Aggression Is Associated With Social Adaptive Functioning in Children With ASD and Anxiety / Carla B. KALVIN in Focus on Autism and Other Developmental Disabilities, 38-3 (September 2023)  

Public ISBD [article]  inFocus on Autism and Other Developmental Disabilities > 38-3 (September 2023) . - p.168-176 Titre : Aggression Is Associated With Social Adaptive Functioning in Children With ASD and Anxiety Type de document : texte imprimé Auteurs : Carla B. KALVIN, Auteur ; Rebecca JORDAN, Auteur ; Sonia ROWLEY, Auteur ; Anna L. WEIS, Auteur ; Karim IBRAHIM, Auteur ; Denis G. SUKHODOLSKY, Auteur Article en page(s) : p.168-176 Langues : Anglais (eng) Mots-clés : autism spectrum disorders;functional skills;independence;social skills;socialization Index. décimale : PER Périodiques Résumé : Social adaptive functioning is notably compromised and may be further impaired by aggressive behavior in children with autism spectrum disorder (ASD). This study examined the association between aggressive behavior and social adaptive skills in children with ASD and the contribution of aggressive behavior to social adaptive skills in a combined sample of children with and without ASD. Participants consisted of children, ages 8 to 15 years, with ASD (n = 52) and who were typically developing (n = 29). Results indicate that aggressive behavior is negatively associated with social adaptive skills in children with ASD and that it contributes to reduced social adaptive functioning above and beyond ASD diagnosis. Findings underscore the importance of considering the role of aggressive behavior when evaluating and promoting social functioning in children with ASD. En ligne : http://dx.doi.org/10.1177/10883576231165265 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509 [article] Aggression Is Associated With Social Adaptive Functioning in Children With ASD and Anxiety [texte imprimé] / Carla B. KALVIN, Auteur ; Rebecca JORDAN, Auteur ; Sonia ROWLEY, Auteur ; Anna L. WEIS, Auteur ; Karim IBRAHIM, Auteur ; Denis G. SUKHODOLSKY, Auteur . - p.168-176. Langues : Anglais (eng) in Focus on Autism and Other Developmental Disabilities > 38-3 (September 2023) . - p.168-176 Mots-clés : autism spectrum disorders;functional skills;independence;social skills;socialization Index. décimale : PER Périodiques Résumé : Social adaptive functioning is notably compromised and may be further impaired by aggressive behavior in children with autism spectrum disorder (ASD). This study examined the association between aggressive behavior and social adaptive skills in children with ASD and the contribution of aggressive behavior to social adaptive skills in a combined sample of children with and without ASD. Participants consisted of children, ages 8 to 15 years, with ASD (n = 52) and who were typically developing (n = 29). Results indicate that aggressive behavior is negatively associated with social adaptive skills in children with ASD and that it contributes to reduced social adaptive functioning above and beyond ASD diagnosis. Findings underscore the importance of considering the role of aggressive behavior when evaluating and promoting social functioning in children with ASD. En ligne : http://dx.doi.org/10.1177/10883576231165265 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509

Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality-Controlled Diffusion Tensor Imaging Study / J. LEI in Autism Research, 12-10 (October 2019)  

Public ISBD [article]  inAutism Research > 12-10 (October 2019) . - p.1472-1483 Titre : Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality-Controlled Diffusion Tensor Imaging Study Type de document : texte imprimé Auteurs : J. LEI, Auteur ; E. LECARIE, Auteur ; J. JURAYJ, Auteur ; S. BOLAND, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Pamela VENTOLA, Auteur ; Kevin A. PELPHREY, Auteur ; R. J. JOU, Auteur Article en page(s) : p.1472-1483 Langues : Anglais (eng) Mots-clés : anisotropy  autism spectrum disorder  diffusion tensor imaging  female  motion  sex characteristics Index. décimale : PER Périodiques Résumé : Previous studies using diffusion tensor imaging (DTI) to investigate white matter (WM) structural connectivity have suggested widespread, although inconsistent WM alterations in autism spectrum disorder (ASD), such as greater reductions in fractional anisotropy (FA). However, findings may lack generalizability because: (a) most have focused solely on the ASD male brain phenotype, and not sex-differences in WM integrity; (b) many lack stringent and transparent data quality control such as controlling for head motion in analysis. This study addressed both issues by using Tract-Based Spatial Statistics (TBSS) to separately compare WM differences in 81 ASD (56 male, 25 female; 4-21 years old) and 39 typically developing (TD; 23 males, 16 females; 5-18 years old) children and young people, carefully group-matched on sex, age, cognitive abilities, and head motion. ASD males and females were also matched on autism symptom severity. Two independent-raters completed a multistep scan quality assurance to remove images that were significantly distorted by motion artifacts before analysis. ASD females exhibited significant widespread reductions in FA compared to TD females, suggesting altered WM integrity. In contrast, no significant localized or widespread WM differences were found between ASD and TD males. This study highlights the importance of data quality control in DTI, and outlines important sex-differences in WM alterations in ASD females. Future studies can explore the extent to which neural structural differences might underlie sex-differences in ASD behavioral phenotype, and guide clinical interventions to be tailored toward the unique needs of ASD females and males. Autism Res 2019, 12: 1472-1483. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Previous Diffusion Tensor Imaging (DTI) studies have found atypical brain structural connectivity in males with autism, although findings are inconclusive in females with autism. To investigate potential sex-differences, we studied males and females with and without autism who showed a similar level of head movement during their brain scan. We found that females with autism had widespread atypical neural connectivity than females without autism, although not in males, highlighting sex-differences. En ligne : http://dx.doi.org/10.1002/aur.2180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality-Controlled Diffusion Tensor Imaging Study [texte imprimé] / J. LEI, Auteur ; E. LECARIE, Auteur ; J. JURAYJ, Auteur ; S. BOLAND, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Pamela VENTOLA, Auteur ; Kevin A. PELPHREY, Auteur ; R. J. JOU, Auteur . - p.1472-1483. Langues : Anglais (eng) in Autism Research > 12-10 (October 2019) . - p.1472-1483 Mots-clés : anisotropy  autism spectrum disorder  diffusion tensor imaging  female  motion  sex characteristics Index. décimale : PER Périodiques Résumé : Previous studies using diffusion tensor imaging (DTI) to investigate white matter (WM) structural connectivity have suggested widespread, although inconsistent WM alterations in autism spectrum disorder (ASD), such as greater reductions in fractional anisotropy (FA). However, findings may lack generalizability because: (a) most have focused solely on the ASD male brain phenotype, and not sex-differences in WM integrity; (b) many lack stringent and transparent data quality control such as controlling for head motion in analysis. This study addressed both issues by using Tract-Based Spatial Statistics (TBSS) to separately compare WM differences in 81 ASD (56 male, 25 female; 4-21 years old) and 39 typically developing (TD; 23 males, 16 females; 5-18 years old) children and young people, carefully group-matched on sex, age, cognitive abilities, and head motion. ASD males and females were also matched on autism symptom severity. Two independent-raters completed a multistep scan quality assurance to remove images that were significantly distorted by motion artifacts before analysis. ASD females exhibited significant widespread reductions in FA compared to TD females, suggesting altered WM integrity. In contrast, no significant localized or widespread WM differences were found between ASD and TD males. This study highlights the importance of data quality control in DTI, and outlines important sex-differences in WM alterations in ASD females. Future studies can explore the extent to which neural structural differences might underlie sex-differences in ASD behavioral phenotype, and guide clinical interventions to be tailored toward the unique needs of ASD females and males. Autism Res 2019, 12: 1472-1483. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Previous Diffusion Tensor Imaging (DTI) studies have found atypical brain structural connectivity in males with autism, although findings are inconclusive in females with autism. To investigate potential sex-differences, we studied males and females with and without autism who showed a similar level of head movement during their brain scan. We found that females with autism had widespread atypical neural connectivity than females without autism, although not in males, highlighting sex-differences. En ligne : http://dx.doi.org/10.1002/aur.2180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder / Alan S. LEWIS in Journal of Autism and Developmental Disorders, 48-8 (August 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757 Titre : An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; Mayra Ortiz LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; M. R. PICCIOTTO, Auteur ; Denis G. SUKHODOLSKY, Auteur Article en page(s) : p.2748-2757 Langues : Anglais (eng) Mots-clés : Adult  Aggression  Autism spectrum disorder  Irritability  Nicotine  Nicotinic acetylcholine receptor  Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder [texte imprimé] / Alan S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; Mayra Ortiz LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; M. R. PICCIOTTO, Auteur ; Denis G. SUKHODOLSKY, Auteur . - p.2748-2757. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757 Mots-clés : Adult  Aggression  Autism spectrum disorder  Irritability  Nicotine  Nicotinic acetylcholine receptor  Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder / K. IBRAHIM in Journal of Autism and Developmental Disorders, 49-9 (September 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3656-3668 Titre : Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : K. IBRAHIM, Auteur ; C. KALVIN, Auteur ; Carolyn L. MARSH, Auteur ; A. ANZANO, Auteur ; L. GORYNOVA, Auteur ; K. CIMINO, Auteur ; Denis G. SUKHODOLSKY, Auteur Article en page(s) : p.3656-3668 Langues : Anglais (eng) Mots-clés : Aggression  Anger rumination  Autism spectrum disorder  Emotion regulation  Restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) are reported to have greater levels of anger rumination than typically developing children. This study examined anger rumination in children with ASD in comparison to children with disruptive behavior disorder without ASD. We also tested if anger rumination is associated with aggression and the core ASD symptoms of restricted and repetitive behaviors (RRBs). This study included three groups of children aged 8-16 years: 63 had ASD (ASD group), 79 had disruptive behavior disorder (DB group), and 40 healthy controls (HC). ASD and DB groups showed greater anger rumination relative to the HC group. Anger rumination was associated with RRBs in children with ASD, suggesting the link to core ASD symptoms. En ligne : http://dx.doi.org/10.1007/s10803-019-04085-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder [texte imprimé] / K. IBRAHIM, Auteur ; C. KALVIN, Auteur ; Carolyn L. MARSH, Auteur ; A. ANZANO, Auteur ; L. GORYNOVA, Auteur ; K. CIMINO, Auteur ; Denis G. SUKHODOLSKY, Auteur . - p.3656-3668. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3656-3668 Mots-clés : Aggression  Anger rumination  Autism spectrum disorder  Emotion regulation  Restricted and repetitive behaviors Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) are reported to have greater levels of anger rumination than typically developing children. This study examined anger rumination in children with ASD in comparison to children with disruptive behavior disorder without ASD. We also tested if anger rumination is associated with aggression and the core ASD symptoms of restricted and repetitive behaviors (RRBs). This study included three groups of children aged 8-16 years: 63 had ASD (ASD group), 79 had disruptive behavior disorder (DB group), and 40 healthy controls (HC). ASD and DB groups showed greater anger rumination relative to the HC group. Anger rumination was associated with RRBs in children with ASD, suggesting the link to core ASD symptoms. En ligne : http://dx.doi.org/10.1007/s10803-019-04085-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Anxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior / Denis G. SUKHODOLSKY in Autism, 24-2 (February 2020)  

Public ISBD [article]  inAutism > 24-2 (February 2020) . - p.400-410 Titre : Anxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior Type de document : texte imprimé Auteurs : Denis G. SUKHODOLSKY, Auteur ; Luc LECAVALIER, Auteur ; Cynthia JOHNSON, Auteur ; Tristram SMITH, Auteur ; Naomi SWIEZY, Auteur ; Karen E. BEARSS, Auteur ; Carla B. KALVIN, Auteur ; Lawrence SCAHILL, Auteur Article en page(s) : p.400-410 Langues : Anglais (eng) Mots-clés : anxiety  autism  autism spectrum disorder  early childhood inventory  young children Index. décimale : PER Périodiques Résumé : Anxiety is a common and impairing problem in children with autism spectrum disorder, but little is known about it in preschool children with autism spectrum disorder. This article reports on the characteristics of anxiety symptoms in young children with autism spectrum disorder using a parent-completed rating scale. One hundred and eighty children (age 3-7 years) participated in a clinical trial of parent training for disruptive behaviors. Anxiety was measured as part of pre-treatment subject characterization with 16 items from the Early Childhood Inventory, a parent-completed scale on child psychiatric symptoms. Parents also completed other measures of behavioral problems. Sixty-seven percent of children were rated by their parents as having two or more clinically significant symptoms of anxiety. There were no differences in the Early Childhood Inventory anxiety severity scores of children with IQ < 70 and those with 70. Higher levels of anxiety were associated with severity of oppositional defiant behavior and social disability. Anxiety symptoms are common in preschoolers with autism spectrum disorder. These findings are consistent with earlier work in school-age children with autism spectrum disorder. There were no differences in anxiety between children with IQ below 70 and those with IQ of 70 and above. Social withdrawal and oppositional behavior were associated with anxiety in young children with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361319866561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Anxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior [texte imprimé] / Denis G. SUKHODOLSKY, Auteur ; Luc LECAVALIER, Auteur ; Cynthia JOHNSON, Auteur ; Tristram SMITH, Auteur ; Naomi SWIEZY, Auteur ; Karen E. BEARSS, Auteur ; Carla B. KALVIN, Auteur ; Lawrence SCAHILL, Auteur . - p.400-410. Langues : Anglais (eng) in Autism > 24-2 (February 2020) . - p.400-410 Mots-clés : anxiety  autism  autism spectrum disorder  early childhood inventory  young children Index. décimale : PER Périodiques Résumé : Anxiety is a common and impairing problem in children with autism spectrum disorder, but little is known about it in preschool children with autism spectrum disorder. This article reports on the characteristics of anxiety symptoms in young children with autism spectrum disorder using a parent-completed rating scale. One hundred and eighty children (age 3-7 years) participated in a clinical trial of parent training for disruptive behaviors. Anxiety was measured as part of pre-treatment subject characterization with 16 items from the Early Childhood Inventory, a parent-completed scale on child psychiatric symptoms. Parents also completed other measures of behavioral problems. Sixty-seven percent of children were rated by their parents as having two or more clinically significant symptoms of anxiety. There were no differences in the Early Childhood Inventory anxiety severity scores of children with IQ < 70 and those with 70. Higher levels of anxiety were associated with severity of oppositional defiant behavior and social disability. Anxiety symptoms are common in preschoolers with autism spectrum disorder. These findings are consistent with earlier work in school-age children with autism spectrum disorder. There were no differences in anxiety between children with IQ below 70 and those with IQ of 70 and above. Social withdrawal and oppositional behavior were associated with anxiety in young children with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361319866561 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index / Carla B. KALVIN in Journal of Autism and Developmental Disorders, 51-5 (May 2021)  

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Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment / Pamela VENTOLA in Journal of Autism and Developmental Disorders, 46-8 (August 2016)  

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Conducting CBT for Anxiety in Children with Autism Spectrum Disorder During COVID-19 Pandemic / Carla B. KALVIN in Journal of Autism and Developmental Disorders, 51-11 (November 2021)  

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Discrepancies between parent and child ratings of anxiety in children with autism spectrum disorder / Carla B. KALVIN in Autism Research, 13-1 (January 2020)  

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Distinct neural bases of disruptive behavior and autism symptom severity in boys with autism spectrum disorder / Daniel Y. J. YANG in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)  

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Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders / Victoria HALLETT in Journal of Autism and Developmental Disorders, 43-10 (October 2013)  

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Feasibility and preliminary efficacy of behavioral activation for treatment of depression in autistic adolescents / Christina BURROUGHS ; Jessica PAPPAGIANOPOULOS ; Eleonora SADIKOVA ; Emily FUHRMANN ; Genevieve BOHAC ; Robert CROSS ; Lauren WITTE ; Gabrielle BRINKMANN ; Rachel LEMLEY ; Denis G. SUKHODOLSKY ; Micah O. MAZUREK in Autism, 28-12 (December 2024)  

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Fine-motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome / Michael H. BLOCH in Journal of Child Psychology and Psychiatry, 47-6 (June 2006)  

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Poor fine-motor and visuospatial skills predict persistence of pediatric-onset obsessive-compulsive disorder into adulthood / Michael H. BLOCH in Journal of Child Psychology and Psychiatry, 52-9 (September 2011)  

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Reduced anxiety following pivotal response treatment in young children with autism spectrum disorder / Jiedi LEI in Research in Autism Spectrum Disorders, 43-44 (November 2017)  

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