Brief report: Game day: A novel method of assessing change in social competence in students with autism spectrum disorder (ASD) / Stephen BENT in Research in Autism Spectrum Disorders, 84 (June 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 84 (June 2021) . - 101766 Titre : Brief report: Game day: A novel method of assessing change in social competence in students with autism spectrum disorder (ASD) Type de document : Texte imprimé et/ou numérique Auteurs : Stephen BENT, Auteur ; Michael G. MCDONALD, Auteur ; Yingtong CHEN, Auteur ; Felicia WIDJAJA, Auteur ; Jessica WAHLBERG, Auteur ; Bushra HOSSAIN, Auteur ; Robert L. HENDREN, Auteur Article en page(s) : 101766 Langues : Anglais (eng) Mots-clés : Autism  Social skills  Outcome measure Index. décimale : PER Périodiques Résumé : Background Group social skills programs for autism spectrum disorder (ASD) have been shown to improve social skills knowledge and parent and teacher survey ratings, but have been limited by a lack of directly observed measures of social skills in unstructured settings. Methods The goal of this study was to examine the feasibility of using a novel, directly observed measure (“game day”) to monitor changes in social skills in students with ASD participating in a 16-week, school-based social skills program (Program for the Education and Enrichment of Relational Skills - PEERS). Game day occurred once a month and consisted of the instructor placing a set of board games in the room and then leaving. Videos of the game day sessions were rated by three reviewers (blinded to the video sequence) using a modified version of the Contextual Assessment of Social Skills (CASS). Results Six students (age range 13–22, 5 male) enrolled and completed all PEERS instruction and 5 monthly game day sessions. Reviewers were able to complete ratings for all scale items except frequency of initiations and responses. The remaining nine CASS items were used to generate a summary score for each child; the mean score improved from 38.5 to 43.6 (p = 0.011). Validated surveys also showed statistically significant improvements in social skills knowledge, problem behaviors, and ASD behaviors. Conclusions This study provides initial evidence that a directly observed measure detects changes in social competence in ASD and may provide a broader assessment of social ability. En ligne : https://doi.org/10.1016/j.rasd.2021.101766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446 [article] Brief report: Game day: A novel method of assessing change in social competence in students with autism spectrum disorder (ASD) [Texte imprimé et/ou numérique] / Stephen BENT, Auteur ; Michael G. MCDONALD, Auteur ; Yingtong CHEN, Auteur ; Felicia WIDJAJA, Auteur ; Jessica WAHLBERG, Auteur ; Bushra HOSSAIN, Auteur ; Robert L. HENDREN, Auteur . - 101766. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 84 (June 2021) . - 101766 Mots-clés : Autism  Social skills  Outcome measure Index. décimale : PER Périodiques Résumé : Background Group social skills programs for autism spectrum disorder (ASD) have been shown to improve social skills knowledge and parent and teacher survey ratings, but have been limited by a lack of directly observed measures of social skills in unstructured settings. Methods The goal of this study was to examine the feasibility of using a novel, directly observed measure (“game day”) to monitor changes in social skills in students with ASD participating in a 16-week, school-based social skills program (Program for the Education and Enrichment of Relational Skills - PEERS). Game day occurred once a month and consisted of the instructor placing a set of board games in the room and then leaving. Videos of the game day sessions were rated by three reviewers (blinded to the video sequence) using a modified version of the Contextual Assessment of Social Skills (CASS). Results Six students (age range 13–22, 5 male) enrolled and completed all PEERS instruction and 5 monthly game day sessions. Reviewers were able to complete ratings for all scale items except frequency of initiations and responses. The remaining nine CASS items were used to generate a summary score for each child; the mean score improved from 38.5 to 43.6 (p = 0.011). Validated surveys also showed statistically significant improvements in social skills knowledge, problem behaviors, and ASD behaviors. Conclusions This study provides initial evidence that a directly observed measure detects changes in social competence in ASD and may provide a broader assessment of social ability. En ligne : https://doi.org/10.1016/j.rasd.2021.101766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446

Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial / Stephen BENT in Journal of Autism and Developmental Disorders, 42-6 (June 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.1127-1132 Titre : Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial Type de document : Texte imprimé et/ou numérique Auteurs : Stephen BENT, Auteur ; Kiah BERTOGLIO, Auteur ; Paul ASHWOOD, Auteur ; Edward NEMETH, Auteur ; Robert L. HENDREN, Auteur Année de publication : 2012 Article en page(s) : p.1127-1132 Langues : Anglais (eng) Mots-clés : Autism  Clinical trial  Alternative therapy Index. décimale : PER Périodiques Résumé : We sought to determine whether HBOT leads to parental reported behavioral changes and alterations in cytokines in children with ASD. Ten children completed 80 sessions of HBOT and all improved by 2 points on the clinician-rated CGI-I scale (much improved) as well as several parent-completed measures of behavior. The lack of a control group limits the ability to determine if improvements were related to HBOT. Enrolled children did not exhibit abnormal cytokine levels at baseline and no significant changes in mean cytokine levels were observed. Although this study was limited by the small sample size and by the variable nature of cytokines, we found no evidence that HBOT affects cytokine levels or that cytokine levels were associated with behavioral changes. En ligne : http://dx.doi.org/10.1007/s10803-011-1337-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156 [article] Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial [Texte imprimé et/ou numérique] / Stephen BENT, Auteur ; Kiah BERTOGLIO, Auteur ; Paul ASHWOOD, Auteur ; Edward NEMETH, Auteur ; Robert L. HENDREN, Auteur . - 2012 . - p.1127-1132. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.1127-1132 Mots-clés : Autism  Clinical trial  Alternative therapy Index. décimale : PER Périodiques Résumé : We sought to determine whether HBOT leads to parental reported behavioral changes and alterations in cytokines in children with ASD. Ten children completed 80 sessions of HBOT and all improved by 2 points on the clinician-rated CGI-I scale (much improved) as well as several parent-completed measures of behavior. The lack of a control group limits the ability to determine if improvements were related to HBOT. Enrolled children did not exhibit abnormal cytokine levels at baseline and no significant changes in mean cytokine levels were observed. Although this study was limited by the small sample size and by the variable nature of cytokines, we found no evidence that HBOT affects cytokine levels or that cytokine levels were associated with behavioral changes. En ligne : http://dx.doi.org/10.1007/s10803-011-1337-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli / Stephen BENT in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 35p. Titre : Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli Type de document : Texte imprimé et/ou numérique Auteurs : Stephen BENT, Auteur ; B. LAWTON, Auteur ; T. WARREN, Auteur ; F. WIDJAJA, Auteur ; K. DANG, Auteur ; J. W. FAHEY, Auteur ; Brian CORNBLATT, Auteur ; J. M. KINCHEN, Auteur ; K. DELUCCHI, Auteur ; R. L. HENDREN, Auteur Article en page(s) : 35p. Langues : Anglais (eng) Mots-clés : Adolescent  Antioxidants/administration & dosage/analysis/therapeutic use  Autistic Disorder/drug therapy/urine  Biomarkers/urine  Brassica/chemistry  Child  Female  Humans  Isothiocyanates/administration & dosage/analysis/therapeutic use  Male  Metabolome  Social Behavior  Young Adult  Antioxidant  Autism  Biomarker  Metabolomics Index. décimale : PER Périodiques Résumé : Background: Children with autism spectrum disorder (ASD) have urinary metabolites suggesting impairments in several pathways, including oxidative stress, inflammation, mitochondrial dysfunction, and gut microbiome alterations. Sulforaphane, a supplement with indirect antioxidant effects that are derived from broccoli sprouts and seeds, was recently shown to lead to improvements in behavior and social responsiveness in children with ASD. We conducted the current open-label study to determine if we could identify changes in urinary metabolites that were associated with clinical improvements with the goal of identifying a potential mechanism of action. Methods: Children and young adults enrolled in a school for children with ASD and related neurodevelopmental disorders were recruited to participate in a 12-week, open-label study of sulforaphane. Fasting urinary metabolites and measures of behavior (Aberrant Behavior Checklist-ABC) and social responsiveness (Social Responsiveness Scale-SRS) were measured at baseline and at the end of the study. Pearson's correlation coefficient was calculated for the pre- to post-intervention change in each of the two clinical scales (ABS and SRS) versus the change in each metabolite. Results: Fifteen children completed the 12-week study. Mean scores on both symptom measures showed improvements (decreases) over the study period, but only the change in the SRS was significant. The ABC improved - 7.1 points (95% CI - 17.4 to 3.2), and the SRS improved - 9.7 points (95% CI - 18.7 to - 0.8). We identified 77 urinary metabolites that were correlated with changes in symptoms, and they clustered into pathways of oxidative stress, amino acid/gut microbiome, neurotransmitters, hormones, and sphingomyelin metabolism. Conclusions: Urinary metabolomics analysis is a useful tool to identify pathways that may be involved in the mechanism of action of treatments targeting abnormal physiology in ASD. Trial registration: This study was prospectively registered at clinicaltrials.gov (NCT02654743) on January 11, 2016. En ligne : https://dx.doi.org/10.1186/s13229-018-0218-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli [Texte imprimé et/ou numérique] / Stephen BENT, Auteur ; B. LAWTON, Auteur ; T. WARREN, Auteur ; F. WIDJAJA, Auteur ; K. DANG, Auteur ; J. W. FAHEY, Auteur ; Brian CORNBLATT, Auteur ; J. M. KINCHEN, Auteur ; K. DELUCCHI, Auteur ; R. L. HENDREN, Auteur . - 35p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 35p. Mots-clés : Adolescent  Antioxidants/administration & dosage/analysis/therapeutic use  Autistic Disorder/drug therapy/urine  Biomarkers/urine  Brassica/chemistry  Child  Female  Humans  Isothiocyanates/administration & dosage/analysis/therapeutic use  Male  Metabolome  Social Behavior  Young Adult  Antioxidant  Autism  Biomarker  Metabolomics Index. décimale : PER Périodiques Résumé : Background: Children with autism spectrum disorder (ASD) have urinary metabolites suggesting impairments in several pathways, including oxidative stress, inflammation, mitochondrial dysfunction, and gut microbiome alterations. Sulforaphane, a supplement with indirect antioxidant effects that are derived from broccoli sprouts and seeds, was recently shown to lead to improvements in behavior and social responsiveness in children with ASD. We conducted the current open-label study to determine if we could identify changes in urinary metabolites that were associated with clinical improvements with the goal of identifying a potential mechanism of action. Methods: Children and young adults enrolled in a school for children with ASD and related neurodevelopmental disorders were recruited to participate in a 12-week, open-label study of sulforaphane. Fasting urinary metabolites and measures of behavior (Aberrant Behavior Checklist-ABC) and social responsiveness (Social Responsiveness Scale-SRS) were measured at baseline and at the end of the study. Pearson's correlation coefficient was calculated for the pre- to post-intervention change in each of the two clinical scales (ABS and SRS) versus the change in each metabolite. Results: Fifteen children completed the 12-week study. Mean scores on both symptom measures showed improvements (decreases) over the study period, but only the change in the SRS was significant. The ABC improved - 7.1 points (95% CI - 17.4 to 3.2), and the SRS improved - 9.7 points (95% CI - 18.7 to - 0.8). We identified 77 urinary metabolites that were correlated with changes in symptoms, and they clustered into pathways of oxidative stress, amino acid/gut microbiome, neurotransmitters, hormones, and sphingomyelin metabolism. Conclusions: Urinary metabolomics analysis is a useful tool to identify pathways that may be involved in the mechanism of action of treatments targeting abnormal physiology in ASD. Trial registration: This study was prospectively registered at clinicaltrials.gov (NCT02654743) on January 11, 2016. En ligne : https://dx.doi.org/10.1186/s13229-018-0218-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Improving Social Knowledge and Skills among Adolescents with Autism: Systematic Review and Meta-Analysis of UCLA PEERS® for Adolescents / S. ZHENG in Journal of Autism and Developmental Disorders, 51-12 (December 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4488-4503 Titre : Improving Social Knowledge and Skills among Adolescents with Autism: Systematic Review and Meta-Analysis of UCLA PEERS® for Adolescents Type de document : Texte imprimé et/ou numérique Auteurs : S. ZHENG, Auteur ; H. KIM, Auteur ; E. SALZMAN, Auteur ; K. ANKENMAN, Auteur ; Stephen BENT, Auteur Article en page(s) : p.4488-4503 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Humans  Peer Group  Social Skills  Adolescents  Autism  Effect sizes  Meta-analysis  Social skills training Index. décimale : PER Périodiques Résumé : UCLA PEERS® for Adolescents is a widely applied program among a number of social skills training programs developed over the years. We synthesized current research evidence on the PEERS program to evaluate the treatment effect on four commonly used outcome measures. 12 studies met inclusion criteria for the review and nine met the criteria for meta-analysis. Results showed moderate to large pooled effects across measures and informants in favor of the PEERS program, with the largest effect seen in social knowledge improvement and the smallest effect in the frequency of get-togethers. The heterogeneity of effects across studies were examined and the limitations of the current evidence were discussed. En ligne : http://dx.doi.org/10.1007/s10803-021-04885-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Improving Social Knowledge and Skills among Adolescents with Autism: Systematic Review and Meta-Analysis of UCLA PEERS® for Adolescents [Texte imprimé et/ou numérique] / S. ZHENG, Auteur ; H. KIM, Auteur ; E. SALZMAN, Auteur ; K. ANKENMAN, Auteur ; Stephen BENT, Auteur . - p.4488-4503. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4488-4503 Mots-clés : Adolescent  Autism Spectrum Disorder  Autistic Disorder  Humans  Peer Group  Social Skills  Adolescents  Autism  Effect sizes  Meta-analysis  Social skills training Index. décimale : PER Périodiques Résumé : UCLA PEERS® for Adolescents is a widely applied program among a number of social skills training programs developed over the years. We synthesized current research evidence on the PEERS program to evaluate the treatment effect on four commonly used outcome measures. 12 studies met inclusion criteria for the review and nine met the criteria for meta-analysis. Results showed moderate to large pooled effects across measures and informants in favor of the PEERS program, with the largest effect seen in social knowledge improvement and the smallest effect in the frequency of get-togethers. The heterogeneity of effects across studies were examined and the limitations of the current evidence were discussed. En ligne : http://dx.doi.org/10.1007/s10803-021-04885-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

Omega-3 Fatty Acids for Autistic Spectrum Disorder: A Systematic Review / Stephen BENT in Journal of Autism and Developmental Disorders, 39-8 (August 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-8 (August 2009) . - p.1145-1154 Titre : Omega-3 Fatty Acids for Autistic Spectrum Disorder: A Systematic Review Type de document : Texte imprimé et/ou numérique Auteurs : Stephen BENT, Auteur ; Kiah BERTOGLIO, Auteur ; Robert L. HENDREN, Auteur Année de publication : 2009 Article en page(s) : p.1145-1154 Note générale : Open Access Langues : Anglais (eng) Mots-clés : Autism Omega-3-fatty-acids Complementary-and-alternative-medicine Index. décimale : PER Périodiques Résumé : We conducted a systematic review to determine the safety and efficacy of omega-3 fatty acids for autistic spectrum disorder (ASD). Articles were identified by a search of MEDLINE, EMBASE, and the Cochrane Database using the terms autism or autistic and omega-3 fatty acids. The search identified 143 potential articles and six satisfied all inclusion criteria. One small randomized controlled trial (n = 13) noted non-significant improvements in hyperactivity and stereotypy. The remaining five studies were small (n = 30, 22, 19, 9, and 1) with four reporting improvements in a wide range of outcomes including language and learning skills, parental observations of general health and behavior, a clinician-administered symptom scale, and clinical observations of anxiety. Due to the limitations of evidence from uncontrolled studies and the presence of only one small randomized controlled trial, there is currently insufficient scientific evidence to determine if omega-3 fatty acids are safe or effective for ASD. En ligne : http://dx.doi.org/10.1007/s10803-009-0724-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=789 [article] Omega-3 Fatty Acids for Autistic Spectrum Disorder: A Systematic Review [Texte imprimé et/ou numérique] / Stephen BENT, Auteur ; Kiah BERTOGLIO, Auteur ; Robert L. HENDREN, Auteur . - 2009 . - p.1145-1154. Open Access Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-8 (August 2009) . - p.1145-1154 Mots-clés : Autism Omega-3-fatty-acids Complementary-and-alternative-medicine Index. décimale : PER Périodiques Résumé : We conducted a systematic review to determine the safety and efficacy of omega-3 fatty acids for autistic spectrum disorder (ASD). Articles were identified by a search of MEDLINE, EMBASE, and the Cochrane Database using the terms autism or autistic and omega-3 fatty acids. The search identified 143 potential articles and six satisfied all inclusion criteria. One small randomized controlled trial (n = 13) noted non-significant improvements in hyperactivity and stereotypy. The remaining five studies were small (n = 30, 22, 19, 9, and 1) with four reporting improvements in a wide range of outcomes including language and learning skills, parental observations of general health and behavior, a clinician-administered symptom scale, and clinical observations of anxiety. Due to the limitations of evidence from uncontrolled studies and the presence of only one small randomized controlled trial, there is currently insufficient scientific evidence to determine if omega-3 fatty acids are safe or effective for ASD. En ligne : http://dx.doi.org/10.1007/s10803-009-0724-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=789

A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder / Stephen BENT in Journal of Autism and Developmental Disorders, 41-5 (May 2011)  

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Prevalence and predictors of complementary and alternative medicine use in a large insured sample of children with Autism Spectrum Disorders / Ashli A. OWEN-SMITH in Research in Autism Spectrum Disorders, 17 (September 2015)  

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