Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics / Suma JACOB in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.293-311 Titre : Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics Type de document : Texte imprimé et/ou numérique Auteurs : Suma JACOB, Auteur ; James F. LECKMAN, Auteur ; Angeli LANDEROS-WEISENBERGER, Auteur Année de publication : 2009 Article en page(s) : p.293-311 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are a phenotypically and etiologically heterogeneous set of disorders that include obsessive-compulsive behaviors (OCB) that partially overlap with symptoms associated with obsessive-compulsive disorder (OCD). The OCB seen in ASD vary depending on the individual's mental and chronological age as well as the etiology of their ASD. Although progress has been made in the measurement of the OCB associated with ASD, more work is needed including the potential identification of heritable endophenotypes. Likewise, important progress toward the understanding of genetic influences in ASD has been made by greater refinement of relevant phenotypes using a broad range of study designs, including twin and family-genetic studies, parametric and nonparametric linkage analyses, as well as candidate gene studies and the study of rare genetic variants. These genetic analyses could lead to the refinement of the OCB phenotypes as larger samples are studied and specific associations are replicated. Like ASD, OCB are likely to prove to be multidimensional and polygenic. Some of the vulnerability genes may prove to be generalist genes influencing the phenotypic expression of both ASD and OCD while others will be specific to subcomponents of the ASD phenotype. In order to discover molecular and genetic mechanisms, collaborative approaches need to generate shared samples, resources, novel genomic technologies, as well as more refined phenotypes and innovative statistical approaches. There is a growing need to identify the range of molecular pathways involved in OCB related to ASD in order to develop novel treatment interventions. En ligne : http://dx.doi.org/10.1002/aur.108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968 [article] Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics [Texte imprimé et/ou numérique] / Suma JACOB, Auteur ; James F. LECKMAN, Auteur ; Angeli LANDEROS-WEISENBERGER, Auteur . - 2009 . - p.293-311. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.293-311 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are a phenotypically and etiologically heterogeneous set of disorders that include obsessive-compulsive behaviors (OCB) that partially overlap with symptoms associated with obsessive-compulsive disorder (OCD). The OCB seen in ASD vary depending on the individual's mental and chronological age as well as the etiology of their ASD. Although progress has been made in the measurement of the OCB associated with ASD, more work is needed including the potential identification of heritable endophenotypes. Likewise, important progress toward the understanding of genetic influences in ASD has been made by greater refinement of relevant phenotypes using a broad range of study designs, including twin and family-genetic studies, parametric and nonparametric linkage analyses, as well as candidate gene studies and the study of rare genetic variants. These genetic analyses could lead to the refinement of the OCB phenotypes as larger samples are studied and specific associations are replicated. Like ASD, OCB are likely to prove to be multidimensional and polygenic. Some of the vulnerability genes may prove to be generalist genes influencing the phenotypic expression of both ASD and OCD while others will be specific to subcomponents of the ASD phenotype. In order to discover molecular and genetic mechanisms, collaborative approaches need to generate shared samples, resources, novel genomic technologies, as well as more refined phenotypes and innovative statistical approaches. There is a growing need to identify the range of molecular pathways involved in OCB related to ASD in order to develop novel treatment interventions. En ligne : http://dx.doi.org/10.1002/aur.108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968

Interface between Autism Spectrum Disorders and Obsessive-Compulsive Behaviors: A Genetic and Developmental Perspective / Suma JACOB

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Interface between Autism Spectrum Disorders and Obsessive-Compulsive Behaviors: A Genetic and Developmental Perspective Type de document : Texte imprimé et/ou numérique Auteurs : Suma JACOB, Auteur ; Angeli LANDEROS-WEISENBERGER, Auteur ; James F. LECKMAN, Auteur Année de publication : 2011 Importance : p.285-303 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL Interface between Autism Spectrum Disorders and Obsessive-Compulsive Behaviors: A Genetic and Developmental Perspective [Texte imprimé et/ou numérique] / Suma JACOB, Auteur ; Angeli LANDEROS-WEISENBERGER, Auteur ; James F. LECKMAN, Auteur . - 2011 . - p.285-303. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

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Poor fine-motor and visuospatial skills predict persistence of pediatric-onset obsessive-compulsive disorder into adulthood / Michael H. BLOCH in Journal of Child Psychology and Psychiatry, 52-9 (September 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-9 (September 2011) . - p.974-983 Titre : Poor fine-motor and visuospatial skills predict persistence of pediatric-onset obsessive-compulsive disorder into adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Michael H. BLOCH, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Philip A. DOMBROWSKI, Auteur ; Kaitlyn E. PANZA, Auteur ; Brittany G. CRAIGLOW, Auteur ; Angeli LANDEROS-WEISENBERGER, Auteur ; James F. LECKMAN, Auteur ; Bradley S. PETERSON, Auteur ; Robert T. SCHULTZ, Auteur Année de publication : 2011 Article en page(s) : p.974-983 Langues : Anglais (eng) Mots-clés : Obsessive-compulsive disorder  longitudinal study  neuropsychological tests  fine-motor skills and visuospatial skills Index. décimale : PER Périodiques Résumé : Background:  Half of pediatric-onset OCD cases remit by adulthood. Studies have demonstrated that initial response to pharmacotherapy, age of onset, prominent hoarding symptoms, and the presence of comorbid tic disorders are associated with long-term outcome. Our goal was to examine the association between childhood performance on neuropsychological testing and persistence of OCD into adulthood. Methods:  Twenty-four children with OCD were followed for an average of 7.5 years into early adulthood. Neuropsychological performance in childhood (<16 years) was measured. The battery included the Wechsler Intelligence Scale for Children (WISC-III), the Purdue pegboard test, the Rey–Osterreith Complex Figure Task (RCFT) and the Beery–Buktenica test of Visual Motor Integration (VMI). We hypothesized that deficits in fine-motor skills, visuospatial skills, and nonverbal memory as well as overall intelligence would be associated with adulthood outcome. We used a Cox proportional hazard model of survival analysis in which time to remission of OCD symptoms was the main outcome variable. Results:  Poor childhood performance on the Purdue pegboard task and the block design subscale of WISC-III was associated with persistence of OCD symptoms into adulthood. IQ, VMI, and nonverbal memory performance did not predict significantly the persistence of OCD. Conclusions:  These results suggest that visuospatial and fine-motor skill deficits are predictive of poor long-term outcome in pediatric-onset OCD. Future longitudinal studies are needed to chart the course of these deficits relative to the course of symptoms in OCD and to determine whether the association of these neuropsychiatric deficits with long-term outcome is specific to pediatric-onset OCD or generalizes to other psychiatric disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02366.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Poor fine-motor and visuospatial skills predict persistence of pediatric-onset obsessive-compulsive disorder into adulthood [Texte imprimé et/ou numérique] / Michael H. BLOCH, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Philip A. DOMBROWSKI, Auteur ; Kaitlyn E. PANZA, Auteur ; Brittany G. CRAIGLOW, Auteur ; Angeli LANDEROS-WEISENBERGER, Auteur ; James F. LECKMAN, Auteur ; Bradley S. PETERSON, Auteur ; Robert T. SCHULTZ, Auteur . - 2011 . - p.974-983. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-9 (September 2011) . - p.974-983 Mots-clés : Obsessive-compulsive disorder  longitudinal study  neuropsychological tests  fine-motor skills and visuospatial skills Index. décimale : PER Périodiques Résumé : Background:  Half of pediatric-onset OCD cases remit by adulthood. Studies have demonstrated that initial response to pharmacotherapy, age of onset, prominent hoarding symptoms, and the presence of comorbid tic disorders are associated with long-term outcome. Our goal was to examine the association between childhood performance on neuropsychological testing and persistence of OCD into adulthood. Methods:  Twenty-four children with OCD were followed for an average of 7.5 years into early adulthood. Neuropsychological performance in childhood (<16 years) was measured. The battery included the Wechsler Intelligence Scale for Children (WISC-III), the Purdue pegboard test, the Rey–Osterreith Complex Figure Task (RCFT) and the Beery–Buktenica test of Visual Motor Integration (VMI). We hypothesized that deficits in fine-motor skills, visuospatial skills, and nonverbal memory as well as overall intelligence would be associated with adulthood outcome. We used a Cox proportional hazard model of survival analysis in which time to remission of OCD symptoms was the main outcome variable. Results:  Poor childhood performance on the Purdue pegboard task and the block design subscale of WISC-III was associated with persistence of OCD symptoms into adulthood. IQ, VMI, and nonverbal memory performance did not predict significantly the persistence of OCD. Conclusions:  These results suggest that visuospatial and fine-motor skill deficits are predictive of poor long-term outcome in pediatric-onset OCD. Future longitudinal studies are needed to chart the course of these deficits relative to the course of symptoms in OCD and to determine whether the association of these neuropsychiatric deficits with long-term outcome is specific to pediatric-onset OCD or generalizes to other psychiatric disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02366.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

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