Changes in the Sulcal Size Associated With Autism Spectrum Disorder Revealed by Sulcal Morphometry / Mahsa SHOKOUHI in Autism Research, 5-4 (August 2012)  

Public ISBD [article]  inAutism Research > 5-4 (August 2012) . - p.245-52 Titre : Changes in the Sulcal Size Associated With Autism Spectrum Disorder Revealed by Sulcal Morphometry Type de document : Texte imprimé et/ou numérique Auteurs : Mahsa SHOKOUHI, Auteur ; Justin H.G. WILLIAMS, Auteur ; Gordon D. WAITER, Auteur ; Barrie CONDON, Auteur Année de publication : 2012 Article en page(s) : p.245-52 Langues : Anglais (eng) Mots-clés : autism  sulcal morphometry  MRI  Brainvisa Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex, neurodevelopmental disorder with various structural abnormalities for different patient groups. Because of the heterogeneity of the disorder, several biomarkers have been suggested so far. Here, we explore the potential of sulcal surface and length as biomarkers. Three-dimensional T1-weighted images of 15 adolescents of normal intelligence with ASD and 15 age-, sex-, and intelligence quotient-matched control adolescents were analysed using Brainvisa 4.0 (http://www.brainvisa.info), which automatically extracts the cortical folds and labels them as 59 sulcal pieces. For each sulcus, the surface, length, and mean geodesic depth were computed using morphometry analysis within this software package. General linear model was conducted to compare the estimated values for the two groups, ASD and control. In the ASD group, the left insula and the right intraparietal sulcus (IPS) had significantly higher values for surface and length, respectively. Nonetheless for all sulcal pieces, the mean geodesic depth was not significantly different between the two groups. Our results suggest that sulcal surface and length can have correlation with morphological changes of cortex in ASD. Greater surface area and length in insula and IPS, respectively, may reflect greater folding. This could result in greater separation of functions with an impact upon the integrative functions of these regions. En ligne : http://dx.doi.org/10.1002/aur.1232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Changes in the Sulcal Size Associated With Autism Spectrum Disorder Revealed by Sulcal Morphometry [Texte imprimé et/ou numérique] / Mahsa SHOKOUHI, Auteur ; Justin H.G. WILLIAMS, Auteur ; Gordon D. WAITER, Auteur ; Barrie CONDON, Auteur . - 2012 . - p.245-52. Langues : Anglais (eng) in Autism Research > 5-4 (August 2012) . - p.245-52 Mots-clés : autism  sulcal morphometry  MRI  Brainvisa Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex, neurodevelopmental disorder with various structural abnormalities for different patient groups. Because of the heterogeneity of the disorder, several biomarkers have been suggested so far. Here, we explore the potential of sulcal surface and length as biomarkers. Three-dimensional T1-weighted images of 15 adolescents of normal intelligence with ASD and 15 age-, sex-, and intelligence quotient-matched control adolescents were analysed using Brainvisa 4.0 (http://www.brainvisa.info), which automatically extracts the cortical folds and labels them as 59 sulcal pieces. For each sulcus, the surface, length, and mean geodesic depth were computed using morphometry analysis within this software package. General linear model was conducted to compare the estimated values for the two groups, ASD and control. In the ASD group, the left insula and the right intraparietal sulcus (IPS) had significantly higher values for surface and length, respectively. Nonetheless for all sulcal pieces, the mean geodesic depth was not significantly different between the two groups. Our results suggest that sulcal surface and length can have correlation with morphological changes of cortex in ASD. Greater surface area and length in insula and IPS, respectively, may reflect greater folding. This could result in greater separation of functions with an impact upon the integrative functions of these regions. En ligne : http://dx.doi.org/10.1002/aur.1232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

Neural correlates of children with avoidant restrictive food intake disorder symptoms: large-scale neuroanatomical analysis of a paediatric population / Holly A. HARRIS ; Gordon D. WAITER ; Pauline W. JANSEN ; Justin H. G. WILLIAMS ; Tonya WHITE in Journal of Child Psychology and Psychiatry, 66-6 (June 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-6 (June 2025) . - p.785-795 Titre : Neural correlates of children with avoidant restrictive food intake disorder symptoms: large-scale neuroanatomical analysis of a paediatric population Type de document : Texte imprimé et/ou numérique Auteurs : Holly A. HARRIS, Auteur ; Gordon D. WAITER, Auteur ; Pauline W. JANSEN, Auteur ; Justin H. G. WILLIAMS, Auteur ; Tonya WHITE, Auteur Article en page(s) : p.785-795 Langues : Anglais (eng) Mots-clés : ARFID  eating disorders  MRI  neuroanatomy  BMI  hunger awareness Index. décimale : PER Périodiques Résumé : Background Avoidant restrictive food intake disorder (ARFID) is a recently recognised feeding and eating disorder and is characterised by a lack of interest and motivation to eat. Despite burgeoning research, few studies to date have explored the underlying neurobiology of ARFID. Research examining the neural underpinnings of ARFID can greatly assist in understanding different mechanisms that play disorder-specific roles. Methods We studied a total of 1,977 10-year-old participants from the Generation R Study, a population-based Dutch cohort, to cross-sectionally examine neuroanatomical differences between those with versus without ARFID-like symptoms. Children were classified with versus without ARFID symptoms using the ARFID Index, a validated evaluative tool comprised of parent-reported and researcher-assessed measurements of picky eating, energy intake, diet quality, growth and psychosocial impact to characterise ARFID symptoms in the paediatric population. Global and regional values of surface area, cortical thickness, and volume from T1-weighted structural magnetic resonance imaging (MRI) scans in those with ARFID symptoms were compared with children not exhibiting symptoms. Results We identified 121 (6.1%) individuals with ARFID symptoms relative to 1,865 (93.9%) individuals without ARFID symptoms. Neuroanatomical findings identified significantly greater frontal (p?=?.00743; d?=?0.21) and superior frontal (p?=?6.56E-04; d?=?0.28) cortical thickness among children with ARFID symptoms. Conclusions This first large-scale study of the neural correlates of ARFID identified greater thickness of frontal cortical regions in children with ARFID symptoms, suggesting a role for executive function in the aetiology of the condition. En ligne : https://doi.org/10.1111/jcpp.14086 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] Neural correlates of children with avoidant restrictive food intake disorder symptoms: large-scale neuroanatomical analysis of a paediatric population [Texte imprimé et/ou numérique] / Holly A. HARRIS, Auteur ; Gordon D. WAITER, Auteur ; Pauline W. JANSEN, Auteur ; Justin H. G. WILLIAMS, Auteur ; Tonya WHITE, Auteur . - p.785-795. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-6 (June 2025) . - p.785-795 Mots-clés : ARFID  eating disorders  MRI  neuroanatomy  BMI  hunger awareness Index. décimale : PER Périodiques Résumé : Background Avoidant restrictive food intake disorder (ARFID) is a recently recognised feeding and eating disorder and is characterised by a lack of interest and motivation to eat. Despite burgeoning research, few studies to date have explored the underlying neurobiology of ARFID. Research examining the neural underpinnings of ARFID can greatly assist in understanding different mechanisms that play disorder-specific roles. Methods We studied a total of 1,977 10-year-old participants from the Generation R Study, a population-based Dutch cohort, to cross-sectionally examine neuroanatomical differences between those with versus without ARFID-like symptoms. Children were classified with versus without ARFID symptoms using the ARFID Index, a validated evaluative tool comprised of parent-reported and researcher-assessed measurements of picky eating, energy intake, diet quality, growth and psychosocial impact to characterise ARFID symptoms in the paediatric population. Global and regional values of surface area, cortical thickness, and volume from T1-weighted structural magnetic resonance imaging (MRI) scans in those with ARFID symptoms were compared with children not exhibiting symptoms. Results We identified 121 (6.1%) individuals with ARFID symptoms relative to 1,865 (93.9%) individuals without ARFID symptoms. Neuroanatomical findings identified significantly greater frontal (p?=?.00743; d?=?0.21) and superior frontal (p?=?6.56E-04; d?=?0.28) cortical thickness among children with ARFID symptoms. Conclusions This first large-scale study of the neural correlates of ARFID identified greater thickness of frontal cortical regions in children with ARFID symptoms, suggesting a role for executive function in the aetiology of the condition. En ligne : https://doi.org/10.1111/jcpp.14086 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

Neuroimaging Self-Other Mapping in Autism / Justin H.G. WILLIAMS

Public ISBD contenu dans Imitation and the Social Mind : Autism and Typical Development / Sally J ROGERS Titre : Neuroimaging Self-Other Mapping in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Justin H.G. WILLIAMS, Auteur ; Gordon D. WAITER, Auteur Année de publication : 2006 Importance : p.352-376 Langues : Anglais (eng) Index. décimale : PAR-G PAR-G - Imitation Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=795 contenu dans Imitation and the Social Mind : Autism and Typical Development / Sally J ROGERS Neuroimaging Self-Other Mapping in Autism [Texte imprimé et/ou numérique] / Justin H.G. WILLIAMS, Auteur ; Gordon D. WAITER, Auteur . - 2006 . - p.352-376. Langues : Anglais (eng) Index. décimale : PAR-G PAR-G - Imitation Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=795

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