortcomings: epigenetic pathway analysis. We argue that the application of pathway-based epigenetic approaches that target DNA methylation at transcription factor binding sites could substantially deepen our mechanistic understanding of how prenatal exposures influence newborn neurobehavior. En ligne : http://dx.doi.org/10.1017/s0954579418000688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Correspondence between physiological and self-report measures of emotion dysregulation: A longitudinal investigation of youth with and without psychopathology / Christina A. VASILEV in Journal of Child Psychology and Psychiatry, 50-11 (November 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-11 (November 2009) . - p.1357-1364 Titre : Correspondence between physiological and self-report measures of emotion dysregulation: A longitudinal investigation of youth with and without psychopathology Type de document : texte imprimé Auteurs : Christina A. VASILEV, Auteur ; Theodore P. BEAUCHAINE, Auteur ; Lisa GATZKE-KOPP, Auteur ; Sheila E. CROWELL, Auteur ; Hilary K. MEAD, Auteur Année de publication : 2009 Article en page(s) : p.1357-1364 Langues : Anglais (eng) Mots-clés : Emotion-dysregulation psychopathology respiratory-sinus-arrhythmia Difficulties-in-Emotion-Regulation-Scale Index. décimale : PER Périodiques Résumé : Background: Several theoretical perspectives suggest that emotion dysregulation is a predisposing risk factor for many psychiatric disorders. Yet despite a rapidly evolving literature, difficulties with emotion regulation (ER) are often measured inconsistently across studies, with little regard to whether different approaches capture the same construct. In this study, we evaluate the correspondence between two widely used measures of emotion dysregulation that cut across self-report and physiological levels of analysis. Our objectives were to (1) evaluate whether youth self-reports of ER difficulties correspond with physiological measures of emotion dysregulation collected at baseline and during sad emotion induction, and (2) validate the Difficulties in Emotion Regulation Scale (DERS) in a youth sample. Method: We measured emotion dysregulation among a sample of youth with depression, conduct problems, comorbid depression/conduct problems, or no psychiatric condition. Youth were assessed initially at ages 8–12 (Year 1) and followed up at Years 2 and 3. Respiratory sinus arrhythmia (RSA), a widely used physiological index of emotion regulation, was measured across all three years during sad emotion induction. At Year 3, the DERS was also administered. Results: Multilevel modeling analyses indicated that slopes in RSA collected across the three assessments were associated with later self-reported ER abilities at the transition into adolescence. These findings were replicated across contexts (baseline and emotional challenge), suggesting that adolescents whose physiological responding to emotional challenge improves also experience fewer difficulties with emotion regulation as they mature. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02172.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=848 [article] Correspondence between physiological and self-report measures of emotion dysregulation: A longitudinal investigation of youth with and without psychopathology [texte imprimé] / Christina A. VASILEV, Auteur ; Theodore P. BEAUCHAINE, Auteur ; Lisa GATZKE-KOPP, Auteur ; Sheila E. CROWELL, Auteur ; Hilary K. MEAD, Auteur . - 2009 . - p.1357-1364. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-11 (November 2009) . - p.1357-1364 Mots-clés : Emotion-dysregulation psychopathology respiratory-sinus-arrhythmia Difficulties-in-Emotion-Regulation-Scale Index. décimale : PER Périodiques Résumé : Background: Several theoretical perspectives suggest that emotion dysregulation is a predisposing risk factor for many psychiatric disorders. Yet despite a rapidly evolving literature, difficulties with emotion regulation (ER) are often measured inconsistently across studies, with little regard to whether different approaches capture the same construct. In this study, we evaluate the correspondence between two widely used measures of emotion dysregulation that cut across self-report and physiological levels of analysis. Our objectives were to (1) evaluate whether youth self-reports of ER difficulties correspond with physiological measures of emotion dysregulation collected at baseline and during sad emotion induction, and (2) validate the Difficulties in Emotion Regulation Scale (DERS) in a youth sample. Method: We measured emotion dysregulation among a sample of youth with depression, conduct problems, comorbid depression/conduct problems, or no psychiatric condition. Youth were assessed initially at ages 8–12 (Year 1) and followed up at Years 2 and 3. Respiratory sinus arrhythmia (RSA), a widely used physiological index of emotion regulation, was measured across all three years during sad emotion induction. At Year 3, the DERS was also administered. Results: Multilevel modeling analyses indicated that slopes in RSA collected across the three assessments were associated with later self-reported ER abilities at the transition into adolescence. These findings were replicated across contexts (baseline and emotional challenge), suggesting that adolescents whose physiological responding to emotional challenge improves also experience fewer difficulties with emotion regulation as they mature. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02172.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=848

Development of self-inflicted injury: Comorbidities and continuities with borderline and antisocial personality traits / Sheila E. CROWELL in Development and Psychopathology, 28-4 pt1 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt1 (November 2016) . - p.1071-1088 Titre : Development of self-inflicted injury: Comorbidities and continuities with borderline and antisocial personality traits Type de document : texte imprimé Auteurs : Sheila E. CROWELL, Auteur ; Erin A. KAUFMAN, Auteur Article en page(s) : p.1071-1088 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Self-inflicted injury (SII) is a continuum of intentionally self-destructive behaviors, including nonsuicidal self-injuries, suicide attempts, and death by suicide. These behaviors are among the most pressing yet perplexing clinical problems, affecting males and females of every race, ethnicity, culture, socioeconomic status, and nearly every age. The complexity of these behaviors has spurred an immense literature documenting risk and vulnerability factors ranging from individual to societal levels of analysis. However, there have been relatively few attempts to articulate a life span developmental model that integrates ontogenenic processes across these diverse systems. The objective of this review is to outline such a model with a focus on how observed patterns of comorbidity and continuity can inform developmental theories, early prevention efforts, and intervention across traditional diagnostic boundaries. Specifically, when SII is viewed through the developmental psychopathology lens, it becomes apparent that early temperamental risk factors are associated with risk for SII and a range of highly comorbid conditions, such as borderline and antisocial personality disorders. Prevention efforts focused on early-emerging biological and temperamental contributors to psychopathology have great potential to reduce risk for many presumably distinct clinical problems. Such work requires identification of early biological vulnerabilities, behaviorally conditioned social mechanisms, as well as societal inequities that contribute to self-injury and underlie intergenerational transmission of risk. En ligne : http://dx.doi.org/10.1017/s0954579416000705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Development of self-inflicted injury: Comorbidities and continuities with borderline and antisocial personality traits [texte imprimé] / Sheila E. CROWELL, Auteur ; Erin A. KAUFMAN, Auteur . - p.1071-1088. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt1 (November 2016) . - p.1071-1088 Index. décimale : PER Périodiques Résumé : Self-inflicted injury (SII) is a continuum of intentionally self-destructive behaviors, including nonsuicidal self-injuries, suicide attempts, and death by suicide. These behaviors are among the most pressing yet perplexing clinical problems, affecting males and females of every race, ethnicity, culture, socioeconomic status, and nearly every age. The complexity of these behaviors has spurred an immense literature documenting risk and vulnerability factors ranging from individual to societal levels of analysis. However, there have been relatively few attempts to articulate a life span developmental model that integrates ontogenenic processes across these diverse systems. The objective of this review is to outline such a model with a focus on how observed patterns of comorbidity and continuity can inform developmental theories, early prevention efforts, and intervention across traditional diagnostic boundaries. Specifically, when SII is viewed through the developmental psychopathology lens, it becomes apparent that early temperamental risk factors are associated with risk for SII and a range of highly comorbid conditions, such as borderline and antisocial personality disorders. Prevention efforts focused on early-emerging biological and temperamental contributors to psychopathology have great potential to reduce risk for many presumably distinct clinical problems. Such work requires identification of early biological vulnerabilities, behaviorally conditioned social mechanisms, as well as societal inequities that contribute to self-injury and underlie intergenerational transmission of risk. En ligne : http://dx.doi.org/10.1017/s0954579416000705 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

From prenatal maternal anxiety and respiratory sinus arrhythmia to toddler internalizing problems: The role of infant negative affectivity / Anna M. ZHOU in Development and Psychopathology, 37-3 (August 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-3 (August 2025) . - p.1482-1494 Titre : From prenatal maternal anxiety and respiratory sinus arrhythmia to toddler internalizing problems: The role of infant negative affectivity Type de document : texte imprimé Auteurs : Anna M. ZHOU, Auteur ; Mengyu GAO, Auteur ; Brendan OSTLUND, Auteur ; Sarah E. MAYLOTT, Auteur ; Nicolette C. MOLINA, Auteur ; Madeleine BRUCE, Auteur ; K. Lee RABY, Auteur ; Elisabeth CONRADT, Auteur ; Sheila E. CROWELL, Auteur Article en page(s) : p.1482-1494 Langues : Anglais (eng) Mots-clés : internalizing problems  negative affectivity  prenatal anxiety  respiratory sinus arrhythmia Index. décimale : PER Périodiques Résumé : Prenatal maternal anxiety is considered a risk factor for the development of child internalizing problems. However, little is known about potential mechanisms that account for these associations. The current study examined whether prenatal maternal anxiety was indirectly associated with toddler internalizing problems via prenatal maternal physiology and infant negative affectivity. We examined these associations in a longitudinal study of 162 expectant mothers from their third trimester until 18 months postpartum. Path analyses showed that higher prenatal anxiety was associated with higher infant negative affectivity at 7 months, which in turn was associated with higher toddler internalizing problems at 18 months. Prenatal anxiety was not indirectly associated with child outcomes via baseline or task-evoked respiratory sinus arrhythmia (RSA) in response to an infant cry while pregnant. However, pregnant women with greater decreases in task-evoked RSA had toddlers with greater internalizing problems, which was mediated by infant negative affectivity at 7 months. Findings suggest that prenatal anxiety and RSA reactivity to an infant cry may be independent risk factors for the development of infant negative affectivity, which in turn increases risk for toddler internalizing problems. These findings contribute to a growing literature on mechanisms that underlie intergenerational transmission of internalizing problems. En ligne : https://www.cambridge.org/core/product/CF53D676EA68F7C244BBE0D9682B22DC Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] From prenatal maternal anxiety and respiratory sinus arrhythmia to toddler internalizing problems: The role of infant negative affectivity [texte imprimé] / Anna M. ZHOU, Auteur ; Mengyu GAO, Auteur ; Brendan OSTLUND, Auteur ; Sarah E. MAYLOTT, Auteur ; Nicolette C. MOLINA, Auteur ; Madeleine BRUCE, Auteur ; K. Lee RABY, Auteur ; Elisabeth CONRADT, Auteur ; Sheila E. CROWELL, Auteur . - p.1482-1494. Langues : Anglais (eng) in Development and Psychopathology > 37-3 (August 2025) . - p.1482-1494 Mots-clés : internalizing problems  negative affectivity  prenatal anxiety  respiratory sinus arrhythmia Index. décimale : PER Périodiques Résumé : Prenatal maternal anxiety is considered a risk factor for the development of child internalizing problems. However, little is known about potential mechanisms that account for these associations. The current study examined whether prenatal maternal anxiety was indirectly associated with toddler internalizing problems via prenatal maternal physiology and infant negative affectivity. We examined these associations in a longitudinal study of 162 expectant mothers from their third trimester until 18 months postpartum. Path analyses showed that higher prenatal anxiety was associated with higher infant negative affectivity at 7 months, which in turn was associated with higher toddler internalizing problems at 18 months. Prenatal anxiety was not indirectly associated with child outcomes via baseline or task-evoked respiratory sinus arrhythmia (RSA) in response to an infant cry while pregnant. However, pregnant women with greater decreases in task-evoked RSA had toddlers with greater internalizing problems, which was mediated by infant negative affectivity at 7 months. Findings suggest that prenatal anxiety and RSA reactivity to an infant cry may be independent risk factors for the development of infant negative affectivity, which in turn increases risk for toddler internalizing problems. These findings contribute to a growing literature on mechanisms that underlie intergenerational transmission of internalizing problems. En ligne : https://www.cambridge.org/core/product/CF53D676EA68F7C244BBE0D9682B22DC Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

Incorporating epigenetic mechanisms to advance fetal programming theories / Elisabeth CONRADT in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.807-824 Titre : Incorporating epigenetic mechanisms to advance fetal programming theories Type de document : texte imprimé Auteurs : Elisabeth CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; Sheila E. CROWELL, Auteur ; K. Lee RABY, Auteur ; L.M. DIAMOND, Auteur ; Bruce ELLIS, Auteur Article en page(s) : p.807-824 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Decades of fetal programming research indicates that we may be able to map the origins of many physical, psychological, and medical variations and morbidities before the birth of the child. While great strides have been made in identifying associations between prenatal insults, such as undernutrition or psychosocial stress, and negative developmental outcomes, far less is known about how adaptive responses to adversity regulate the developing phenotype to match stressful conditions. As the application of epigenetic methods to human behavior has exploded in the last decade, research has begun to shed light on the role of epigenetic mechanisms in explaining how prenatal conditions shape later susceptibilities to mental and physical health problems. In this review, we describe and attempt to integrate two dominant fetal programming models: the cumulative stress model (a disease-focused approach) and the match-mismatch model (an evolutionary-developmental approach). In conjunction with biological sensitivity to context theory, we employ these two models to generate new hypotheses regarding epigenetic mechanisms through which prenatal and postnatal experiences program child stress reactivity and, in turn, promote development of adaptive versus maladaptive phenotypic outcomes. We conclude by outlining priority questions and future directions for the fetal programming field. En ligne : http://dx.doi.org/10.1017/s0954579418000469 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] Incorporating epigenetic mechanisms to advance fetal programming theories [texte imprimé] / Elisabeth CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; Sheila E. CROWELL, Auteur ; K. Lee RABY, Auteur ; L.M. DIAMOND, Auteur ; Bruce ELLIS, Auteur . - p.807-824. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.807-824 Index. décimale : PER Périodiques Résumé : Decades of fetal programming research indicates that we may be able to map the origins of many physical, psychological, and medical variations and morbidities before the birth of the child. While great strides have been made in identifying associations between prenatal insults, such as undernutrition or psychosocial stress, and negative developmental outcomes, far less is known about how adaptive responses to adversity regulate the developing phenotype to match stressful conditions. As the application of epigenetic methods to human behavior has exploded in the last decade, research has begun to shed light on the role of epigenetic mechanisms in explaining how prenatal conditions shape later susceptibilities to mental and physical health problems. In this review, we describe and attempt to integrate two dominant fetal programming models: the cumulative stress model (a disease-focused approach) and the match-mismatch model (an evolutionary-developmental approach). In conjunction with biological sensitivity to context theory, we employ these two models to generate new hypotheses regarding epigenetic mechanisms through which prenatal and postnatal experiences program child stress reactivity and, in turn, promote development of adaptive versus maladaptive phenotypic outcomes. We conclude by outlining priority questions and future directions for the fetal programming field. En ligne : http://dx.doi.org/10.1017/s0954579418000469 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Intergenerational transmission of emotion dysregulation: Part I. Psychopathology, self-injury, and parasympathetic responsivity among pregnant women / Betty LIN in Development and Psychopathology, 31-3 (August 2019)  

Permalink

Intergenerational transmission of emotion dysregulation: Part II. Developmental origins of newborn neurobehavior / Brendan OSTLUND in Development and Psychopathology, 31-3 (August 2019)  

Permalink

Multifinality in the development of personality disorders: A Biology × Sex × Environment interaction model of antisocial and borderline traits / Theodore P. BEAUCHAINE in Development and Psychopathology, 21-3 (August 2009)  

Permalink

A multilevel developmental psychopathology model of childbirth and the perinatal transition / Elisabeth CONRADT ; Patricia K. KERIG ; Paula G. WILLIAMS ; Sheila E. CROWELL in Development and Psychopathology, 36-2 (May 2024)  

Permalink

Prenatal maternal transdiagnostic, RDoC-informed predictors of newborn neurobehavior: Differences by sex / Mengyu GAO in Development and Psychopathology, 33-5 (December 2021)  

Permalink

Quantifying respiratory sinus arrhythmia: Effects of misspecifying breathing frequencies across development / Tiffany M. SHADER in Development and Psychopathology, 30-1 (February 2018)  

Permalink

The effects of allostatic load on neural systems subserving motivation, mood regulation, and social affiliation / Theodore P. BEAUCHAINE in Development and Psychopathology, 23-4 (November 2011)  

Permalink

Understanding emotion dysregulation from infancy to toddlerhood with a multilevel perspective: The buffering effect of maternal sensitivity / Mindy A. BROWN in Development and Psychopathology, 37-2 (May 2025)  

Permalink

Using automated computer vision and machine learning to code facial expressions of affect and arousal: Implications for emotion dysregulation research / Nathaniel HAINES in Development and Psychopathology, 31-3 (August 2019)  

Permalink

Using development and psychopathology principles to inform the Research Domain Criteria (RDoC) framework / Elisabeth CONRADT in Development and Psychopathology, 33-5 (December 2021)  

Permalink

---

1 2 (1 - 15 / 16) Par page : 25 50 100 200