Abnormalities in the anterior cingulate cortex associated with attentional and inhibitory control deficits: A neurophysiological study on children with autism spectrum disorders / Agnes S. CHAN in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.254-266 Titre : Abnormalities in the anterior cingulate cortex associated with attentional and inhibitory control deficits: A neurophysiological study on children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Agnes S. CHAN, Auteur ; Virginia C.N. WONG, Auteur ; Yvonne M.Y. HAN, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Connie LEUNG, Auteur Année de publication : 2011 Article en page(s) : p.254-266 Langues : Anglais (eng) Mots-clés : Anterior-cingulate Attention Inhibitory-control EEG Autism Children Index. décimale : PER Périodiques Résumé : Previous studies showed that the anterior cingulate cortex (ACC) is activated when individuals engage in attention and inhibitory control tasks. The present study examined whether ACC activity is associated with behavioral performance of the two tasks. Twenty normal and 20 children with autism spectrum disorders (ASDs) were subjected to neuropsychological assessments on attention and inhibitory control, as well as electroencephalography recording. Children with ASD performed significantly worse than normal children on attention tasks as shown in their poorer performance on the Digit Span test, the greater number of Omission Errors on both the Continuous Performance Test II and the Go/No-Go tasks. They also performed significantly worse than normal children on inhibitory control tasks as shown by the greater number of False Alarms on the Object Recognition and Hong Kong List Learning Test. Their ACC activities, as indicated by relative theta power, were found to be significantly lower than those of normal controls during performance of the Go/No-Go task. Depressed ACC activities were further found to be significantly associated with poorer performance in attention and inhibition. Clinical implications on the use of theta activities in the ACC as an indicator to monitor intervention progress in children with ASD were discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.04.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 [article] Abnormalities in the anterior cingulate cortex associated with attentional and inhibitory control deficits: A neurophysiological study on children with autism spectrum disorders [Texte imprimé et/ou numérique] / Agnes S. CHAN, Auteur ; Virginia C.N. WONG, Auteur ; Yvonne M.Y. HAN, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Connie LEUNG, Auteur . - 2011 . - p.254-266. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.254-266 Mots-clés : Anterior-cingulate Attention Inhibitory-control EEG Autism Children Index. décimale : PER Périodiques Résumé : Previous studies showed that the anterior cingulate cortex (ACC) is activated when individuals engage in attention and inhibitory control tasks. The present study examined whether ACC activity is associated with behavioral performance of the two tasks. Twenty normal and 20 children with autism spectrum disorders (ASDs) were subjected to neuropsychological assessments on attention and inhibitory control, as well as electroencephalography recording. Children with ASD performed significantly worse than normal children on attention tasks as shown in their poorer performance on the Digit Span test, the greater number of Omission Errors on both the Continuous Performance Test II and the Go/No-Go tasks. They also performed significantly worse than normal children on inhibitory control tasks as shown by the greater number of False Alarms on the Object Recognition and Hong Kong List Learning Test. Their ACC activities, as indicated by relative theta power, were found to be significantly lower than those of normal controls during performance of the Go/No-Go task. Depressed ACC activities were further found to be significantly associated with poorer performance in attention and inhibition. Clinical implications on the use of theta activities in the ACC as an indicator to monitor intervention progress in children with ASD were discussed. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.04.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111

Disordered connectivity associated with memory deficits in children with autism spectrum disorders / Agnes S. CHAN in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.237-245 Titre : Disordered connectivity associated with memory deficits in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Agnes S. CHAN, Auteur ; Yvonne M.Y. HAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Cho Yee TO, Auteur ; Raymond C. K. CHAN, Auteur Année de publication : 2011 Article en page(s) : p.237-245 Langues : Anglais (eng) Mots-clés : Autism EEG Coherence Memory Theta Children Index. décimale : PER Périodiques Résumé : The present study examined the memory performance and cortical connectivity of children with ASD, and investigated whether the memory deficits exhibited by these children were associated with the cortical connectivity. Twenty-one children with ASD and 21 children with normal development (NC), aged 5–14 years, participated in the study. Each child was administered a neuropsychological battery that included the Test of Non-verbal Intelligence (TONI-III), Digit Span test (DS), Rey-Osterrieth Complex Figure Test (Rey-O), and Hong Kong List Learning Test (HKLLT); and an EEG recording session when performing the visual encoding Object Recognition (OR) task. Six neuropsychological measures from the test battery and six EEG coherence measures in the theta band were compared between the children with ASD and normal children. Results indicated that children with ASD performed at comparable levels with normal children in the DS and Rey-O, but were significantly poorer in HKLLT and OR. They also exhibited significantly elevated long-range coherences in the fronto-posterior connections involving the left hemisphere (left anterior–left posterior; left anterior–right posterior). Pearson correlation showed significant negative associations between the anterior–posterior EEG coherences and memory performance. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.04.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 [article] Disordered connectivity associated with memory deficits in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Agnes S. CHAN, Auteur ; Yvonne M.Y. HAN, Auteur ; Sophia L. SZE, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Cho Yee TO, Auteur ; Raymond C. K. CHAN, Auteur . - 2011 . - p.237-245. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.237-245 Mots-clés : Autism EEG Coherence Memory Theta Children Index. décimale : PER Périodiques Résumé : The present study examined the memory performance and cortical connectivity of children with ASD, and investigated whether the memory deficits exhibited by these children were associated with the cortical connectivity. Twenty-one children with ASD and 21 children with normal development (NC), aged 5–14 years, participated in the study. Each child was administered a neuropsychological battery that included the Test of Non-verbal Intelligence (TONI-III), Digit Span test (DS), Rey-Osterrieth Complex Figure Test (Rey-O), and Hong Kong List Learning Test (HKLLT); and an EEG recording session when performing the visual encoding Object Recognition (OR) task. Six neuropsychological measures from the test battery and six EEG coherence measures in the theta band were compared between the children with ASD and normal children. Results indicated that children with ASD performed at comparable levels with normal children in the DS and Rey-O, but were significantly poorer in HKLLT and OR. They also exhibited significantly elevated long-range coherences in the fronto-posterior connections involving the left hemisphere (left anterior–left posterior; left anterior–right posterior). Pearson correlation showed significant negative associations between the anterior–posterior EEG coherences and memory performance. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.04.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111

Lymphocyte subset alterations related to executive function deficits and repetitive stereotyped behavior in autism / Yvonne M.Y. HAN in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.486-494 Titre : Lymphocyte subset alterations related to executive function deficits and repetitive stereotyped behavior in autism Type de document : Texte imprimé et/ou numérique Auteurs : Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M.K. LAM, Auteur Année de publication : 2011 Article en page(s) : p.486-494 Langues : Anglais (eng) Mots-clés : Immune-function Neuropsychological-function Autism Index. décimale : PER Périodiques Résumé : Increasing evidence suggests that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASD). The present study examined whether immunological abnormalities are associated with cognitive deficits in children with ASD. Eighteen high-functioning (HFA) and 19 low-functioning (LFA) children with ASD, aged 8–17 years, were assessed on cognitive functioning using IQ tests and executive functions tests including the Five Point test, Children Color Trail-making Test, D2 Test of Concentration, Tower of California Test; Hong Kong List Learning Test, and Go/No-Go test. They were also assessed on autoimmune symptoms, reported by their parents; and immunological measures including T lymphocytes (CD3+), B lymphocytes (CD19+), T helper lymphocytes (CD3+CD4+), suppressor/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) cells (CD3−CD16+ and/or CD56+). LFA children showed greater deficits in executive functions as well as higher levels of total lymphocyte, T lymphocyte and suppressor/cytotoxic T lymphocyte levels than HFA children (all p < 0.05). Their executive functions were also significantly associated with the three lymphocyte levels (all p < 0.05). These findings support the notion that altered immune functions may act on the neural tissues of individuals with ASD, which in turn leads to their cognitive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.06.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 [article] Lymphocyte subset alterations related to executive function deficits and repetitive stereotyped behavior in autism [Texte imprimé et/ou numérique] / Yvonne M.Y. HAN, Auteur ; Agnes S. CHAN, Auteur ; Mei-chun CHEUNG, Auteur ; Winnie Wing-man LEUNG, Auteur ; Chun Kwok WONG, Auteur ; Joseph M.K. LAM, Auteur . - 2011 . - p.486-494. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.486-494 Mots-clés : Immune-function Neuropsychological-function Autism Index. décimale : PER Périodiques Résumé : Increasing evidence suggests that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASD). The present study examined whether immunological abnormalities are associated with cognitive deficits in children with ASD. Eighteen high-functioning (HFA) and 19 low-functioning (LFA) children with ASD, aged 8–17 years, were assessed on cognitive functioning using IQ tests and executive functions tests including the Five Point test, Children Color Trail-making Test, D2 Test of Concentration, Tower of California Test; Hong Kong List Learning Test, and Go/No-Go test. They were also assessed on autoimmune symptoms, reported by their parents; and immunological measures including T lymphocytes (CD3+), B lymphocytes (CD19+), T helper lymphocytes (CD3+CD4+), suppressor/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) cells (CD3−CD16+ and/or CD56+). LFA children showed greater deficits in executive functions as well as higher levels of total lymphocyte, T lymphocyte and suppressor/cytotoxic T lymphocyte levels than HFA children (all p < 0.05). Their executive functions were also significantly associated with the three lymphocyte levels (all p < 0.05). These findings support the notion that altered immune functions may act on the neural tissues of individuals with ASD, which in turn leads to their cognitive dysfunctions. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.06.013 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111

Verbal memory deficits in relation to organization strategy in high- and low-functioning autistic children / Mei-chun CHEUNG in Research in Autism Spectrum Disorders, 4-4 (October-December 2010)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 4-4 (October-December 2010) . - p.764-771 Titre : Verbal memory deficits in relation to organization strategy in high- and low-functioning autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Mei-chun CHEUNG, Auteur ; Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Winnie Wing-man LEUNG, Auteur ; Cho Yee TO, Auteur Année de publication : 2010 Article en page(s) : p.764-771 Langues : Anglais (eng) Mots-clés : Memory  Encoding  Retrieval  Organization  Autism  Children Index. décimale : PER Périodiques Résumé : The present study examined the verbal memory profile and its relation to organizational strategies in high-functioning (Hi-AUT) and low-functioning (Lo-AUT) children with autism. Twenty-two Hi-AUT and 16 Lo-AUT, and 22 age-, gender- and handedness-matched normal children (NC) were required to remember a list of semantically related words for immediate and delayed recall and recognition. All autistic children showed impaired free recall, a reduced discrimination score and an elevated false alarm rate at recognition. While Hi-AUT children showed encoding and retrieval deficit, Lo-AUT children demonstrated more severe encoding problem and an additional retention difficulty. Lo-AUT, but not the Hi-AUT, children showed impaired semantic clustering. The recall performance in autistic children was not as strongly correlated with semantic clustering as in NC. The dual deficits of encoding and retrieval in autistic children, regardless of functioning level, implicate a frontal-lobe problem commonly observed in autism. The additional retention difficulty shown by low-functioning autistic children may be suggestive of pathological temporal-lobe involvement. The present findings may provide insights into future exploration of memory intervention for autistic children. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.02.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=167 [article] Verbal memory deficits in relation to organization strategy in high- and low-functioning autistic children [Texte imprimé et/ou numérique] / Mei-chun CHEUNG, Auteur ; Agnes S. CHAN, Auteur ; Sophia L. SZE, Auteur ; Winnie Wing-man LEUNG, Auteur ; Cho Yee TO, Auteur . - 2010 . - p.764-771. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 4-4 (October-December 2010) . - p.764-771 Mots-clés : Memory  Encoding  Retrieval  Organization  Autism  Children Index. décimale : PER Périodiques Résumé : The present study examined the verbal memory profile and its relation to organizational strategies in high-functioning (Hi-AUT) and low-functioning (Lo-AUT) children with autism. Twenty-two Hi-AUT and 16 Lo-AUT, and 22 age-, gender- and handedness-matched normal children (NC) were required to remember a list of semantically related words for immediate and delayed recall and recognition. All autistic children showed impaired free recall, a reduced discrimination score and an elevated false alarm rate at recognition. While Hi-AUT children showed encoding and retrieval deficit, Lo-AUT children demonstrated more severe encoding problem and an additional retention difficulty. Lo-AUT, but not the Hi-AUT, children showed impaired semantic clustering. The recall performance in autistic children was not as strongly correlated with semantic clustering as in NC. The dual deficits of encoding and retrieval in autistic children, regardless of functioning level, implicate a frontal-lobe problem commonly observed in autism. The additional retention difficulty shown by low-functioning autistic children may be suggestive of pathological temporal-lobe involvement. The present findings may provide insights into future exploration of memory intervention for autistic children. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.02.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=167

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