Annotation: Tourette syndrome: a relentless drumbeat – driven by misguided brain oscillations / James F. LECKMAN in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.537–550 Titre : Annotation: Tourette syndrome: a relentless drumbeat – driven by misguided brain oscillations Type de document : Texte imprimé et/ou numérique Auteurs : James F. LECKMAN, Auteur ; Flora M. VACCARINO, Auteur ; Paul S.A. KALANITHI, Auteur ; Aribert ROTHENBERGER, Auteur Année de publication : 2006 Article en page(s) : p.537–550 Langues : Anglais (eng) Mots-clés : Tourette-syndrome oscillations basal-ganglia fast-spiking-GABAergic-interneurons thalamocortical-dysrhythmia habit-reversal-training Index. décimale : PER Périodiques Résumé : Objective: This annotation reviews recent evidence that points to the likely role of aberrant neural oscillations in the pathogenesis of Tourette syndrome (TS). Methods: The available anatomic and electrophysiological findings in TS are reviewed in the context of an emerging picture of the crucial role that neural oscillations play in maintaining normal central nervous system (CNS) function. Results: Neurons form behavior-dependent oscillating networks of various sizes and frequencies that bias input selection and facilitate synaptic plasticity, mechanisms that cooperatively support temporal representation as well as the transfer and long-term consolidation of information. Coherent network activity is likely to modulate sensorimotor gating as well as focused motor actions. When these networks are dysrhythmic, there may be a loss of control of sensory information and motor action. The known electrophysiological effects of medications and surgical interventions used to treat TS likely have an ameliorative effect on these aberrant oscillations. Similarly, a strong case can be made that successful behavioral treatments involve the willful training regions of the prefrontal cortex to engage in tic suppression and the performance of competing motor responses to unwanted sensory urges such that these prefrontal regions become effective modulators of aberrant thalamocortical rhythms. Conclusions: A deeper understanding of neural oscillations may illuminate the complex, challenging, enigmatic, internal world that is TS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01620.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=738 [article] Annotation: Tourette syndrome: a relentless drumbeat – driven by misguided brain oscillations [Texte imprimé et/ou numérique] / James F. LECKMAN, Auteur ; Flora M. VACCARINO, Auteur ; Paul S.A. KALANITHI, Auteur ; Aribert ROTHENBERGER, Auteur . - 2006 . - p.537–550. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-6 (June 2006) . - p.537–550 Mots-clés : Tourette-syndrome oscillations basal-ganglia fast-spiking-GABAergic-interneurons thalamocortical-dysrhythmia habit-reversal-training Index. décimale : PER Périodiques Résumé : Objective: This annotation reviews recent evidence that points to the likely role of aberrant neural oscillations in the pathogenesis of Tourette syndrome (TS). Methods: The available anatomic and electrophysiological findings in TS are reviewed in the context of an emerging picture of the crucial role that neural oscillations play in maintaining normal central nervous system (CNS) function. Results: Neurons form behavior-dependent oscillating networks of various sizes and frequencies that bias input selection and facilitate synaptic plasticity, mechanisms that cooperatively support temporal representation as well as the transfer and long-term consolidation of information. Coherent network activity is likely to modulate sensorimotor gating as well as focused motor actions. When these networks are dysrhythmic, there may be a loss of control of sensory information and motor action. The known electrophysiological effects of medications and surgical interventions used to treat TS likely have an ameliorative effect on these aberrant oscillations. Similarly, a strong case can be made that successful behavioral treatments involve the willful training regions of the prefrontal cortex to engage in tic suppression and the performance of competing motor responses to unwanted sensory urges such that these prefrontal regions become effective modulators of aberrant thalamocortical rhythms. Conclusions: A deeper understanding of neural oscillations may illuminate the complex, challenging, enigmatic, internal world that is TS. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01620.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=738

Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics / Suma JACOB in Autism Research, 2-6 (December 2009)  

Public ISBD [article]  inAutism Research > 2-6 (December 2009) . - p.293-311 Titre : Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics Type de document : Texte imprimé et/ou numérique Auteurs : Suma JACOB, Auteur ; James F. LECKMAN, Auteur ; Angeli LANDEROS-WEISENBERGER, Auteur Année de publication : 2009 Article en page(s) : p.293-311 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are a phenotypically and etiologically heterogeneous set of disorders that include obsessive-compulsive behaviors (OCB) that partially overlap with symptoms associated with obsessive-compulsive disorder (OCD). The OCB seen in ASD vary depending on the individual's mental and chronological age as well as the etiology of their ASD. Although progress has been made in the measurement of the OCB associated with ASD, more work is needed including the potential identification of heritable endophenotypes. Likewise, important progress toward the understanding of genetic influences in ASD has been made by greater refinement of relevant phenotypes using a broad range of study designs, including twin and family-genetic studies, parametric and nonparametric linkage analyses, as well as candidate gene studies and the study of rare genetic variants. These genetic analyses could lead to the refinement of the OCB phenotypes as larger samples are studied and specific associations are replicated. Like ASD, OCB are likely to prove to be multidimensional and polygenic. Some of the vulnerability genes may prove to be generalist genes influencing the phenotypic expression of both ASD and OCD while others will be specific to subcomponents of the ASD phenotype. In order to discover molecular and genetic mechanisms, collaborative approaches need to generate shared samples, resources, novel genomic technologies, as well as more refined phenotypes and innovative statistical approaches. There is a growing need to identify the range of molecular pathways involved in OCB related to ASD in order to develop novel treatment interventions. En ligne : http://dx.doi.org/10.1002/aur.108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968 [article] Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics [Texte imprimé et/ou numérique] / Suma JACOB, Auteur ; James F. LECKMAN, Auteur ; Angeli LANDEROS-WEISENBERGER, Auteur . - 2009 . - p.293-311. Langues : Anglais (eng) in Autism Research > 2-6 (December 2009) . - p.293-311 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are a phenotypically and etiologically heterogeneous set of disorders that include obsessive-compulsive behaviors (OCB) that partially overlap with symptoms associated with obsessive-compulsive disorder (OCD). The OCB seen in ASD vary depending on the individual's mental and chronological age as well as the etiology of their ASD. Although progress has been made in the measurement of the OCB associated with ASD, more work is needed including the potential identification of heritable endophenotypes. Likewise, important progress toward the understanding of genetic influences in ASD has been made by greater refinement of relevant phenotypes using a broad range of study designs, including twin and family-genetic studies, parametric and nonparametric linkage analyses, as well as candidate gene studies and the study of rare genetic variants. These genetic analyses could lead to the refinement of the OCB phenotypes as larger samples are studied and specific associations are replicated. Like ASD, OCB are likely to prove to be multidimensional and polygenic. Some of the vulnerability genes may prove to be generalist genes influencing the phenotypic expression of both ASD and OCD while others will be specific to subcomponents of the ASD phenotype. In order to discover molecular and genetic mechanisms, collaborative approaches need to generate shared samples, resources, novel genomic technologies, as well as more refined phenotypes and innovative statistical approaches. There is a growing need to identify the range of molecular pathways involved in OCB related to ASD in order to develop novel treatment interventions. En ligne : http://dx.doi.org/10.1002/aur.108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=968

Breastfeeding, brain activation to own infant cry, and maternal sensitivity / Pilyoung KIM in Journal of Child Psychology and Psychiatry, 52-8 (August 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-8 (August 2011) . - p.907-915 Titre : Breastfeeding, brain activation to own infant cry, and maternal sensitivity Type de document : Texte imprimé et/ou numérique Auteurs : Pilyoung KIM, Auteur ; Ruth FELDMAN, Auteur ; Linda C. MAYES, Auteur ; Virginia EICHER, Auteur ; Nancy THOMPSON, Auteur ; James F. LECKMAN, Auteur ; James E. SWAIN, Auteur Année de publication : 2011 Article en page(s) : p.907-915 Langues : Anglais (eng) Mots-clés : Breastfeeding  infancy  maternal sensitivity  mother–infant interaction  neuroimaging Index. décimale : PER Périodiques Résumé : Background:  Research points to the importance of breastfeeding for promoting close mother–infant contact and social-emotional development. Recent functional magnetic resonance imaging (fMRI) studies have identified brain regions related to maternal behaviors. However, little research has addressed the neurobiological mechanisms underlying the relationship between breastfeeding and maternal behavior in human mothers. We investigated the associations between breastfeeding, maternal brain response to own infant stimuli, and maternal sensitivity in the early postpartum. Methods:  Seventeen biological mothers of healthy infants participated in two matched groups according to feeding method – exclusive breastfeeding and exclusive formula-feeding at 2–4 weeks postpartum. fMRI scanning was conducted in the first postpartum month to examine maternal brain activation in response to her own baby’s cry versus control baby-cry. Dyadic interactions between mothers and infants at 3–4 months postpartum were videotaped in the home and blindly coded for maternal sensitivity. Results:  In the first postpartum month, breastfeeding mothers showed greater activations in the superior frontal gyrus, insula, precuneus, striatum, and amygdala while listening to their own baby-cry as compared to formula-feeding mothers. For both breastfeeding and formula-feeding mothers, greater activations in the right superior frontal gyrus and amygdala were associated with higher maternal sensitivity at 3–4 months postpartum. Conclusions:  Results suggest links between breastfeeding and greater response to infant cues in brain regions implicated in maternal–infant bonding and empathy during the early postpartum. Such brain activations may facilitate greater maternal sensitivity as infants enter their social world. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02406.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Breastfeeding, brain activation to own infant cry, and maternal sensitivity [Texte imprimé et/ou numérique] / Pilyoung KIM, Auteur ; Ruth FELDMAN, Auteur ; Linda C. MAYES, Auteur ; Virginia EICHER, Auteur ; Nancy THOMPSON, Auteur ; James F. LECKMAN, Auteur ; James E. SWAIN, Auteur . - 2011 . - p.907-915. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-8 (August 2011) . - p.907-915 Mots-clés : Breastfeeding  infancy  maternal sensitivity  mother–infant interaction  neuroimaging Index. décimale : PER Périodiques Résumé : Background:  Research points to the importance of breastfeeding for promoting close mother–infant contact and social-emotional development. Recent functional magnetic resonance imaging (fMRI) studies have identified brain regions related to maternal behaviors. However, little research has addressed the neurobiological mechanisms underlying the relationship between breastfeeding and maternal behavior in human mothers. We investigated the associations between breastfeeding, maternal brain response to own infant stimuli, and maternal sensitivity in the early postpartum. Methods:  Seventeen biological mothers of healthy infants participated in two matched groups according to feeding method – exclusive breastfeeding and exclusive formula-feeding at 2–4 weeks postpartum. fMRI scanning was conducted in the first postpartum month to examine maternal brain activation in response to her own baby’s cry versus control baby-cry. Dyadic interactions between mothers and infants at 3–4 months postpartum were videotaped in the home and blindly coded for maternal sensitivity. Results:  In the first postpartum month, breastfeeding mothers showed greater activations in the superior frontal gyrus, insula, precuneus, striatum, and amygdala while listening to their own baby-cry as compared to formula-feeding mothers. For both breastfeeding and formula-feeding mothers, greater activations in the right superior frontal gyrus and amygdala were associated with higher maternal sensitivity at 3–4 months postpartum. Conclusions:  Results suggest links between breastfeeding and greater response to infant cues in brain regions implicated in maternal–infant bonding and empathy during the early postpartum. Such brain activations may facilitate greater maternal sensitivity as infants enter their social world. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02406.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Commentary: What does immunology have to do with brain development and psychopathology? – a commentary on O'Connor et al. (2014) / James F. LECKMAN in Journal of Child Psychology and Psychiatry, 55-6 (June 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-6 (June 2014) . - p.632-634 Titre : Commentary: What does immunology have to do with brain development and psychopathology? – a commentary on O'Connor et al. (2014) Type de document : Texte imprimé et/ou numérique Auteurs : James F. LECKMAN, Auteur Année de publication : 2014 Article en page(s) : p.632-634 Langues : Anglais (eng) Mots-clés : Brain development  developmental psychoneuroimmunology  immune epigenetics  stress  resilience Index. décimale : PER Périodiques Résumé : In the past, we have typically regarded the ‘immune system’ as a complex set of cellular and molecular processes that protect us against pathogens, from viruses to parasitic worms. It is now clear that the cellular and molecular processes that make up our ‘immune system’ are also crucial to normal brain development and play a role in the pathoaetiology of many mental and physical disorders. In their Annual Research Review, O'Connor, Moynihan and Caserta (2014) provide a useful introduction to this emerging area of science that is highly relevant to our field and is a natural outgrowth of their earlier and ongoing work in psychoneuroimmunology. However, their review goes well beyond these seminal findings. While work in developmental psychoneuroimmunology engenders a good deal of excitement among academic researchers, the ‘promise’ of the field clearly remains greater than the ‘deliverables’, in terms of any direct effect on patient care. This commentary looks at the implication of these findings for clinical practice and where future research efforts should be expended. En ligne : http://dx.doi.org/10.1111/jcpp.12259 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=234 [article] Commentary: What does immunology have to do with brain development and psychopathology? – a commentary on O'Connor et al. (2014) [Texte imprimé et/ou numérique] / James F. LECKMAN, Auteur . - 2014 . - p.632-634. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-6 (June 2014) . - p.632-634 Mots-clés : Brain development  developmental psychoneuroimmunology  immune epigenetics  stress  resilience Index. décimale : PER Périodiques Résumé : In the past, we have typically regarded the ‘immune system’ as a complex set of cellular and molecular processes that protect us against pathogens, from viruses to parasitic worms. It is now clear that the cellular and molecular processes that make up our ‘immune system’ are also crucial to normal brain development and play a role in the pathoaetiology of many mental and physical disorders. In their Annual Research Review, O'Connor, Moynihan and Caserta (2014) provide a useful introduction to this emerging area of science that is highly relevant to our field and is a natural outgrowth of their earlier and ongoing work in psychoneuroimmunology. However, their review goes well beyond these seminal findings. While work in developmental psychoneuroimmunology engenders a good deal of excitement among academic researchers, the ‘promise’ of the field clearly remains greater than the ‘deliverables’, in terms of any direct effect on patient care. This commentary looks at the implication of these findings for clinical practice and where future research efforts should be expended. En ligne : http://dx.doi.org/10.1111/jcpp.12259 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=234

Critical Notice : Genes and behavior: nature–nurture interplay explained / James F. LECKMAN in Journal of Child Psychology and Psychiatry, 48-2 (February 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-2 (February 2007) . - p.219–220 Titre : Critical Notice : Genes and behavior: nature–nurture interplay explained Type de document : Texte imprimé et/ou numérique Auteurs : James F. LECKMAN, Auteur Année de publication : 2007 Article en page(s) : p.219–220 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01697.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=423 [article] Critical Notice : Genes and behavior: nature–nurture interplay explained [Texte imprimé et/ou numérique] / James F. LECKMAN, Auteur . - 2007 . - p.219–220. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-2 (February 2007) . - p.219–220 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01697.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=423

Editorial Commentary: Challenges and potential of DSM-5 and ICD-11 revisions / James F. LECKMAN in Journal of Child Psychology and Psychiatry, 53-5 (May 2012)  

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Editorial Commentary: Resilience in child development – interconnected pathways to wellbeing / Catherine PANTER-BRICK in Journal of Child Psychology and Psychiatry, 54-4 (April 2013)  

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Editorial: Developmental neuroscience comes of age / James F. LECKMAN in Journal of Child Psychology and Psychiatry, 52-4 (April 2011)  

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Editorial: Developmental transitions to psychopathology: from genomics and epigenomics to social policy / James F. LECKMAN in Journal of Child Psychology and Psychiatry, 51-4 (April 2010)  

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Editorial: Envisioning the Future after 50 Years of Science and Discovery / Tony CHARMAN in Journal of Child Psychology and Psychiatry, 50-1-2 (January/February 2009)  

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Editorial: A global perspective on child and adolescent mental health / James F. LECKMAN in Journal of Child Psychology and Psychiatry, 49-3 (March 2008)  

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Editorial Perspective: When OCD takes over…the family! Coercive and disruptive behaviours in paediatric obsessive compulsive disorder / Eli R. LEBOWITZ in Journal of Child Psychology and Psychiatry, 52-12 (December 2011)  

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Fine-motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome / Michael H. BLOCH in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

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Gene variants associated with antisocial behaviour: a latent variable approach / Mary Jane BENTLEY in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)  

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Interface between Autism Spectrum Disorders and Obsessive-Compulsive Behaviors: A Genetic and Developmental Perspective / Suma JACOB

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